期刊文献+
共找到216篇文章
< 1 2 11 >
每页显示 20 50 100
Structure-guided analysis of Arabidopsis JASMONATE-INDUCED OXYGENASE(JOX)2 reveals key residues for recognition of jasmonic acid substrate by plant JOXs 被引量:5
1
作者 Xin Zhang Dongli Wang +6 位作者 Joyce Elberse linlu Qi Wei Shi You-Liang Peng Robert C.Schuurink Guido Van den Ackerveken Junfeng Liu 《Molecular Plant》 SCIE CAS CSCD 2021年第5期820-828,共9页
The jasmonic acid(JA)signaling pathway is used by plants to control wound responses.The persistent accumulation of JA inhibits plant growth,and the hydroxylation of JA to 12-hydroxy-JA by JASMONATE-INDUCED OXYGENASEs(... The jasmonic acid(JA)signaling pathway is used by plants to control wound responses.The persistent accumulation of JA inhibits plant growth,and the hydroxylation of JA to 12-hydroxy-JA by JASMONATE-INDUCED OXYGENASEs(JOXs,also named jasmonic acid oxidases)is therefore vital for plant growth,while structural details of JA recognition by JOXs are unknown.Here,we present the 2.65Åresolution X-ray crystal structure of Arabidopsis JOX2 in complex with its substrate JA and its co-substrates 2-oxoglutarate and Fe(Ⅱ).JOX2 contains a distorted double-stranded p helix(DSBH)core flanked by a helices and loops.JA is bound in the narrow substrate pocket by hydrogen bonds with the arginine triad R225,R350,and R354 and by hydrophobic interactions mainly with the phenylalanine triad F157,F317,and F346.The most critical residues for JA binding are F157 and R225,both from the DSBH core,which interact with the cyclopentane ring of JA.The spatial distribution of critical residues for JA binding and the shape of the substrate-binding pocket together define the substrate selectivity of the JOXs.Sequence alignment shows that these critical residues are conserved among JOXs from higher plants.Collectively,our study provides insights into the mechanism by which higher plants hydroxylate the hormone JA. 展开更多
关键词 crystal structure JASMONATE-INDUCED OXYGENASEs(JOXs) jasmonic acid(JA) 12-OH-JA HYDROXYLATION
原文传递
Efficient singlet oxygen generation by excitonic energy transfer on ultrathin g-C_(3)N_(4) for selective photocatalytic oxidation of methyl-phenyl-sulfide with O_(2) 被引量:5
2
作者 Fan Yang Xiaoyu Chu +6 位作者 Jianhui Sun Yuhang Zhang Zhijun Li Haiyue Liu linlu Bai Yang Qu Liqiang Jing 《Chinese Chemical Letters》 SCIE CAS CSCD 2020年第10期2784-2788,共5页
Efficient generation of singlet oxygen(1 O_(2)) by an excitonic ene rgy transfer process is highly desired on a semiconductor photocatalyst for selective oxidation of methyl phenyl sulfide(MPS).Herein,it is demonstrat... Efficient generation of singlet oxygen(1 O_(2)) by an excitonic ene rgy transfer process is highly desired on a semiconductor photocatalyst for selective oxidation of methyl phenyl sulfide(MPS).Herein,it is demonstrated that a large amount of 1 O_(2) is produced on pristine graphitic carbon nitride(CN) nanosheet compared with bismuth oxybromide(BiOBr) and comme rcial P25 titanium dioxide(TiO_(2)).This leads to a certain photoactivity of CN for MPS oxidation.The observed ~77% selectivity for CN depends on the competitive results of excitonic energy transfer for 1 O_(2) formation and charge carrier separation for superoxide radical(O_(2)·) production,which are based on the phosphorescence spectra and electron paramagnetic resonance signals,respectively.Moreover,ultrathin CN nanosheets are synthesized by thermal treatment with the cyanuric acid-melamine hydrogen bonded aggregates as precursors.It is confirmed that the amount of produced 1 O_(2) could be increased by decreasing the thickness of resultant CN nanosheets.The optimized ultrathin CN nanosheet(~4 nm) exhibits excellent photoactivity with high selectivity(~99%).It is suggested that the excitonic energy transfer for 1 O_(2) formation is close related to the intrinsic exciton binding energy and the two-dimensional quantum confinement effect.This work establishes a basic mechanistic understanding on the excitonic processes in CN,and develops a feasible route to design CN-based photocatalysts for efficient 1 O_(2) generation. 展开更多
关键词 g-C_(3)N_(4)nanosheet Singlet oxygen generation Excitonic energy transfer Photocatalysis Organic selective oxidat
原文传递
Synthesis of Ni^2+cation modified TS-1 molecular sieve nanosheets as effective photocatalysts for alcohol oxidation and pollutant degradation 被引量:4
3
作者 Imran Khan Xiaoyu Chu +3 位作者 Yanduo Liu Salman Khan linlu Bai Liqiang Jing 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 北大核心 2020年第10期1589-1602,共14页
lmprovement of the charge separation of titanosilicate molecular sieves is critical to their use asphotocatalysts for oxidative organic transformations.In this work,MFI TS-1 molecular sievenanosheets(TS-1 NS)were synt... lmprovement of the charge separation of titanosilicate molecular sieves is critical to their use asphotocatalysts for oxidative organic transformations.In this work,MFI TS-1 molecular sievenanosheets(TS-1 NS)were synthesized by a low-temperature hydrothermal method using a tai-lored diquaternary ammonium surfactant as the structure-directing agent.Introducing Ni^2+cationsat the ion-exchange sites of the TS-1 NS framework significantly enhanced its photoactivity in aero-bic alcohol oxidation.The optimized Ni cation-functionalized TS-1 NS(Ni/TS-1 NS)provide impres-sive photoactivity,with a benzyl alcohol(BA)conversion of 78.9%and benzyl aldehyde(BAD)se-lectivity of 98.8%using O as the only oxidant under full light irradiation;this BAD yield is approx-imately six times greater than that obtained for bulk TS-1,and is maintained for five runs.The ex-cellent photoactivity of Ni/TS-1 NS is attributed to the significantly enlarged surface area of thetwo-dimensional morphology TS-1 NS,extra mesopores,and greatly improved charge separation.Compared with bulk TS-1,Ni/TS-1 NS has a much shorter charge transfer distance.Theas-introduced Ni species could capture the photoelectrons to further improve the charge separa-tion.This work opens the way to a class of highly selective,robust,and low-cost titanosilicate mo-lecular sieve-based photocatalysts with industrial potential for selective oxidative transformationsand pollutant degradation. 展开更多
关键词 TS-1 nanosheet Photocatalytic alcohol oxidation Charge separation Ni species as electron capturer O2 activation
下载PDF
Quantifying the impacts of emissions and meteorology on the interannual variations of air pollutants in major Chinese cities from 2015 to 2021
4
作者 Qili DAI Tianjiao DAI +4 位作者 linlu HOU Linxuan LI Xiaohui BI Yufen ZHANG Yinchang FENG 《Science China Earth Sciences》 SCIE EI CAS CSCD 2023年第8期1725-1737,共13页
Air pollutant concentration is a function of emission rates and meteorology.To accurately evaluate the effect of control measures,the meteorological covariate must be corrected from the observations.This study quantif... Air pollutant concentration is a function of emission rates and meteorology.To accurately evaluate the effect of control measures,the meteorological covariate must be corrected from the observations.This study quantified the impacts of emission abatement and meteorological condition on the interannual variations of SO_(2),NO_(2),CO,O_(3),PM_(10) and PM_(2.5) concentrations in 31 major Chinese cities using an optimized machine learning-based meteorological normalization technique.Overall,the annual average concentrations of SO_(2),NO_(2),CO,PM_(10)and PM_(2.5)were reduced by 86%,51%,99%,86% and 88%from 2015 to 2020,respectively,in the studied cities,attributable to their emission reductions.However,the concentration of O_(3) was found with no significant decrease with the reduction of precursors.Emission abatement notably improved air quality between 2015 and 2018.Such a decline in emissions tended to progressively slow down since 2018.Overall,the meteorological conditions in 2016–2017 and 2018–2019 were unfavorable for a better air quality,while it became favorable in 2020–2021.Specifically,emission abatement in 2021 further lowered the concentrations of SO_(2),NO_(2),CO,and PM_(2.5),while the emission of PM_(10) increased.And changes in precursors emissions worsened O_(3) air quality.To meet the demand of improving air quality,more aggressive abatement measures need to be formulated to synergistically reduce NOx,volatile organic compounds,and coarse particles. 展开更多
关键词 Air pollution Air quality Machine learning METEOROLOGY EMISSIONS Policy evaluation
原文传递
Improving the band alignment at PtSe_(2)grain boundaries with selective adsorption of TCNQ
5
作者 Yanhui Hou Ziqiang Xu +8 位作者 Yan Shao linlu Wu Zhongliu Liu Genyu Hu Wei Ji Jingsi Qiao Xu Wu Hong-Jun Gao Yeliang Wang 《Nano Research》 SCIE EI CSCD 2023年第2期3358-3363,共6页
Grain boundaries in two-dimensional(2D)semiconductors generally induce distorted band alignment and interfacial charge,which impair their electronic properties for device applications.Here,we report the improvement of... Grain boundaries in two-dimensional(2D)semiconductors generally induce distorted band alignment and interfacial charge,which impair their electronic properties for device applications.Here,we report the improvement of band alignment at the grain boundaries of PtSe_(2),a 2D semiconductor,with selective adsorption of a presentative organic acceptor,tetracyanoquinodimethane(TCNQ).TCNQ molecules show selective adsorption at the PtSe_(2)grain boundary with strong interfacial charge.The adsorption of TCNQ distinctly improves the band alignment at the PtSe_(2)grain boundaries.With the charge transfer between the grain boundary and TCNQ,the local charge is inhibited,and the band bending at the grain boundary is suppressed,as revealed by the scanning tunneling microscopy and spectroscopy(STM/S)results.Our finding provides an effective method for the advancement of the band alignment at the grain boundary by functional molecules,improving the electronic properties of 2D semiconductors for their future applications. 展开更多
关键词 organic-two-dimensional(2D)heterostructure PtSe_(2) grain boundary band alignment scanning tunneling microscopy(STM)
原文传递
Comparative Secretome Analysis of Magnaporthe oryzae Identified Proteins Involved in Virulence and Cell Wall Integrity 被引量:2
6
作者 Ning Liu linlu Qi +9 位作者 Manna Huang Deng Chen Changfa Yin Yiying Zhang Xingbin Wang Guixin Yuan Rui-Jin Wang Jun Yang You-Liang Peng Xunli Lu 《Genomics, Proteomics & Bioinformatics》 SCIE CAS CSCD 2022年第4期728-746,共19页
Plant fungal pathogens secrete numerous proteins into the apoplast at the plant–fungus contact sites to facilitate colonization.However,only a few secretory proteins were functionally characterized in Magnaporthe ory... Plant fungal pathogens secrete numerous proteins into the apoplast at the plant–fungus contact sites to facilitate colonization.However,only a few secretory proteins were functionally characterized in Magnaporthe oryzae,the fungal pathogen causing rice blast disease worldwide.Asparagine-linked glycosylation 3(Alg3)is an a-1,3-mannosyltransferase functioning in the Nglycan synthesis of N-glycosylated secretory proteins.Fungal pathogenicity and cell wall integrity are impaired inΔalg3 mutants,but the secreted proteins affected inΔalg3 mutants are largely unknown.In this study,we compared the secretomes of the wild-type strain and theΔalg3 mutant and identified 51 proteins that require Alg3 for proper secretion.These proteins were predicted to be involved in metabolic processes,interspecies interactions,cell wall organization,and response to chemicals.Nine proteins were selected for further validation.We found that these proteins were localized at the apoplastic region surrounding the fungal infection hyphae.Moreover,the Nglycosylation of these proteins was significantly changed in theΔalg3 mutant,leading to the decreased protein secretion and abnormal protein localization.Furthermore,we tested the biological functions of two genes,INV1(encoding invertase 1,a secreted invertase)and AMCase(encoding acid mammalian chinitase,a secreted chitinase).The fungal virulence was significantly reduced,and the cell wall integrity was altered in theΔinv1 andΔamcase mutant strains.Moreover,the N-glycosylation was essential for the function and secretion of AMCase.Taken together,our study provides new insight into the role of N-glycosylated secretory proteins in fungal virulence and cell wall integrity. 展开更多
关键词 Magnaporthe oryzae SECRETOME N-GLYCOSYLATION Invertase 1 Acid mammalian chinitase
原文传递
S1P/S1PR1 signaling differentially regulates the allogeneic response of CD4 and CD8 T cells by modulating mitochondrial fission 被引量:2
7
作者 linlu Tian Yongxia Wu +8 位作者 Hee-Jin Choi Xiaohui Sui Xinlei Li M.Hanief Sofi Mohamed Faisal Kassir Xiao Chen Shikhar Mehrotra Besim Ogretmen Xue-zhong Yu 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2022年第11期1235-1250,共16页
Graft-versus-host disease (GVHD) significantly contributes to patient morbidity and mortality after allogeneic hematopoietic cell transplantation (allo-HSCT). Sphingosine-1-phosphate (S1P) signaling is involved in the... Graft-versus-host disease (GVHD) significantly contributes to patient morbidity and mortality after allogeneic hematopoietic cell transplantation (allo-HSCT). Sphingosine-1-phosphate (S1P) signaling is involved in the biogenetic processes of different immune cells. In the current study, we demonstrated that recipient sphingosine kinase 1 (Sphk1), but not Sphk2, was required for optimal S1PR1-dependent donor T-cell allogeneic responses by secreting S1P. Using genetic and pharmacologic approaches, we demonstrated that inhibition of Sphk1 or S1PR1 substantially attenuated acute GVHD (aGVHD) while retaining the graft-versus-leukemia (GVL) effect. At the cellular level, the Sphk1/S1P/S1PR1 pathway differentially modulated the alloreactivity of CD4+ and CD8+ T cells;it facilitated T-cell differentiation into Th1/Th17 cells but not Tregs and promoted CD4+ T-cell infiltration into GVHD target organs but was dispensable for the CTL activity of allogeneic CD8+ T cells. At the molecular level, the Sphk1/S1P/S1PR1 pathway augmented mitochondrial fission and increased mitochondrial mass in allogeneic CD4+ but not CD8+ T cells by activating the AMPK/AKT/mTOR/Drp1 pathway, providing a mechanistic basis for GVL maintenance when S1P signaling was inhibited. For translational purposes, we detected the regulatory efficacy of pharmacologic inhibitors of Sphk1 and S1PR1 in GVHD induced by human T cells in a xenograft model. Our study provides novel mechanistic insight into how the Sphk1/S1P/S1PR1 pathway modulates T-cell alloreactivity and validates Sphk1 or S1PR1 as a therapeutic target for the prevention of GVHD and leukemia relapse. This novel strategy may be readily translated into the clinic to benefit patients with hematologic malignancies and disorders. 展开更多
关键词 Sphk1 S1P S1PR GVHD GVL mitochondrial fission
原文传递
Protein self-assembly: technology and strategy 被引量:1
8
作者 linlu Zhao Shanpeng Qiao Junqiu Liu 《Science China Chemistry》 SCIE EI CAS CSCD 2016年第12期1531-1540,共10页
Proteins, as the premier building blocks in nature, exhibit extraordinary ability in life activities during which process proteins mostly self-assemble into large complexes to exert prominent functions. Inspired by th... Proteins, as the premier building blocks in nature, exhibit extraordinary ability in life activities during which process proteins mostly self-assemble into large complexes to exert prominent functions. Inspired by this, recent chemical and biological stud- ies mainly focus on supramolecular self-assembly of proteins into high ordered architectures, especially the assembly suategy to unravel tile formation and function of protein nanostructures. In this review, we st, mmarize the progress made in the engi- neering of supramolecular protein architectures according to the strategies used to control the orient:ilion and the order of the assembly process. Furthermore, potential applications in biomedical areas of the supramolecular protein nanostructures will also be reviewed. 展开更多
关键词 protein assembly supramolecular strategy SELF-ASSEMBLY electrostatic interaction metal-ligand coordination
原文传递
新生儿脐血中性粒细胞吞噬功能降低的研究
9
作者 王才智 王梓璇 +5 位作者 周玉 林路 赵雅菲 冀彩丽 华梦晴 宋传旺 《齐齐哈尔医学院学报》 2022年第15期1410-1413,共4页
目的探讨新生儿脐血中性粒细胞(PMN)吞噬功能的变化及其影响因素。方法收集2021年6—8月来自本院的健康成人血和脐血标本各13例,分离新鲜PMN,流式细胞仪检测PMN吞噬大肠杆菌的情况,ELISA法检测成人外周血和新生儿脐血血清中前列腺素E2(P... 目的探讨新生儿脐血中性粒细胞(PMN)吞噬功能的变化及其影响因素。方法收集2021年6—8月来自本院的健康成人血和脐血标本各13例,分离新鲜PMN,流式细胞仪检测PMN吞噬大肠杆菌的情况,ELISA法检测成人外周血和新生儿脐血血清中前列腺素E2(PGE2)的含量。应用不同浓度的PGE2(0-500 ng/ml)刺激PMN株HL-60细胞及PGE2(100 ng/ml)刺激新鲜分离的成人PMN 48小时后,流式细胞术观察HL-60细胞和PMN吞噬大肠杆菌的情况。结果与成人PMN相比,新生儿PMN吞噬大肠杆菌百分率明显降低(P<0.01),但脐血PGE2的浓度较成人外周血明显升高(P<0.01);PGE2(100-500 ng/ml)刺激组HL-60细胞吞噬细菌百分率明显低于0 ng/ml组(P<0.01);成人PMN受PGE2(100 ng/ml)刺激后吞噬百分率明显降低(P<0.05)。结论新生儿脐血PMN吞噬功能降低,这可能是由于PGE2对PMN的抑制作用引起。 展开更多
关键词 中性粒细胞(PMN) 吞噬功能 新生儿脐血 前列腺素E2(PGE2)
下载PDF
Releasing nitrogen from ammoniated lignin by white rot fungus cometabolizes environmental pollutants 被引量:1
10
作者 linlu ZHAODe-qing +2 位作者 ZHOUXian-tao QIUYu-gui ZHANGGan: 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2003年第5期577-582,共6页
The nitrogen modified lignocelluloses(NML) produced under oxic ammoniation was metabolized by white rot fungus, NH + 4 N was released, NO - 3 N concentration was decreased and total nitrogen loss was blocked wi... The nitrogen modified lignocelluloses(NML) produced under oxic ammoniation was metabolized by white rot fungus, NH + 4 N was released, NO - 3 N concentration was decreased and total nitrogen loss was blocked within incubation period. During releasing nitrogen from the metabolism of NML, white rot fungus cometabolized recalcitrant environmental pollutants and showed higher degradation capability. Results indicated that this NML complex colonized by white rot fungus might be effective with economic feasibility when they are applied into the vast field ecosystem, it might stabilize NH + 4 nitrogen flux and bioremediate the polluted environmental sites. 展开更多
关键词 white rot fungus ammoniated lignin COMETABOLISM POLLUTANTS
下载PDF
Band alignment and interlayer hybridization in monolayer organic/WSe_(2) heterojunction
11
作者 Yanping Guo linlu Wu +11 位作者 Jinghao Deng Linwei Zhou Wei Jiang Shuangzan Lu Da Huo Jiamin Ji Yusong Bai Xiaoyu Lin Shunping Zhang Hongxing Xu Wei Ji Chendong Zhang 《Nano Research》 SCIE EI CSCD 2022年第2期1276-1281,共6页
Semiconducting heterojunctions(HJs),comprised of atomically thin transition metal dichalcogenides(TMDs),have shown great potentials in electronic and optoelectronic applications.Organic/TMD hybrid bilayers hold enhanc... Semiconducting heterojunctions(HJs),comprised of atomically thin transition metal dichalcogenides(TMDs),have shown great potentials in electronic and optoelectronic applications.Organic/TMD hybrid bilayers hold enhanced pumping efficiency of interfacial excitons,tunable electronic structures and optical properties,and other superior advantages to these inorganic HJs.Here,we report a direct probe of the interfacial electronic structures of a crystalline monolayer(ML)perylene-3,4,9,10-tetracarboxylic-dianhydride(PTCDA)/ML-WSe_(2) HJ using scanning tunneling microscopy,photoluminescence,and first-principle calculations.Strong PTCDAAA/Se_(2) interfacial interactions lead to appreciable hybridization of the WSe_(2) conduction band with PTCDA unoccupied states,accompanying with a significant amount of PTCDA-to-WSe_(2) charge transfer(by 0.06 e/PTCDA).A type-ll band alignment was directly determined with a valence band offset of-1.69 eV,and an apparent conduction band offset of-1.57 eV.Moreover,we found that the local stacking geometry at the HJ interface differentiates the hybridized interfacial states. 展开更多
关键词 two-dimensional materials organic/transition metal dichalcogenide(TMD)heterojunction interlayer hybridization band diagram
原文传递
Potential Impacts of Proposed Chenglingji Hydraulic Project on Wetlands in Dongting Lake 被引量:1
12
作者 LU Cai SHI linlu +3 位作者 GUAN Lei ZHOU Yan JING Lei LEI Guangchun 《湿地科学》 CSCD 北大核心 2018年第3期377-392,共16页
Water level fluctuation of is an important ecological character of lakes in monsoon climate zone.It is the key driver to seasonal change of the wetlands and associated habitats,which provide vital inhabiting condition... Water level fluctuation of is an important ecological character of lakes in monsoon climate zone.It is the key driver to seasonal change of the wetlands and associated habitats,which provide vital inhabiting conditions for different species in summer and winter,or,wet season and dry season.Due the hydrologic regime changes in the recent years after the operation of Three Gorges Dam,in 2012,the government of Hunan province proposed Chenglingji Hydraulic Project,aiming at water level control in dry season at Chenglingji,where the outlet of Dongting Lake located.Through different operations on water retreat process,five scenarios on the water level control from 21 m to 24 m were set in the plan.The potential ecological impacts of the project are under enormous public concern.To analyze potential impacts from different scenarios of water level control on the wetlands,this paper studied the topography of Dongting Lake bed and wetlands in dry season,by using Digital Elevation Model(DEM)and 15 images from HJ satellite and 1 image from Landsat TM.The wetlands at water levels of 19 m to 27 m were analyzed.The study revealed that there were 4 terrain steps on Dongting Lake bed from the West Dongting Lake to East Dongting Lake.Water level control at Chenglingji would increase area of open water in East Dongting Lake and Hengling Lake areas,while its effect on South Dongting Lake and West Dongting Lake areas due to higher terrain was weaker.Particularly,the area percentages of South Dongting Lake area did not change with water level fluctuation,due to its 2 elevation steps.The area percentages of various types of the wetlands in Dongting Lake area during the processes of water level rising and retreating were quite different,even in the relatively close water level interval.The retreating area of open water in autumn was larger than that during the spring flooding.The 23 m was the key water level,a turning point of the area change of the wetlands in Dongting Lake area.Areas of open water,mudflat,meadows and their percent 展开更多
关键词 Dongting LAKE Chenglingji HYDRAULIC PROJECT FLUCTUATION of water LEVEL impact WETLANDS
原文传递
Critical role of zebrafish dnajb5 in myocardial proliferation and regeneration
13
作者 Meijun Pang Connie Xiong +5 位作者 Chenglu Xiao Jianyong Du Lixia Zheng linlu Bai Xiaojun Zhu Jing-Wei Xiong 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2020年第8期493-496,共4页
Myocardial infarction is a devastating disease worldwide.At present,nearly 40 million patients suffer from heart failure.Owing to a lack of adequate blood supply,25%of cardiomyocytes are subjected to apoptosis and nec... Myocardial infarction is a devastating disease worldwide.At present,nearly 40 million patients suffer from heart failure.Owing to a lack of adequate blood supply,25%of cardiomyocytes are subjected to apoptosis and necrosis within a few hours after infarction.It remains challenging to find effective therapeutic methods for heart failure.On the other hand,zebrafish and neonatal mouse hearts have a strong ability to regenerate(Poss et al.,2002;Raya et al.,2003;Porrello et al.,2011),and their regeneration derives from existing cardiomyocytes(Jopling et al.,2010;Kikuchi et al.. 展开更多
关键词 al. INFARCTION NEONATAL
原文传递
Touchable cell biophysics property recognition platforms enable multifunctional blood smart health care
14
作者 Longfei Chen Yantong Liu +16 位作者 Hongshan Xu linlu Ma Yifan Wang Le Yu Fang Wang Jiaomeng Zhu Xuejia Hu Kezhen Yi Yi Yang Hui Shen Fuling Zhou Xiaoqi Gao Yanxiang Cheng Long Bai Yongwei Duan Fubing Wang Yimin Zhu 《Microsystems & Nanoengineering》 SCIE EI CSCD 2021年第6期207-219,共13页
As a crucial biophysical property,red blood cell(RBC)deformability is pathologically altered in numerous disease states,and biochemical and structural changes occur over time in stored samples of otherwise normal RBCs... As a crucial biophysical property,red blood cell(RBC)deformability is pathologically altered in numerous disease states,and biochemical and structural changes occur over time in stored samples of otherwise normal RBCs.However,there is still a gap in applying it further to point-of-care blood devices due to the large external equipment(high-resolution microscope and microfluidic pump),associated operational difficulties,and professional analysis.Herein,we revolutionarily propose a smart optofluidic system to provide a differential diagnosis for blood testing via precise cell biophysics property recognition both mechanically and morphologically.Deformation of the RBC population is caused by pressing the hydrogel via an integrated mechanical transfer device.The biophysical properties of the cell population are obtained by the designed smartphone algorithm.Artificial intelligence-based modeling of cell biophysics properties related to blood diseases and quality was developed for online testing.We currently achieve 100%diagnostic accuracy for five typical clinical blood diseases(90 megaloblastic anemia,78 myelofibrosis,84 iron deficiency anemia,48 thrombotic thrombocytopenic purpura,and 48 thalassemias)via real-world prospective implementation;furthermore,personalized blood quality(for transfusion in cardiac surgery)monitoring is achieved with an accuracy of 96.9%.This work suggests a potential basis for next-generation blood smart health care devices. 展开更多
关键词 SMART PROPERTY enable
原文传递
STING negatively regulates allogeneic T-cell responses by constraining antigen-presenting cell function
15
作者 Hee-Jin ChoiTaylor Ticer Yongxia Wu +13 位作者 Chih-Hang Anthony Tang Corey Mealer David Bastian M.Hanief Sofi linlu Tian Steven Schutt Hee-Jin Choi Taylor Ticer Mengmeng Zhang Xiaohui Sui Lei Huang Andrew L.Mellor Chih-Chi Andrew Hu Xue-Zhong Yu 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2021年第3期632-643,共12页
Stimulator of interferon genes(STING)-mediated innate immune activation plays a key role in tumor-and self-DNA-elicited antitumor immunity and autoimmunity.However,STING can also suppress tumor immunity and autoimmuni... Stimulator of interferon genes(STING)-mediated innate immune activation plays a key role in tumor-and self-DNA-elicited antitumor immunity and autoimmunity.However,STING can also suppress tumor immunity and autoimmunity.STING signaling In host nonhematopoietic cells was reported to either protect against or promote graft-versus-host disease(GVHD),a major complication of allogeneic hematopoietic cell transplantation(allo-HCT).Host hematopoietic antigen-presenting cells(APCs)play key roles in donor T-cell priming during GVHD initiation.However,how STING regulates host hematopoietic APCs after allo-HCT remains unknown.We utilized murine models of allo-HCT to assess the role of STING in hematopoietic APCs.STING-deficient recipients developed more severe GVHD after major histocompatibility complex-mismatched allo-HCT.Using bone marrow chimeras,we found that STING deficiency in host hematopoietic cells was primarily responsible for exacerbating the disease.Furthermore,STING on host CD11c+cells played a dominant role in suppressing allogeneic T-cell responses.Mechanistically,STING deficiency resulted in increased survival,activation,and function of APCs,including macrophages and dendritic cells.Consistently,constitutive activation of STING attenuated the survival,activation,and function of APCs isolated from STING V154M knock-in mice.STING-deficient APCs augmented donor T-cell expansion,chemokine receptor expression,and migration into intestinal tissues,resulting in accelerated/exacerbated GVHD.Using pharmacologic approaches,we demonstrated that systemic administration of a STING agonist(bis-(3'-5')-cyclic dimeric guanosine monophosphate)to recipient mice before transplantation significantly reduced GVHD mortality.In conclusion,we revealed a novel role of STING in APC activity that dictates T-cell allogeneic responses and validated STING as a potential therapeutic target for controlling GVHD after allo-HCT. 展开更多
关键词 Stimulator of interferon genes antigen-presenting cells allogeneic hematopoietic cell transplantation graft-versushost diseases hematopoietic stem-cell transplantation T cells
原文传递
High temperature strength and ductility of the(C+N)strengthening Fe-Cr-Mn(W,V)steels
16
作者 BenfuHu QuanmaoYu +3 位作者 linlu ChengchangJia HiroshiKinoshita HeishichiroTakahashi 《Journal of University of Science and Technology Beijing》 CSCD 2002年第4期292-297,共6页
Fe-Cr-Mn(W, V) austenite steels used as low radioactive structural materialsin fusion reactor have been investigated. The results show that the high temperature strength andthe creep fracture life of Fe-Cr-Mn(W, V) st... Fe-Cr-Mn(W, V) austenite steels used as low radioactive structural materialsin fusion reactor have been investigated. The results show that the high temperature strength andthe creep fracture life of Fe-Cr-Mn(W, V) steels can be effectively improved through (C+N)complex-strengthening, so can be the high temperature ductility. The strength and ductility of thesteels are superior to that of SUS316 steels and JPCAS below 673 K. The relationship betweenstrength, ductility and the formation temperature is related to the evolution of deformationmicrostructure. The fracture and microstructure observation above 673 K indicates that the main wayto further improve ductility at high temperature is the control of carbide coarsening at the grainboundaries. 展开更多
关键词 Fe-Cr-Mn steels high temperature strength deformation martensite stacking faults (SF)
下载PDF
ITERATIVE QUASI-LIKELIHOOD FOR SEEMINGLY UNRELATED REGRESSION SYSTEMS
17
作者 linlu FANYUNZHENG +1 位作者 DUJUN YUANYUAN 《Chinese Annals of Mathematics,Series B》 SCIE CSCD 2005年第3期335-346,共12页
In the seemingly unrelated regression systems, the existing quasi-likelihood is always involved in the difficult problem of calculating inverse of a high order matrix specially for large systems. To avoid this problem... In the seemingly unrelated regression systems, the existing quasi-likelihood is always involved in the difficult problem of calculating inverse of a high order matrix specially for large systems. To avoid this problem, the new quasi-likelihood proposed in this paper is based mainly on a linearly iterative process of some unbiased estimating functions.Some finite sample properties and asymptotic behaviours for this new quasi-likelihood are investigated. These results show that the new quasi-likelihood for parameter of interest is E-sufficient, iteratively efficient and approximately efficient. Some examples are given to illustrate the theoretical results. 展开更多
关键词 Seemingly unrelated regression system QUASI-LIKELIHOOD Unbiased estimating function
原文传递
经尿道等离子双极电切术治疗中国高危高龄良性前列腺增生症效果的系统评价与荟萃分析 被引量:81
18
作者 张中元 赵明娟 +4 位作者 洪保安 马琳璐 靳英辉 曾宪涛 龚侃 《中华医学杂志》 CAS CSCD 北大核心 2019年第10期778-782,共5页
目的评价经尿道等离子双极电切术治疗中国高危高龄良性前列腺增生症患者的有效性和安全性。方法计算机检索PubMed、Cochrane Library、CNKI、CBM和万方数据库,搜集经尿道等离子双极电切术治疗中国高危高龄良性前列腺增生症的病例系列研... 目的评价经尿道等离子双极电切术治疗中国高危高龄良性前列腺增生症患者的有效性和安全性。方法计算机检索PubMed、Cochrane Library、CNKI、CBM和万方数据库,搜集经尿道等离子双极电切术治疗中国高危高龄良性前列腺增生症的病例系列研究,检索时间为建库至2018年9月14日。由两名评价者独立提取数据与质量评价,采用Comprehensive Meta-Analysis V2软件进行荟萃分析。结果最终纳入18项研究,共1 899例患者。术后第1、3、6、12和24个月的Qmax改变量分别为12.28 ml/s(95%CI:8.42~16.14)、12.88 ml/s(95%CI:9.85~15.92)、14.32 ml/s(95%CI:10.47~18.18)、14.93 ml/s(95%CI:10.19~19.67)和20.00 ml/s(95%CI:19.08~20.92);IPSS评分改变量分别为-18.60(95%CI:-23.20^-14.00)、-17.62(95%CI:-20.21^-15.03)、-19.14(95%CI:-20.70^-17.59)、-19.06(95%CI:-21.53^-16.60)和-22.90(95%CI:-24.26^-21.54);QoL评分改变量分别为-2.38(95%CI:-4.26^-0.50)、-3.39(95%CI:-4.57^-2.21)、-3.75(95%CI:-4.14^-3.36)、-3.36(95%CI:-4.56^-2.16)和-4.58(95%CI:-4.75^-4.41);PVR改变量分别为-231.16 ml(95%CI:-288.30^-174.01)、-76.10 ml(95%CI:-116.71^-35.50)、-159.90 ml(95%CI:-207.21^-112.59)和-87.70 ml(95%CI:-91.91^-83.48),术后不良反应发生率均不高。结论经尿道等离子双极电切术治疗高危高龄良性前列腺增生症患者有较好的临床疗效和安全性。 展开更多
关键词 经尿道等离子双极电切术 良性前列性增生症 高龄高危患者 系统评价 META分析
原文传递
斯坦福大学的创新创业教育:系统审视与经验启示 被引量:34
19
作者 李琳璐 《高教探索》 CSSCI 北大核心 2020年第3期56-65,共10页
高校创新创业教育生态系统的建构是全面推进高校创新创业教育和世界一流大学建设的新引擎,对于推进优秀创业型大学的创建具有一定的理论意义和实践价值。从生态系统的视域出发,将创新创业教育和生态系统相结合,探索创新创业教育生态系... 高校创新创业教育生态系统的建构是全面推进高校创新创业教育和世界一流大学建设的新引擎,对于推进优秀创业型大学的创建具有一定的理论意义和实践价值。从生态系统的视域出发,将创新创业教育和生态系统相结合,探索创新创业教育生态系统的内涵,分析高校创新创业教育生态系统的构成要素及其运行机制。以斯坦福大学为案例对其关于创新创业的精神与文化、课程体系与师资力量、支持性机构组织、企业等创新创业教育生态系统的构成要素以及运行机制进行深入的全景式描述和分析,在此基础之上总结归纳出其对中国高校构建创新创业教育生态系统的启示。 展开更多
关键词 创新创业教育生态系统 创新创业教育 斯坦福大学
下载PDF
国际贸易与中国技术进步方向——基于要素价格扭曲的中介效应分析 被引量:23
20
作者 罗知 宣琳露 李浩然 《经济评论》 CSSCI 北大核心 2018年第3期74-89,共16页
很多学者测算出中国的技术进步方向是偏向资本的,但是什么因素导致了这一结果?除了理论中指出的要素价格和禀赋等内在因素,外在因素也有可能诱导技术进步偏向某种要素,国际贸易就是其中最重要的原因之一。一些学者认为,通过国际贸易可... 很多学者测算出中国的技术进步方向是偏向资本的,但是什么因素导致了这一结果?除了理论中指出的要素价格和禀赋等内在因素,外在因素也有可能诱导技术进步偏向某种要素,国际贸易就是其中最重要的原因之一。一些学者认为,通过国际贸易可以直接引进发达国家的技术,而技术模仿使我国直接复制了发达国家偏向于资本的技术,所以我国的技术进步也偏向资本。本文则发现,国际贸易是通过影响要素价格这一途径促使技术进步偏向资本。本文利用1997-2012年省级层面数据测算了中国的技术进步偏向和要素价格扭曲程度。实证结果显示,进口贸易会使得技术进步偏向资本,但是出口贸易并不影响技术进步的偏向。进一步的,引入要素价格扭曲这一中介因素后,我们发现进口贸易减轻了劳动价格扭曲,进而使得资本价格相对劳动价格而言越发低于其边际产出,促使企业选择了偏向资本的技术进步方式。 展开更多
关键词 技术进步方向 国际贸易 要素价格扭曲 中介效应
原文传递
上一页 1 2 11 下一页 到第
使用帮助 返回顶部