Large volumetric expansion of cathode hosts and sluggish transport kinetics in the cathode–electrolyte interface,as well as dendrite growth and hydrogen evolution at Zn anode side are considered as the system problem...Large volumetric expansion of cathode hosts and sluggish transport kinetics in the cathode–electrolyte interface,as well as dendrite growth and hydrogen evolution at Zn anode side are considered as the system problems that cause the electrochemical failure of aqueous Zn-vanadium oxide battery.In this work,a multifunctional anti-proton electrolyte was proposed to synchronously solve all those issues.Theoretical and experimental studies confirm that PEG 400 additive can regulate the Zn^(2+) solvation structure and inhibit the ionization of free water molecules of the electrolyte.Then,smaller lattice expansion of vanadium oxide hosts and less associated by-product formation can be realized by using such electrolyte.Besides,such electrolyte is also beneficial to guide the uniform Zn deposition and suppress the side reaction of hydrogen evolution.Owing to the integrated synergetic modifica-tion,a high-rate and ultrastable aqueous Zn-V_(2)O_(3)/C battery can be constructed,which can remain a specific capacity of 222.8 m Ah g^(-1)after 6000 cycles at 5 A g^(-1),and 121.8 m Ah g^(-1) even after 18,000 cycles at 20 A g^(-1),respectively.Such“all-in-one”solution based on the electrolyte design provides a new strategy for developing high-performance aqueous Zn-ion battery.展开更多
Powdery mildew, caused by the biotrophic fungus Blumeria graminis f. sp. tritici(Bgt), is a global disease that poses a serious threat to wheat production. To explore additional resistance gene, a wheatDasypyrum villo...Powdery mildew, caused by the biotrophic fungus Blumeria graminis f. sp. tritici(Bgt), is a global disease that poses a serious threat to wheat production. To explore additional resistance gene, a wheatDasypyrum villosum 1 V#5(1 D) disomic substitution line NAU1813(2 n = 42) with high level of seedling resistance to powdery mildew was used to generate the recombination between chromosomes 1 V#5 and1 D. Four introgression lines, including t1 VS#5 ditelosomic addition line NAU1815, t1 VL#5 ditelosomic addition line NAU1816, homozygous T1 DL·1 VS#5 translocation line NAU1817, and homozygous T1 DS·1 VL#5 translocation line NAU1818 were developed from the selfing progenies of 1 V#5 and 1 D double monosomic line that derived from F1 hybrids of NAU1813/NAU0686. All of them were characterized by fluorescence in situ hybridization, genomic in situ hybridization, 1 V-specific markers analysis, and powdery mildew tests at different developmental stages. A new powdery mildew resistance gene named Pm67 was physically located in the terminal bin(FL 0.70–1.00) of 1 VS#5. Lines with Pm67 exhibited seedling stage immunity and tissue-differentiated reactions at adult plant stage. The sheaths, stems, and spikes of the Pm67 line were still immune, but the leaves showed a low degree of susceptibility.Microscopic observation showed that most penetration attempts were stopped in association with papillae on the sheath, and colonies cannot form conidia on the susceptible leaf of Pm67 line at adult plant stage, suggesting that the defence layers of the Pm67 line is tissue-differentiated. Thus, the T1 DL·1 VS#5 translocation line NAU1817 provides a new germplasm in wheat breeding for improvement of powdery mildew resistance.展开更多
To the Editor:Multiple myeloma(MM)is a plasma cell disorder characterized by heterogeneous features.^([1])Accurate risk stratification could predict diverse prognoses of patients with myeloma and attain risk-adapted t...To the Editor:Multiple myeloma(MM)is a plasma cell disorder characterized by heterogeneous features.^([1])Accurate risk stratification could predict diverse prognoses of patients with myeloma and attain risk-adapted therapy to extend their lifespan.Recently,the European Myeloma Network(EMN)conducted a large retrospective analysis involving more than 7000 patients with myeloma and developed a new risk model defined as the Second Revision of International Staging System(R2-ISS),with excellent risk distribution among patients enrolled in clinical trials.^([2])The R2-ISS stratifications were based on weighted risk scores of different prognostic factors:ISS II 1.0 point,ISS III 1.5 points,del(17p)1.0 point,elevated lactate dehydrogenase(LDH)1.0 point,t(4;14)1.0 point,and 1q21+0.5 points.展开更多
RNA modifications have been involved in numerous biological processes, and aberrations of these modifications are tightly associated with various diseases including cancer. Herein, we developed graphenebased solid-pha...RNA modifications have been involved in numerous biological processes, and aberrations of these modifications are tightly associated with various diseases including cancer. Herein, we developed graphenebased solid-phase extraction and robust ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) combined with stable isotope-dilution for simultaneous enrichment and accurate determination of 17 modified nucleosides in human urine. We found graphene could effectively adsorb various modified nucleosides in human urine samples. With this method, we identified and quantified these modified nucleosides in urine samples collected from lung cancer patients and healthy controls.We revealed that the levels of 12 modified nucleosides were all diminished in urine from lung cancer patients, compared with healthy controls. It is worth noting that we demonstrated, for the first time, the presence of 5,2-O-dimethyluridine(m~5U_m) in human urine. Together, we established a robust analytical method for simultaneous determinations of 17 modified nucleosides in human urine, and our results revealed a close correlation between the concentrations of urinary modified nucleosides and the occurrence of lung cancer, implying the potential applications of these modified nucleosides as noninvasive biomarkers for the early detection of lung cancer. Moreover, this study will stimulate future investigations on the regulatory roles of RNA modifications in the initiation and progression of lung cancer.展开更多
The pathogenesis of portal hypertension remains unclear,and is believed to involve dysfunction of liver sinusoidal endotheli-al cells(LSEC),activation of hepatic stellate cells(HSC),dys-regulation of endogenous hydrog...The pathogenesis of portal hypertension remains unclear,and is believed to involve dysfunction of liver sinusoidal endotheli-al cells(LSEC),activation of hepatic stellate cells(HSC),dys-regulation of endogenous hydrogen sulfide(H_(2)S)synthesis,and hypoxia-induced angiogenic responses.H_(2)S,a novel gas transmitter,plays an important role in various pathophysi-ological processes,especially in hepatic angiogenesis.Inhibi-tion of endogenous H_(2)S synthase by pharmaceutical agents or gene silencing may enhance the angiogenic response of en-dothelial cells.Hypoxia-inducible factor-1(HIF-1)is the main transcription factor of hypoxia,which induces hepatic angio-genesis through up-regulation of vascular endothelial growth factor(VEGF)in HSC and LSEC.H_(2)S has also been shown to be involved in the regulation of VEGF-mediated angiogen-esis.Therefore,H_(2)S and HIF-1 may be potential therapeutic targets for portal hypertension.The effects of H_(2)S donors or prodrugs on the hemodynamics of portal hypertension and the mechanism of H_(2)S-induced angiogenesis are promising areas for future research.展开更多
Although lithium-sulfur batteries(LSBs)exhibit high theoretical energy density,their practical application is hindered by poor conductivity of the sulfur cathode,the shuttle effect,and the irreversible deposition of L...Although lithium-sulfur batteries(LSBs)exhibit high theoretical energy density,their practical application is hindered by poor conductivity of the sulfur cathode,the shuttle effect,and the irreversible deposition of Li_(2)S.To address these issues,a novel composite,using electrospinning technology,consisting of Fe_(3)Se_(4)and porous nitrogen-doped carbon nanofibers was designed for the interlayer of LSBs.The porous carbon nanofiber structure facilitates the transport of ions and electrons,while the Fe_(3)Se_(4)material adsorbs lithium polysulfides(LiPSs)and accelerates its catalytic conversion process.Furthermore,the Fe_(3)Se_(4)material interacts with soluble LiPSs to generate a new polysulfide intermediate,Li_(x)FeS_(y)complex,which changes the electrochemical reaction pathway and facilitates the three-dimensional deposition of Li_(2)S,enhancing the reversibility of LSBs.The designed LSB demonstrates a high specific capacity of1529.6 mA h g^(-1)in the first cycle at 0.2 C.The rate performance is also excellent,maintaining an ultra-high specific capacity of 779.7 mA h g^(-1)at a high rate of 8 C.This investigation explores the mechanism of the interaction between the interlayer and LiPSs,and provides a new strategy to regulate the reaction kinetics and Li_(2)S deposition in LSBs.展开更多
In this study,the hexagonal NaYF_(4):Yb^(3+)/Ho^(3+)/Ce^(3+) microcrystals were synthesized controllably,and upconversion luminescence excited at 940 nm and its application in temperature-responsive anti-counterfeitin...In this study,the hexagonal NaYF_(4):Yb^(3+)/Ho^(3+)/Ce^(3+) microcrystals were synthesized controllably,and upconversion luminescence excited at 940 nm and its application in temperature-responsive anti-counterfeiting are reported.It is clarified that the Ln^(3+)(Ln=Y+Yb+Ho+Ce)density ratio of bottom plane to side plane in the unit cell can be regulated by Ce^(3+) doping.It is also proved that the energy transfer of Yb^(3+) to Ho^(3+) is responsible for the activation of Ho^(3+)under 940 nm excitation,while the cross relaxation between Ho^(3+)and Ce^(3+)participates in the redistribution of electron population of^(5)S_(2)/^(5)F_(4)and^(5)F_(5)levels.Both theory and experiment confirm that the intensity ratio of red to green emission(I_(R)/I_(G))as a function of temperature as an independent variable has good linear characteristics in the temperature range of 300-500 K.Due to the good responsiveness of multicolor luminescence to temperature,the hexagonal NaYF_(4):Yb^(3+)/Ho^(3+)/Ce^(3+) with tunable morphology is a promising candidate for advanced temperature-responsive upconversion anti-counterfeiting.Our results provide a new pathway for the controllable synthesis of hexagonal NaYF_(4)microcrystals as well as the regulation of upconversion luminescence that is excited by wavelengths other than 980 nm and its application in anti-counterfeiting.展开更多
In this work,the hierarchical CoNiO_(2)@CeO_(2)nanosheet composites were successfully prepared by a one-step hydrothermal process with a subsequent annealing process for the first time.The CeO_(2)nanoparticles success...In this work,the hierarchical CoNiO_(2)@CeO_(2)nanosheet composites were successfully prepared by a one-step hydrothermal process with a subsequent annealing process for the first time.The CeO_(2)nanoparticles successfully deposit on the surface of CoNiO_(2)nanosheet,and benefit the improvement of electrical contact between CoNiO_(2)and CeO_(2).CeO_(2)modification improve the reversibility of insertion/extraction of Li-ions and electrochemical reaction activity,and promotes the transport of Li-ions.Benefited of the unique architecture and component,the CoNiO_(2)@CeO_(2)nanosheet composites show high-reversible capacities,excellent cycling stability and good rate capability.The CoNiO_(2)@CeO_(2)(5.0 wt%)shows a charge/discharge capacity of 867.1/843.2 m Ah g^(-1)after 600 cycles at 1 A g^(-1),but the pristine CoNiO_(2)@CeO_(2)nanosheet only delivers a charge/discharge capacity of 516.9/517.6 m Ah g^(-1)after 500 cycles.The first-principles calculation reveals that valid interfaces between CeO_(2)and NiCoO_(2)can be formed,and the formation process of the interfaces is exothermic.The strong interfacial interaction resulting in an excellent structure stability and thus a cycling stability of the CoNiO_(2)@CeO_(2)material.This work provides an effective strategy to develop highperformance anode materials for advanced a lithium-ion battery,and the CoNiO_(2)@CeO_(2)nanosheet shows a sizeable potential as an anode material for next generation of high-energy Li-ion batteries.展开更多
Adoptive cell therapy(ACT)has emerged with remarkable efficacies for tumor immunotherapy.Chimeric antigen receptor(CAR)T cell therapy,as one of most promising ACTs,has achieved prominent effects in treating malignant ...Adoptive cell therapy(ACT)has emerged with remarkable efficacies for tumor immunotherapy.Chimeric antigen receptor(CAR)T cell therapy,as one of most promising ACTs,has achieved prominent effects in treating malignant hematological tumors.However,the insufficient killing activity and limited persistence of T cells in the immunosuppressive tumor microenvironment limit the further application of ACTs for cancer patients.Many studies have focused on improving cytotoxicity and persistence of T cells to achieve improved therapeutic effects.In this study,we explored the potential function in ACT of ginsenoside Rg1,the main pharmacologically active component of ginseng.We introduced Rg1 during the in vitro activation and expansion phase of T cells,and found that Rg1 treatment upregulated two T cell activation markers,CD69 and CD25,while promoting T cell differentiation towards a mature state.Transcriptome sequencing revealed that Rg1 influenced T cell metabolic reprogramming by strengthening mitochondrial biosynthesis.When co-cultured with tumor cells,Rg1-treated T cells showed stronger cytotoxicity than untreated cells.Moreover,adding Rg1 to the culture endowed CAR-T cells with enhanced anti-tumor efficacy.This study suggests that ginsenoside Rg1 provides a potential approach for improving the anti-tumor efficacy of ACT by enhancing T cell effector functions.展开更多
A Fe_(2)O_(3)-MWNTs(multi-walled carbon nanotubes)composite with a reinforced concrete structure was fabricated employing a two-step method which involves a sol-gel process followed by high-temperature in situ sinteri...A Fe_(2)O_(3)-MWNTs(multi-walled carbon nanotubes)composite with a reinforced concrete structure was fabricated employing a two-step method which involves a sol-gel process followed by high-temperature in situ sintering.This Fe_(2)O_(3)-MWNTs composite,intended to be used as an anode material for lithium-ion batteries,maintained a reversible capacity as high as 896.3 mA·h/g after 100 cycles at a current density of 100 mA/g and the initial coulombic efficiency reached 75.5%.The rate capabilities of the Fe_(2)O_(3)-MWNTs composite,evaluated using the ratios of capacity at 100,200,500,1000,2000 and 100 mA/g after every 10 cycles,were determined to be 904.7,852.1,759.0,653.8,566.8 and 866.3 mA·h/g,respectively.Such a superior electrochemical performance of the Fe_(2)O_(3)-MWNTs composite is mainly attributed to the reinforced concrete construction,in which the MWNTs function as the skeleton and conductive network.Such a structure contributes to shortening the transport pathways for both Li+and electrons,enhancing conductivity and accommodating volume expansion during prolonged cycling.This Fe_(2)O_(3)-MWNTs composite with the designed structure is a promising anode material for high-performance lithium-ion batteries.展开更多
Hybrid CuO-Co_(3)O_(4)nanosphere building blocks have been embedded between the layered nanosheets of reduced graphene oxides with a three dimensional(3D)hybrid architecture(CuO-Co_(3)O_(4)-RGO),which are successfully...Hybrid CuO-Co_(3)O_(4)nanosphere building blocks have been embedded between the layered nanosheets of reduced graphene oxides with a three dimensional(3D)hybrid architecture(CuO-Co_(3)O_(4)-RGO),which are successfully applied as enhanced anodes for lithium-ion batteries(LIBs).The CuO-Co_(3)O_(4)-RGO sandwiched nanostructures exhibit a reversible capacity of~847 mA·h·g^(-1)after 200 cycles’cycling at 100 mA·g^(-1)with a capacity retention of 79%.The CuO-Co_(3)O_(4)-RGO compounds show superior electrochemical properties than the comparative CuO-Co_(3)O_(4),Co_(3)O_(4)and CuO anodes,which may be ascribed to the following reasons:the hybridizing multicomponent can probably give the complementary advantages;the mutual benefit of uniformly distributing nanospheres across the layered RGO nanosheets can avoid the agglomeration of both the RGO nanosheets and the CuO-Co_(3)O_(4) nanospheres;the 3D storage structure as well as the graphene wrapped composite could enhance the electrical conductivity and reduce volume expansion effect associated with the discharge-charge process.展开更多
Influenza virus (IAV)infection is a major cause of severe respiratory illness that affects almost every country in the world.IAV infections result in respiratory illness and even acute lung injury and death,but the un...Influenza virus (IAV)infection is a major cause of severe respiratory illness that affects almost every country in the world.IAV infections result in respiratory illness and even acute lung injury and death,but the underlying mechanisms responsible for IAV pathogenesis have not yet been fully elucidated.In this study,the basic fibroblast growth factor 2 (FGF2)level was markedly increased in H1N1 virus-infected humans and mice.FGF2,which is predominately derived from epithelial cells,recruits and activates neutrophils via the FGFR2-PI3K-AKT-NFKB signaling pathway.FGF2 depletion or knockout exacerbated influenzaassociated disease by impairing neutrophil recruitment and activation.More importantly,administration of the recombinant FGF2 protein significantly aUeviated the severity of IAV-induced lung injury and promoted the survival of IAV-infected mice.Based on the results from experiments in which neutrophils were depleted and adoptively transferred,FGF2 protected mice against IAV , infection by recruiting neutrophils.Thus,FGF2 plays a critical role in preventing IAV-induced lung injury,and FGF2 is a promising potential therapeutic target during IAV infection.展开更多
Aging is accompanied by the decline of organismal functions and a series of prominent hallmarks,including genetic and epigenetic alterations.These aging-associated epigenetic changes include DNA methylation,histone mo...Aging is accompanied by the decline of organismal functions and a series of prominent hallmarks,including genetic and epigenetic alterations.These aging-associated epigenetic changes include DNA methylation,histone modification,chromatin remodeling,non-coding RNA(ncRNA)regulation,and RNA modification,all of which participate in the regulation of the aging process,and hence contribute to aging-related diseases.Therefore,understanding the epigenetic mechanisms in aging will provide new avenues to develop strategies to delay aging.Indeed,aging interventions based on manipulating epigenetic mechanisms have led to the alleviation of aging or the extension of the lifespan in animal models.Small molecule-based therapies and reprogramming strategies that enable epigenetic rejuvenation have been developed for ameliorating or reversing aging-related conditions.In addition,adopting health-promoting activities,such as caloric restriction,exercise,and calibrating circadian rhythm,has been demonstrated to delay aging.Furthermore,various clinical trials for aging intervention are ongoing,providing more evidence of the safety and efficacy of these therapies.Here,we review recent work on the epigenetic regulation of aging and outline the advances in intervention strategies for aging and age-associated diseases.A better understanding of the critical roles of epigenetics in the aging process will lead to more clinical advances in the prevention of human aging and therapy of aging-related diseases.展开更多
MgSO4 is chosen as an additive to address the capacity fading issue in the rechargeable zinc-ion battery system of MgxV2O5·nH2O//ZnSO4//zinc.Electrolytes with different concentration ratios of ZnSO4 and MgSO4 are...MgSO4 is chosen as an additive to address the capacity fading issue in the rechargeable zinc-ion battery system of MgxV2O5·nH2O//ZnSO4//zinc.Electrolytes with different concentration ratios of ZnSO4 and MgSO4 are investigated.The batteries measured in the 1 M ZnSO4^-1 M MgSO4 electrolyte outplay other competitors,which deliver a high specific capacity of 374 mAh g^-1 at a current density of 100 mA g^-1 and exhibit a competitive rate performance with the reversible capacity of 175 mAh g^-1 at 5 A g^-1.This study provides a promising route to improve the performance of vanadium-based cathodes for aqueous zinc-ion batteries with electrolyte optimization in cost-effective electrolytes.展开更多
Lonicerae japonicaeFlos (LJF) is widely used in traditional Chinese medicines for the treatment of various diseases, which is now in great demand every year and has a broad development prospect. However, the flowering...Lonicerae japonicaeFlos (LJF) is widely used in traditional Chinese medicines for the treatment of various diseases, which is now in great demand every year and has a broad development prospect. However, the flowering phase of common LJF varieties is so short, which seriously restricts the development of LJF industry. As a new cultivated kind of Lonicerae japonicae Flos, “Hua Jin 6” has characteristics in long flowering phase and conveniently picking, which makes it have a broad development prospect. The aim of this study is to provide scientific guidance for its suitable harvest period by measuring yield and quality of “Hua Jin 6” from different harvest time. Studies show that flower size had a slowly rising trend from the first day to the seventh day, and then slowly declined or kept stable. There were no significant differences of total phenolic acid contents in different samples from different days, but contents of total flavonoids were on the rise and up to maximum in the ninth day. The contents of total iridoids had an increasing tendency from the first day to the fifth day and then kept relatively stable in other days. We demonstrated that the quality of “Hua Jin 6” is relatively stable and suitable for harvesting in all flower buds white stage in term of HPLC fingerprints. Our findings can make it possible to select the suitable time for different harvest purpose.展开更多
The ground penetrating radar （GPR） detection data is a wide band signal, always disturbed by some noise, such as ambient random noise and muhiple refleetion waves. The noise affects the target identification of unde...The ground penetrating radar （GPR） detection data is a wide band signal, always disturbed by some noise, such as ambient random noise and muhiple refleetion waves. The noise affects the target identification of underground medium seriously. A method based on principal component analysis （PCA） was proposed to ex- tract the target signal and remove the uncorrelated noise. According to the correlation of signal, the authors get the eigenvalues and corresponding eigenvectors by decomposing the covariance matrix of GPR data and make linear transformation for the GPR data to get the principal components （PCs）. The lower-order PCs stand h^r the strong correlated target signals of the raw data, and the higher-order ones present the uneorrelated noise. Thus the authors can extract the target signal and filter uncorrelated noise effectively by the PCA. This method was demonstrated on real ultra-wideband through-wall radar data and simulated GPR data. Both of the results show that the PCA method can effectively extract the GPR target signal and remove the uncorrelated noise.展开更多
The in vivo degradation behavior of metallic nanoparticles(NPs) is very important for their biomedical applications and safety evaluation.Here,a method of laser ablation-single particle inductively coupled plasma mass...The in vivo degradation behavior of metallic nanoparticles(NPs) is very important for their biomedical applications and safety evaluation.Here,a method of laser ablation-single particle inductively coupled plasma mass spectrometry(LA-sp-ICP-MS) is shown to have high spatial resolution,sensitivity and accuracy for simultaneous imaging the in situ distribution of particulate Ag(P-Ag) and released ionic Ag(IonAg) in the sub-organs of spleen,liver and kidney after intravenous injection of Ag nanoparticles(50 nm,AgNPs) to mice.Under the optimized parameters of 0.4 J/cm^(2) laser fluence on a 30 μm spot with dwell time at 100 μs,the signals of P-Ag and Ion-Ag in the organic tissues can be easily distinguished from the mass spectra.The method of iterative threshold algorithm has been used to distract the signals of P-Ag and Ion-Ag and separate each other.The resulting images for the first time provide visualized evidence that a considerable amount of P-Ag accumulated in the splenic marginal zone,but widely distributed in the liver parenchyma at 24 h after injection of AgNPs,and in the meantime,obvious amounts of ionic Ag released and distributed in the organs.In addition,the imaging results indicate that the AgNP excretion in the kidney is mainly in ionic forms.The investigation here demonstrates that the developed LA-sp-ICPMS method with high spatial resolution,sensitivity and visualization capability can become a powerful tool in the clinical context of metallic NPs.展开更多
Nitrogen-doped mesoporous carbon material was prepared via a simple one-step thermolysis method via the carbonization of ionic liquid, 1-cyanomethyl-3-methylimidazolium bis（trifluoromethylsulfonyl）imide （[MCNIm]^＋...Nitrogen-doped mesoporous carbon material was prepared via a simple one-step thermolysis method via the carbonization of ionic liquid, 1-cyanomethyl-3-methylimidazolium bis（trifluoromethylsulfonyl）imide （[MCNIm]^＋[Nf2T]^-）. The nanostructure of the resultant carbon material was characterized by X-ray diffraction（XRD） and transmission electron microscopy（TEM） and the types of N-containing groups of the carbon material were investigated by X-ray photoelectron spectroscopy（XPS）. The N-content of the carbon material is 18.6%（mass fraction） based on the elemental analysis. The produced mesoporous carbon material was further used as the solid sorbent for H2 and CO2. The hydrogen uptake capacity and H2 isosteric heat of the carbon material were discussed. Furthermore, the nitrogen-containing carbon material as good sorbent shows relatively high adsorption and separation ability for CO2 from CH4, for which the heat of CO2 adsorption（Qst） is 31.8 kJ/mol. The mesoporous structure and nitrogen functionality make the carbon material with high adsorption capacity and selectivity for CO2 and ability to store Ha, indicating that this kind of nitrogen-doped carbon material originated from ionic liquids is a promising sorbent material for high-performance separation and adsorption.展开更多
Objective:The ulcerative colitis endoscopic index of severity(UCEIS)and the Mayo endoscopic score(MES)are developed as objective methods of evaluating endoscopic severity in patients with ulcerative colitis(UC).The ai...Objective:The ulcerative colitis endoscopic index of severity(UCEIS)and the Mayo endoscopic score(MES)are developed as objective methods of evaluating endoscopic severity in patients with ulcerative colitis(UC).The aim of this study is to investigate the diagnostic accuracy of the UCEIS and MES in predicting the patient's response to mesalazine.Methods:Consecutive patients with UC who had undergone colonoscopy within 1 month before starting mesalazine between October 2011 and July 2016 were retrospectively collected at the Department of Gastroenterology,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine.The median follow-up was 81 months,and all the data were analyzed in January 2021.The primary outcome was the need for step-up treatment,which included the use of corticosteroids,immunomodulatory,or surgery during admission and follow-up.Data were analyzed using the c2 or Fisher exact test,Spearman test,t-test,and ManneWhitney U test.Results:Totally,65 patients were enrolled,of whom 12(18.5%)needed step-up treatment due to nonresponse to mesalazine.The UCEIS score,MES,and the ulcerative colitis disease activity index(UCDAI)score were significantly higher in patients who had nonresponse to mesalazine(UCEIS score:6.92±0.69 vs.4.45±1.17,p<0.001;MES:2.67±0.49 vs.2.15±0.69,p=0.024;UCDAI score:9.33±1.87 vs.6.70±2.38,p=0.002).In the multivariate analysis,the UCEIS score(OR=25.65,95%CI:3.048 e45.985,p=0.003),UCDAI score(OR=1.605,95%CI:1.144e2.254,p=0.006),and C-reactive protein level(OR=1.056,95%CI:1.006e1.108,p=0.026)were independent risk factors of nonresponse.The area under the ROC curve of UCEIS was 0.95,with a sensitivity of 100%and specificity of 84.6%,a cut-off value of 6,which outperformed the MES with an area under the ROC curve of 0.70.When the UCEIS score≥6,60%of patients eventually needed step-up treatment.Conclusions:The UCEIS is a useful instrument for predicting the therapeutic effect in patients with UC treated with mesalazine.The high probability of mesalazine treatment failure and b展开更多
In the long-running of sulphur hexafluoride(SF_(6))-insulated equipment,SF_(6) inevitably decomposes to various decomposition products under electric discharge,including SOF_(2) and SO2F_(2).In this work,single Pt mod...In the long-running of sulphur hexafluoride(SF_(6))-insulated equipment,SF_(6) inevitably decomposes to various decomposition products under electric discharge,including SOF_(2) and SO2F_(2).In this work,single Pt modified molybdenum disulphide(Pt-MoS_(2))monolayer,and double Pt modified molybdenum disulphide(Pt_(2)-MoS_(2))monolayer are proposed to analyse its adsorption and sensing properties to SOF_(2) and SO2F_(2) with single and double gas molecules adsorption based on density functional theory.The adsorption energy,density of states,and molecular orbit theory are employed to analyse the adsorption and sensing mechanism.It turns out that the Pt-MoS_(2) and Pt_(2)-MoS_(2) present outstanding adsorption capacity to gas molecules.Specifically,double SOF_(2) adsorption on Pt_(2)-MoS_(2) shows the best adsorption performance,and the conductivity of the adsorption system changes the most in the adsorption process.Overall,both Pt-MoS_(2) and Pt_(2)-MoS_(2) perform as an excellent gas sensor.This study provides a theoretical basis to develop Pt-MoS_(2) and Pt_(2)-MoS_(2) based materials for SOF_(2) and SO2F_(2) detection in SF_(6)-insulated equipment.展开更多
基金financially supported by the National Natural Science Foundation of China(Nos.22178221,51774203)Shenzhen Science and Technology Program(Nos.JCYJ20200109105805902,JCYJ20200109105801725)+1 种基金Natural Science Foundation of Guangdong Province(Nos.2021A1515110751)China Postdoctoral Science Foundation(Nos.2021M702255)。
文摘Large volumetric expansion of cathode hosts and sluggish transport kinetics in the cathode–electrolyte interface,as well as dendrite growth and hydrogen evolution at Zn anode side are considered as the system problems that cause the electrochemical failure of aqueous Zn-vanadium oxide battery.In this work,a multifunctional anti-proton electrolyte was proposed to synchronously solve all those issues.Theoretical and experimental studies confirm that PEG 400 additive can regulate the Zn^(2+) solvation structure and inhibit the ionization of free water molecules of the electrolyte.Then,smaller lattice expansion of vanadium oxide hosts and less associated by-product formation can be realized by using such electrolyte.Besides,such electrolyte is also beneficial to guide the uniform Zn deposition and suppress the side reaction of hydrogen evolution.Owing to the integrated synergetic modifica-tion,a high-rate and ultrastable aqueous Zn-V_(2)O_(3)/C battery can be constructed,which can remain a specific capacity of 222.8 m Ah g^(-1)after 6000 cycles at 5 A g^(-1),and 121.8 m Ah g^(-1) even after 18,000 cycles at 20 A g^(-1),respectively.Such“all-in-one”solution based on the electrolyte design provides a new strategy for developing high-performance aqueous Zn-ion battery.
基金supported by the National Natural Science Foundation of China(31971938)the Natural Science Foundation of Jiangsu Province(BK20181316)+1 种基金the Special Fund for Independent Innovation of Agricultural Science and Technology in Jiangsu,China(CX(19)1001)Fundamental Research Funds for the Central Universities(KYZ201809)。
文摘Powdery mildew, caused by the biotrophic fungus Blumeria graminis f. sp. tritici(Bgt), is a global disease that poses a serious threat to wheat production. To explore additional resistance gene, a wheatDasypyrum villosum 1 V#5(1 D) disomic substitution line NAU1813(2 n = 42) with high level of seedling resistance to powdery mildew was used to generate the recombination between chromosomes 1 V#5 and1 D. Four introgression lines, including t1 VS#5 ditelosomic addition line NAU1815, t1 VL#5 ditelosomic addition line NAU1816, homozygous T1 DL·1 VS#5 translocation line NAU1817, and homozygous T1 DS·1 VL#5 translocation line NAU1818 were developed from the selfing progenies of 1 V#5 and 1 D double monosomic line that derived from F1 hybrids of NAU1813/NAU0686. All of them were characterized by fluorescence in situ hybridization, genomic in situ hybridization, 1 V-specific markers analysis, and powdery mildew tests at different developmental stages. A new powdery mildew resistance gene named Pm67 was physically located in the terminal bin(FL 0.70–1.00) of 1 VS#5. Lines with Pm67 exhibited seedling stage immunity and tissue-differentiated reactions at adult plant stage. The sheaths, stems, and spikes of the Pm67 line were still immune, but the leaves showed a low degree of susceptibility.Microscopic observation showed that most penetration attempts were stopped in association with papillae on the sheath, and colonies cannot form conidia on the susceptible leaf of Pm67 line at adult plant stage, suggesting that the defence layers of the Pm67 line is tissue-differentiated. Thus, the T1 DL·1 VS#5 translocation line NAU1817 provides a new germplasm in wheat breeding for improvement of powdery mildew resistance.
基金supported by the National Natural Science Foundation of China(Nos.81920108006,82270218)the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(Nos.2021-I2M-1-041,2022-I2M-1-022).
文摘To the Editor:Multiple myeloma(MM)is a plasma cell disorder characterized by heterogeneous features.^([1])Accurate risk stratification could predict diverse prognoses of patients with myeloma and attain risk-adapted therapy to extend their lifespan.Recently,the European Myeloma Network(EMN)conducted a large retrospective analysis involving more than 7000 patients with myeloma and developed a new risk model defined as the Second Revision of International Staging System(R2-ISS),with excellent risk distribution among patients enrolled in clinical trials.^([2])The R2-ISS stratifications were based on weighted risk scores of different prognostic factors:ISS II 1.0 point,ISS III 1.5 points,del(17p)1.0 point,elevated lactate dehydrogenase(LDH)1.0 point,t(4;14)1.0 point,and 1q21+0.5 points.
基金financially supported by National Natural Science Foundation of China (No.22176167)Fundamental Research Funds for the Central Universities (No.226-2023-00088)Key R&D Program of Zhejiang Province (No.2021C03125)。
文摘RNA modifications have been involved in numerous biological processes, and aberrations of these modifications are tightly associated with various diseases including cancer. Herein, we developed graphenebased solid-phase extraction and robust ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) combined with stable isotope-dilution for simultaneous enrichment and accurate determination of 17 modified nucleosides in human urine. We found graphene could effectively adsorb various modified nucleosides in human urine samples. With this method, we identified and quantified these modified nucleosides in urine samples collected from lung cancer patients and healthy controls.We revealed that the levels of 12 modified nucleosides were all diminished in urine from lung cancer patients, compared with healthy controls. It is worth noting that we demonstrated, for the first time, the presence of 5,2-O-dimethyluridine(m~5U_m) in human urine. Together, we established a robust analytical method for simultaneous determinations of 17 modified nucleosides in human urine, and our results revealed a close correlation between the concentrations of urinary modified nucleosides and the occurrence of lung cancer, implying the potential applications of these modified nucleosides as noninvasive biomarkers for the early detection of lung cancer. Moreover, this study will stimulate future investigations on the regulatory roles of RNA modifications in the initiation and progression of lung cancer.
基金the National Natural Science Foundation(81970525)Sino-German Coopera-tion Group(GZ1517).
文摘The pathogenesis of portal hypertension remains unclear,and is believed to involve dysfunction of liver sinusoidal endotheli-al cells(LSEC),activation of hepatic stellate cells(HSC),dys-regulation of endogenous hydrogen sulfide(H_(2)S)synthesis,and hypoxia-induced angiogenic responses.H_(2)S,a novel gas transmitter,plays an important role in various pathophysi-ological processes,especially in hepatic angiogenesis.Inhibi-tion of endogenous H_(2)S synthase by pharmaceutical agents or gene silencing may enhance the angiogenic response of en-dothelial cells.Hypoxia-inducible factor-1(HIF-1)is the main transcription factor of hypoxia,which induces hepatic angio-genesis through up-regulation of vascular endothelial growth factor(VEGF)in HSC and LSEC.H_(2)S has also been shown to be involved in the regulation of VEGF-mediated angiogen-esis.Therefore,H_(2)S and HIF-1 may be potential therapeutic targets for portal hypertension.The effects of H_(2)S donors or prodrugs on the hemodynamics of portal hypertension and the mechanism of H_(2)S-induced angiogenesis are promising areas for future research.
基金financially supported by the National Natural Science Foundation of China(No.22372103)Guangdong Basic and Applied Basic Research Foundation,China(2021A1515010241,2024A1515010032)the Shenzhen Science and Technology Foundation,China(JCYJ20220531103216037)。
文摘Although lithium-sulfur batteries(LSBs)exhibit high theoretical energy density,their practical application is hindered by poor conductivity of the sulfur cathode,the shuttle effect,and the irreversible deposition of Li_(2)S.To address these issues,a novel composite,using electrospinning technology,consisting of Fe_(3)Se_(4)and porous nitrogen-doped carbon nanofibers was designed for the interlayer of LSBs.The porous carbon nanofiber structure facilitates the transport of ions and electrons,while the Fe_(3)Se_(4)material adsorbs lithium polysulfides(LiPSs)and accelerates its catalytic conversion process.Furthermore,the Fe_(3)Se_(4)material interacts with soluble LiPSs to generate a new polysulfide intermediate,Li_(x)FeS_(y)complex,which changes the electrochemical reaction pathway and facilitates the three-dimensional deposition of Li_(2)S,enhancing the reversibility of LSBs.The designed LSB demonstrates a high specific capacity of1529.6 mA h g^(-1)in the first cycle at 0.2 C.The rate performance is also excellent,maintaining an ultra-high specific capacity of 779.7 mA h g^(-1)at a high rate of 8 C.This investigation explores the mechanism of the interaction between the interlayer and LiPSs,and provides a new strategy to regulate the reaction kinetics and Li_(2)S deposition in LSBs.
基金Project supported by the National Natural Science Foundation of China(11575059)Natural Science Foundation of Huzhou City(2018YZ08)。
文摘In this study,the hexagonal NaYF_(4):Yb^(3+)/Ho^(3+)/Ce^(3+) microcrystals were synthesized controllably,and upconversion luminescence excited at 940 nm and its application in temperature-responsive anti-counterfeiting are reported.It is clarified that the Ln^(3+)(Ln=Y+Yb+Ho+Ce)density ratio of bottom plane to side plane in the unit cell can be regulated by Ce^(3+) doping.It is also proved that the energy transfer of Yb^(3+) to Ho^(3+) is responsible for the activation of Ho^(3+)under 940 nm excitation,while the cross relaxation between Ho^(3+)and Ce^(3+)participates in the redistribution of electron population of^(5)S_(2)/^(5)F_(4)and^(5)F_(5)levels.Both theory and experiment confirm that the intensity ratio of red to green emission(I_(R)/I_(G))as a function of temperature as an independent variable has good linear characteristics in the temperature range of 300-500 K.Due to the good responsiveness of multicolor luminescence to temperature,the hexagonal NaYF_(4):Yb^(3+)/Ho^(3+)/Ce^(3+) with tunable morphology is a promising candidate for advanced temperature-responsive upconversion anti-counterfeiting.Our results provide a new pathway for the controllable synthesis of hexagonal NaYF_(4)microcrystals as well as the regulation of upconversion luminescence that is excited by wavelengths other than 980 nm and its application in anti-counterfeiting.
基金financially supported by the National Natural Science Foundation of China(nos.U1960107 and 21773060)Key Program for International S&T Cooperation Projects of China(no.2017YFE0124300)the Fundamental Research Funds for the Central Universities(no.N182304014)
文摘In this work,the hierarchical CoNiO_(2)@CeO_(2)nanosheet composites were successfully prepared by a one-step hydrothermal process with a subsequent annealing process for the first time.The CeO_(2)nanoparticles successfully deposit on the surface of CoNiO_(2)nanosheet,and benefit the improvement of electrical contact between CoNiO_(2)and CeO_(2).CeO_(2)modification improve the reversibility of insertion/extraction of Li-ions and electrochemical reaction activity,and promotes the transport of Li-ions.Benefited of the unique architecture and component,the CoNiO_(2)@CeO_(2)nanosheet composites show high-reversible capacities,excellent cycling stability and good rate capability.The CoNiO_(2)@CeO_(2)(5.0 wt%)shows a charge/discharge capacity of 867.1/843.2 m Ah g^(-1)after 600 cycles at 1 A g^(-1),but the pristine CoNiO_(2)@CeO_(2)nanosheet only delivers a charge/discharge capacity of 516.9/517.6 m Ah g^(-1)after 500 cycles.The first-principles calculation reveals that valid interfaces between CeO_(2)and NiCoO_(2)can be formed,and the formation process of the interfaces is exothermic.The strong interfacial interaction resulting in an excellent structure stability and thus a cycling stability of the CoNiO_(2)@CeO_(2)material.This work provides an effective strategy to develop highperformance anode materials for advanced a lithium-ion battery,and the CoNiO_(2)@CeO_(2)nanosheet shows a sizeable potential as an anode material for next generation of high-energy Li-ion batteries.
基金supported by the National Natural Science Foundation of China(No.82020108004 and 81873424)the Natural Science Foundation of Chongqing,China(No.CSTB2022NSCQ-MSX1287)+2 种基金Special Funding for the Frontiers of Military Medical Basics(No.2018YQYLY002)Key Technical Innovation Projects in Clinical Fields of Xinqiao Hospital(No.2018JSLC0020)the Young Doctor Talent Incubation Program of Xinqiao Hospital(No.2022YQB016).
文摘Adoptive cell therapy(ACT)has emerged with remarkable efficacies for tumor immunotherapy.Chimeric antigen receptor(CAR)T cell therapy,as one of most promising ACTs,has achieved prominent effects in treating malignant hematological tumors.However,the insufficient killing activity and limited persistence of T cells in the immunosuppressive tumor microenvironment limit the further application of ACTs for cancer patients.Many studies have focused on improving cytotoxicity and persistence of T cells to achieve improved therapeutic effects.In this study,we explored the potential function in ACT of ginsenoside Rg1,the main pharmacologically active component of ginseng.We introduced Rg1 during the in vitro activation and expansion phase of T cells,and found that Rg1 treatment upregulated two T cell activation markers,CD69 and CD25,while promoting T cell differentiation towards a mature state.Transcriptome sequencing revealed that Rg1 influenced T cell metabolic reprogramming by strengthening mitochondrial biosynthesis.When co-cultured with tumor cells,Rg1-treated T cells showed stronger cytotoxicity than untreated cells.Moreover,adding Rg1 to the culture endowed CAR-T cells with enhanced anti-tumor efficacy.This study suggests that ginsenoside Rg1 provides a potential approach for improving the anti-tumor efficacy of ACT by enhancing T cell effector functions.
基金National Natural Science Foundation of China(Nos.21471100,21704066)Guangdong Basic and Applied Basic Research Foundation,China(No.2021A1515010241)Shenzhen Natural Science Fund,China(the Stable Support Plan Program)(No.20200813081943001).
文摘A Fe_(2)O_(3)-MWNTs(multi-walled carbon nanotubes)composite with a reinforced concrete structure was fabricated employing a two-step method which involves a sol-gel process followed by high-temperature in situ sintering.This Fe_(2)O_(3)-MWNTs composite,intended to be used as an anode material for lithium-ion batteries,maintained a reversible capacity as high as 896.3 mA·h/g after 100 cycles at a current density of 100 mA/g and the initial coulombic efficiency reached 75.5%.The rate capabilities of the Fe_(2)O_(3)-MWNTs composite,evaluated using the ratios of capacity at 100,200,500,1000,2000 and 100 mA/g after every 10 cycles,were determined to be 904.7,852.1,759.0,653.8,566.8 and 866.3 mA·h/g,respectively.Such a superior electrochemical performance of the Fe_(2)O_(3)-MWNTs composite is mainly attributed to the reinforced concrete construction,in which the MWNTs function as the skeleton and conductive network.Such a structure contributes to shortening the transport pathways for both Li+and electrons,enhancing conductivity and accommodating volume expansion during prolonged cycling.This Fe_(2)O_(3)-MWNTs composite with the designed structure is a promising anode material for high-performance lithium-ion batteries.
基金financially supported by the National Natural Science Foundation of China (21471100, 22005199)the Shenzhen Natural Science Fundation (20200813081943001)the Natural Science Foundation of Guangdong Province,China(2021A1515010241, 2021A1515010142)
文摘Hybrid CuO-Co_(3)O_(4)nanosphere building blocks have been embedded between the layered nanosheets of reduced graphene oxides with a three dimensional(3D)hybrid architecture(CuO-Co_(3)O_(4)-RGO),which are successfully applied as enhanced anodes for lithium-ion batteries(LIBs).The CuO-Co_(3)O_(4)-RGO sandwiched nanostructures exhibit a reversible capacity of~847 mA·h·g^(-1)after 200 cycles’cycling at 100 mA·g^(-1)with a capacity retention of 79%.The CuO-Co_(3)O_(4)-RGO compounds show superior electrochemical properties than the comparative CuO-Co_(3)O_(4),Co_(3)O_(4)and CuO anodes,which may be ascribed to the following reasons:the hybridizing multicomponent can probably give the complementary advantages;the mutual benefit of uniformly distributing nanospheres across the layered RGO nanosheets can avoid the agglomeration of both the RGO nanosheets and the CuO-Co_(3)O_(4) nanospheres;the 3D storage structure as well as the graphene wrapped composite could enhance the electrical conductivity and reduce volume expansion effect associated with the discharge-charge process.
基金funding from the National High Technology Research and Development Program of China (SS2015AA020924)the National Natural Science Foundation of China (81771700)+2 种基金the Ministry of Science and Technology of China (2013ZXI0004003 and SS2012AA020905)the National Major Research and Development Program (2016YFA0502203 and 2017YFC1200800)P.Y.was supported by the Beijing Nova Program (Z141107001814054).
文摘Influenza virus (IAV)infection is a major cause of severe respiratory illness that affects almost every country in the world.IAV infections result in respiratory illness and even acute lung injury and death,but the underlying mechanisms responsible for IAV pathogenesis have not yet been fully elucidated.In this study,the basic fibroblast growth factor 2 (FGF2)level was markedly increased in H1N1 virus-infected humans and mice.FGF2,which is predominately derived from epithelial cells,recruits and activates neutrophils via the FGFR2-PI3K-AKT-NFKB signaling pathway.FGF2 depletion or knockout exacerbated influenzaassociated disease by impairing neutrophil recruitment and activation.More importantly,administration of the recombinant FGF2 protein significantly aUeviated the severity of IAV-induced lung injury and promoted the survival of IAV-infected mice.Based on the results from experiments in which neutrophils were depleted and adoptively transferred,FGF2 protected mice against IAV , infection by recruiting neutrophils.Thus,FGF2 plays a critical role in preventing IAV-induced lung injury,and FGF2 is a promising potential therapeutic target during IAV infection.
基金National Key Research and Development Program of China(2020YFA0804000)Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16010000)+5 种基金CAS Project for Young Scientists in Basic Research(YSBR-076,YSBR-012)National Natural Science Foundation of China(81921006,92149301,92168201,92049116,32121001,82100140,31970597)National Key Research and Development Program of China(2020YFA08034012019YFA0802202)Program of the Beijing Natural Science Foundation(Z190019)Tencent Foundation(2021–1045),K.C.Wong Education Foundation(GJTD-2019-08),Youth Innovation Promotion Association of CAS(E1CAZW0401)Science&Technology Innovation 2030 of The Ministry of Science and Technology of China(2022ZD0214200).
文摘Aging is accompanied by the decline of organismal functions and a series of prominent hallmarks,including genetic and epigenetic alterations.These aging-associated epigenetic changes include DNA methylation,histone modification,chromatin remodeling,non-coding RNA(ncRNA)regulation,and RNA modification,all of which participate in the regulation of the aging process,and hence contribute to aging-related diseases.Therefore,understanding the epigenetic mechanisms in aging will provide new avenues to develop strategies to delay aging.Indeed,aging interventions based on manipulating epigenetic mechanisms have led to the alleviation of aging or the extension of the lifespan in animal models.Small molecule-based therapies and reprogramming strategies that enable epigenetic rejuvenation have been developed for ameliorating or reversing aging-related conditions.In addition,adopting health-promoting activities,such as caloric restriction,exercise,and calibrating circadian rhythm,has been demonstrated to delay aging.Furthermore,various clinical trials for aging intervention are ongoing,providing more evidence of the safety and efficacy of these therapies.Here,we review recent work on the epigenetic regulation of aging and outline the advances in intervention strategies for aging and age-associated diseases.A better understanding of the critical roles of epigenetics in the aging process will lead to more clinical advances in the prevention of human aging and therapy of aging-related diseases.
基金the National Natural Science Foundation of China(Grant Nos.51602200,61874074)Science and Technology Project of Shenzhen(JCYJ20170817101100705)the(Key)Project of Department of Education of Guangdong Province(Grant No.2016KZDXM008).Y.Z.thanks the support from Science and Technology Project of Shenzhen(ZDSYS201707271014468).L.S.thanks the support from Shenzhen Science and Technology Project Program(JCYJ20170817094552356).
文摘MgSO4 is chosen as an additive to address the capacity fading issue in the rechargeable zinc-ion battery system of MgxV2O5·nH2O//ZnSO4//zinc.Electrolytes with different concentration ratios of ZnSO4 and MgSO4 are investigated.The batteries measured in the 1 M ZnSO4^-1 M MgSO4 electrolyte outplay other competitors,which deliver a high specific capacity of 374 mAh g^-1 at a current density of 100 mA g^-1 and exhibit a competitive rate performance with the reversible capacity of 175 mAh g^-1 at 5 A g^-1.This study provides a promising route to improve the performance of vanadium-based cathodes for aqueous zinc-ion batteries with electrolyte optimization in cost-effective electrolytes.
文摘Lonicerae japonicaeFlos (LJF) is widely used in traditional Chinese medicines for the treatment of various diseases, which is now in great demand every year and has a broad development prospect. However, the flowering phase of common LJF varieties is so short, which seriously restricts the development of LJF industry. As a new cultivated kind of Lonicerae japonicae Flos, “Hua Jin 6” has characteristics in long flowering phase and conveniently picking, which makes it have a broad development prospect. The aim of this study is to provide scientific guidance for its suitable harvest period by measuring yield and quality of “Hua Jin 6” from different harvest time. Studies show that flower size had a slowly rising trend from the first day to the seventh day, and then slowly declined or kept stable. There were no significant differences of total phenolic acid contents in different samples from different days, but contents of total flavonoids were on the rise and up to maximum in the ninth day. The contents of total iridoids had an increasing tendency from the first day to the fifth day and then kept relatively stable in other days. We demonstrated that the quality of “Hua Jin 6” is relatively stable and suitable for harvesting in all flower buds white stage in term of HPLC fingerprints. Our findings can make it possible to select the suitable time for different harvest purpose.
基金Supported by project of Natural Science Foundation of China(No.41174097)
文摘The ground penetrating radar （GPR） detection data is a wide band signal, always disturbed by some noise, such as ambient random noise and muhiple refleetion waves. The noise affects the target identification of underground medium seriously. A method based on principal component analysis （PCA） was proposed to ex- tract the target signal and remove the uncorrelated noise. According to the correlation of signal, the authors get the eigenvalues and corresponding eigenvectors by decomposing the covariance matrix of GPR data and make linear transformation for the GPR data to get the principal components （PCs）. The lower-order PCs stand h^r the strong correlated target signals of the raw data, and the higher-order ones present the uneorrelated noise. Thus the authors can extract the target signal and filter uncorrelated noise effectively by the PCA. This method was demonstrated on real ultra-wideband through-wall radar data and simulated GPR data. Both of the results show that the PCA method can effectively extract the GPR target signal and remove the uncorrelated noise.
基金supported by the National Natural Science Foundation of China (Nos. 11975251, 11875268)。
文摘The in vivo degradation behavior of metallic nanoparticles(NPs) is very important for their biomedical applications and safety evaluation.Here,a method of laser ablation-single particle inductively coupled plasma mass spectrometry(LA-sp-ICP-MS) is shown to have high spatial resolution,sensitivity and accuracy for simultaneous imaging the in situ distribution of particulate Ag(P-Ag) and released ionic Ag(IonAg) in the sub-organs of spleen,liver and kidney after intravenous injection of Ag nanoparticles(50 nm,AgNPs) to mice.Under the optimized parameters of 0.4 J/cm^(2) laser fluence on a 30 μm spot with dwell time at 100 μs,the signals of P-Ag and Ion-Ag in the organic tissues can be easily distinguished from the mass spectra.The method of iterative threshold algorithm has been used to distract the signals of P-Ag and Ion-Ag and separate each other.The resulting images for the first time provide visualized evidence that a considerable amount of P-Ag accumulated in the splenic marginal zone,but widely distributed in the liver parenchyma at 24 h after injection of AgNPs,and in the meantime,obvious amounts of ionic Ag released and distributed in the organs.In addition,the imaging results indicate that the AgNP excretion in the kidney is mainly in ionic forms.The investigation here demonstrates that the developed LA-sp-ICPMS method with high spatial resolution,sensitivity and visualization capability can become a powerful tool in the clinical context of metallic NPs.
基金Supported by the National Natural Science Foundation of China（No.21403048） and the PhD Research Startup Program of Harbin Normal University, China（No.XKB201310）.
文摘Nitrogen-doped mesoporous carbon material was prepared via a simple one-step thermolysis method via the carbonization of ionic liquid, 1-cyanomethyl-3-methylimidazolium bis（trifluoromethylsulfonyl）imide （[MCNIm]^＋[Nf2T]^-）. The nanostructure of the resultant carbon material was characterized by X-ray diffraction（XRD） and transmission electron microscopy（TEM） and the types of N-containing groups of the carbon material were investigated by X-ray photoelectron spectroscopy（XPS）. The N-content of the carbon material is 18.6%（mass fraction） based on the elemental analysis. The produced mesoporous carbon material was further used as the solid sorbent for H2 and CO2. The hydrogen uptake capacity and H2 isosteric heat of the carbon material were discussed. Furthermore, the nitrogen-containing carbon material as good sorbent shows relatively high adsorption and separation ability for CO2 from CH4, for which the heat of CO2 adsorption（Qst） is 31.8 kJ/mol. The mesoporous structure and nitrogen functionality make the carbon material with high adsorption capacity and selectivity for CO2 and ability to store Ha, indicating that this kind of nitrogen-doped carbon material originated from ionic liquids is a promising sorbent material for high-performance separation and adsorption.
基金the Natural Science Foundation of Zhejiang Province(LQ21H030010&Q19H030064)Medical Health Science and Technology Project of the Zhejiang Provincial Health Commission(2021417815).
文摘Objective:The ulcerative colitis endoscopic index of severity(UCEIS)and the Mayo endoscopic score(MES)are developed as objective methods of evaluating endoscopic severity in patients with ulcerative colitis(UC).The aim of this study is to investigate the diagnostic accuracy of the UCEIS and MES in predicting the patient's response to mesalazine.Methods:Consecutive patients with UC who had undergone colonoscopy within 1 month before starting mesalazine between October 2011 and July 2016 were retrospectively collected at the Department of Gastroenterology,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine.The median follow-up was 81 months,and all the data were analyzed in January 2021.The primary outcome was the need for step-up treatment,which included the use of corticosteroids,immunomodulatory,or surgery during admission and follow-up.Data were analyzed using the c2 or Fisher exact test,Spearman test,t-test,and ManneWhitney U test.Results:Totally,65 patients were enrolled,of whom 12(18.5%)needed step-up treatment due to nonresponse to mesalazine.The UCEIS score,MES,and the ulcerative colitis disease activity index(UCDAI)score were significantly higher in patients who had nonresponse to mesalazine(UCEIS score:6.92±0.69 vs.4.45±1.17,p<0.001;MES:2.67±0.49 vs.2.15±0.69,p=0.024;UCDAI score:9.33±1.87 vs.6.70±2.38,p=0.002).In the multivariate analysis,the UCEIS score(OR=25.65,95%CI:3.048 e45.985,p=0.003),UCDAI score(OR=1.605,95%CI:1.144e2.254,p=0.006),and C-reactive protein level(OR=1.056,95%CI:1.006e1.108,p=0.026)were independent risk factors of nonresponse.The area under the ROC curve of UCEIS was 0.95,with a sensitivity of 100%and specificity of 84.6%,a cut-off value of 6,which outperformed the MES with an area under the ROC curve of 0.70.When the UCEIS score≥6,60%of patients eventually needed step-up treatment.Conclusions:The UCEIS is a useful instrument for predicting the therapeutic effect in patients with UC treated with mesalazine.The high probability of mesalazine treatment failure and b
基金This work was supported by the National Natural Science Foundation of China(grant no.51907165)Key Laboratory of Industrial Internet of Things&Networked Control(grant no.2018FF04)Chongqing Research Program of Basic Research and Frontier Technology(grant no.cstc2018jcyjAX0068)。
文摘In the long-running of sulphur hexafluoride(SF_(6))-insulated equipment,SF_(6) inevitably decomposes to various decomposition products under electric discharge,including SOF_(2) and SO2F_(2).In this work,single Pt modified molybdenum disulphide(Pt-MoS_(2))monolayer,and double Pt modified molybdenum disulphide(Pt_(2)-MoS_(2))monolayer are proposed to analyse its adsorption and sensing properties to SOF_(2) and SO2F_(2) with single and double gas molecules adsorption based on density functional theory.The adsorption energy,density of states,and molecular orbit theory are employed to analyse the adsorption and sensing mechanism.It turns out that the Pt-MoS_(2) and Pt_(2)-MoS_(2) present outstanding adsorption capacity to gas molecules.Specifically,double SOF_(2) adsorption on Pt_(2)-MoS_(2) shows the best adsorption performance,and the conductivity of the adsorption system changes the most in the adsorption process.Overall,both Pt-MoS_(2) and Pt_(2)-MoS_(2) perform as an excellent gas sensor.This study provides a theoretical basis to develop Pt-MoS_(2) and Pt_(2)-MoS_(2) based materials for SOF_(2) and SO2F_(2) detection in SF_(6)-insulated equipment.
