Interventional radiology,which originated within diagnostic radiology,is a newly developed medical field of minimally invasive endovascular therapy.Dr.Charles T.Dotter,who is widely regarded as the father of intervent...Interventional radiology,which originated within diagnostic radiology,is a newly developed medical field of minimally invasive endovascular therapy.Dr.Charles T.Dotter,who is widely regarded as the father of interventional radiology(1),successfully treated an82-year-old woman with lower extremity artery stenosis by dilatation using a guidewire and coaxial Teflon catheters,and published the case report in Circulation in 1964(2).In 1967,Dr.Alexander R.Margulis named this type of therapy as'interventional diagnostic radiology'(3).In the same year.展开更多
Various computed tomography (CT) appearances of cerebral venous sinus thrombosis (CVST) were associated with different prognosis and the patients with large intracranial hematoma will have adverse outcomes, but no in-...Various computed tomography (CT) appearances of cerebral venous sinus thrombosis (CVST) were associated with different prognosis and the patients with large intracranial hematoma will have adverse outcomes, but no in-depth study of non-contrast CT image appearances was carried out. We aimed to test the hypothesis that non-contrast CT image characteristics on admission are associated with and predict the outcome of CVST at 3 months. Methods: Three hundred and six patients with CVST between 2008 and 2017 were col ected. Age, sex, onset of CVST(acute, subacute, or chronic), etiology, clinical manifestations, midline shift, occluded venous sinus, location of infarction, non-contrast CT image characteristics, and the 3-month outcome were recorded. In addition, we established a non-contrast CT image-based classification and grading system to test the hypothesis;the CVST patients were classified into four grades (namely non-contrast CT image-based classification): grade I, no obvious abnormality;grade II, simple vein infarction without hemorrhage or with subarachnoid hemorrhage;grade II , cerebral venous infarction with subarachnoid hemorrhage;and grade IV, cerebral vein infarction with hematoma. Al enrolled patients had received subcutaneous injections of low molecular weight heparin subcutaneous injection for 14 days. Thereafter, oral anticoagulant therapy with warfarin was continued. Patients with epilepsy were given antiepileptic drugs, and patients with cerebral herniation received decompressive craniotomy. Results: Our observational findings revealed that midline shift (> 5 mm), location of lesion (frontal lobe and temporal lobe), and cerebral venous infarction with subarachnoid or hematoma (grade II and IV) were associated with 3-month poor outcome (p < 0.05);the respective increased risks were 12.730 [risk ratio (RR) 12.730, 95% confidence interval (CI) 1.680–96.490, p = 0.014], 46.538 (RR 146.538, 95% CI 6.222–348.079, p = 0.000), 32.549 (RR 32.549, 95% CI 2.180–486.104, p = 0.012), 37.725 (RR 37.725, 95%展开更多
BACKGROUND： The attack of meningiomas has sex and age differences. Previous studies indicated that children and adult patients had different clinical and pathological features. Due to the limitation of conditions and...BACKGROUND： The attack of meningiomas has sex and age differences. Previous studies indicated that children and adult patients had different clinical and pathological features. Due to the limitation of conditions and technique of diagnosis and treatment, some clinical and pathological features of meningiomas in children should be further recognized. OBJECTIVE： To summarize the clinical and pathological features in 15 children with intracranial meningiomas DESIGN ： A retrospective case analysis SETTING： The hospitals which the first author had been working inPARTICIPANTS ： Fifteen children with intracranial meningiomas were selected from the hospitals the frst author had been working in from June 1996 to June 2006. There were 9 boys and 6 girls, aged 1.8-15 years, with an average of 9.8 years. The duration from attack to diagnosis was 1 month to 2.5 years, with an average of 13 months. Inclusive criteria： （1） Clinically diagnosed, operated and confirmed pathologically; （2）≤ 15 years; （3） The children and their relatives were all informed and agree with the detection. METHOOS ： The clinical manifestations, imaging data, preoperative diagnosis and misdiagnosis, site and size of tumor, operative treatment and pathological data were retrospectively summarized. Thirteen of 15 children with intracranial meningiomas were followed up by means of reexamination for 1-8 years, and the postoperative recurrence were observed. MAIN OUTCOME MEASURES： Clinical manifestations, imaging data, preoperative diagnosis and misdiagnosis, site and size of tumor, operative treatment, pathological data, recurrence conditions of 1 to 8 years follow-up.RESULTS ： Thirteen of the 15 children with intracranial meningiomas were involved in the analysis of results, and 2 lost to the follow-up. （1） The main clinical manifestations at diagnosis were headache in 11 cases （73%, 11/15）, vomiting in 8 cases （53%, 8/15）, papilledema in 9 cases （60%, 9/15）, hypopsia in 6 cases （40%, 6115）, epilepsy in 5 展开更多
Employing Simulated Annealing Algorithm (SAA) and many measured data, acalculation model of work roll wear was built in the 2 800 mm 4-high mill of Wuhan Iron and Steel(Group) Co. (WISCO). The model was a semi-theory ...Employing Simulated Annealing Algorithm (SAA) and many measured data, acalculation model of work roll wear was built in the 2 800 mm 4-high mill of Wuhan Iron and Steel(Group) Co. (WISCO). The model was a semi-theory practical formula. Its pattern and magnitude werestill hardly defined with classical optimization methods. But the problem could be resolved by SAA.It was pretty high precision to predict the values for the wear profiles of work roll in a rollingunit. After one-year application, the results show that the model is feasible in engineering, and itcan be applied to predict the wear profiles of work roll in other mills.展开更多
AIM:To study the significance of p16 and p15 transcription suppression with hypermethylation of their genes′5′CpG islands during human hepatocellular carcinogenesis.METHODS:The mRNA expression levels of p16 and p15 ...AIM:To study the significance of p16 and p15 transcription suppression with hypermethylation of their genes′5′CpG islands during human hepatocellular carcinogenesis.METHODS:The mRNA expression levels of p16 and p15 genes were evaluated in cancerous,para-cancerous and non-cancerous tissues of 20 HCC,3 normal liver tissues from 3 accidentally died healthy adults using simi-quantitatively Northerm blot.The methylation status was also assessed with methylation specfic PCR.RESULTS:p16 mRNA expression level was decressed in the cancerous tissues in 60%(12/20) of HCC patients,of which 2 cases had no p16 mRNA detected,5 cases(25%) displayed variation in the order of cancerous<para-cancerous<non-cancerous liver tissues.p15 mRNA expression level was decreased in the cancerous tissues in 50%(10/20) HCC patients,of which one case had no p15 mRNA detected,4 cases (20%) displayed variation in the order of cancerous<para-cancerous<non-cancerous liver tissues.In cancerous,para-cancerous and non-cancerous tissues,p16 promoter CpG islands hypernethylation occurred 65% ,60% and 35%,while p15 promoter CpG islands hypermethylation occurred 50%,40% and 25%.of 12 HCCs with lower p16 promoter CpG islands methylation(91.6%).Hundred percent(10/10) HCCs with lower p15 mRNA expression level showed p15 promoter CpG islands methylation.Significant correlation between 5′CpG islands methylation and p16/p15 mRNA expression suppression was found.The dexreased expression of p16/p15 mRNA or metyylation of p16.p15 promoters 5′CpG island was significantly,0.01.2,0.00271,0.0218,respectively,(p<0.05).CONCLUSION:p16 and p15 genes transcriptional inactivation might play an important role in hepataocarcinogenesis.5′CpG islands methylation might bi the major mechanism of p16 and p15 genes inactivation in primary HCC in the studied population.5′CpG islands methylation of p16 and p15 genes might be an early event in hepatocarcinogenesis.展开更多
AIM: To determine the effectiveness of pre-liver transplant (LT) transarterial embolization (TAE) in treating hepatocellular carcinoma (HCC) and the patient categories,which are likely to have a good outcome after LT....AIM: To determine the effectiveness of pre-liver transplant (LT) transarterial embolization (TAE) in treating hepatocellular carcinoma (HCC) and the patient categories,which are likely to have a good outcome after LT.METHODS: Twenty-nine patients with hepatitis-related cirrhosis and unresectable HCC after LT were studied over a 7-year period. The patients were divided into two groups: group A patients (19/29) received pre-LT TAE,whereas group B (10/29) underwent LT without prior TAE.According to Milan criteria, group A patients were further subdivided into: group A1 (12/19) who met the criteria,and group A2 (7/19) who did not. Patient survivals were compared.RESULTS: In the explanted liver, CT images correlated well with pathological specimens showing that TAE induced massive tumor necrosis (＞85%) in 63.1% of patients in group A and all 7 patients in group A2 exhibited tumor downgrading that met Milan criteria. The overall 5-year actuarial survival rate was 80.6%. The TAE group had a better survival (84% at 5 years) than the non-TAE (75% at 4 years). The 3-year survival of group A2 (83%)was also higher than that of group A1 (79%). Tumor necrosis ＞85% was associated with excellent survival of 100% at 3 years, which was significantly better than the others who showed ＜85% tumor necrosis (57.1% at 3 years) or who did not have TAE (75% at 3 years).CONCLUSION: TAE is an effective treatment for HCC before LT. Excellent long-term survival was achieved in patients that did not fit Milan criteria. Our results broadened and redefined the selection policy for LT among patients with HCC. Meticulous pre-LT TAE helps in further reducing the rate of dropout from waiting lists and should be considered for patients with advanced HCC.展开更多
文摘Interventional radiology,which originated within diagnostic radiology,is a newly developed medical field of minimally invasive endovascular therapy.Dr.Charles T.Dotter,who is widely regarded as the father of interventional radiology(1),successfully treated an82-year-old woman with lower extremity artery stenosis by dilatation using a guidewire and coaxial Teflon catheters,and published the case report in Circulation in 1964(2).In 1967,Dr.Alexander R.Margulis named this type of therapy as'interventional diagnostic radiology'(3).In the same year.
文摘Various computed tomography (CT) appearances of cerebral venous sinus thrombosis (CVST) were associated with different prognosis and the patients with large intracranial hematoma will have adverse outcomes, but no in-depth study of non-contrast CT image appearances was carried out. We aimed to test the hypothesis that non-contrast CT image characteristics on admission are associated with and predict the outcome of CVST at 3 months. Methods: Three hundred and six patients with CVST between 2008 and 2017 were col ected. Age, sex, onset of CVST(acute, subacute, or chronic), etiology, clinical manifestations, midline shift, occluded venous sinus, location of infarction, non-contrast CT image characteristics, and the 3-month outcome were recorded. In addition, we established a non-contrast CT image-based classification and grading system to test the hypothesis;the CVST patients were classified into four grades (namely non-contrast CT image-based classification): grade I, no obvious abnormality;grade II, simple vein infarction without hemorrhage or with subarachnoid hemorrhage;grade II , cerebral venous infarction with subarachnoid hemorrhage;and grade IV, cerebral vein infarction with hematoma. Al enrolled patients had received subcutaneous injections of low molecular weight heparin subcutaneous injection for 14 days. Thereafter, oral anticoagulant therapy with warfarin was continued. Patients with epilepsy were given antiepileptic drugs, and patients with cerebral herniation received decompressive craniotomy. Results: Our observational findings revealed that midline shift (> 5 mm), location of lesion (frontal lobe and temporal lobe), and cerebral venous infarction with subarachnoid or hematoma (grade II and IV) were associated with 3-month poor outcome (p < 0.05);the respective increased risks were 12.730 [risk ratio (RR) 12.730, 95% confidence interval (CI) 1.680–96.490, p = 0.014], 46.538 (RR 146.538, 95% CI 6.222–348.079, p = 0.000), 32.549 (RR 32.549, 95% CI 2.180–486.104, p = 0.012), 37.725 (RR 37.725, 95%
文摘BACKGROUND： The attack of meningiomas has sex and age differences. Previous studies indicated that children and adult patients had different clinical and pathological features. Due to the limitation of conditions and technique of diagnosis and treatment, some clinical and pathological features of meningiomas in children should be further recognized. OBJECTIVE： To summarize the clinical and pathological features in 15 children with intracranial meningiomas DESIGN ： A retrospective case analysis SETTING： The hospitals which the first author had been working inPARTICIPANTS ： Fifteen children with intracranial meningiomas were selected from the hospitals the frst author had been working in from June 1996 to June 2006. There were 9 boys and 6 girls, aged 1.8-15 years, with an average of 9.8 years. The duration from attack to diagnosis was 1 month to 2.5 years, with an average of 13 months. Inclusive criteria： （1） Clinically diagnosed, operated and confirmed pathologically; （2）≤ 15 years; （3） The children and their relatives were all informed and agree with the detection. METHOOS ： The clinical manifestations, imaging data, preoperative diagnosis and misdiagnosis, site and size of tumor, operative treatment and pathological data were retrospectively summarized. Thirteen of 15 children with intracranial meningiomas were followed up by means of reexamination for 1-8 years, and the postoperative recurrence were observed. MAIN OUTCOME MEASURES： Clinical manifestations, imaging data, preoperative diagnosis and misdiagnosis, site and size of tumor, operative treatment, pathological data, recurrence conditions of 1 to 8 years follow-up.RESULTS ： Thirteen of the 15 children with intracranial meningiomas were involved in the analysis of results, and 2 lost to the follow-up. （1） The main clinical manifestations at diagnosis were headache in 11 cases （73%, 11/15）, vomiting in 8 cases （53%, 8/15）, papilledema in 9 cases （60%, 9/15）, hypopsia in 6 cases （40%, 6115）, epilepsy in 5
基金[This work was financially supported by the National Natural Science Foundation of China (No.59835170).]
文摘Employing Simulated Annealing Algorithm (SAA) and many measured data, acalculation model of work roll wear was built in the 2 800 mm 4-high mill of Wuhan Iron and Steel(Group) Co. (WISCO). The model was a semi-theory practical formula. Its pattern and magnitude werestill hardly defined with classical optimization methods. But the problem could be resolved by SAA.It was pretty high precision to predict the values for the wear profiles of work roll in a rollingunit. After one-year application, the results show that the model is feasible in engineering, and itcan be applied to predict the wear profiles of work roll in other mills.
基金Supported by the National Natural Science Foundation of China.No.39670702
文摘AIM:To study the significance of p16 and p15 transcription suppression with hypermethylation of their genes′5′CpG islands during human hepatocellular carcinogenesis.METHODS:The mRNA expression levels of p16 and p15 genes were evaluated in cancerous,para-cancerous and non-cancerous tissues of 20 HCC,3 normal liver tissues from 3 accidentally died healthy adults using simi-quantitatively Northerm blot.The methylation status was also assessed with methylation specfic PCR.RESULTS:p16 mRNA expression level was decressed in the cancerous tissues in 60%(12/20) of HCC patients,of which 2 cases had no p16 mRNA detected,5 cases(25%) displayed variation in the order of cancerous<para-cancerous<non-cancerous liver tissues.p15 mRNA expression level was decreased in the cancerous tissues in 50%(10/20) HCC patients,of which one case had no p15 mRNA detected,4 cases (20%) displayed variation in the order of cancerous<para-cancerous<non-cancerous liver tissues.In cancerous,para-cancerous and non-cancerous tissues,p16 promoter CpG islands hypernethylation occurred 65% ,60% and 35%,while p15 promoter CpG islands hypermethylation occurred 50%,40% and 25%.of 12 HCCs with lower p16 promoter CpG islands methylation(91.6%).Hundred percent(10/10) HCCs with lower p15 mRNA expression level showed p15 promoter CpG islands methylation.Significant correlation between 5′CpG islands methylation and p16/p15 mRNA expression suppression was found.The dexreased expression of p16/p15 mRNA or metyylation of p16.p15 promoters 5′CpG island was significantly,0.01.2,0.00271,0.0218,respectively,(p<0.05).CONCLUSION:p16 and p15 genes transcriptional inactivation might play an important role in hepataocarcinogenesis.5′CpG islands methylation might bi the major mechanism of p16 and p15 genes inactivation in primary HCC in the studied population.5′CpG islands methylation of p16 and p15 genes might be an early event in hepatocarcinogenesis.
基金Supported by Project Grant NHRI-EX94-9228SP from the National Health Research InstitutesNSC 93-2314-B-182A-084 from the National Science Council,Taiwan, China
文摘AIM: To determine the effectiveness of pre-liver transplant (LT) transarterial embolization (TAE) in treating hepatocellular carcinoma (HCC) and the patient categories,which are likely to have a good outcome after LT.METHODS: Twenty-nine patients with hepatitis-related cirrhosis and unresectable HCC after LT were studied over a 7-year period. The patients were divided into two groups: group A patients (19/29) received pre-LT TAE,whereas group B (10/29) underwent LT without prior TAE.According to Milan criteria, group A patients were further subdivided into: group A1 (12/19) who met the criteria,and group A2 (7/19) who did not. Patient survivals were compared.RESULTS: In the explanted liver, CT images correlated well with pathological specimens showing that TAE induced massive tumor necrosis (＞85%) in 63.1% of patients in group A and all 7 patients in group A2 exhibited tumor downgrading that met Milan criteria. The overall 5-year actuarial survival rate was 80.6%. The TAE group had a better survival (84% at 5 years) than the non-TAE (75% at 4 years). The 3-year survival of group A2 (83%)was also higher than that of group A1 (79%). Tumor necrosis ＞85% was associated with excellent survival of 100% at 3 years, which was significantly better than the others who showed ＜85% tumor necrosis (57.1% at 3 years) or who did not have TAE (75% at 3 years).CONCLUSION: TAE is an effective treatment for HCC before LT. Excellent long-term survival was achieved in patients that did not fit Milan criteria. Our results broadened and redefined the selection policy for LT among patients with HCC. Meticulous pre-LT TAE helps in further reducing the rate of dropout from waiting lists and should be considered for patients with advanced HCC.
