Background:The benefit of systemic treatments in esophageal squamous cell carcinoma(ESCC)which has pro-gressed after chemotherapy is still uncertain and optimal regimens based on randomized trials have not yet been es...Background:The benefit of systemic treatments in esophageal squamous cell carcinoma(ESCC)which has pro-gressed after chemotherapy is still uncertain and optimal regimens based on randomized trials have not yet been established.We aimed to compare the efficacy of irinotecan plus S-1 with S-1 monotherapy in recurrent or metastatic ESCC patients who had resistance to platinum-or taxane-based chemotherapy.Methods:We conducted a prospective randomized,multicenter,open-label,phase 3 trial in 15 centers across China.Eligible patients were adults with histologically confirmed recurrent or metastatic ESCC,and were randomly assigned(ratio,1:1)to receive either irinotecan plus S-1(intravenous infusion of irinotecan[160 mg/m2]on day 1 and oral S-1[80-120 mg]on days 1-10,repeated every 14 days)or oral S-1 monotherapy(80-120 mg/day on days 1-14,repeated every 21 days)using a central computerized minimization procedure.The primary endpoint was progression-free survival(PFS).Results:Between December 23,2014 and July 25,2016,we screened 148 patients and randomly assigned 123 patients to receive either irinotecan plus S-1 regimen(n=61)or S-1 monotherapy(n=62).After a median follow-up of 29.2 months(95%confidence interval[CI]17.5-40.9 months),the median PFS was significantly longer in the irinotecan plus S-1 group than in the S-1 monotherapy group(3.8 months[95%CI 2.9-4.3 months]vs.1.7 months[95%CI 1.4-2.7 months],hazard ratio=0.58,95%CI 0.38-0.86,P=0.006).The objective response rates were 24.6%in the irinotecan plus S-1 group and 9.7%in the S-1 monotherapy group(P=0.002).The patients in the irinotecan plus S-1 group presented with increased rates of grade 3-4 leukopenia(16.4%vs.0%),neutropenia(14.8%vs.1.6%),and nausea(4.9%vs.0%).No significant difference in grade 3-4 diarrhea and no treatment-related deaths were observed in both groups.Conclusions: The combination of irinotecan with S-1 was similarly tolerable but significantly prolonged PFS compared to S-1 monotherapy as a second- or third-line treatment in patients with recurren展开更多
Bound states in the continuum(BICs)have exhibited extraordinary properties in photonics for enhanced light-matter interactions that enable appealing applications in nonlinear optics,biosensors,and ultrafast optical sw...Bound states in the continuum(BICs)have exhibited extraordinary properties in photonics for enhanced light-matter interactions that enable appealing applications in nonlinear optics,biosensors,and ultrafast optical switches.The most common strategy to apply BICs in a metasurface is by breaking symmetry of resonators in the uniform array that leaks the otherwise uncoupled mode to free space and exhibits an inverse quadratic relationship between quality factor(Q)and asymmetry.Here,we propose a scheme to further reduce scattering losses and improve the robustness of symmetry-protected BICs by decreasing the radiation density with a hybrid BIC lattice.We observe a significant increase of radiative Q in the hybrid lattice compared to the uniform lattice with a factor larger than 14.6.In the hybrid BIC lattice,modes are transferred toГpoint inherited from high symmetric X,Y,and M points in the Brillouin zone that reveal as multiple Fano resonances in the far field and would find applications in hyperspectral sensing.This work initiates a novel and generalized path toward reducing scattering losses and improving the robustness of BICs in terms of lattice engineering that would release the rigid requirements of fabrication accuracy and benefit applications of photonics and optoelectronic devices.展开更多
Recent advancements in photonic bound states in the continuum(BICs)have opened up exciting new possibilities for the design of optoelectronic devices with improved performance.In this perspective article,we provide an...Recent advancements in photonic bound states in the continuum(BICs)have opened up exciting new possibilities for the design of optoelectronic devices with improved performance.In this perspective article,we provide an overview of recent progress in photonic BICs based on metamaterials and photonic crystals,focusing on both the underlying physics and their practical applications.The first part of this article introduces 2 different interpretations of BICs,based on far-field interference of multipoles and near-field analysis of topological charges.We then discuss recent research on manipulating the far-field radiation properties of BICs through engineering topological charges.The second part of the article summarizes recent developments in the applications of BICs,including chiral light and vortex beam generation,nonlinear optical frequency conversion,sensors,and nanolasers.Finally,we conclude with a discussion of the potential of photonic BICs to advance terahertz applications in areas such as generation and detection,modulation,sensing,and isolation.Webelieve that continued researchinthis area will lead to exciting new advancements in optoelectronics,particularly in the field of terahertz devices.展开更多
Quasi-bound states in the continuum(quasi-BICs)offer an excellent platform for the flexible and efficient control of light-matter interactions by breaking the structural symmetry.The active quasi-BIC device has great ...Quasi-bound states in the continuum(quasi-BICs)offer an excellent platform for the flexible and efficient control of light-matter interactions by breaking the structural symmetry.The active quasi-BIC device has great application potential in fields such as optical sensing,nonlinear optics,and filters.Herein,we experimentally demonstrate an active terahertz(THz)quasi-BIC device induced by the polarization conversion in a liquid crystal(LC)-integrated metasurface,which consists of a symmetrically broken double-gap split ring resonator(DSRR),an LC layer,and double graphite electrodes.In the process of LC orientation control under the external field,the device realizes the active control from the OFF state to the ON state.In the OFF state,the LC has no polarization conversion effect,and the device behaves in a non-resonant state;but for the ON state,the device exhibits obvious quasi-BIC resonance.Furthermore,we achieve asymmetric transmission based on polarization-induced quasiBIC modulation precisely at the quasi-BIC resonance position,and its isolation can be controlled by the external field.The study on dynamic quasi-BIC by the LC-integrated metasurface introduces a very promising route for active THz devices,which guarantees potential applications for THz communications,switching,and sensing systems.展开更多
基金This study was supported by the National Key Basic Research Program of China(973 Program No.2015CB553902)
文摘Background:The benefit of systemic treatments in esophageal squamous cell carcinoma(ESCC)which has pro-gressed after chemotherapy is still uncertain and optimal regimens based on randomized trials have not yet been established.We aimed to compare the efficacy of irinotecan plus S-1 with S-1 monotherapy in recurrent or metastatic ESCC patients who had resistance to platinum-or taxane-based chemotherapy.Methods:We conducted a prospective randomized,multicenter,open-label,phase 3 trial in 15 centers across China.Eligible patients were adults with histologically confirmed recurrent or metastatic ESCC,and were randomly assigned(ratio,1:1)to receive either irinotecan plus S-1(intravenous infusion of irinotecan[160 mg/m2]on day 1 and oral S-1[80-120 mg]on days 1-10,repeated every 14 days)or oral S-1 monotherapy(80-120 mg/day on days 1-14,repeated every 21 days)using a central computerized minimization procedure.The primary endpoint was progression-free survival(PFS).Results:Between December 23,2014 and July 25,2016,we screened 148 patients and randomly assigned 123 patients to receive either irinotecan plus S-1 regimen(n=61)or S-1 monotherapy(n=62).After a median follow-up of 29.2 months(95%confidence interval[CI]17.5-40.9 months),the median PFS was significantly longer in the irinotecan plus S-1 group than in the S-1 monotherapy group(3.8 months[95%CI 2.9-4.3 months]vs.1.7 months[95%CI 1.4-2.7 months],hazard ratio=0.58,95%CI 0.38-0.86,P=0.006).The objective response rates were 24.6%in the irinotecan plus S-1 group and 9.7%in the S-1 monotherapy group(P=0.002).The patients in the irinotecan plus S-1 group presented with increased rates of grade 3-4 leukopenia(16.4%vs.0%),neutropenia(14.8%vs.1.6%),and nausea(4.9%vs.0%).No significant difference in grade 3-4 diarrhea and no treatment-related deaths were observed in both groups.Conclusions: The combination of irinotecan with S-1 was similarly tolerable but significantly prolonged PFS compared to S-1 monotherapy as a second- or third-line treatment in patients with recurren
基金This work was supported by the National Natural Science Foundation of China(Award No.62175099)Guangdong Basic and Applied Basic Research Foundation(Award No.2023A1515011085)+1 种基金Stable Support Program for Higher Education Institutions from Shenzhen Science,Technology&Innovation Commission(Award No.20220815151149004)Global recruitment program of young experts of China,and startup funding of Southern University of Science and Technology.The authors acknowledge the assistance of SUSTech Core Research Facilities and thank Yao Wang for helpful discussions on fabrication.
文摘Bound states in the continuum(BICs)have exhibited extraordinary properties in photonics for enhanced light-matter interactions that enable appealing applications in nonlinear optics,biosensors,and ultrafast optical switches.The most common strategy to apply BICs in a metasurface is by breaking symmetry of resonators in the uniform array that leaks the otherwise uncoupled mode to free space and exhibits an inverse quadratic relationship between quality factor(Q)and asymmetry.Here,we propose a scheme to further reduce scattering losses and improve the robustness of symmetry-protected BICs by decreasing the radiation density with a hybrid BIC lattice.We observe a significant increase of radiative Q in the hybrid lattice compared to the uniform lattice with a factor larger than 14.6.In the hybrid BIC lattice,modes are transferred toГpoint inherited from high symmetric X,Y,and M points in the Brillouin zone that reveal as multiple Fano resonances in the far field and would find applications in hyperspectral sensing.This work initiates a novel and generalized path toward reducing scattering losses and improving the robustness of BICs in terms of lattice engineering that would release the rigid requirements of fabrication accuracy and benefit applications of photonics and optoelectronic devices.
基金supported by the National Natural Science Foundation of China (Award No.:62175099)the Guangdong Basic and Applied Basic Research Foundation (Award No.:2023A1515011085)+1 种基金the Stable Support Program for Higher Education Institutions from Shenzhen Science,Technology&Innovation Commission (Award No.:20220815151149004)startup funding of Southern University of Science and Technology。
文摘Recent advancements in photonic bound states in the continuum(BICs)have opened up exciting new possibilities for the design of optoelectronic devices with improved performance.In this perspective article,we provide an overview of recent progress in photonic BICs based on metamaterials and photonic crystals,focusing on both the underlying physics and their practical applications.The first part of this article introduces 2 different interpretations of BICs,based on far-field interference of multipoles and near-field analysis of topological charges.We then discuss recent research on manipulating the far-field radiation properties of BICs through engineering topological charges.The second part of the article summarizes recent developments in the applications of BICs,including chiral light and vortex beam generation,nonlinear optical frequency conversion,sensors,and nanolasers.Finally,we conclude with a discussion of the potential of photonic BICs to advance terahertz applications in areas such as generation and detection,modulation,sensing,and isolation.Webelieve that continued researchinthis area will lead to exciting new advancements in optoelectronics,particularly in the field of terahertz devices.
基金National Natural Science Foundation of China(62005143,62175099,62335011)Basic and Applied Basic Research Foundation of Guangdong Province(2023A1515011085)+1 种基金Shenzhen Science and Technology Innovation Program(20220815151149004,20230807093617036,JSGGKQTD20221101115656030)Regular Undergraduate University Teacher Visiting and Training Funding of Shandong Province。
文摘Quasi-bound states in the continuum(quasi-BICs)offer an excellent platform for the flexible and efficient control of light-matter interactions by breaking the structural symmetry.The active quasi-BIC device has great application potential in fields such as optical sensing,nonlinear optics,and filters.Herein,we experimentally demonstrate an active terahertz(THz)quasi-BIC device induced by the polarization conversion in a liquid crystal(LC)-integrated metasurface,which consists of a symmetrically broken double-gap split ring resonator(DSRR),an LC layer,and double graphite electrodes.In the process of LC orientation control under the external field,the device realizes the active control from the OFF state to the ON state.In the OFF state,the LC has no polarization conversion effect,and the device behaves in a non-resonant state;but for the ON state,the device exhibits obvious quasi-BIC resonance.Furthermore,we achieve asymmetric transmission based on polarization-induced quasiBIC modulation precisely at the quasi-BIC resonance position,and its isolation can be controlled by the external field.The study on dynamic quasi-BIC by the LC-integrated metasurface introduces a very promising route for active THz devices,which guarantees potential applications for THz communications,switching,and sensing systems.
