目的探讨早期宫颈鳞癌组织中程序性死亡配体-1(programmed death ligand-1,PD-L1)和脱嘌呤/脱嘧啶内切核酸酶1(apurinic/apyrimidinic endonuclease1,APE1)的表达与临床特征及预后的关系。方法采用免疫组织化学的方法(IHC)检测PD-L1和A...目的探讨早期宫颈鳞癌组织中程序性死亡配体-1(programmed death ligand-1,PD-L1)和脱嘌呤/脱嘧啶内切核酸酶1(apurinic/apyrimidinic endonuclease1,APE1)的表达与临床特征及预后的关系。方法采用免疫组织化学的方法(IHC)检测PD-L1和APE1蛋白在64例早期宫颈鳞癌组织中的表达,分析PD-L1、APE1表达以及两者共表达与早期宫颈癌临床特征的关系;采用Spearman等级相关分析检测APE1与PD-L1表达的相关性,Kaplan-Meier法分析早期宫颈鳞癌患者中APE1与PD-L1的表达与术后生存的关系,Cox回归模型分析早期宫颈鳞癌患者预后的危险因素。结果早期宫颈癌患者APE1和PD-L1蛋白表达阳性率分别为70.31%和67.18%。PD-L1的表达与分期、淋巴结转移有显著相关性(P<0.05),而APE1的表达仅与淋巴结转移密切相关(P=0.038)。另外,APE1与PD-L1的表达正相关(r2=0.347,P=0.005),且两者共表达与淋巴结转移相关,其术后生存期比单一阳性表达的宫颈癌患者明显缩短(P<0.05)。多因素COX回归模型结果显示,APE1的表达和淋巴结转移是影响早期宫颈鳞癌预后的独立危险因素,危险度分别为16.187(P=0.01)和27.340(P<0.001)。结论PD-L1和APE1表达的联合检测对早期宫颈鳞癌预后评估具有潜在的临床价值。展开更多
The degradation of phenol was carried out using heterogeneous Fenton-type catalysts in the presence of H_2O_2 and UV. Catalysts were prepared by exchanging and immobilizing Fe 2+ in zeolite 13X, silica gel or Al_2O...The degradation of phenol was carried out using heterogeneous Fenton-type catalysts in the presence of H_2O_2 and UV. Catalysts were prepared by exchanging and immobilizing Fe 2+ in zeolite 13X, silica gel or Al_2O_3. The concentration of phenol solution was 100 mg/L. The amount of H_2O_2 added was the stoichiometric amount of H_2O_2 required for the total oxidation of phenol. Under the irradiation of medium pressure light (300 W) phenol was mineralized within 1 h in the presence of Fe 2+/zeolite 13X. The COD removal rate was enhanced in the presence of Fe 2+/zeolite 13X compared to that of Fe 2+/silica gel or Fe 2+/Al_2O_3. Analogous homogenous photo-Fenton reaction with equivalent Fe 2+ was also carried out to evaluate the catalysis efficiency of Fe 2+/zeolite 13X. Results showed that the COD removal rate was near to that of homogeneous Fenton, while heterogeneous Fe 2+/zeolite 13X catalyst could be recycled.展开更多
Background：A limitation of bronchoscopic balloon dilatation （BBD） is that airflow must be completely blocked for as long as possible during the operation.However,the patient often cannot hold his or her breath for ...Background：A limitation of bronchoscopic balloon dilatation （BBD） is that airflow must be completely blocked for as long as possible during the operation.However,the patient often cannot hold his or her breath for a long period affecting the efficacy of the procedure.In this study,we used an extra-small-diameter tube to provide assisted ventilation to patients undergoing BBD and assessed the efficacy and safety of this technique.Methods：Bronchoscopic balloon dilatation was performed in 26 patients with benign tracheal stenosis using an extra-small-diameter tube.The tracheal diameter,dyspnea index,blood gas analysis results,and complications were evaluated before and after BBD.Statistical analyses were performed by SPSS version 16.0 for Windows （SPSS,Inc.,Chicago,IL,USA）.Results：Sixty-three BBD procedures were performed in 26 patients.Dyspnea immediately improved in all patients after BBD.The tracheal diameter significantly increased from 5.5 ± 1.5 mm to 13.0 ± 1.3 mm （P 〈 0.001）,and the dyspnea index significantly decreased from 3.4 ± 0.8 to 0.5 ± 0.6 （P 〈 0.001）.There was no significant change in the partial pressure of oxygen during the operation （before,102.5 ± 27.5 mmHg;during,96.9 ± 30.4 mmHg;and after,97.2 ± 21.5 mmHg;P =0.364）,but there was slight temporary retention of carbon dioxide during the operation （before,43.5 ± 4.2 mmHg;during,49.4 ± 6.8 mmHg;and after,40.1 ± 3.9 mmHg;P 〈 0.001）.Conclusion：Small-diameter tube-assisted BBD is an effective and safe method for the management of benign tracheal stenosis.展开更多
In this study, supported nonmetal (boron) doping TiO2 coating photocatalysts were prepared by chemical vapor deposition (CVD) to enhance the activity under visible light irradiation and avoid the recovering of TiO2. B...In this study, supported nonmetal (boron) doping TiO2 coating photocatalysts were prepared by chemical vapor deposition (CVD) to enhance the activity under visible light irradiation and avoid the recovering of TiO2. Boron atoms were successfully doped into the lattice of TiO2 through CVD, as evidenced from XPS analysis. B-doped TiO2 coating catalysts showed drastic and strong absorption in the visible light range with a red shift in the band gap transition. This novel B-TiO2 coating photocatalyst showed higher photocatalytic activity in methyl orange degradation under visible light irradiation than that of the pure TiO2 photocatalyst.展开更多
文摘目的探讨早期宫颈鳞癌组织中程序性死亡配体-1(programmed death ligand-1,PD-L1)和脱嘌呤/脱嘧啶内切核酸酶1(apurinic/apyrimidinic endonuclease1,APE1)的表达与临床特征及预后的关系。方法采用免疫组织化学的方法(IHC)检测PD-L1和APE1蛋白在64例早期宫颈鳞癌组织中的表达,分析PD-L1、APE1表达以及两者共表达与早期宫颈癌临床特征的关系;采用Spearman等级相关分析检测APE1与PD-L1表达的相关性,Kaplan-Meier法分析早期宫颈鳞癌患者中APE1与PD-L1的表达与术后生存的关系,Cox回归模型分析早期宫颈鳞癌患者预后的危险因素。结果早期宫颈癌患者APE1和PD-L1蛋白表达阳性率分别为70.31%和67.18%。PD-L1的表达与分期、淋巴结转移有显著相关性(P<0.05),而APE1的表达仅与淋巴结转移密切相关(P=0.038)。另外,APE1与PD-L1的表达正相关(r2=0.347,P=0.005),且两者共表达与淋巴结转移相关,其术后生存期比单一阳性表达的宫颈癌患者明显缩短(P<0.05)。多因素COX回归模型结果显示,APE1的表达和淋巴结转移是影响早期宫颈鳞癌预后的独立危险因素,危险度分别为16.187(P=0.01)和27.340(P<0.001)。结论PD-L1和APE1表达的联合检测对早期宫颈鳞癌预后评估具有潜在的临床价值。
基金TheNationalNaturalScienceFoundationofChina (No .2 0 1760 5 3 )
文摘The degradation of phenol was carried out using heterogeneous Fenton-type catalysts in the presence of H_2O_2 and UV. Catalysts were prepared by exchanging and immobilizing Fe 2+ in zeolite 13X, silica gel or Al_2O_3. The concentration of phenol solution was 100 mg/L. The amount of H_2O_2 added was the stoichiometric amount of H_2O_2 required for the total oxidation of phenol. Under the irradiation of medium pressure light (300 W) phenol was mineralized within 1 h in the presence of Fe 2+/zeolite 13X. The COD removal rate was enhanced in the presence of Fe 2+/zeolite 13X compared to that of Fe 2+/silica gel or Fe 2+/Al_2O_3. Analogous homogenous photo-Fenton reaction with equivalent Fe 2+ was also carried out to evaluate the catalysis efficiency of Fe 2+/zeolite 13X. Results showed that the COD removal rate was near to that of homogeneous Fenton, while heterogeneous Fe 2+/zeolite 13X catalyst could be recycled.
文摘Background：A limitation of bronchoscopic balloon dilatation （BBD） is that airflow must be completely blocked for as long as possible during the operation.However,the patient often cannot hold his or her breath for a long period affecting the efficacy of the procedure.In this study,we used an extra-small-diameter tube to provide assisted ventilation to patients undergoing BBD and assessed the efficacy and safety of this technique.Methods：Bronchoscopic balloon dilatation was performed in 26 patients with benign tracheal stenosis using an extra-small-diameter tube.The tracheal diameter,dyspnea index,blood gas analysis results,and complications were evaluated before and after BBD.Statistical analyses were performed by SPSS version 16.0 for Windows （SPSS,Inc.,Chicago,IL,USA）.Results：Sixty-three BBD procedures were performed in 26 patients.Dyspnea immediately improved in all patients after BBD.The tracheal diameter significantly increased from 5.5 ± 1.5 mm to 13.0 ± 1.3 mm （P 〈 0.001）,and the dyspnea index significantly decreased from 3.4 ± 0.8 to 0.5 ± 0.6 （P 〈 0.001）.There was no significant change in the partial pressure of oxygen during the operation （before,102.5 ± 27.5 mmHg;during,96.9 ± 30.4 mmHg;and after,97.2 ± 21.5 mmHg;P =0.364）,but there was slight temporary retention of carbon dioxide during the operation （before,43.5 ± 4.2 mmHg;during,49.4 ± 6.8 mmHg;and after,40.1 ± 3.9 mmHg;P 〈 0.001）.Conclusion：Small-diameter tube-assisted BBD is an effective and safe method for the management of benign tracheal stenosis.
基金Project (Nos. 90610005 and 20576120) supported by the National Natural Science Foundation of China
文摘In this study, supported nonmetal (boron) doping TiO2 coating photocatalysts were prepared by chemical vapor deposition (CVD) to enhance the activity under visible light irradiation and avoid the recovering of TiO2. Boron atoms were successfully doped into the lattice of TiO2 through CVD, as evidenced from XPS analysis. B-doped TiO2 coating catalysts showed drastic and strong absorption in the visible light range with a red shift in the band gap transition. This novel B-TiO2 coating photocatalyst showed higher photocatalytic activity in methyl orange degradation under visible light irradiation than that of the pure TiO2 photocatalyst.
