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Inhibition of the maize salt overly sensitive pathway by ZmSK3 and ZmSK4 被引量:3
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作者 Jianfang Li Xueyan Zhou +10 位作者 Yan Wang Shu Song Liang Ma Qian He Minhui Lu kaina Zhang Yongqing Yang Qian Zhao Weiwei Jin Caifu Jiang Yan Guo 《Journal of Genetics and Genomics》 SCIE CSCD 2023年第12期960-970,共11页
Soil salinity is a worldwide problem that adversely affects plant growth and crop productivity. The salt overly sensitive (SOS) pathway is evolutionarily conserved and essential for plant salt tolerance. In this study... Soil salinity is a worldwide problem that adversely affects plant growth and crop productivity. The salt overly sensitive (SOS) pathway is evolutionarily conserved and essential for plant salt tolerance. In this study, we reveal how the maize shaggy/glycogen synthase kinase 3-like kinases ZmSK3 and ZmSK4, orthologs of brassinosteroid insensitive 2 in Arabidopsis thaliana, regulate the maize SOS pathway. ZmSK3 and ZmSK4 interact with and phosphorylate ZmSOS2, a core member of the maize SOS pathway. The mutants defective in ZmSK3 or ZmSK4 are hyposensitive to salt stress, with higher salt-induced activity of ZmSOS2 than that in the wild type. Furthermore, the Ca^(2+) sensors ZmSOS3 and ZmSOS3-like calcium binding protein 8 (ZmSCaBP8) activate ZmSOS2 to maintain Na^(+)/K^(+) homeostasis under salt stress and may participate in the regulation of ZmSOS2 by ZmSK3 and ZmSK4. These findings discover the regulation of the maize SOS pathway and provide important gene targets for breeding salt-tolerant maize. 展开更多
关键词 Salt stress Maize SOS pathway ZmSK3 ZmSK4 ZmSCaBP8
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甲基化抗肿瘤药物治疗中的DNA修复:治疗效果与健康结局(英文) 被引量:3
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作者 Bernd kaina 《癌变.畸变.突变》 CAS CSCD 2016年第5期333-341,347,共10页
在甲基化抗肿瘤药物治疗中,DNA修复是决定治疗效果与不良生物效应(如突变、癌变和致畸)的一个关键机制。本文主要对甲基化抗肿瘤药物在DNA修复过程的作用进行综述。尽管这些抗肿瘤药物无选择性地靶向作用于癌细胞和正常细胞的DNA,但因... 在甲基化抗肿瘤药物治疗中,DNA修复是决定治疗效果与不良生物效应(如突变、癌变和致畸)的一个关键机制。本文主要对甲基化抗肿瘤药物在DNA修复过程的作用进行综述。尽管这些抗肿瘤药物无选择性地靶向作用于癌细胞和正常细胞的DNA,但因其削弱了癌细胞内某些特异的DNA修复活动,从而更多地杀死癌细胞。单功能的烷化剂显示出甲基化改变特性(丙卡巴肼、达卡巴嗪、链脲佐菌素、替莫唑胺),或者氯乙基化形成单加合物并在下一步反应中引起DNA链内交联(洛莫司汀、尼莫地6平、卡莫司汀、福莫司汀)。癌细胞对抗肿瘤药物的一个主要机制是通过自杀酶O-甲基鸟嘌呤-DNA甲基转移酶(MGMT)直接逆转6 6DNA损伤,形成O-甲基鸟嘌呤和O-氯化鸟嘌呤。由于MGMT对恶性肿瘤治疗的结局有显著影响,它被认为是一个耐药的重要标志,特别是在高级恶性胶质瘤。MGMT也被认为是甲基化抗肿瘤药物有效性的预测标志,许多临床试验正在分析MGMT抑制对治疗效果的影响。其他涉及甲基化抗肿瘤药物耐药的DNA修复因素包括错配修复、通过同源重组和DNA双链断裂(DSB)信号启动的相关修复。碱基切除修复和alk B同源蛋白(如ABH2)也可能与烷化类药物耐药有关,该现象在高表达MGMT的细胞株异常明显。对于这些机制的进一步了解,将有助于设计更为有效的治疗方案,同时减少副作用。 展开更多
关键词 替莫唑胺 O6甲基鸟嘌呤-甲基转移酶 烷基转移酶 启动子甲基化 修复 肿瘤 生物标记 药物抗性 胶质母细胞瘤
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Power Plant Indicator Light Detection System Based on Improved YOLOv5 被引量:1
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作者 Yunzuo Zhang kaina Guo 《Journal of Beijing Institute of Technology》 EI CAS 2022年第6期605-612,共8页
Electricity plays a vital role in daily life and economic development.The status of the indicator lights of the power plant needs to be checked regularly to ensure the normal supply of electricity.Aiming at the proble... Electricity plays a vital role in daily life and economic development.The status of the indicator lights of the power plant needs to be checked regularly to ensure the normal supply of electricity.Aiming at the problem of a large amount of data and different sizes of indicator light detection,we propose an improved You Only Look Once vision 5(YOLOv5)power plant indicator light detection algorithm.The algorithm improves the feature extraction ability based on YOLOv5s.First,our algorithm enhances the ability of the network to perceive small objects by combining attention modules for multi-scale feature extraction.Second,we adjust the loss function to ensure the stability of the object frame during the regression process and improve the conver-gence accuracy.Finally,transfer learning is used to augment the dataset to improve the robustness of the algorithm.The experimental results show that the average accuracy of the proposed squeeze-and-excitation YOLOv5s(SE-YOLOv5s)algorithm is increased by 4.39%to 95.31%compared with the YOLOv5s algorithm.The proposed algorithm can better meet the engineering needs of power plant indicator light detection. 展开更多
关键词 You Only Look Once vision 5(YOLOv5) attention module loss function transfer learning object detection system
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Pedestrian Crossing Detection Based on HOG and SVM 被引量:1
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作者 Yunzuo Zhang kaina Guo +2 位作者 Wei Guo Jiayu Zhang Yi Li 《Journal of Cyber Security》 2021年第2期79-88,共10页
In recent years,pedestrian detection is a hot research topic in the field of computer vision and artificial intelligence,it is widely used in the field of security and pedestrian analysis.However,due to a large amount... In recent years,pedestrian detection is a hot research topic in the field of computer vision and artificial intelligence,it is widely used in the field of security and pedestrian analysis.However,due to a large amount of calculation in the traditional pedestrian detection technology,the speed of many systems for pedestrian recognition is very limited.But in some restricted areas,such as construction hazardous areas,real-time detection of pedestrians and cross-border behaviors is required.To more conveniently and efficiently detect whether there are pedestrians in the restricted area and cross-border behavior,this paper proposes a pedestrian cross-border detection method based on HOG(Histogram of Oriented Gradient)and SVM(Support Vector Machine).This method extracts the moving target through the GMM(Gaussian Mixture Model)background modeling and then extracts the characteristics of the moving target through gradient HOG.Finally,it uses SVM training to distinguish pedestrians from non-pedestrians,completes the detection of pedestrians,and labels the targets.The test results show that only the HOG feature extraction of the candidate area can greatly reduce the amount of calculation and reduce the time of feature extraction,eliminate background interference,thereby improving the efficiency of detection,and can be applied to occasions with real-time requirements. 展开更多
关键词 Pedestrian detection HOG SVM GMM
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Proposals from binary tree and spatio-temporal tunnel for temporal segmentation of rough videos
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作者 ZHANG Yunzuo GUO kaina 《Optoelectronics Letters》 EI 2022年第12期763-768,共6页
Existing temporal segmentation methods suffer from the problems of high computational complexity and complicated steps. To address this issue, we present a method that combines the binary tree and spatio-temporal tunn... Existing temporal segmentation methods suffer from the problems of high computational complexity and complicated steps. To address this issue, we present a method that combines the binary tree and spatio-temporal tunnel(STT) for temporal segmentation of rough videos. First, we compute initial cumulative spatio-temporal flow to determine flow overflow of sub-video which is divided from a rough video. Second, the decision tree is generated by combining binary tree and balance factor to dynamically adjust the sampling line of the STT. Finally, pixels on the sampling line are extracted to generate an adaptive STT for temporal proposals. Experimental results show that the computational complexity of the proposed method is significantly better than that of the comparison methods while ensuring accuracy. 展开更多
关键词 binary tree video
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捷报频传 日本影视剧海报美图SHOW
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作者 猫又 kaina 《音乐世界》 2009年第12期89-95,共7页
作为宣传手法之一,海报也是影视剧作品中不可或缺的一个重要环节。在这个方面,不得不说注重细节的日本演艺圈,对于海报的制作相当花心思。光是看这些海报,便可让你浮想联翩,继而产生观看本作的冲动。
关键词 影视剧 海报 SHOW 日本 宣传手法 演艺圈
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Single-Choice Aided Marking System Research Based on Back Propagation Neural Network
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作者 Yunzuo Zhang Yi Li +3 位作者 Wei Guo Lei Huo Jiayu Zhang kaina Guo 《Journal of Cyber Security》 2021年第1期45-54,共10页
In the field of educational examination,automatic marking technology plays an essential role in improving the efficiency of marking and liberating the labor force.At present,the implementation of the policy of expandi... In the field of educational examination,automatic marking technology plays an essential role in improving the efficiency of marking and liberating the labor force.At present,the implementation of the policy of expanding erolments has caused a serious decline in the teacher-student ratio in colleges and universities.The traditional marking system based on Optical Mark Reader technology can no longer meet the requirements of liberating the labor force of teachers in small and medium-sized examinations.With the development of image processing and artificial neural network technology,the recognition of handwritten character in the field of pattern recognition has attracted the attention of many researchers.In this paper,filtering and de-noise processing and binary processing are used as preprocessing methods for handwriting recognition.Extract the pixel feature of handwritten characters through digital image processing of handwritten character pictures,and then,get the feature vector from these feature fragments and use it as the description of the character.The extracted feature values are used to train the neural network to realize the recognition of handwritten English letters and numerical characters.Experimental results on Chars74K and MNIST data sets show that the recognition accuracy of some handwritten English letters and numerical characters can reach 90%and 99%,respectively. 展开更多
关键词 Image preprocessing BP neural network handwriting recognition marking system
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玉木宏 Romance,Symphony Of Life
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作者 kaina 《音乐世界》 2010年第4期126-127,共2页
玉木宏觉得自己也许拥有浪漫家的气质,无论是对于工作还是生活,在一快一慢,一紧一松之间,寻找属于自己的适合空间,谱写自己的交响情人乐章。
关键词 玉木宏 演员 表演艺术 个人气质
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SHINING TONIGHT 腾讯网2008星光大典现场直击
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作者 kaina 《音乐世界》 2009年第2期24-25,共2页
2008年12月15日晚,由腾讯网与腾讯公益慈善基金会主办的“特步·腾讯网2008星光大典”在北京欢乐谷华侨城大剧院隆重举行,继前两年的星光大典之后,活动将主题定为了“中国加油”,两岸三地近百位明星出席了当晚的活动,更与3.5... 2008年12月15日晚,由腾讯网与腾讯公益慈善基金会主办的“特步·腾讯网2008星光大典”在北京欢乐谷华侨城大剧院隆重举行,继前两年的星光大典之后,活动将主题定为了“中国加油”,两岸三地近百位明星出席了当晚的活动,更与3.5亿网民共享了这场星光夺目的盛宴。 展开更多
关键词 现场 慈善基金会 两岸三地 华侨城 明星 网民
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两个人有温度 袁成杰×戚薇
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作者 kaina 《音乐世界》 2009年第3期88-91,共4页
提起袁成杰,会令人习惯地想起他的搭档戚薇,不知不觉中,“男才女貌”已在很多人心中留下了深刻印象。从《外滩18号》到新作《梦幻奇缘》,袁成杰与戚薇一路走来,一起经历了很多,关于音乐,关于生活,很多事情也变成了两个人的共同... 提起袁成杰,会令人习惯地想起他的搭档戚薇,不知不觉中,“男才女貌”已在很多人心中留下了深刻印象。从《外滩18号》到新作《梦幻奇缘》,袁成杰与戚薇一路走来,一起经历了很多,关于音乐,关于生活,很多事情也变成了两个人的共同财富,因为是两个人,所以永远温暖。 展开更多
关键词 个人 温度 才女 生活 温暖
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A级保存——Johnny's BEST SHOT FILE
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作者 猫又 kaina 《音乐世界》 2009年第3期92-101,共10页
这些艺人,在08年有过特别的经验,得到更深的发展,在他们的心中,08年的回忆,就像这些照片一样,定格在最美丽的一刻。08年的回忆是属于他们的,这些靓图是属于我们的,现在,一并为你呈现。
关键词 影视艺人 艺术工作者 松本润 锦户亮
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国内上架
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作者 kaina 《音乐世界》 2009年第16期22-23,共2页
棒棒堂《我是传奇》专辑一路蜕变 结束了在香港地区红墈举行的“棒棒堂 我是传奇2009亚洲巡回演唱会”.出道三年的“棒棒堂”马上又推出了他们的第二张概念式专辑,挥别青涩,这次以魅力黑,炫光银,华丽金的三种基色作为主调。
关键词 上架 国内 香港地区 视觉体验 心路历程 歌词创作 专辑 传奇
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帅管家的10个条件
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作者 猫又 kaina 《音乐世界》 2009年第5期74-79,共6页
一部《我的帅管家》播的正火热,剧中水(山鸟)比吕扮演的管家理人成了无数女孩心中的“梦幻执事”,帅气、温文尔雅.体贴……除了这些,帅管家还需要哪些条件?当今日本的人气帅哥们,还有谁具有成为“梦幻执事”的潜质,不比一下怎... 一部《我的帅管家》播的正火热,剧中水(山鸟)比吕扮演的管家理人成了无数女孩心中的“梦幻执事”,帅气、温文尔雅.体贴……除了这些,帅管家还需要哪些条件?当今日本的人气帅哥们,还有谁具有成为“梦幻执事”的潜质,不比一下怎么知道呢? 展开更多
关键词 艺术工作者 电影评论 《我的帅管家》 演员 日本
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型男's个人事情:水岛HIRO
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作者 kaina 《音乐世界》 2010年第1期80-81,共2页
电视剧《东京DOGS》中的水岛,不仅留了胡子,还穿上皮衣外套,透出一股浓浓的不羁感,全新形象令人倍感新鲜,看来这次的“型男”的确塑造有方,要怎样像水岛那样“美”“型”兼具呢?那还要让本人介绍一下自己的扮型秘笈哦。
关键词 人事 DOGS 电视剧 “美”
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平原绫香 A Song In My Life
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作者 kaina 《音乐世界》 2010年第1期86-87,共2页
初听平原绫香的歌.扎实的唱功和极富磁性的低音令人印象深刻她的音乐可以大气.同时也能细腻地感动充满了值得回味的地方。平原绫香的说话声与唱歌时又有善些许不同轻柔而又舒服这次电话采访的过程中.更令人直觉生活中的她是个平易近... 初听平原绫香的歌.扎实的唱功和极富磁性的低音令人印象深刻她的音乐可以大气.同时也能细腻地感动充满了值得回味的地方。平原绫香的说话声与唱歌时又有善些许不同轻柔而又舒服这次电话采访的过程中.更令人直觉生活中的她是个平易近人的人。 展开更多
关键词 平原 平易近人 电话采访
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薛之谦
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作者 kaina 《音乐世界》 2010年第4期54-61,共8页
刺骨寒意的冬日夜幕,被橘色路灯渲染的街道,冬季低温中的某一天,迎来了薛之谦的这一次采访。
关键词 薛之谦 歌手 音乐 艺术
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龟梨和也 Love All The Time
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作者 kaina 《音乐世界》 2010年第4期76-77,共2页
积极,主动,自制……龟梨和也在恋爱中喜欢充当主动的一方,偶尔也会有显露出害羞和简单的一面,和他谈恋爱能享受不断的惊喜,在细节之处又能感受他真挚的爱,这样的恋人自然很受女孩子欢迎啦。
关键词 LOVE TIME The 女孩子 恋爱
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A genome-wide screening for DNA repair genes:much more players than hitherto known
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作者 Bernd kaina 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2020年第1期806-807,共2页
Since the discovery of the structure of DNA and the statement by Francis Crick that DNA is“…so precious that probably many distinct repair mechanisms would exist”,1 a plethora of DNA alterations induced by exogenou... Since the discovery of the structure of DNA and the statement by Francis Crick that DNA is“…so precious that probably many distinct repair mechanisms would exist”,1 a plethora of DNA alterations induced by exogenous and endogenous genotoxins has been identified,together with complex cellular processes that sense the damage,remove it from the macromolecule or tolerate it during replication.Kinase-driven pathways signal downstream to complex networks,which regulate the balance between survival and death,and are collectively referred to as the DNA damage response(DDR).The classical DNA repair and DDR pathways have been elucidated in detail and a tight entanglement has been uncovered between ATM-ATR-DNA-PK driven pathways,chromatin remodeling,damage recruiting factors,and mechanisms removing or tolerating DNA damage in a simple(damage reversal)or more complex way(Fig.1). 展开更多
关键词 NETWORKS DAMAGE removing
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SMAP Shanghai Magic Time
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作者 kaina 《音乐世界》 2010年第19期36-37,共2页
因为SMAP的到来,使10月的上海聚焦了太多的目光和关注。在6月世博活动取消的遗憾之后,SMAP兑现诺言,将今年日本巡回演唱会的最终站演出放在了上海,对于中国Fans们而言,这是一份难以用言语来表达的极致惊喜。
关键词 SMAP 音乐 歌手 唱片
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冬季紧急降落
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作者 kaina 《音乐世界》 2010年第4期42-43,共2页
时隔一年半,“蓝色旋风”再度到来,“月9”电视剧《Gode Blue-直升机紧急救援-》带来了华丽的冬季档续篇。熟悉的身影、全新的故事,毫无疑问,这季的“月9”依然是当仁不让的量级焦点。
关键词 冬季 紧急救援 电视剧 直升机
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