A concise route to access 5H-imidazo[2,1-a]isoindole heterofused compounds by copper（I）-catalyzed intra- molecular coupling of non-activated aryl bromides with azoles is reported. With CuI as catalyst, 1,10-phenanth...A concise route to access 5H-imidazo[2,1-a]isoindole heterofused compounds by copper（I）-catalyzed intra- molecular coupling of non-activated aryl bromides with azoles is reported. With CuI as catalyst, 1,10-phenanth- roline as ligand, and K3PO4 as base, the reactions of 1-（2-bromobenzyl）-IH-imidazoles in DMF/o-xylene （I ： 1, V ： V） at 145 ℃ afford the corresponding substituted 5H-imidazo[2,1-a]isoindoles in high yields via intramolecu- lar C-arylation.展开更多
文摘A concise route to access 5H-imidazo[2,1-a]isoindole heterofused compounds by copper（I）-catalyzed intra- molecular coupling of non-activated aryl bromides with azoles is reported. With CuI as catalyst, 1,10-phenanth- roline as ligand, and K3PO4 as base, the reactions of 1-（2-bromobenzyl）-IH-imidazoles in DMF/o-xylene （I ： 1, V ： V） at 145 ℃ afford the corresponding substituted 5H-imidazo[2,1-a]isoindoles in high yields via intramolecu- lar C-arylation.
