自组装纳米材料在药物递送方面的应用具有巨大的潜能.其尺寸的可调控性、病理环境响应性等物理化学行为,使得自组装纳米载体可以通过改进主动靶向、被动靶向、血液长循环等方面来提高药物递送能力.然而,相对于大量基础研究的投入,目前...自组装纳米材料在药物递送方面的应用具有巨大的潜能.其尺寸的可调控性、病理环境响应性等物理化学行为,使得自组装纳米载体可以通过改进主动靶向、被动靶向、血液长循环等方面来提高药物递送能力.然而,相对于大量基础研究的投入,目前的临床转化依然面临着巨大的挑战.其中除了药物研发固有的高风险特征外,其主要原因还包括自组装纳米材料在体的稳定性、递送效率以及代谢毒性等问题.由此,我们从自然的自组装过程中得到启发,率先发展了活体自组装(in vivo self-assembly)的策略.它是指通过将外源性的分子引入到特定的生理和病理环境下,在细胞、组织甚至活体生物内进行自组装,形成可控的高级有序结构.通过调控其在复杂生物环境下时空可控的组装,从而实现特定的功能.体内自组装纳米药物具有组装诱导滞留(assembly induced retention,AIR)效应,能够显著增强药物在靶点病灶部位的富集和滞留,增强递送效率,提高药物利用率,同时降低药物在肝肾部位的蓄积,降低了毒性副作用,为癌症等重大疾病的诊断和治疗提供了新思路和新策略.展开更多
<strong>Objective:</strong> To explore the application of intelligent equipment in non-negative pressure isolation ward for COVID-2019 patients. <strong>Method:</strong> From February 1 to Marc...<strong>Objective:</strong> To explore the application of intelligent equipment in non-negative pressure isolation ward for COVID-2019 patients. <strong>Method:</strong> From February 1 to March 17, 2020, intelligent equipment, such as communication interaction system, intelligent disinfection robot, delivering robot, were used in non- negative pressure isolation ward of COVID-2019. With the help of communication interaction system to supervise the implementation of infection prevention and control, and observe the incorrect situation of pee use and personal behavior before and after the implementation. The disinfection robot and meal delivery robot were used in ward disinfection and life nursing combined with nursing practice. <strong>Result:</strong> Through the supervision of communication interaction system, the frequency of pee use and personal behavior was reduced. The frequency of bad articles before and after improvement was wearing protective clothing (2.80%/0.84%), taking off protective clothing (5.87%/0.84%), personal behavior observation (8.38%/1.90%), P < 0.01. The robot disinfected and delivered medicine for 912.5 h, saving 225 shifts of nursing staff. <strong>Conclusion:</strong> Intelligent equipment is a good option for infection control in isolation ward of COVID-2019. It can not only reduce the workload of health workers, but also the cross-infection.展开更多
<strong>Objectives:</strong> To control the Corona Virus Disease (COVID-19) epidemic, it is meaningful to improve the home quarantine ability and home-quarantine compliancy of patients released from medica...<strong>Objectives:</strong> To control the Corona Virus Disease (COVID-19) epidemic, it is meaningful to improve the home quarantine ability and home-quarantine compliancy of patients released from medical isolation, and to prevent cross-contamination. This study aimed to up protocols for COVID-19 patients released from medical isolation. <strong>Methods:</strong> A total of 35 patients discharged from the isolation ward of the Third Affiliated Hospital of Guangzhou Sun Yat-sen University from January 22, 2020 to February 18, 2020 were included. The patients received health education through discharge preparation, education leaflets and videos. The patients were followed up on the 2nd, 7th and 14th day after discharge through WeChat and phone call. On the 2nd and 14th day after discharge, the patients completed the knowledge assessment, self-perceived burden survey and satisfaction survey using a self-made home quarantine knowledge paper. <strong>Results:</strong> There were statistical differences in the knowledge and understanding of home quarantine and self-perceived burden between the 2nd day and 14th day after home quarantine (P < 0.05). The completion rate of home quarantine was 94.3%, and the satisfaction rate was 96.7%. <strong>Conclusion:</strong> By improving the discharge preparation, conducting in-time follow-up after discharge via WeChat and phone call, and performing multi-channel health education, the follow-up researchers could help the patients perform a more effective home quarantine, which could effectively prevent the spread of COVID-19 epidemic.展开更多
文摘自组装纳米材料在药物递送方面的应用具有巨大的潜能.其尺寸的可调控性、病理环境响应性等物理化学行为,使得自组装纳米载体可以通过改进主动靶向、被动靶向、血液长循环等方面来提高药物递送能力.然而,相对于大量基础研究的投入,目前的临床转化依然面临着巨大的挑战.其中除了药物研发固有的高风险特征外,其主要原因还包括自组装纳米材料在体的稳定性、递送效率以及代谢毒性等问题.由此,我们从自然的自组装过程中得到启发,率先发展了活体自组装(in vivo self-assembly)的策略.它是指通过将外源性的分子引入到特定的生理和病理环境下,在细胞、组织甚至活体生物内进行自组装,形成可控的高级有序结构.通过调控其在复杂生物环境下时空可控的组装,从而实现特定的功能.体内自组装纳米药物具有组装诱导滞留(assembly induced retention,AIR)效应,能够显著增强药物在靶点病灶部位的富集和滞留,增强递送效率,提高药物利用率,同时降低药物在肝肾部位的蓄积,降低了毒性副作用,为癌症等重大疾病的诊断和治疗提供了新思路和新策略.
文摘<strong>Objective:</strong> To explore the application of intelligent equipment in non-negative pressure isolation ward for COVID-2019 patients. <strong>Method:</strong> From February 1 to March 17, 2020, intelligent equipment, such as communication interaction system, intelligent disinfection robot, delivering robot, were used in non- negative pressure isolation ward of COVID-2019. With the help of communication interaction system to supervise the implementation of infection prevention and control, and observe the incorrect situation of pee use and personal behavior before and after the implementation. The disinfection robot and meal delivery robot were used in ward disinfection and life nursing combined with nursing practice. <strong>Result:</strong> Through the supervision of communication interaction system, the frequency of pee use and personal behavior was reduced. The frequency of bad articles before and after improvement was wearing protective clothing (2.80%/0.84%), taking off protective clothing (5.87%/0.84%), personal behavior observation (8.38%/1.90%), P < 0.01. The robot disinfected and delivered medicine for 912.5 h, saving 225 shifts of nursing staff. <strong>Conclusion:</strong> Intelligent equipment is a good option for infection control in isolation ward of COVID-2019. It can not only reduce the workload of health workers, but also the cross-infection.
文摘<strong>Objectives:</strong> To control the Corona Virus Disease (COVID-19) epidemic, it is meaningful to improve the home quarantine ability and home-quarantine compliancy of patients released from medical isolation, and to prevent cross-contamination. This study aimed to up protocols for COVID-19 patients released from medical isolation. <strong>Methods:</strong> A total of 35 patients discharged from the isolation ward of the Third Affiliated Hospital of Guangzhou Sun Yat-sen University from January 22, 2020 to February 18, 2020 were included. The patients received health education through discharge preparation, education leaflets and videos. The patients were followed up on the 2nd, 7th and 14th day after discharge through WeChat and phone call. On the 2nd and 14th day after discharge, the patients completed the knowledge assessment, self-perceived burden survey and satisfaction survey using a self-made home quarantine knowledge paper. <strong>Results:</strong> There were statistical differences in the knowledge and understanding of home quarantine and self-perceived burden between the 2nd day and 14th day after home quarantine (P < 0.05). The completion rate of home quarantine was 94.3%, and the satisfaction rate was 96.7%. <strong>Conclusion:</strong> By improving the discharge preparation, conducting in-time follow-up after discharge via WeChat and phone call, and performing multi-channel health education, the follow-up researchers could help the patients perform a more effective home quarantine, which could effectively prevent the spread of COVID-19 epidemic.
基金supported by the National Natural Science Foundation of China(No.81360388)Guangxi Natural Science Foundation (No.2016 GXNSFAA380258)+1 种基金Self-financing Project of Guangxi Health and Family Planning Commission(No.z2016282)Guangxi Graduate Education Innovation Program (No.YCSW2017104)
