Most migraine patients suffer from cutaneous allodynia; however, the underlying mechanisms are unclear. Calcitonin gene-related peptide（CGRP） plays an important role in the pathophysiology of migraine, and it is the...Most migraine patients suffer from cutaneous allodynia; however, the underlying mechanisms are unclear. Calcitonin gene-related peptide（CGRP） plays an important role in the pathophysiology of migraine, and it is therefore, a potential therapeutic target for treating the pain. In the present study, a rat model of conscious migraine, induced by repeated electrical stimulation of the superior sagittal sinus, was established and treated with electroacupuncture at Fengchi（GB20）（depth of 2–3 mm, frequency of 2/15 Hz, intensity of 0.5–1.0 m A, 15 minutes/day, for 7 consecutive days）. Electroacupuncture at GB20 significantly alleviated the decrease in hind paw and facial withdrawal thresholds and significantly lessened the increase in the levels of CGRP in the trigeminal ganglion, trigeminal nucleus caudalis and ventroposterior medial thalamic nucleus in rats with migraine. No CGRP-positive cells were detected in the trigeminal nucleus caudalis or ventroposterior medial thalamic nucleus by immunofluorescence. Our findings suggest that electroacupuncture treatment ameliorates migraine pain and associated cutaneous allodynia by modulating the trigeminovascular system ascending pathway, at least in part by inhibiting CGRP expression in the trigeminal ganglion.展开更多
温室能够有效改善茄科作物(包括番茄、辣椒、茄子等)生长过程,温室环境控制策略对作物实现高效高产至关重要。为了充分利用国内外的研究成果、促进我国温室环境控制策略的研究应用,分别从常规比例微积分(Proportional Integral Derivati...温室能够有效改善茄科作物(包括番茄、辣椒、茄子等)生长过程,温室环境控制策略对作物实现高效高产至关重要。为了充分利用国内外的研究成果、促进我国温室环境控制策略的研究应用,分别从常规比例微积分(Proportional Integral Derivative,PID)控制、模糊控制、人工智能控制、温室小气候模型和作物生长模型等5个方面,综述了温室环境控制策略的研究进展。针对目前我国该领域存在的问题,提出了今后应将智能温室控制与作物生长模型耦合,构建智慧型作物生长模型;针对不同区域作物的生长预测,与遥感技术进行结合,增强模型的普适性,形成具有中国特色的温室环境控制策略。展开更多
基金supported by the National Natural Science Foundation of China,No.81603683a grant from the National Basic Research Program of China,No.2014CB543203a grant from the Beijing Municipal Science&Technology Commission of China,No.Z171100001017033
文摘Most migraine patients suffer from cutaneous allodynia; however, the underlying mechanisms are unclear. Calcitonin gene-related peptide（CGRP） plays an important role in the pathophysiology of migraine, and it is therefore, a potential therapeutic target for treating the pain. In the present study, a rat model of conscious migraine, induced by repeated electrical stimulation of the superior sagittal sinus, was established and treated with electroacupuncture at Fengchi（GB20）（depth of 2–3 mm, frequency of 2/15 Hz, intensity of 0.5–1.0 m A, 15 minutes/day, for 7 consecutive days）. Electroacupuncture at GB20 significantly alleviated the decrease in hind paw and facial withdrawal thresholds and significantly lessened the increase in the levels of CGRP in the trigeminal ganglion, trigeminal nucleus caudalis and ventroposterior medial thalamic nucleus in rats with migraine. No CGRP-positive cells were detected in the trigeminal nucleus caudalis or ventroposterior medial thalamic nucleus by immunofluorescence. Our findings suggest that electroacupuncture treatment ameliorates migraine pain and associated cutaneous allodynia by modulating the trigeminovascular system ascending pathway, at least in part by inhibiting CGRP expression in the trigeminal ganglion.
文摘温室能够有效改善茄科作物(包括番茄、辣椒、茄子等)生长过程,温室环境控制策略对作物实现高效高产至关重要。为了充分利用国内外的研究成果、促进我国温室环境控制策略的研究应用,分别从常规比例微积分(Proportional Integral Derivative,PID)控制、模糊控制、人工智能控制、温室小气候模型和作物生长模型等5个方面,综述了温室环境控制策略的研究进展。针对目前我国该领域存在的问题,提出了今后应将智能温室控制与作物生长模型耦合,构建智慧型作物生长模型;针对不同区域作物的生长预测,与遥感技术进行结合,增强模型的普适性,形成具有中国特色的温室环境控制策略。
