The nuclear receptor superfamily and the transcriptional factors associated with cytokines are inherently different families of signaling molecules and activate gene transcription by binding to their respective respon...The nuclear receptor superfamily and the transcriptional factors associated with cytokines are inherently different families of signaling molecules and activate gene transcription by binding to their respective responsive element.However,it has become increasingly clear from our works and others that nuclear receptors are important regulators of cytokine production and function through complex and varied interactions between these distinct transcriptional factors.This review provides a general overview of the mechanism of action of nuclear receptors and their transcriptional crosstalk with transcriptional factors associated with cytokine transduction pathways.One of the most important mechanistic aspects is protein to protein interaction through a direct or co-regulator-mediated indirect manner.Such crosstalk is crucially involved in physiological and therapeutic roles of nuclear receptors and their iigands in immunity, inflammation and cytokine-related tumors.Cellular & Molecular Immunology.2004;1(6):416-424.展开更多
An aerosol process for making aluminum nitride nano-powder by decompositionof single compound diethylalumimm az-ide was described. X-ray diffraction (XRD) and transmissionelectron microscopy (TEM) were used to study c...An aerosol process for making aluminum nitride nano-powder by decompositionof single compound diethylalumimm az-ide was described. X-ray diffraction (XRD) and transmissionelectron microscopy (TEM) were used to study characters of the A1N powder. It is shown that theprocess can produce spherical A1N powder with mean particle diameters ranging from 10 to 50 nm at500-800°C. The generated amorphous A1N powder is characterized by a BET (Brunauer-Emmett-Teller)surface area of 103 m2/g and is very reactive to moisture.展开更多
文摘The nuclear receptor superfamily and the transcriptional factors associated with cytokines are inherently different families of signaling molecules and activate gene transcription by binding to their respective responsive element.However,it has become increasingly clear from our works and others that nuclear receptors are important regulators of cytokine production and function through complex and varied interactions between these distinct transcriptional factors.This review provides a general overview of the mechanism of action of nuclear receptors and their transcriptional crosstalk with transcriptional factors associated with cytokine transduction pathways.One of the most important mechanistic aspects is protein to protein interaction through a direct or co-regulator-mediated indirect manner.Such crosstalk is crucially involved in physiological and therapeutic roles of nuclear receptors and their iigands in immunity, inflammation and cytokine-related tumors.Cellular & Molecular Immunology.2004;1(6):416-424.
文摘An aerosol process for making aluminum nitride nano-powder by decompositionof single compound diethylalumimm az-ide was described. X-ray diffraction (XRD) and transmissionelectron microscopy (TEM) were used to study characters of the A1N powder. It is shown that theprocess can produce spherical A1N powder with mean particle diameters ranging from 10 to 50 nm at500-800°C. The generated amorphous A1N powder is characterized by a BET (Brunauer-Emmett-Teller)surface area of 103 m2/g and is very reactive to moisture.
