It has been a half-decade since the first direct detection of gravitational waves, which signifies the coming of the era of the gravitational-wave astronomy and gravitational-wave cosmology. The increasing number of t...It has been a half-decade since the first direct detection of gravitational waves, which signifies the coming of the era of the gravitational-wave astronomy and gravitational-wave cosmology. The increasing number of the detected gravitational-wave events has revealed the promising capability of constraining various aspects of cosmology, astronomy, and gravity. Due to the limited space in this review article, we will briefly summarize the recent progress over the past five years, but with a special focus on some of our own work for the Key Project "Physics associated with the gravitational waves" supported by the National Natural Science Foundation of China. In particular,(1) we have presented the mechanism of the gravitational-wave production during some physical processes of the early Universe, such as inflation, preheating and phase transition, and the cosmological implications of gravitational-wave measurements;(2) we have put constraints on the neutron star maximum mass according to GW170817 observations;(3) we have developed a numerical relativity algorithm based on the finite element method and a waveform model for the binary black hole coalescence along an eccentric orbit.展开更多
We study the possibility of probing high scale phase transitions that are inaccessible by LIGO.Our study shows that the stochastic gravitational-wave radiation from cosmic strings that are formed after the first-order...We study the possibility of probing high scale phase transitions that are inaccessible by LIGO.Our study shows that the stochastic gravitational-wave radiation from cosmic strings that are formed after the first-order phase transition can be detected by space-based interferometers when the phase transition temperature is T_(n)~O(10^(8−11))GeV.展开更多
In this study,we investigated the cosmological implications of a complex singlet scalar S with non-trivial B−L charges in the conformal U(1)B−L theory.It was found that,in a sizable region of parameter space,S may dis...In this study,we investigated the cosmological implications of a complex singlet scalar S with non-trivial B−L charges in the conformal U(1)B−L theory.It was found that,in a sizable region of parameter space,S may disturb the resonant leptogenesis mechanism,which is used to generate baryon asymmetry,and affect the symmetry breaking dynamics in the strong first order phase transition.The stochastic gravitational waves(GWs)produced at the phase transition can be probed in future GW experiments.The GW searches prefer a relatively light S at the TeV-scale;however,this is difficult to detect directly at future high-energy colliders.展开更多
In this work, we make the first study of electroweak baryogenesis（EWBG） based on the LHC data in the CP-violating next-to-minimal supersymmetric model（NMSSM） where a strongly first order electroweak phase transit...In this work, we make the first study of electroweak baryogenesis（EWBG） based on the LHC data in the CP-violating next-to-minimal supersymmetric model（NMSSM） where a strongly first order electroweak phase transition（EWPT） is obtained in the general complex Higgs potential. With representative benchmark points which pass the current LEP and LHC constraints, we demonstrate the structure of EWPT for those points and how a strongly first order EWPT is obtained in the complex NMSSM where the resulting gravitational wave production properties are found to be within the reaches of future space-based interferometers like BBO and Ultimate-DECIGO. We further calculate the generated baryon asymmetries where the CP violating sources are（1）： higgsino-singlino dominated,（2）： higgsino-gaugino dominated or（3）： from both sources. It is shown that all three representing scenarios could evade the strong constraints set by various electric dipole moments（EDM） searches where cancellations among the EDM contributions occur at the tree level（higgsino-singlino dominated） or loop level（higgsino-gaugino dominated）.The 125 GeV SM like Higgs can be either the second lightest neutral Higgs H_2 or the third lightest neutral Higgs H_3. Finally, we comment on the future direct and indirect probe of CPV in the Higgs sector from the collider and EDM experiments.展开更多
BACKGROUND： Pseudomonas aeruginosa mannose-sensitive hemagglutinin （PA-MSHA） parenteral injection is used as a broad-spectrum immunomodulator. It remains unclear whether PA-MSHA exhibits inhibitory effects on tumor...BACKGROUND： Pseudomonas aeruginosa mannose-sensitive hemagglutinin （PA-MSHA） parenteral injection is used as a broad-spectrum immunomodulator. It remains unclear whether PA-MSHA exhibits inhibitory effects on tumor cell growth. OBJECTIVE： To investigate inhibitory mechanisms of PA-MSHA-induced proliferation in rat C6 glioma cells in vitro. DESIGN, TIME AND SETTING： Comparative observation and in vitro experiments were performed at the Key Laboratory of Natural Medicine, Kunming Medical College, China from July 2008 to April 2009. MATERIALS： Rat C6 glioma cell line （Shanghai Institute of Cell Biology, Chinese Academy of Sciences, China） and PA-MSHA parenteral injection （Beijing Wanteer Bio-Pharmaceutical, China） were used in the present study. METHODS： Rat C6 glioma cells in logarithmic growth phase were harvested in vitro. Adherent monolayer cells were respectively treated with PA-MSHA at final colony-forming units （cfu） of 1 ×10^8 cfu/mL, 2 × 10^8 cfu/mL, 4 × 10^8 cfu/mL, 6 × 10^8 cfu/mL, and 8 ×10^8 cfu/mL following 24 hours of conventional culture. MAIN OUTCOME MEASURES： MTT colorimetric assay was utilized to determine the inhibitory rate of C6 glioma cells following treatment with various concentrations of PA-MSHA at different times. Cell apoptosis was detected by fluorescent microscopy following Hoechst 33258 staining. Flow cytometry was used to measure PA-MSHA effects on C6 cell cycle. RESULTS： Inhibitory rate of C6 glioma cells increased with prolonged time and increased dose. Hoechst 33258 staining revealed obvious morphological changes in apoptotic C6 glioma cells. Flow cytometry revealed hypodiploid peaks, Le., apoptotic peak, and the apoptotic rate in cells during S-phase significantly increased with increased concentrations in the experimental groups. CONCLUSION： With in vitro experiments, PA-MSHA preparations inhibited C6 glioma cell proliferation in a time- and dose-dependent manner. These mechanisms are likely associated with cell apoptosis induction and inhibit展开更多
This paper was published online on 6 August 2018 with the acknowledgement of an author being missed.The acknowledgement of the last author,Jing Shu,should be added as“The work of JS is supported by the National Natur...This paper was published online on 6 August 2018 with the acknowledgement of an author being missed.The acknowledgement of the last author,Jing Shu,should be added as“The work of JS is supported by the National Natural Science Foundation of China under grant No.11647601,No.11690022 and No.11675243 and also supported by the Strategic Priority Research Program of the Chinese Academy of Sciences under grant No.XDB21010200 and No.XDB23030100.Part of the results described in this paper are obtained on the HPC Cluster of SKLTP/ITP?CAS.”.展开更多
基金supported by the National Natural Science Foundation of China (Grant Nos.11690021,11690022,11690023,and 11690024)。
文摘It has been a half-decade since the first direct detection of gravitational waves, which signifies the coming of the era of the gravitational-wave astronomy and gravitational-wave cosmology. The increasing number of the detected gravitational-wave events has revealed the promising capability of constraining various aspects of cosmology, astronomy, and gravity. Due to the limited space in this review article, we will briefly summarize the recent progress over the past five years, but with a special focus on some of our own work for the Key Project "Physics associated with the gravitational waves" supported by the National Natural Science Foundation of China. In particular,(1) we have presented the mechanism of the gravitational-wave production during some physical processes of the early Universe, such as inflation, preheating and phase transition, and the cosmological implications of gravitational-wave measurements;(2) we have put constraints on the neutron star maximum mass according to GW170817 observations;(3) we have developed a numerical relativity algorithm based on the finite element method and a waveform model for the binary black hole coalescence along an eccentric orbit.
基金supported in part by the National Key Research and Development Program of China(2021YFC2203004)in part by the National Natural Science Foundation of China(12075041,12047564)+1 种基金the Fundamental Research Funds for the Central Universities of China(2021CDJQY-011,2020CDJQY-Z003)Chongqing Natural Science Foundation(cstc2020jcyj-msxmX0814)。
文摘We study the possibility of probing high scale phase transitions that are inaccessible by LIGO.Our study shows that the stochastic gravitational-wave radiation from cosmic strings that are formed after the first-order phase transition can be detected by space-based interferometers when the phase transition temperature is T_(n)~O(10^(8−11))GeV.
基金Supported by the National Natural Science Foundation of China (12075041, 12047564)the Fundamental Research Funds for the Central Universities of China (2021CDJQY-011, 2020CDJQY-Z003)+3 种基金Chongqing Natural Science Foundation (cstc2020jcyj-msxmX0814)Supported by the China Postdoctoral Science Foundation (2019TQ0329)partially Supported by the U.S. Department of Energy grant (DE-SC0009956)supported by the US Department of Energy (DE-SC0017987)
文摘In this study,we investigated the cosmological implications of a complex singlet scalar S with non-trivial B−L charges in the conformal U(1)B−L theory.It was found that,in a sizable region of parameter space,S may disturb the resonant leptogenesis mechanism,which is used to generate baryon asymmetry,and affect the symmetry breaking dynamics in the strong first order phase transition.The stochastic gravitational waves(GWs)produced at the phase transition can be probed in future GW experiments.The GW searches prefer a relatively light S at the TeV-scale;however,this is difficult to detect directly at future high-energy colliders.
基金Supported by the National Natural Science Foundation of China(11605016,11647307)Basic Science Research gram through the National Research Foundation of Korea(NRF) funded by the Ministry of Education,Science and Technology(NRF-2016R1A2B4008759)the National Research Foundation of Korea(NRF) funded by the Ministry of Science and ICT(2017H1D3A1A01014046)
文摘In this work, we make the first study of electroweak baryogenesis（EWBG） based on the LHC data in the CP-violating next-to-minimal supersymmetric model（NMSSM） where a strongly first order electroweak phase transition（EWPT） is obtained in the general complex Higgs potential. With representative benchmark points which pass the current LEP and LHC constraints, we demonstrate the structure of EWPT for those points and how a strongly first order EWPT is obtained in the complex NMSSM where the resulting gravitational wave production properties are found to be within the reaches of future space-based interferometers like BBO and Ultimate-DECIGO. We further calculate the generated baryon asymmetries where the CP violating sources are（1）： higgsino-singlino dominated,（2）： higgsino-gaugino dominated or（3）： from both sources. It is shown that all three representing scenarios could evade the strong constraints set by various electric dipole moments（EDM） searches where cancellations among the EDM contributions occur at the tree level（higgsino-singlino dominated） or loop level（higgsino-gaugino dominated）.The 125 GeV SM like Higgs can be either the second lightest neutral Higgs H_2 or the third lightest neutral Higgs H_3. Finally, we comment on the future direct and indirect probe of CPV in the Higgs sector from the collider and EDM experiments.
文摘BACKGROUND： Pseudomonas aeruginosa mannose-sensitive hemagglutinin （PA-MSHA） parenteral injection is used as a broad-spectrum immunomodulator. It remains unclear whether PA-MSHA exhibits inhibitory effects on tumor cell growth. OBJECTIVE： To investigate inhibitory mechanisms of PA-MSHA-induced proliferation in rat C6 glioma cells in vitro. DESIGN, TIME AND SETTING： Comparative observation and in vitro experiments were performed at the Key Laboratory of Natural Medicine, Kunming Medical College, China from July 2008 to April 2009. MATERIALS： Rat C6 glioma cell line （Shanghai Institute of Cell Biology, Chinese Academy of Sciences, China） and PA-MSHA parenteral injection （Beijing Wanteer Bio-Pharmaceutical, China） were used in the present study. METHODS： Rat C6 glioma cells in logarithmic growth phase were harvested in vitro. Adherent monolayer cells were respectively treated with PA-MSHA at final colony-forming units （cfu） of 1 ×10^8 cfu/mL, 2 × 10^8 cfu/mL, 4 × 10^8 cfu/mL, 6 × 10^8 cfu/mL, and 8 ×10^8 cfu/mL following 24 hours of conventional culture. MAIN OUTCOME MEASURES： MTT colorimetric assay was utilized to determine the inhibitory rate of C6 glioma cells following treatment with various concentrations of PA-MSHA at different times. Cell apoptosis was detected by fluorescent microscopy following Hoechst 33258 staining. Flow cytometry was used to measure PA-MSHA effects on C6 cell cycle. RESULTS： Inhibitory rate of C6 glioma cells increased with prolonged time and increased dose. Hoechst 33258 staining revealed obvious morphological changes in apoptotic C6 glioma cells. Flow cytometry revealed hypodiploid peaks, Le., apoptotic peak, and the apoptotic rate in cells during S-phase significantly increased with increased concentrations in the experimental groups. CONCLUSION： With in vitro experiments, PA-MSHA preparations inhibited C6 glioma cell proliferation in a time- and dose-dependent manner. These mechanisms are likely associated with cell apoptosis induction and inhibit
文摘This paper was published online on 6 August 2018 with the acknowledgement of an author being missed.The acknowledgement of the last author,Jing Shu,should be added as“The work of JS is supported by the National Natural Science Foundation of China under grant No.11647601,No.11690022 and No.11675243 and also supported by the Strategic Priority Research Program of the Chinese Academy of Sciences under grant No.XDB21010200 and No.XDB23030100.Part of the results described in this paper are obtained on the HPC Cluster of SKLTP/ITP?CAS.”.
