目的探讨动态增强磁共振成像(dynamic contrast-enhanced magnetic resonance imaging,DCE-MRI)技术在子宫颈癌临床分期中的应用价值。方法对2019年1月至2021年12月在郑州大学第二附属医院行手术治疗的186例子宫颈癌患者进行回顾性分析...目的探讨动态增强磁共振成像(dynamic contrast-enhanced magnetic resonance imaging,DCE-MRI)技术在子宫颈癌临床分期中的应用价值。方法对2019年1月至2021年12月在郑州大学第二附属医院行手术治疗的186例子宫颈癌患者进行回顾性分析。所有患者术前均行DCE-MRI技术以协助评估临床分期、宫颈肌层浸润、子宫体浸润、阴道累及、宫旁转移、淋巴结转移等相关参数,以术后病理为金标准进行验证,分析DCE-MRI技术术前评估子宫颈癌分期的准确度、灵敏度及特异度。结果186例子宫颈癌患者临床分期与手术病理分期一致性较好(Kappa=0.862,P<0.001),165例(88.71%)临床分期与手术病理分期一致。DCE-MRI诊断阴道累及的准确度为96.24%、灵敏度为86.96%、特异度为97.55%;诊断淋巴结转移的准确度为97.31%、灵敏度为82.35%、特异度为98.82%;诊断深肌层浸润的准确度为86.56%、灵敏度为90.79%、特异度为83.63%。结论DCE-MRI技术在诊断阴道累及、淋巴结转移、深肌层浸润等方面具有较高的灵敏度与特异度,可为子宫颈癌术前临床分期评估提供参考。展开更多
A multiphase field model coupled with a lattice Boltzmann(PF-LBM)model is proposed to simulate the distribution mechanism of bubbles and solutes at the solid-liquid interface,the interaction between dendrites and bubb...A multiphase field model coupled with a lattice Boltzmann(PF-LBM)model is proposed to simulate the distribution mechanism of bubbles and solutes at the solid-liquid interface,the interaction between dendrites and bubbles,and the effects of different temperatures,anisotropic strengths and tilting angles on the solidified organization of the SCN-0.24wt.%butanedinitrile alloy during the solidification process.The model adopts a multiphase field model to simulate the growth of dendrites,calculates the growth motions of dendrites based on the interfacial solute equilibrium;and adopts a lattice Boltzmann model(LBM)based on the Shan-Chen multiphase flow to simulate the growth and motions of bubbles in the liquid phase,which includes the interaction between solid-liquid-gas phases.The simulation results show that during the directional growth of columnar dendrites,bubbles first precipitate out slowly at the very bottom of the dendrites,and then rise up due to the different solid-liquid densities and pressure differences.The bubbles will interact with the dendrite in the process of flow migration,such as extrusion,overflow,fusion and disappearance.In the case of wide gaps in the dendrite channels,bubbles will fuse to form larger irregular bubbles,and in the case of dense channels,bubbles will deform due to the extrusion of dendrites.In the simulated region,as the dendrites converge and diverge,the bubbles precipitate out of the dendrites by compression and diffusion,which also causes physical phenomena such as fusion and spillage of the bubbles.These results reveal the physical mechanisms of bubble nucleation,growth and kinematic evolution during solidification and interaction with dendrite growth.展开更多
We present optical frequency combs with a spectral emission of 48 cm-1and an output power of 420 m W based on a single-core quantum cascade laser at λ ~ 8.7μm. A flat top spectrum sustains up to 130 comb modes deliv...We present optical frequency combs with a spectral emission of 48 cm-1and an output power of 420 m W based on a single-core quantum cascade laser at λ ~ 8.7μm. A flat top spectrum sustains up to 130 comb modes delivering ~ 3.2 m W of optical power per mode, making it a valuable tool for dual comb spectroscopy. The homogeneous gain medium, relying on a slightly diagonal bound-to-continuum structure, promises to provide a broad and stable gain for comb operating. Remarkably, the dispersion of this device is measured within 300 fs2/mm to ensure stable comb operation over 90% of the total current range. The comb is observed with a narrow beatnote linewidth around 2 k Hz and has weak dependence on the applied current for stable comb operation.展开更多
We investigate a strain compensation method for the growth of complex interband cascade laser structures. For thick In As/Al Sb superlattice clad layers, the sublayer thicknesses were adjusted so that the tensile stra...We investigate a strain compensation method for the growth of complex interband cascade laser structures. For thick In As/Al Sb superlattice clad layers, the sublayer thicknesses were adjusted so that the tensile strain energy in the In As sublayer was equal to the compressive strain energy in the Al Sb sublayer. For the four-constituent active region, as the compressive strain in the Ga0.65In0.35Sb alloy layer was large, a tensile strain was incorporated in the chirped In As/Al Sb superlattice region for strain compensation to the Ga0.65In0.35Sb alloy. A laser structure of thickness 6 μm was grown on the Ga Sb substrate by molecular beam epitaxy. The wafer exhibited good surface morphology and high crystalline quality.展开更多
文摘目的探讨动态增强磁共振成像(dynamic contrast-enhanced magnetic resonance imaging,DCE-MRI)技术在子宫颈癌临床分期中的应用价值。方法对2019年1月至2021年12月在郑州大学第二附属医院行手术治疗的186例子宫颈癌患者进行回顾性分析。所有患者术前均行DCE-MRI技术以协助评估临床分期、宫颈肌层浸润、子宫体浸润、阴道累及、宫旁转移、淋巴结转移等相关参数,以术后病理为金标准进行验证,分析DCE-MRI技术术前评估子宫颈癌分期的准确度、灵敏度及特异度。结果186例子宫颈癌患者临床分期与手术病理分期一致性较好(Kappa=0.862,P<0.001),165例(88.71%)临床分期与手术病理分期一致。DCE-MRI诊断阴道累及的准确度为96.24%、灵敏度为86.96%、特异度为97.55%;诊断淋巴结转移的准确度为97.31%、灵敏度为82.35%、特异度为98.82%;诊断深肌层浸润的准确度为86.56%、灵敏度为90.79%、特异度为83.63%。结论DCE-MRI技术在诊断阴道累及、淋巴结转移、深肌层浸润等方面具有较高的灵敏度与特异度,可为子宫颈癌术前临床分期评估提供参考。
基金Project supported by the National Natural Science Foundation of China(Grant Nos.52161002,51661020,and 11364024)the Postdoctoral Science Foundation of China(Grant No.2014M560371)the Funds for Distinguished Young Scientists of Lanzhou University of Technology of China(Grant No.J201304).
文摘A multiphase field model coupled with a lattice Boltzmann(PF-LBM)model is proposed to simulate the distribution mechanism of bubbles and solutes at the solid-liquid interface,the interaction between dendrites and bubbles,and the effects of different temperatures,anisotropic strengths and tilting angles on the solidified organization of the SCN-0.24wt.%butanedinitrile alloy during the solidification process.The model adopts a multiphase field model to simulate the growth of dendrites,calculates the growth motions of dendrites based on the interfacial solute equilibrium;and adopts a lattice Boltzmann model(LBM)based on the Shan-Chen multiphase flow to simulate the growth and motions of bubbles in the liquid phase,which includes the interaction between solid-liquid-gas phases.The simulation results show that during the directional growth of columnar dendrites,bubbles first precipitate out slowly at the very bottom of the dendrites,and then rise up due to the different solid-liquid densities and pressure differences.The bubbles will interact with the dendrite in the process of flow migration,such as extrusion,overflow,fusion and disappearance.In the case of wide gaps in the dendrite channels,bubbles will fuse to form larger irregular bubbles,and in the case of dense channels,bubbles will deform due to the extrusion of dendrites.In the simulated region,as the dendrites converge and diverge,the bubbles precipitate out of the dendrites by compression and diffusion,which also causes physical phenomena such as fusion and spillage of the bubbles.These results reveal the physical mechanisms of bubble nucleation,growth and kinematic evolution during solidification and interaction with dendrite growth.
基金supported by the National Natural Science Foundation of China(Grant Nos.61734006,61835011,61991430,and 62174158)the Youth Innovation Promotion Association of the Chinese Academy of Sciences(Grant No.2021107)the Key Program of the Chinese Academy of Sciences(Grant Nos.XDB43000000,YJKYYQ20190002,and QYZDJ-SSW-JSC027)。
文摘We present optical frequency combs with a spectral emission of 48 cm-1and an output power of 420 m W based on a single-core quantum cascade laser at λ ~ 8.7μm. A flat top spectrum sustains up to 130 comb modes delivering ~ 3.2 m W of optical power per mode, making it a valuable tool for dual comb spectroscopy. The homogeneous gain medium, relying on a slightly diagonal bound-to-continuum structure, promises to provide a broad and stable gain for comb operating. Remarkably, the dispersion of this device is measured within 300 fs2/mm to ensure stable comb operation over 90% of the total current range. The comb is observed with a narrow beatnote linewidth around 2 k Hz and has weak dependence on the applied current for stable comb operation.
基金Project supported by the National Key Research and Development Project of China (Grant No. 2018YFB2200500)the National Natural Science Foundation of China (Grant Nos. 61790583, 61835011, 62174158 and 61991431)+1 种基金Youth Innovation Promotion Association of the Chinese Academy of Sciences (Grant No. 2021107)the Key Program of the Chinese Academy of Sciences (Grant No. XDB43000000)。
文摘We investigate a strain compensation method for the growth of complex interband cascade laser structures. For thick In As/Al Sb superlattice clad layers, the sublayer thicknesses were adjusted so that the tensile strain energy in the In As sublayer was equal to the compressive strain energy in the Al Sb sublayer. For the four-constituent active region, as the compressive strain in the Ga0.65In0.35Sb alloy layer was large, a tensile strain was incorporated in the chirped In As/Al Sb superlattice region for strain compensation to the Ga0.65In0.35Sb alloy. A laser structure of thickness 6 μm was grown on the Ga Sb substrate by molecular beam epitaxy. The wafer exhibited good surface morphology and high crystalline quality.
