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Lipopolysaccharide induced intestinal epithelial injury:a novel organoids-based model for sepsis in vitro 被引量:5
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作者 Sisi Huang Sheng Zhang +6 位作者 Limin Chen Xiaojun Pan Zhenliang Wen Yizhu Chen lidi Zhang Jiao Liu Dechang Chen 《Chinese Medical Journal》 SCIE CAS CSCD 2022年第18期2232-2239,共8页
Background: Advances in organoid culture technology have provided a greater understanding of disease pathogenesis, which has been rarely studied in sepsis before. We aim to establish a suitable organoids-based intesti... Background: Advances in organoid culture technology have provided a greater understanding of disease pathogenesis, which has been rarely studied in sepsis before. We aim to establish a suitable organoids-based intestinal injury model for sepsis.Methods: Stable passaged organoids were constructed and pre-treated with lipopolysaccharide (LPS) to mimic sepsis-induced intestinal injury. The LPS-induced sepsis model was used as a reference. We used quantitative real-time polymerase chain reaction to evaluate the RNA levels of inflammatory factors and antimicrobial peptides. Enzyme-linked immunosorbent assay was used to evaluate the protein levels, hematoxylin and eosin staining was used to evaluate the pathology of the small intestine of mice, and immunohistochemistry and immunofluorescence were used to evaluate the intestinal epithelial barrier function. Perkin Elmer OperettaTM was used to obtain high-resolution images of three-dimensional organoids.Results: An LPS concentration >150 μg/mL after 24 h was identified to cause organoid growth restriction. The fluorescence intensity of zonula occludens-1 and occludins at LPS concentrations >100 μg/mL decreased significantly after 24 h. After LPS stimulation for 8 h, the RNA expression levels of interleukin (IL)-1α, tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, IL-6, and regenerating islet-derived protein 3 alpha, beta, and gamma increased. These results resembled those of intestinal epithelial layer alterations in a mouse sepsis model. For IL-10, the RNA expression level increased only when the LPS level >200 μg/mL for 24 h.Conclusions: This study provides the primary intestinalin vitro model to study the effects of LPS-induced intestinal injury resembling sepsis. This model provides a platform for immune associated mechanism exploration and effective drug screening. 展开更多
关键词 ORGANOIDS SEPSIS LIPOPOLYSACCHARIDE Barrier function Inflammatory factors
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Rare earth passivation and corrosion resistance of zinc coated NdFeB magnets 被引量:4
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作者 Jing Chen Hongyi Yang +8 位作者 Guangqing Xu Pengjie Zhang Jun Lv Wei Sun Bingshan lidi Jun Huang Dongmei Wang Xia Shu Yucheng Wu 《Journal of Rare Earths》 SCIE EI CAS CSCD 2022年第2期302-308,I0005,共8页
Rare earth passivation was conducted on Zn coated NdFeB magnets by chemical reaction to enhance the corrosion resistance performance.Morphologies,micro structures and compositions of different passivated coatings were... Rare earth passivation was conducted on Zn coated NdFeB magnets by chemical reaction to enhance the corrosion resistance performance.Morphologies,micro structures and compositions of different passivated coatings were studied by X-ray diffraction,field emission scanning electron microscopy,and X-ray photoelectron spectroscopy,respectively.The corrosion behavior was evaluated by electrochemical measurement and neutral salt spray test.The results show that the rare earth passivation can enhance the corrosion resistance of Zn coated NdFeB magnets.When the concentration of cerium nitrate is 5 g/L,the passivated specimens can achieve the longest NSS time of 360 h,which is 144 h longer than that of the pristine Zn/NdFeB magnets.The passivation layer on the Zn coating surface contributes to the enhancement of the magnets’corrosion resistance. 展开更多
关键词 Sintered NdFeB magnets Rare earth passivation Zn coating ELECTROPLATING Corrosion resistance
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Massive Envenomation by Bees Sting in a Child in Togo 被引量:1
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作者 Djatougbe Ayaovi Elie Akolly Koffi Mawuse Guedenon +3 位作者 Enyonam Tsolenyanu lidi Kama Bessi Didier Koffi Gnamey Yao Atakouma 《Open Journal of Pediatrics》 2016年第3期232-236,共5页
Attacks by swarm of bees realize arrays of mass poisoning. We report the case of a 9 years old boy whoes severity was related to the large number of bees which was about 400 and their locations spread throughout the s... Attacks by swarm of bees realize arrays of mass poisoning. We report the case of a 9 years old boy whoes severity was related to the large number of bees which was about 400 and their locations spread throughout the skin surface with a preponderance to the cephalic end. Complications were hemolytic anemia, kidney failure and convulsions. The outcome was favorable with symptomatic care and hemodialysis. 展开更多
关键词 BEE ENVENOMATION Renal Failure CHILD TOGO
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Activating transcription factor 4 protects mice against sepsis-induced intestinal injury by regulating gut-resident macrophages differentiation 被引量:3
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作者 Zhenliang Wen Xi Xiong +10 位作者 Dechang Chen Lujing Shao Xiaomeng Tang Xuan Shen Sheng Zhang Sisi Huang lidi Zhang Yizhu Chen Yucai Zhang Chunxia Wang Jiao Liu 《Chinese Medical Journal》 SCIE CAS CSCD 2022年第21期2585-2595,共11页
Background: Gut-resident macrophages (gMacs) supplemented by monocytes-to-gMacs differentiation play a critical role in maintaining intestinal homeostasis. Activating transcription factor 4 (ATF4) is involved in immun... Background: Gut-resident macrophages (gMacs) supplemented by monocytes-to-gMacs differentiation play a critical role in maintaining intestinal homeostasis. Activating transcription factor 4 (ATF4) is involved in immune cell differentiation. We therefore set out to investigate the role of ATF4-regulated monocytes-to-gMacs differentiation in sepsis-induced intestinal injury.Methods: Sepsis was induced in C57BL/6 wild type (WT) mice andAtf4-knockdown (Atf4+/-) mice by cecal ligation and puncture or administration of lipopolysaccharide (LPS). Colon, peripheral blood mononuclear cells, sera, lung, liver, and mesenteric lymph nodes were collected for flow cytometry, hematoxylin and eosin staining, immunohistochemistry, quantitative reverse transcription polymerase chain reaction, and enzyme-linked immunosorbent assay, respectively.Results: CD64, CD11b, Ly6C, major histocompatibility complex-II (MHC-II), CX3CR1, Ly6G, and SSC were identified as optimal primary markers for detecting the process of monocytes-to-gMacs differentiation in the colon of WT mice. Monocytes-to-gMacs differentiation was impaired in the colon during sepsis and was associated with decreased expression of ATF4 in P1 (Ly6Chi monocytes), the precursor cells of gMacs.Atf4 knockdown exacerbated the impairment of monocytes-to-gMacs differentiation in response to LPS, resulting in a significant reduction of gMacs in the colon. Furthermore, compared with WT mice,Atf4+/- mice exhibited higher pathology scores, increased expression of inflammatory factor genes (TNF-α, IL-1β), suppressed expression of CD31 and vascular endothelial-cadherin in the colon, and increased translocation of intestinal bacteria to lymph nodes and lungs following exposure to LPS. However, the aggravation of sepsis-induced intestinal injury resulting fromAtf4 knockdown was not caused by the enhanced inflammatory effect of Ly6Chi monocytes and gMacs.Conclusion: ATF4, as a novel regulator of monocytes-to-gMacs differentiation, plays a critical role in protecting mice against sepsis-ind 展开更多
关键词 Activating transcription factor 4 Mice LIPOPOLYSACCHARIDES MONOCYTES Leukocytes mononuclear Cell differentiation MACROPHAGES Sepsis Homeostasis gMacs Intestinal injury
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Concentration and Chemical Speciation of Heavy Metals in Sludge and Removal of Metals by Bio-surfactants Application 被引量:1
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作者 lidi Gao Naoki Kano Hiroshi Imaizumi 《Journal of Chemistry and Chemical Engineering》 2013年第12期1188-1202,共15页
The concentration and chemical speciation of heavy metals including REEs (rare earth elements), Th (thorium) and U (uranium) in domestic sludge and electroplating sludge were investigated, and those of the domes... The concentration and chemical speciation of heavy metals including REEs (rare earth elements), Th (thorium) and U (uranium) in domestic sludge and electroplating sludge were investigated, and those of the domestic sludge were compared with those of natural soil. Removal of heavy metals in electroplating sludge was studied with bio-surfactants (saponin and sophorolipid) by batch and column experiments. The results suggested that heavy metals have greater concentrations and exist as more relatively unstable fraction in sludge than those in Natural soil. Nonionic saponin is more efficient than sophorolipid for the removal of heavy metals from the electroplating sludge, and mainly reacts with carbonate state (i.e., F3) and Fe-Mn oxide state (i.e., F5) fractions. The recovery efficiency of heavy metals in leachates from the electroplate sludge was attained 88%-97%. Saponin can be reused and be a promising and cost-effective material for the removal of heavy metals in sludge. 展开更多
关键词 SLUDGE chemical speciation heavy metals bio-surfactant column washing.
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Look at the current situation and development of Chinese motorcycle industry through production access
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作者 By ZHAO lidi FAN Guochen GUO Lingsong 《中国汽车(英文版)》 2004年第9期16-18,共3页
At the end of 2002, the former State Economic and Trade Commission issued the Regulations on Production Access of Motorcycles together with detailed rules for implementation. Motorcycle makers were supposed to reach t... At the end of 2002, the former State Economic and Trade Commission issued the Regulations on Production Access of Motorcycles together with detailed rules for implementation. Motorcycle makers were supposed to reach the Phase I demand of the Regulations by the end of 2003. The implementation of the document has had an enormous bearing on China’s motorcycle industry. 展开更多
关键词 enormous issued GUANGDONG document supposed Jiangsu LISTED BULLETIN LIKELY FASTER
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Standardizing signs on public information in the New Coastal Area
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作者 Mou Yue Wang lidi 《China Standardization》 2007年第3期28-31,共4页
The public information signs( The term public information signs will be abbreviated to public signs in the following text.)in the urban areas not only offer convenience for people to move around, but also reflect the ... The public information signs( The term public information signs will be abbreviated to public signs in the following text.)in the urban areas not only offer convenience for people to move around, but also reflect the level of development and progress of those areas. It is essential to the creative development and uplifting of the New Costal Area (thereafter, NCA) to have a good understanding of its present situation with regard to its public signs, to discuss the related issues in the development, to work out a system that is up to international standard and develop its own standards in the course of implementing the national strategies on standardizing public signs. 展开更多
关键词 PUBLIC INFORMATION SIGN SYSTEM LEARNING FROM LTHERS FUNCTIONS
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动物生态学中还原与整体方法的协同作用
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作者 lidi.,WZ 宋春林 《生态学进展》 CSCD 1989年第3期219-220,183,共3页
关键词 动物生态学 还原方法 整体方法
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PENETRATION QUALITY EVALUATION IN ROBOTIZED ARC WELDING BASED ON SUPP0RT VECTOR MACHINE
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作者 YeFeng SongYonglun +1 位作者 lidi LaiYizong 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2003年第4期387-390,共4页
A quality monitoring method by means of support vector machines (SVM) forrobotized gas metal arc welding (GMAW) is introduced. Through the feature extraction of the weldingprocess signal, a SVM classifier is construct... A quality monitoring method by means of support vector machines (SVM) forrobotized gas metal arc welding (GMAW) is introduced. Through the feature extraction of the weldingprocess signal, a SVM classifier is constructed to establish the relationship between the feature ofprocess parameters and the quality of weld penetration. Under the samples obtained from auto partswelding production line, the learning machine with a radial basis function kernel shows goodperformance. And this method can be feasible to identity defect online in welding production. 展开更多
关键词 WELDING Quality monitoring Support vector machine
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Structure and Positioning of Three Transmembrane Segments from Slcllal in SDS Micelles
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作者 QI Haiyan TANG Wanxia +1 位作者 BAI Liming GAO lidi 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2017年第2期221-226,共6页
Slcllal is an integral membrane protein with 12 predicted transmembrane domams(TM). In the presentwork, the secondary structures and positioning of the peptides associated with SIclIaI-TM2, TM3 andTM4(wild-type pep... Slcllal is an integral membrane protein with 12 predicted transmembrane domams(TM). In the presentwork, the secondary structures and positioning of the peptides associated with SIclIaI-TM2, TM3 andTM4(wild-type peptides and fimctional mutants) in sodium dodecyl sulfate(SDS) were analyzed using circulardichroism(CD) and fluorescence techniques. The results indicate that TM3 is significantly different in secondarystructure and topology from TM2 and TM4 in SDS. The peptide TM3 is less structured and is embedded in the SDSless deeply than TM2 and TM4 at pH=4, 5.5 and 7. In addition, the position of TM3 is remarkably shifted towards thedirection of the SDS surface with increasing pH, whereas the locations of TM2 and TM4 in SDS are less affected bypH. The E 139A substitution in TM3 significantly impairs the pH dependence of the buried depth of TM3 and causes adecrease in helicity in SDS at the three pH values. The G169D mutation has little effect on the topological arrange-ment of TM4 in SDS. In contrast, TM2 and TM4 are topologically similar. 展开更多
关键词 Slcllal TRANSMEMBRANE domain POSITIONING SODIUM dodecyl sulfate(SDS) Circular dichroism(CD)
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配用连续油管的电潜泵系统
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作者 lidi.,DJ 苏开科 《国外石油机械》 1997年第6期35-40,共6页
介绍第一台与连续油管配套使用的电潜泵。长期以来连续油管一直用于既无钻井机或修井机,又受成本限制的许多修井作业。在许多地区,经费短缺且又缺少修井机,在考虑用电潜泵系统进行人工举升时就会受到限制。本文介绍的现场实例表明用连... 介绍第一台与连续油管配套使用的电潜泵。长期以来连续油管一直用于既无钻井机或修井机,又受成本限制的许多修井作业。在许多地区,经费短缺且又缺少修井机,在考虑用电潜泵系统进行人工举升时就会受到限制。本文介绍的现场实例表明用连续油管作业机安装电潜泵是有效的。讨论的完井设计原理与具体的现场配置有关。已证实用连续油管装置配电潜泵作为一种人工举升的手段是可行的。 展开更多
关键词 采油 连续油管 油管 电潜泵系统 电泵采油
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Research and implementation of digital detection method on closed loop FOG
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作者 lidi LIXu-you SUNYao 《Journal of Marine Science and Application》 2004年第1期37-40,共4页
In the strapdown inertial navigation system, the Fiber Optical Gyro(FOG) must have high precision to give accurate navigation information. In this paper, a digital closed loop detection method based on the ramp wave m... In the strapdown inertial navigation system, the Fiber Optical Gyro(FOG) must have high precision to give accurate navigation information. In this paper, a digital closed loop detection method based on the ramp wave modulating technigue is introduced. DSP and FPGA have many advantages in digital signal proeessing. In the design, by using DSP, a complex arithmetic operation is completed to meet the needs of closed loop control of FOG within a short time. All kinds of control signals are produced easily by FPGA, under which DSP could work properly. Combining the DSP and FPGA,the detecting method is implemented successfully. In the end, the result of test and performance is given. From the result we can conclude that the precision of FOG is improved and the noises are limited to a low level. 展开更多
关键词 FOG ramp wave signal detection phase modulation DSP FPGA
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Identification and validation of prognostic factors in patients with COVID-19: A retrospective study based on artificial intelligence algorithms
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作者 Sheng Zhang Sisi Huang +10 位作者 Jiao Liu Xuan Dong Mei Meng Limin Chen Zhenliang Wen lidi Zhang Yizhu Chen Hangxiang Du Yongan Liu Tao Wang Dechang Chen 《Journal of Intensive Medicine》 2021年第2期103-109,共7页
Background:Novel coronavirus disease 2019(COVID-19)is an ongoing global pandemic with high mortality.Although several studies have reported different risk factors for mortality in patients based on traditional analyti... Background:Novel coronavirus disease 2019(COVID-19)is an ongoing global pandemic with high mortality.Although several studies have reported different risk factors for mortality in patients based on traditional analytics,few studies have used artificial intelligence(AI)algorithms.This study investigated prognostic factors for COVID-19 patients using AI methods.Methods:COVID-19 patients who were admitted in Wuhan Infectious Diseases Hospital from December 29,2019 to March 2,2020 were included.The whole cohort was randomly divided into training and testing sets at a 6:4 ratio.Demographic and clinical data were analyzed to identify predictors of mortality using least absolute shrinkage and selection operator(LASSO)regression and LASSO-based artificial neural network(ANN)models.The predictive performance of the models was evaluated using receiver operating characteristic(ROC)curve analysis.Results:A total of 1145 patients(610 male,53.3%)were included in the study.Of the 1145 patients,704 were assigned to the training set and 441 were assigned to the testing set.The median age of the patients was 57 years(range:47-66 years).Severity of illness,age,platelet count,leukocyte count,prealbumin,C-reactive protein(CRP),total bilirubin,Acute Physiology and Chronic Health Evaluation(APACHE)II score,and Sequential Organ Failure Assessment(SOFA)score were identified as independent prognostic factors for mortality.Incorporating these nine factors into the LASSO regression model yielded a correct classification rate of 0.98,with area under the ROC curve(AUC)values of 0.980 and 0.990 in the training and testing cohorts,respectively.Incorporating the same factors into the LASSO-based ANN model yielded a correct classification rate of 0.990,with an AUC of 0.980 in both the training and testing cohorts.Conclusions:Both the LASSO regression and LASSO-based ANN model accurately predicted the clinical outcome of patients with COVID-19.Severity of illness,age,platelet count,leukocyte count,prealbumin,CRP,total bilirubin,APACHE II score,and 展开更多
关键词 COVID-19 Least absolute shrinkage and selection operator(LASSO)regression model Artificial neural network model Artificial intelligence PROGNOSIS
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Photocurrent of TiO_2 Photoelectrode Enhanced by Nafion Modification
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作者 PANKai LIUZhao-yue +9 位作者 HUJian-qiang LIJun LIZi-heng lidi LIUYang LIUMin LIJing-hong WANGDe-jun BAIYu-bai LITie-jin 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2005年第3期360-364,共5页
关键词 NAFION TiO_2 photoelectrode Potential drop PHOTOCURRENT
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小规模限制性在线课程在《内科护理学》教学中的应用 被引量:26
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作者 吴林秀 周小雅 +4 位作者 张丽娣 吴潇芸 何华梅 黄文婷 莫小云 《解放军护理杂志》 CSCD 北大核心 2019年第8期83-86,共4页
目的构建基于信息化技术的《内科护理学》的大学课堂小规模限制性在线课程(small private online course,SPOC)学习模式并实践运用,探讨其效果。方法随机抽样法选取2018年9月至2019年1月广西卫生职业技术学院2017级高职护理专业12个班级... 目的构建基于信息化技术的《内科护理学》的大学课堂小规模限制性在线课程(small private online course,SPOC)学习模式并实践运用,探讨其效果。方法随机抽样法选取2018年9月至2019年1月广西卫生职业技术学院2017级高职护理专业12个班级的730名学生为研究对象,按照随机数字表法将12个班级随机分为观察组(n=364)和对照组(n=366),观察组采用SPOC模式,对照组采用常规教学模式。结果观察组的理论成绩、自主学习能力得分较对照组高,差异有统计学意义(均P<0.05);83.01%的学生对大学课堂SPOC模式的评价为非常满意,学生对其认可程度高。结论大学课堂SPOC模式有助于促进知识内化、提高学生自主学习能力。 展开更多
关键词 信息化技术 大学课堂SPOC 混合式学习 内科护理学
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基于神经网络的光伏阵列多峰MPPT的研究 被引量:24
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作者 吴登盛 王立地 +1 位作者 刘通 孟晓芳 《电测与仪表》 北大核心 2019年第7期69-74,83,共7页
为了减少神经网络训练数据的数量,根据局部阴影条件下光伏阵列的输出特性,提出基本阴影遮挡类型概念,使得神经网络仅需要训练少量数据,就可以准确地预测最大功率点电压。首先,通过实际光伏阵列数据测试仅训练基本阴影遮挡类型的BP神经... 为了减少神经网络训练数据的数量,根据局部阴影条件下光伏阵列的输出特性,提出基本阴影遮挡类型概念,使得神经网络仅需要训练少量数据,就可以准确地预测最大功率点电压。首先,通过实际光伏阵列数据测试仅训练基本阴影遮挡类型的BP神经网络对最大功率点电压的跟踪效果。然后,搭建光伏发电MPPT仿真系统,对比扰动法、固定电压法和BP神经网络结合扰动法在阴影类型、光照强度和温度三方面变化时对MPP的跟踪效果。最后,通过分析表明,经过基本阴影遮挡类型训练的BP神经网络结合扰动法能够有效地跟踪最大功率点,即基本阴影遮挡类型能够减少神经网络跟踪多峰MPP的训练数据获取量。 展开更多
关键词 多峰MPPT 基本阴影遮挡类型 局部阴影 BP神经网络
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精神科专科护理质量敏感性指标体系的构建 被引量:23
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作者 邵静 罗薇 +3 位作者 耿丽弟 王晨 刘晓 王志仁 《中国护理管理》 CSCD 2021年第6期931-936,共6页
目的:构建适用于精神科专科的护理质量敏感性指标体系,为精神科专科医院和综合医院精神科护理质量监测及评价提供标准、可量化的依据。方法:成立研究小组,以结构-过程-结果三维质量评价模式为理论基础,结合文献分析法分析结果和研究小... 目的:构建适用于精神科专科的护理质量敏感性指标体系,为精神科专科医院和综合医院精神科护理质量监测及评价提供标准、可量化的依据。方法:成立研究小组,以结构-过程-结果三维质量评价模式为理论基础,结合文献分析法分析结果和研究小组成员讨论结果初步拟定指标,通过两轮德尔菲专家函询,确立精神科专科护理质量敏感性指标体系。结果:最终构建了包含3项一级指标、19项二级指标的精神科专科护理质量敏感性指标体系;两轮德尔菲专家函询积极系数均为100.0%,专家权威系数分别为0.905、0.918,专家协调系数在0.112~0.148(P<0.05)。结论:基于德尔菲法构建的精神科专科护理质量敏感性指标体系科学、可信、实用,有利于精神科专科护理质量的管理和持续改进。 展开更多
关键词 护理质量 敏感性 指标体系 精神科 德尔菲法
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基于认知诊断评估的听力理解互补性机制探究 被引量:20
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作者 闵尚超 熊笠地 《现代外语》 CSSCI 北大核心 2019年第2期254-266,共13页
本研究探索了英语听力理解中的互补性机制及其体现。研究者从校本考试出发,选取了四个不同性质的认知诊断模型并将听力能力划分为六个认知属性,从粒化认知属性层面探究听力理解的认知过程。结果显示:1)听力理解过程中存在互补性机制;2)... 本研究探索了英语听力理解中的互补性机制及其体现。研究者从校本考试出发,选取了四个不同性质的认知诊断模型并将听力能力划分为六个认知属性,从粒化认知属性层面探究听力理解的认知过程。结果显示:1)听力理解过程中存在互补性机制;2)这种补偿性主要体现在技能性知识上,语言知识是听力理解的基础,但技能知识的掌握能更好地提高听力水平,不过补偿性机制的启动可能存在一定的阈值;此外,本研究还尝试提出听力理解贡献性框架,以期对影响听力的各个因素有更系统的阐释。 展开更多
关键词 听力能力 互补性 认知诊断模型 校本考试
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综合能源背景下的配电网规划研究 被引量:19
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作者 张立地 窦迅 +1 位作者 王俊 张盼 《供用电》 2018年第4期37-45,共9页
优化协调包含电、气、热等多种能源的综合能源系统,是提高能源利用率、应对气候变化以及实现能源可持续发展的重要途径。文章阐述了综合能源系统中电力与其他能源联合的发展现状,综述了电力系统与其他能源系统联合下的配电网规划内容,... 优化协调包含电、气、热等多种能源的综合能源系统,是提高能源利用率、应对气候变化以及实现能源可持续发展的重要途径。文章阐述了综合能源系统中电力与其他能源联合的发展现状,综述了电力系统与其他能源系统联合下的配电网规划内容,为综合能源背景下配电网规划的研究提供参考。 展开更多
关键词 综合能源 配电网规划 电-交通系统交互 电-气系统交互 电-分布式电源交互 电-需求响应交互.
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3D-ASL技术在高级别脑胶质瘤术后复发诊断与鉴别诊断中的应用 被引量:16
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作者 潘锋 诸一吕 +2 位作者 姚丽娣 苏中周 周林江 《医学影像学杂志》 2018年第8期1234-1237,共4页
目的探讨3D-ASL技术在高级别脑胶质瘤术后复发诊断与鉴别诊断中价值。方法选取52例高级别脑胶质瘤术后放疗后在MRI随访出现术区异常强化病灶的患者,其中经过二次手术或随访确诊肿瘤复发者34例为A组,确诊放射性脑损伤者18例为B组。2组患... 目的探讨3D-ASL技术在高级别脑胶质瘤术后复发诊断与鉴别诊断中价值。方法选取52例高级别脑胶质瘤术后放疗后在MRI随访出现术区异常强化病灶的患者,其中经过二次手术或随访确诊肿瘤复发者34例为A组,确诊放射性脑损伤者18例为B组。2组患者均行常规MRI平扫、增强及3D-ASL检查;测量3D-ASL血流灌注图像中的病灶实质部分最大血流量值(CBFmax)和对侧镜像区、对侧白质、灰质的CBFmax值,所得数值标准化后做统计学分析。分别通过常规MRI和常规MRI联合3D-ASL技术做出诊断,将2种方法的诊断符合率行统计学比较。结果平均最大相对脑血流量(r CBFmax)比值在两组患者之间的差异有统计学意义;联合应用3DASL技术对胶质瘤复发的诊断正确率有明显提高,两种诊断方法差异有统计学意义。结论 3D-ASL技术安全无创,无需注射造影剂,可以用于胶质瘤复发与放射损伤的鉴别,常规MRI联合3D-ASL有助于提高胶质瘤复发的诊断正确率。 展开更多
关键词 磁共振成像 3D动脉自旋标记 高级别脑胶质瘤 术后复发 放射性脑损伤
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