Objective: To investigate the effects of Composition of Ophiopogon polysaccharide, Notoginseng total saponins and Rhizoma Coptidis alkaloids(CONR) on myocardial apoptosis of diabetic atherosclerosis(DA) rabbits Method...Objective: To investigate the effects of Composition of Ophiopogon polysaccharide, Notoginseng total saponins and Rhizoma Coptidis alkaloids(CONR) on myocardial apoptosis of diabetic atherosclerosis(DA) rabbits Methods: Sixty male New Zealand white rabbits were randomly divided into 6 groups [control group, model group, CONR high-dose group(450 mg/kg), CONR medium-dose group(150 mg/kg), CONR low-dose group(50 mg/kg), and simvastatin group] by using a completely random method, 10 in each group. DA model was established by intravenously injected alloxan combined with high-fat diet and abdominal aortic balloon injury. After mediation for 10 weeks, fasting blood glucose(FBG), glycosylated hemoglobin(GHB), glycosylated serum protein(GSP), fructoseamine(FRA), aldose reductase(AR), advanced glycation end products(AGEs) in serum were measured by enzyme linked immunosorbent assay(ELISA) method;the expression of receptor of AGEs(RAGE) in myocardial tissue were observed by immunohistochemical method;and p-Jun N-terminal kinase(p-JNK), caspase-3, B-cell lymphoma-2(bcl-2) protein expression in myocardial tissue were measured by Western blotting. The myocardial apoptosis was detected by Td T-mediated d UTPnick-end labeling(TUNEL) method, and apoptosis index(AI) was calculated. Results: Compared with the control group, serum FBG, GHB, GSP, FRA, AR, AGEs and the expression of myocardium RAGE, p-JNK, caspase-3 proteins, as well as apoptosis index(AI) were significantly increased and bcl-2 protein was significantly decreased in the model group(P<0.01). Compared with the model group, the levels of serum FBG, GHB, GSP, FRA and AR showed a significant decline in CONR high-and medium-dose groups(P<0.01). FBG and GHB showed a significant decline in CONR low-dose group(P<0.01). Compared with the model group, the expression of serum AGEs and myocardium RAGE, p-JNK and caspase-3 protein as well as AI were significantly decreased and bcl-2 protein was significantly up-regulated in all treatment groups(P<0.01);high-dose CONR had the most si展开更多
The chemical structures, optical properties and laser-induced damage thresholds of magnesium fluoride films annealed at different temperatures were investigated. The results showed that the stoichiometry of MgF2 film ...The chemical structures, optical properties and laser-induced damage thresholds of magnesium fluoride films annealed at different temperatures were investigated. The results showed that the stoichiometry of MgF2 film changed a little with the increase in annealing temperature. Analysis of the optical properties indicated that excellent antireflection behavior of the film in the range of 200-400 nm can be obtained by the samples coated with MgF2 film. The refractive index increased and the extinction coefficient decreased with increasing annealing temperature. Compared with the asdeposited films, the laser-induced damage threshold was improved after annealing process and decreased with the increase in annealing temperature, which was probably due to the denser film and more absorption centers under higher annealing temperature.展开更多
Resistive switching characteristics of hafnium oxide are studied for possible nonvolatile memory device applications.The HfOx films with different oxygen contents are deposited by rf magnetron sputtering under differe...Resistive switching characteristics of hafnium oxide are studied for possible nonvolatile memory device applications.The HfOx films with different oxygen contents are deposited by rf magnetron sputtering under different O_(2) flow rates.The films are amorphous,and the stoichiometric of the film is improved by increasing the O_(2) flow rate.Current-voltage characteristics of the TiN/HfOx/ITO device are investigated with 1 mA compliance.The bipolar resistive switching behavior is observed for the TiN/HfOx/ITO structure,and the resistive switching mechanism of the TiN/HfOx/ITO structure is explained by trap-controlled space charge limit current conduction.展开更多
Hafnium oxide films are deposited on Si(100)substrates by means of rf magnetron sputtering.The interfacial structure is studied using high-resolution transmission electron microscopy(HRTEM)and x-ray photoelectron spec...Hafnium oxide films are deposited on Si(100)substrates by means of rf magnetron sputtering.The interfacial structure is studied using high-resolution transmission electron microscopy(HRTEM)and x-ray photoelectron spectroscopy(XPS),and the electrical properties of the Au/HfO_(2)/Si stack are analyzed by frequency−dependent capacitance-voltage(C–V–f)measurements.The amorphous interfacial layer between HfO_(2) and the Si substrate is observed by the HRTEM method.From the results of XPS,the interfacial layer comprises hafnium silicate and silicon oxide.For C–V–f measurements,the C–V plots show a peak at a low frequency and the change in frequency has effects on the intensity of the peak.As expected,rapid thermal annealing can passivate the interface states of the HfO_(2)/Si stack.展开更多
The first-principles calculations based on density functional theory are used to obtain structural,mechanical,and electronic properties of Zr-Te compounds.The optimized structural parameters are consistent with the av...The first-principles calculations based on density functional theory are used to obtain structural,mechanical,and electronic properties of Zr-Te compounds.The optimized structural parameters are consistent with the available experimental data.The calculated mechanical properties and formation energy show that the Zr-Te compounds are all mechanically and thermodynamically stable.The bulk modulus B,shear modulus G,Young’s modulus E,Debye temperatureΘD,and sound velocity vm are listed,which are positively correlated with the increasing of atomic fraction of Zr.The behaviors of density of states of Zr-Te compounds are obtained.Furthermore,the electronic properties are discussed to clarify the bonding characteristics of compounds.The electronic characteristics demonstrate that the Zr-Te systems with different phases are both covalent and metallic.展开更多
基金Supported by National Natural Science Foundation of China(No.81374026)。
文摘Objective: To investigate the effects of Composition of Ophiopogon polysaccharide, Notoginseng total saponins and Rhizoma Coptidis alkaloids(CONR) on myocardial apoptosis of diabetic atherosclerosis(DA) rabbits Methods: Sixty male New Zealand white rabbits were randomly divided into 6 groups [control group, model group, CONR high-dose group(450 mg/kg), CONR medium-dose group(150 mg/kg), CONR low-dose group(50 mg/kg), and simvastatin group] by using a completely random method, 10 in each group. DA model was established by intravenously injected alloxan combined with high-fat diet and abdominal aortic balloon injury. After mediation for 10 weeks, fasting blood glucose(FBG), glycosylated hemoglobin(GHB), glycosylated serum protein(GSP), fructoseamine(FRA), aldose reductase(AR), advanced glycation end products(AGEs) in serum were measured by enzyme linked immunosorbent assay(ELISA) method;the expression of receptor of AGEs(RAGE) in myocardial tissue were observed by immunohistochemical method;and p-Jun N-terminal kinase(p-JNK), caspase-3, B-cell lymphoma-2(bcl-2) protein expression in myocardial tissue were measured by Western blotting. The myocardial apoptosis was detected by Td T-mediated d UTPnick-end labeling(TUNEL) method, and apoptosis index(AI) was calculated. Results: Compared with the control group, serum FBG, GHB, GSP, FRA, AR, AGEs and the expression of myocardium RAGE, p-JNK, caspase-3 proteins, as well as apoptosis index(AI) were significantly increased and bcl-2 protein was significantly decreased in the model group(P<0.01). Compared with the model group, the levels of serum FBG, GHB, GSP, FRA and AR showed a significant decline in CONR high-and medium-dose groups(P<0.01). FBG and GHB showed a significant decline in CONR low-dose group(P<0.01). Compared with the model group, the expression of serum AGEs and myocardium RAGE, p-JNK and caspase-3 protein as well as AI were significantly decreased and bcl-2 protein was significantly up-regulated in all treatment groups(P<0.01);high-dose CONR had the most si
基金financially supported by the Research Fund of the State Key Laboratory of Solidification Processing,Northwestern Polytechnical University,China(Grant No.155-QP-2016)the Fundamental Research Funds for the Central Universities(No.3102014JCQ01032)the 111 Project(No.B08040)
文摘The chemical structures, optical properties and laser-induced damage thresholds of magnesium fluoride films annealed at different temperatures were investigated. The results showed that the stoichiometry of MgF2 film changed a little with the increase in annealing temperature. Analysis of the optical properties indicated that excellent antireflection behavior of the film in the range of 200-400 nm can be obtained by the samples coated with MgF2 film. The refractive index increased and the extinction coefficient decreased with increasing annealing temperature. Compared with the asdeposited films, the laser-induced damage threshold was improved after annealing process and decreased with the increase in annealing temperature, which was probably due to the denser film and more absorption centers under higher annealing temperature.
基金Supported by the National Natural Science Foundation of China under Grant No 51202196the Northwestern Polytechnical University(NPU)Foundation for Fundamental Research(No JC201111)+1 种基金the Research Fund of the State Key Laboratory of Solidification Processing(NWPU)(No 58-TZ-2011)the 111 Project(No B08040).
文摘Resistive switching characteristics of hafnium oxide are studied for possible nonvolatile memory device applications.The HfOx films with different oxygen contents are deposited by rf magnetron sputtering under different O_(2) flow rates.The films are amorphous,and the stoichiometric of the film is improved by increasing the O_(2) flow rate.Current-voltage characteristics of the TiN/HfOx/ITO device are investigated with 1 mA compliance.The bipolar resistive switching behavior is observed for the TiN/HfOx/ITO structure,and the resistive switching mechanism of the TiN/HfOx/ITO structure is explained by trap-controlled space charge limit current conduction.
基金by the Northwestern Polytechnical University(NPU)Foundation for Fundamental Research under Grant No JC201111the Research Fund of the State Key Laboratory of Solidification Processing(NWPU)under Grant No 58-TZ-2011,and the 111 Project under Grant No B08040.
文摘Hafnium oxide films are deposited on Si(100)substrates by means of rf magnetron sputtering.The interfacial structure is studied using high-resolution transmission electron microscopy(HRTEM)and x-ray photoelectron spectroscopy(XPS),and the electrical properties of the Au/HfO_(2)/Si stack are analyzed by frequency−dependent capacitance-voltage(C–V–f)measurements.The amorphous interfacial layer between HfO_(2) and the Si substrate is observed by the HRTEM method.From the results of XPS,the interfacial layer comprises hafnium silicate and silicon oxide.For C–V–f measurements,the C–V plots show a peak at a low frequency and the change in frequency has effects on the intensity of the peak.As expected,rapid thermal annealing can passivate the interface states of the HfO_(2)/Si stack.
基金Project supported by the National Natural Science Foundation of China(Grant No.11574254)the Key Research Project of Science and Technology Department of Shaanxi Province,China(Grant Nos.2018GY-044 and 2017ZDXM-GY-114)+2 种基金the Innovation Talent Promotion Project of Shaanxi Province,China(Grant No.2019KJXX-034)the Science and Technology Program of Sichuan Province,China(Grant No.2018JY0161)the Fund of the State Key Laboratory of Solidification Processing,Northwestern Polytechnical University,China(Grant No.SKLSP201843).
文摘The first-principles calculations based on density functional theory are used to obtain structural,mechanical,and electronic properties of Zr-Te compounds.The optimized structural parameters are consistent with the available experimental data.The calculated mechanical properties and formation energy show that the Zr-Te compounds are all mechanically and thermodynamically stable.The bulk modulus B,shear modulus G,Young’s modulus E,Debye temperatureΘD,and sound velocity vm are listed,which are positively correlated with the increasing of atomic fraction of Zr.The behaviors of density of states of Zr-Te compounds are obtained.Furthermore,the electronic properties are discussed to clarify the bonding characteristics of compounds.The electronic characteristics demonstrate that the Zr-Te systems with different phases are both covalent and metallic.
