农村通信基站的能耗已逐年上升,夏热冬冷地区如何利用自然冷源来代替基站空调成为当前农村通信基站节能减排的核心问题之一。针对这一情况提出了一种应用于农村通信基站散热的铜/甲醇回路热管(LHP)装置,试验研究了不同布置方式、不同充...农村通信基站的能耗已逐年上升,夏热冬冷地区如何利用自然冷源来代替基站空调成为当前农村通信基站节能减排的核心问题之一。针对这一情况提出了一种应用于农村通信基站散热的铜/甲醇回路热管(LHP)装置,试验研究了不同布置方式、不同充液率以及不同空气流速下LHP的换热特性。研究结果表明:当LHP蒸发端布置在机柜3/4处,能有效降低机柜整体散热量,满足基站运行温度30℃界限,同时能优化LHP启动特性和基站换热特性;保证热管运行在最优工况下,热管充液率应为50%;为了提高LHP换热效率,机械送风风速维持在3~5 m/s,能满足LHP换热要求,并且降低了风机能耗;当机柜的设备散热功率为1 k W的时候,热阻达到了0.008 K/W左右,表明回路热管系统运用在基站散热具有良好的传热特性。展开更多
The mammalian target of rapamycin(m TOR) pathway is abnormally activated in lung cancer.However, the anti-lung cancer effect of m TOR inhibitors as monotherapy is modest. Here, we identified that ginsenoside Rh2, an a...The mammalian target of rapamycin(m TOR) pathway is abnormally activated in lung cancer.However, the anti-lung cancer effect of m TOR inhibitors as monotherapy is modest. Here, we identified that ginsenoside Rh2, an active component of Panax ginseng C. A. Mey., enhanced the anti-cancer effect of the m TOR inhibitor everolimus both in vitro and in vivo. Moreover, ginsenoside Rh2 alleviated the hepatic fat accumulation caused by everolimus in xenograft nude mice models. The combination of everolimus and ginsenoside Rh2(labeled Eve-Rh2) induced caspase-independent cell death and cytoplasmic vacuolation in lung cancer cells, indicating that Eve-Rh2 prevented tumor progression by triggering paraptosis. EveRh2 up-regulated the expression of c-MYC in cancer cells as well as tumor tissues. The increased cMYC mediated the accumulation of tribbles homolog 3(TRIB3)/P62+ aggresomes and consequently triggered paraptosis, bypassing the classical c-MYC/MAX pathway. Our study offers a potential effective and safe strategy for the treatment of lung cancer. Moreover, we have identified a new mechanism of TRIB3/P62+ aggresomes-triggered paraptosis and revealed a unique function of c-MYC.展开更多
Common-image gathers are extensively used in amplitude versus angle(AVA)and migration velocity analysis(MVA).The current state of methods for anisotropic angle gathers extraction use slant-stack,local Fourier transfor...Common-image gathers are extensively used in amplitude versus angle(AVA)and migration velocity analysis(MVA).The current state of methods for anisotropic angle gathers extraction use slant-stack,local Fourier transform or low-rank approximation,which requires much computation.Based on an anisotropic-Helmholtz P/S wave-mode decomposition method,we propose a novel and efficient approach to produce angle-domain common-image gathers(ADCIGs)in the elastic reverse time migration(ERTM)of VTI media.To start with,we derive an anisotropic-Helmholtz decomposition operator from the Christoffel equation in VTI media,and use this operator to derive the decomposed formulations for anisotropic P/S waves.Second,we employ the first-order Taylor expansion to calculate the normalized term of decomposed formulations and obtain the anisotropic-Helmholtz decomposition method,which generates the separated P/S wavefields with correct amplitudes and phases.Third,we develop a novel way that uses the anisotropic-Helmholtz decomposition operator to define the polari-zation angles for anisotropic P/S waves and substitute these angles to decomposing formulations.The polarization angles are then calculated directly from the separated vector P-and S-wavefields and converted to the phase angles.The ADCIGs are thusly produced by applying the phase angles to VTI ERTM.In addition,we develop a concise approximate expression of residual moveout(RMO)for PP-reflections of flat reflectors in VTI media,which avoids the complex transformations between the group angles and the phase angles.The approximate RMO curves show a good agreement with the exact solution and can be used as a tool to assess the migration velocity errors.As demonstrated by two selected examples,our ADCIGs not only produce the correct kinematic responses with regards to different velocity pertubatation,but also generate the reliable amplitude responses versus different angle.The final stacking images of ADCIGs data exhibit the identical imaging effect as that of VTI ERTM.展开更多
Nagilactone E(NLE),a natural product with anticancer activities,is isolated from Podocarpus nagi.In this study,we reported that NLE increased programmed death ligand 1(PD-L1)expressions at both protein and mRNA levels...Nagilactone E(NLE),a natural product with anticancer activities,is isolated from Podocarpus nagi.In this study,we reported that NLE increased programmed death ligand 1(PD-L1)expressions at both protein and mRNA levels in human lung cancer cells,and enhanced its localization on the cell membrane.Mechanistically,NLE increased the phosphorylation and expression of cJun,and promoted the localization of c-Jun in the nucleus,while silencing of c-Jun by small interfering RNA(siRNA)reduced NLEinduced PD-L1.Further study showed that NLE activated the c-Jun N-terminal kinases(JNK),the upstream of c-Jun,and its inhibitor SP600125 reversed the NLE-increased PD-L1.Moreover,NLE-induced PD-L1 increased the binding intensity of PD-1 on the cell surface.In summary,NLE upregulates the expression of PD-L1 in lung cancer cells through the activation of JNK-c-Jun axis,which has the potential to combine with the PD-1/PD-L1 antibody therapies in lung cancer.展开更多
Objective:Several studies indicated that tonsillectomy can improve the prognosis of patients with immunoglobulin A nephropathy(IgAN).However,the relationship between tonsillar immunity and IgAN is still unclear.Method...Objective:Several studies indicated that tonsillectomy can improve the prognosis of patients with immunoglobulin A nephropathy(IgAN).However,the relationship between tonsillar immunity and IgAN is still unclear.Methods:A total of 14 IgAN patients were recruited in the current study from May 2015 to April 2016 in Tongji Hospital.B cells,dendritic cells(DCs),and IgAl positive cells in human tonsils were detected using immunofluorescence and immunohistochemistry.Correlations between these cells and clinicopathologic features were evaluated.展开更多
AIM:To investigate whether neuron-glial antigen 2(NG2) could be an effective prognostic marker in hepatocellular carcinoma(HCC).METHODS:NG2 expression was semi-quantitatively scored from the immunohistochemistry(IHC) ...AIM:To investigate whether neuron-glial antigen 2(NG2) could be an effective prognostic marker in hepatocellular carcinoma(HCC).METHODS:NG2 expression was semi-quantitatively scored from the immunohistochemistry(IHC) data based on the number of positive cells and the staining intensity.A total of 132 HCC specimens and 96 adjacent noncancerous tissue samples were analyzed by IHC for NG2 protein expression.To confirm the NG2 expression levels observed by IHC,we measured NG2 expression in 30 randomly selected tumor and adjacent noncancerous tissue samples by quantitative real-time polymerase chain reaction and Western blot.The correlations between NG2 protein expression and the clinicopathological features of HCC patients were analyzed using the χ2 test.To assess the prognostic value of NG2 for HCC,the association between NG2 expression and survival was analyzed using the KaplanMeier method with the log-rank test.To further evaluate the prognostic value of NG2 expression,a Cox multivariate proportional hazards regression analysis was performed with all the variables to derive risk estimates related to disease-free and overall survival and to control for confounders.RESULTS:High NG2 expression was observed in significantly more primary tumor samples(63.6%; 84/132) compared with the adjacent noncancerous tissue samples(28.1%; 27/96)(P < 0.0001).Moreover,high NG2 protein expression was closely associated with tumor differentiation(χ2 = 9.436,P = 0.0089),recurrence(χ2 = 5.769,P = 0.0163),tumor-nodemetastasis(TNM) stage(χ2 = 8.976,P = 0.0027),and invasion(χ2 = 5.476,P = 0.0193).However,no significant relationship was observed between NG2 protein expression in HCC and other parameters,such as age,sex,tumor size,serum alpha fetoprotein(AFP),tumor number,or tumor capsule.The log-rank test indicated a significant difference in the overall survival of HCC patients with high NG2 expression compared with those with low NG2 expression(29.2% vs 9.5%,P < 0.001).Moreover,NG2 expression in HCC tissue significantly correlated wi展开更多
文摘农村通信基站的能耗已逐年上升,夏热冬冷地区如何利用自然冷源来代替基站空调成为当前农村通信基站节能减排的核心问题之一。针对这一情况提出了一种应用于农村通信基站散热的铜/甲醇回路热管(LHP)装置,试验研究了不同布置方式、不同充液率以及不同空气流速下LHP的换热特性。研究结果表明:当LHP蒸发端布置在机柜3/4处,能有效降低机柜整体散热量,满足基站运行温度30℃界限,同时能优化LHP启动特性和基站换热特性;保证热管运行在最优工况下,热管充液率应为50%;为了提高LHP换热效率,机械送风风速维持在3~5 m/s,能满足LHP换热要求,并且降低了风机能耗;当机柜的设备散热功率为1 k W的时候,热阻达到了0.008 K/W左右,表明回路热管系统运用在基站散热具有良好的传热特性。
基金supported by the National Natural Science Foundation of China(No.81973516)partially supported by the Science and Technology Development Fund,Macao S.A.R,China(Nos.024/2016/A1 and 0129/2019/A3)University of Macao(No.CPG2021-00022-ICMS)。
文摘The mammalian target of rapamycin(m TOR) pathway is abnormally activated in lung cancer.However, the anti-lung cancer effect of m TOR inhibitors as monotherapy is modest. Here, we identified that ginsenoside Rh2, an active component of Panax ginseng C. A. Mey., enhanced the anti-cancer effect of the m TOR inhibitor everolimus both in vitro and in vivo. Moreover, ginsenoside Rh2 alleviated the hepatic fat accumulation caused by everolimus in xenograft nude mice models. The combination of everolimus and ginsenoside Rh2(labeled Eve-Rh2) induced caspase-independent cell death and cytoplasmic vacuolation in lung cancer cells, indicating that Eve-Rh2 prevented tumor progression by triggering paraptosis. EveRh2 up-regulated the expression of c-MYC in cancer cells as well as tumor tissues. The increased cMYC mediated the accumulation of tribbles homolog 3(TRIB3)/P62+ aggresomes and consequently triggered paraptosis, bypassing the classical c-MYC/MAX pathway. Our study offers a potential effective and safe strategy for the treatment of lung cancer. Moreover, we have identified a new mechanism of TRIB3/P62+ aggresomes-triggered paraptosis and revealed a unique function of c-MYC.
基金supported by the National Key R&D Program of China(2020YFA0710604 and 2017YFC1500303)the Science Foundation of the China University of Petroleum,Beijing(2462019YJRC007 and 2462020YXZZ047)the Strategic Cooperation Technology Projects of CNPC and CUPB(ZLZX2020-05).
文摘Common-image gathers are extensively used in amplitude versus angle(AVA)and migration velocity analysis(MVA).The current state of methods for anisotropic angle gathers extraction use slant-stack,local Fourier transform or low-rank approximation,which requires much computation.Based on an anisotropic-Helmholtz P/S wave-mode decomposition method,we propose a novel and efficient approach to produce angle-domain common-image gathers(ADCIGs)in the elastic reverse time migration(ERTM)of VTI media.To start with,we derive an anisotropic-Helmholtz decomposition operator from the Christoffel equation in VTI media,and use this operator to derive the decomposed formulations for anisotropic P/S waves.Second,we employ the first-order Taylor expansion to calculate the normalized term of decomposed formulations and obtain the anisotropic-Helmholtz decomposition method,which generates the separated P/S wavefields with correct amplitudes and phases.Third,we develop a novel way that uses the anisotropic-Helmholtz decomposition operator to define the polari-zation angles for anisotropic P/S waves and substitute these angles to decomposing formulations.The polarization angles are then calculated directly from the separated vector P-and S-wavefields and converted to the phase angles.The ADCIGs are thusly produced by applying the phase angles to VTI ERTM.In addition,we develop a concise approximate expression of residual moveout(RMO)for PP-reflections of flat reflectors in VTI media,which avoids the complex transformations between the group angles and the phase angles.The approximate RMO curves show a good agreement with the exact solution and can be used as a tool to assess the migration velocity errors.As demonstrated by two selected examples,our ADCIGs not only produce the correct kinematic responses with regards to different velocity pertubatation,but also generate the reliable amplitude responses versus different angle.The final stacking images of ADCIGs data exhibit the identical imaging effect as that of VTI ERTM.
基金supported by the Science and Technology Development Fund,Macao SAR(No.176/2017/A3)University of Macao(No.MYRG2018-00165-ICMS/CPG.020-00016-ICMS/MYRG2017-00109-ICMS)。
文摘Nagilactone E(NLE),a natural product with anticancer activities,is isolated from Podocarpus nagi.In this study,we reported that NLE increased programmed death ligand 1(PD-L1)expressions at both protein and mRNA levels in human lung cancer cells,and enhanced its localization on the cell membrane.Mechanistically,NLE increased the phosphorylation and expression of cJun,and promoted the localization of c-Jun in the nucleus,while silencing of c-Jun by small interfering RNA(siRNA)reduced NLEinduced PD-L1.Further study showed that NLE activated the c-Jun N-terminal kinases(JNK),the upstream of c-Jun,and its inhibitor SP600125 reversed the NLE-increased PD-L1.Moreover,NLE-induced PD-L1 increased the binding intensity of PD-1 on the cell surface.In summary,NLE upregulates the expression of PD-L1 in lung cancer cells through the activation of JNK-c-Jun axis,which has the potential to combine with the PD-1/PD-L1 antibody therapies in lung cancer.
基金This project was supported by the National Natural Science Foundation of China(No.82000658,No.81770686,and No.81970591)and Huazhong University of Science and Technology research funds for self-dependent innovation(No.2017KFYXJJ101).
文摘Objective:Several studies indicated that tonsillectomy can improve the prognosis of patients with immunoglobulin A nephropathy(IgAN).However,the relationship between tonsillar immunity and IgAN is still unclear.Methods:A total of 14 IgAN patients were recruited in the current study from May 2015 to April 2016 in Tongji Hospital.B cells,dendritic cells(DCs),and IgAl positive cells in human tonsils were detected using immunofluorescence and immunohistochemistry.Correlations between these cells and clinicopathologic features were evaluated.
基金Supported by National Natural Science Foundation of China,No.81170425 and No.81071979Hepatobiliary Surgery Department of the Southwest Hospital(Chongqing,China)Third Military Medical University(Chongqing,China)
文摘AIM:To investigate whether neuron-glial antigen 2(NG2) could be an effective prognostic marker in hepatocellular carcinoma(HCC).METHODS:NG2 expression was semi-quantitatively scored from the immunohistochemistry(IHC) data based on the number of positive cells and the staining intensity.A total of 132 HCC specimens and 96 adjacent noncancerous tissue samples were analyzed by IHC for NG2 protein expression.To confirm the NG2 expression levels observed by IHC,we measured NG2 expression in 30 randomly selected tumor and adjacent noncancerous tissue samples by quantitative real-time polymerase chain reaction and Western blot.The correlations between NG2 protein expression and the clinicopathological features of HCC patients were analyzed using the χ2 test.To assess the prognostic value of NG2 for HCC,the association between NG2 expression and survival was analyzed using the KaplanMeier method with the log-rank test.To further evaluate the prognostic value of NG2 expression,a Cox multivariate proportional hazards regression analysis was performed with all the variables to derive risk estimates related to disease-free and overall survival and to control for confounders.RESULTS:High NG2 expression was observed in significantly more primary tumor samples(63.6%; 84/132) compared with the adjacent noncancerous tissue samples(28.1%; 27/96)(P < 0.0001).Moreover,high NG2 protein expression was closely associated with tumor differentiation(χ2 = 9.436,P = 0.0089),recurrence(χ2 = 5.769,P = 0.0163),tumor-nodemetastasis(TNM) stage(χ2 = 8.976,P = 0.0027),and invasion(χ2 = 5.476,P = 0.0193).However,no significant relationship was observed between NG2 protein expression in HCC and other parameters,such as age,sex,tumor size,serum alpha fetoprotein(AFP),tumor number,or tumor capsule.The log-rank test indicated a significant difference in the overall survival of HCC patients with high NG2 expression compared with those with low NG2 expression(29.2% vs 9.5%,P < 0.001).Moreover,NG2 expression in HCC tissue significantly correlated wi
