Background：Little attention has been paid to the role of subcortical deep gray matter （SDGM） structures in type 2 diabetes mellitus （T2DM）-induced cognitive impairment,especially hippocampal subfields.Our aims we...Background：Little attention has been paid to the role of subcortical deep gray matter （SDGM） structures in type 2 diabetes mellitus （T2DM）-induced cognitive impairment,especially hippocampal subfields.Our aims were to assess the in vivo volumes of SDGM structures and hippocampal subfields using magnetic resonance imaging （MRI） and to test their associations with cognitive performance in T2DM.Methods：A total of 80 T2DM patients and 80 neurologically unimpaired healthy controls matched by age,sex and education level was enrolled in this study.We assessed the volumes of the SDGM structures and seven hippocampal subfields on MRI using a novel technique that enabled automated volumetry.We used Mini-Mental State Examination and Montreal Cognitive Assessment （MoCA） scores as measures of cognitive performance.The association of glycosylated hemoglobin （HbAlc） with SDGM structures and neuropsychological tests and correlations between hippocampal subfields and neuropsychological tests were assessed by partial correlation analysis in T2DM.Results：Bilaterally,the hippocampal volumes were smaller in T2DM patients,mainly in the CA1 and subiculum subfields.Partial correlation analysis showed that the MoCA scores,particularly those regarding delayed memory,were significantly positively correlated with reduced hippocampal CA 1 and subiculum volumes in T2DM patients.Additionally,higher HbA1c levels were significantly associated with poor memory performance and hippocampal atrophy among T2DM patients.Conclusions：These data indicate that the hippocampus might be the main affected region among the SDGM structures in T2DM.These structural changes in the hippocampal CA1 and subiculum areas might be at the core of underlying neurobiological mechanisms of hippocampal dysfunction,suggesting that degeneration in these regions could be responsible for memory impairments in T2DM patients.展开更多
Background Little is known about the influence of metabolic syndrome （MetS） on coronary artery calcification （CAC） in China. In this article, we aimed to explore the distribution of CAC in populations with and wit...Background Little is known about the influence of metabolic syndrome （MetS） on coronary artery calcification （CAC） in China. In this article, we aimed to explore the distribution of CAC in populations with and without MetS, and estimate the influence of MetS and its components on CAC in a community-based population of Beijing. Methods A total of 1647 local residents of Beijing, age 40-77 years, were recruited for a cardiovascular risk factors survey and were determined fasting plasma glucose （FPG）, blood lipids, and 64 multi-detector computed tomography （64-MDCT） coronary artery calcium score （CACS） measurement （Agatston scoring）. The distribution of CAC was described, and the influence of MetS components on CAC was evaluated. Results In this population, the prevalence and extent of CAC increased with increasing age and both were higher in MetS subjects compared to nonMetS subjects （all P 〈0.05）, with the exception of those older than 65 years old. The risk of CAC increased with increasing numbers of MetS components, and the odds ratios for predicting positive CAC in subjects with 1, 2, 3, and 〉4 MetS components were 1.60, 1.84, 2.12, and 3.12, respectively （all P 〈0.05）. Elevated blood pressure, elevated FPG, elevated triglycerides, and overweight increased the risk of CAC, yielding odds ratios of 2.64, 1.67, 1.32, and 1.37, respectively （all P 〈0.05）. Conclusions In the Beijing community-based population, MetS increases the risk of CAC. The risk of CAC increases with increasing numbers of MetS components. Not only the number, but also the variety of risk factors for MetS is correlated with the risk of CAC. Elevated blood pressure, hyperglycemia, hypertriglyceridemia and overweight increase the risk of CAC.展开更多
Left ventricular pseudoaneurysm is a rare complication of chest trauma. Accurate diagnosis and early surgical intervention is essential for patients with large or expanding left ventricular pseudoaneurysms due to the ...Left ventricular pseudoaneurysm is a rare complication of chest trauma. Accurate diagnosis and early surgical intervention is essential for patients with large or expanding left ventricular pseudoaneurysms due to the high propensity of fatal rupture and thromboembolism or arrhythmia.展开更多
基金This study was financially supported by the Innovation Fund for Younger Investigators of Southwest Hospital of the Third Military Medical University，the National Natural Science Foundation of China
文摘Background：Little attention has been paid to the role of subcortical deep gray matter （SDGM） structures in type 2 diabetes mellitus （T2DM）-induced cognitive impairment,especially hippocampal subfields.Our aims were to assess the in vivo volumes of SDGM structures and hippocampal subfields using magnetic resonance imaging （MRI） and to test their associations with cognitive performance in T2DM.Methods：A total of 80 T2DM patients and 80 neurologically unimpaired healthy controls matched by age,sex and education level was enrolled in this study.We assessed the volumes of the SDGM structures and seven hippocampal subfields on MRI using a novel technique that enabled automated volumetry.We used Mini-Mental State Examination and Montreal Cognitive Assessment （MoCA） scores as measures of cognitive performance.The association of glycosylated hemoglobin （HbAlc） with SDGM structures and neuropsychological tests and correlations between hippocampal subfields and neuropsychological tests were assessed by partial correlation analysis in T2DM.Results：Bilaterally,the hippocampal volumes were smaller in T2DM patients,mainly in the CA1 and subiculum subfields.Partial correlation analysis showed that the MoCA scores,particularly those regarding delayed memory,were significantly positively correlated with reduced hippocampal CA 1 and subiculum volumes in T2DM patients.Additionally,higher HbA1c levels were significantly associated with poor memory performance and hippocampal atrophy among T2DM patients.Conclusions：These data indicate that the hippocampus might be the main affected region among the SDGM structures in T2DM.These structural changes in the hippocampal CA1 and subiculum areas might be at the core of underlying neurobiological mechanisms of hippocampal dysfunction,suggesting that degeneration in these regions could be responsible for memory impairments in T2DM patients.
文摘Background Little is known about the influence of metabolic syndrome （MetS） on coronary artery calcification （CAC） in China. In this article, we aimed to explore the distribution of CAC in populations with and without MetS, and estimate the influence of MetS and its components on CAC in a community-based population of Beijing. Methods A total of 1647 local residents of Beijing, age 40-77 years, were recruited for a cardiovascular risk factors survey and were determined fasting plasma glucose （FPG）, blood lipids, and 64 multi-detector computed tomography （64-MDCT） coronary artery calcium score （CACS） measurement （Agatston scoring）. The distribution of CAC was described, and the influence of MetS components on CAC was evaluated. Results In this population, the prevalence and extent of CAC increased with increasing age and both were higher in MetS subjects compared to nonMetS subjects （all P 〈0.05）, with the exception of those older than 65 years old. The risk of CAC increased with increasing numbers of MetS components, and the odds ratios for predicting positive CAC in subjects with 1, 2, 3, and 〉4 MetS components were 1.60, 1.84, 2.12, and 3.12, respectively （all P 〈0.05）. Elevated blood pressure, elevated FPG, elevated triglycerides, and overweight increased the risk of CAC, yielding odds ratios of 2.64, 1.67, 1.32, and 1.37, respectively （all P 〈0.05）. Conclusions In the Beijing community-based population, MetS increases the risk of CAC. The risk of CAC increases with increasing numbers of MetS components. Not only the number, but also the variety of risk factors for MetS is correlated with the risk of CAC. Elevated blood pressure, hyperglycemia, hypertriglyceridemia and overweight increase the risk of CAC.
文摘Left ventricular pseudoaneurysm is a rare complication of chest trauma. Accurate diagnosis and early surgical intervention is essential for patients with large or expanding left ventricular pseudoaneurysms due to the high propensity of fatal rupture and thromboembolism or arrhythmia.
