Natural adult aging is associated with many functional impairments of the human neuromuscular system.One of the more observable alterations is the loss of contractile muscle mass,termed sarcopenia.The loss of muscle m...Natural adult aging is associated with many functional impairments of the human neuromuscular system.One of the more observable alterations is the loss of contractile muscle mass,termed sarcopenia.The loss of muscle mass occurs primarily due to a progressive loss of viable motor units,and accompanying atrophy of remaining muscle fibers.Not only does the loss of muscle mass contribute to impaired function in old age,but alterations in fiber type and myosin heavy chain isoform expression also contribute to weaker,slower,and less powerful contracting muscles.This review will focus on motor unit loss associated with natural adult aging,age-related fatigability,and the age-related differences in strength across contractile muscle actions.展开更多
基金supported by an operating grant to Dr.Charles Rice from the Natural Sciences and Engineering Research Council of Canada (NSERC)supported by the Canadian Institutes of Health Research (CIHR)+1 种基金the Michael Smith Foundation for Health Research (MSFHR)supported by Alberta Innovates Health Solutions (AIHS)
文摘Natural adult aging is associated with many functional impairments of the human neuromuscular system.One of the more observable alterations is the loss of contractile muscle mass,termed sarcopenia.The loss of muscle mass occurs primarily due to a progressive loss of viable motor units,and accompanying atrophy of remaining muscle fibers.Not only does the loss of muscle mass contribute to impaired function in old age,but alterations in fiber type and myosin heavy chain isoform expression also contribute to weaker,slower,and less powerful contracting muscles.This review will focus on motor unit loss associated with natural adult aging,age-related fatigability,and the age-related differences in strength across contractile muscle actions.
