OBJECTIVE To evaluate the associations of lipid indicators and mortality in Beijing Elderly Comprehensive Health Cohort Study.METHODS A prospective cohort was conducted based on Beijing Elderly Comprehensive Health Co...OBJECTIVE To evaluate the associations of lipid indicators and mortality in Beijing Elderly Comprehensive Health Cohort Study.METHODS A prospective cohort was conducted based on Beijing Elderly Comprehensive Health Cohort Study with 4499 com-munity older adults.After the baseline survey,the last follow-up was March 31,2021 with an average 8.13 years of follow-up.Cox proportional hazard model was used to estimate the hazard ratios(HR)with 95%CI for cardiovascular disease(CVD)death and all-cause death in associations with baseline lipid indicators.RESULTS A total of 4499 participants were recruited,and the mean levels of uric acid,body mass index,systolic blood pres-sure,diastolic blood pressure,fasting plasma glucose,total cholesterol(TC),triglyceride,and low-density lipoprotein cholesterol(LDL-C)showed an upward trend with the increasing remnant cholesterol(RC)quarters(Ptrend<0.05),while the downward tr-end was found in high-density lipoprotein cholesterol(HDL-C).During the total 36,596 person-years follow-up,the CVD mortal-ity and all-cause mortality during an average 8.13 years of follow-up was 3.87%(95%CI:3.30%-4.43%)and 14.83%(95%CI:13.79%-15.86%)with 174 CVD death participants and 667 all-cause death participants.After adjusting for confounders,the higher level of TC(HR=0.854,95%CI:0.730-0.997),LDL-C(HR=0.817,95%CI:0.680-0.982)and HDL-C(HR=0.443,95%CI:0.271-0.724)were associated with lower risk of CVD death,and the higher level of HDL-C(HR=0.637,95%CI:0.501-0.810)were associated with lower risk of all-cause death.The higher level of RC(HR=1.276,95%CI:1.010-1.613)increase the risk of CVD death.Com-pared with the normal lipid group,TC≥6.20 mmol/L group and LDL-C≥4.10 mmol/L group were no longer associated with lower risk of CVD death,while RC≥0.80 mmol/L group was still associated with higher risk of CVD death.In normal lipid gr-oup,the higher levels of TC,LDL-C and HDL-C were related with lower CVD death.CONCLUSIONS In community older adults,higher levels of TC and HDL-C were associated with lower CVD m展开更多
BACKGROUND: Fourier transform infrared (FT-IR) spectroscopy is a physical method applied to the study of cellular changes at the molecular level in various normal and diseased human tissues, including cancer. This stu...BACKGROUND: Fourier transform infrared (FT-IR) spectroscopy is a physical method applied to the study of cellular changes at the molecular level in various normal and diseased human tissues, including cancer. This study was undertaken to establish a cellular basis for the diagnosis of carcinoma tissue, using FT-IR spectroscopy to study a carcinoma cell line and investigating the specific spectral features of the cell line. METHODS: The FT-IR spectra of cultured gallbladder carcinoma cells (GBC-SD) smeared on a BaF(2) window were measured with a Nicolet Magna750-II FT-IR spectrometer. A comparative study was subsequently carried out between the spectra of cultured gallbladder carcinoma cells and those of corresponding carcinoma tissue. RESULTS: Several infrared spectral features were obtained, and the results suggest that the spectral features of the carcinoma cell line reflect those of carcinoma tissue, though the latter are more complex, probably due to the intrinsic complexity of the tissue. CONCLUSION: The diagnosis of carcinoma tissue by FTIR spectroscopy has a sufficient cellular basis.展开更多
We report on a novel architecture to suppress the multi-pulse formation in an all-polarization-maintaining figure-9 erbium-doped fiber laser under high pump power. A 2×2 fiber coupler is introduced into the phase...We report on a novel architecture to suppress the multi-pulse formation in an all-polarization-maintaining figure-9 erbium-doped fiber laser under high pump power. A 2×2 fiber coupler is introduced into the phase-biased nonlinear amplifying loop mirror to extract part of intracavity laser power as a laser output, and the dependence of output couple ratio of fiber coupler on the mode-locking state is experimentally investigated. The intracavity nonlinear effect is mitigated by lowering the intracavity laser power, which is conducive to avoiding the multi-pulse formation. In the meantime, the loss-imbalance induced by fiber coupler is helpful in improving the self-starting ability. With the proposed laser structure,the multiple pulse formation can be suppressed and high power single pulse train can be obtained. The laser emits three pulse trains which is convenient for some applications. Finally, the output power values of three ports are 5.3 m W, 51.3 m W,and 13.2 m W, respectively. The total single pulse output power is 69.8 m W, which is more than 10 times the result without OC2. The total slope efficiency is about 10.1%. The repetition rate of three pulse trains is 21.17 MHz, and the pulse widths are 2.8 ps, 2.63 ps, and 6.66 ps, respectively.展开更多
基金supported by the National Natural Science Foundation of China(No.82173589&No.82173590)the National Key Research and Development Program of China(2022YFC2503605)+1 种基金the Capital’s Funds for Health Improvement and Research(2022-2G-5031),the Beijing Nova Program(No.20220484020)the Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province(2-6-2020E10004).
文摘OBJECTIVE To evaluate the associations of lipid indicators and mortality in Beijing Elderly Comprehensive Health Cohort Study.METHODS A prospective cohort was conducted based on Beijing Elderly Comprehensive Health Cohort Study with 4499 com-munity older adults.After the baseline survey,the last follow-up was March 31,2021 with an average 8.13 years of follow-up.Cox proportional hazard model was used to estimate the hazard ratios(HR)with 95%CI for cardiovascular disease(CVD)death and all-cause death in associations with baseline lipid indicators.RESULTS A total of 4499 participants were recruited,and the mean levels of uric acid,body mass index,systolic blood pres-sure,diastolic blood pressure,fasting plasma glucose,total cholesterol(TC),triglyceride,and low-density lipoprotein cholesterol(LDL-C)showed an upward trend with the increasing remnant cholesterol(RC)quarters(Ptrend<0.05),while the downward tr-end was found in high-density lipoprotein cholesterol(HDL-C).During the total 36,596 person-years follow-up,the CVD mortal-ity and all-cause mortality during an average 8.13 years of follow-up was 3.87%(95%CI:3.30%-4.43%)and 14.83%(95%CI:13.79%-15.86%)with 174 CVD death participants and 667 all-cause death participants.After adjusting for confounders,the higher level of TC(HR=0.854,95%CI:0.730-0.997),LDL-C(HR=0.817,95%CI:0.680-0.982)and HDL-C(HR=0.443,95%CI:0.271-0.724)were associated with lower risk of CVD death,and the higher level of HDL-C(HR=0.637,95%CI:0.501-0.810)were associated with lower risk of all-cause death.The higher level of RC(HR=1.276,95%CI:1.010-1.613)increase the risk of CVD death.Com-pared with the normal lipid group,TC≥6.20 mmol/L group and LDL-C≥4.10 mmol/L group were no longer associated with lower risk of CVD death,while RC≥0.80 mmol/L group was still associated with higher risk of CVD death.In normal lipid gr-oup,the higher levels of TC,LDL-C and HDL-C were related with lower CVD death.CONCLUSIONS In community older adults,higher levels of TC and HDL-C were associated with lower CVD m
基金supported by a grant from the National Natural Science Foundation of China(No.30500119)
文摘BACKGROUND: Fourier transform infrared (FT-IR) spectroscopy is a physical method applied to the study of cellular changes at the molecular level in various normal and diseased human tissues, including cancer. This study was undertaken to establish a cellular basis for the diagnosis of carcinoma tissue, using FT-IR spectroscopy to study a carcinoma cell line and investigating the specific spectral features of the cell line. METHODS: The FT-IR spectra of cultured gallbladder carcinoma cells (GBC-SD) smeared on a BaF(2) window were measured with a Nicolet Magna750-II FT-IR spectrometer. A comparative study was subsequently carried out between the spectra of cultured gallbladder carcinoma cells and those of corresponding carcinoma tissue. RESULTS: Several infrared spectral features were obtained, and the results suggest that the spectral features of the carcinoma cell line reflect those of carcinoma tissue, though the latter are more complex, probably due to the intrinsic complexity of the tissue. CONCLUSION: The diagnosis of carcinoma tissue by FTIR spectroscopy has a sufficient cellular basis.
基金Project supported by the National Natural Science Foundation of China(Grant No.51905528)the Key Research Project of Bureau of Frontier Sciences and Education+1 种基金Chinese Academy of Sciences(Grant No.QYZDY-SSW-JSC008)the National Key Research and Development Project,China(Grant Nos.2019YFB2005600 and 2018YFB2003403)。
文摘We report on a novel architecture to suppress the multi-pulse formation in an all-polarization-maintaining figure-9 erbium-doped fiber laser under high pump power. A 2×2 fiber coupler is introduced into the phase-biased nonlinear amplifying loop mirror to extract part of intracavity laser power as a laser output, and the dependence of output couple ratio of fiber coupler on the mode-locking state is experimentally investigated. The intracavity nonlinear effect is mitigated by lowering the intracavity laser power, which is conducive to avoiding the multi-pulse formation. In the meantime, the loss-imbalance induced by fiber coupler is helpful in improving the self-starting ability. With the proposed laser structure,the multiple pulse formation can be suppressed and high power single pulse train can be obtained. The laser emits three pulse trains which is convenient for some applications. Finally, the output power values of three ports are 5.3 m W, 51.3 m W,and 13.2 m W, respectively. The total single pulse output power is 69.8 m W, which is more than 10 times the result without OC2. The total slope efficiency is about 10.1%. The repetition rate of three pulse trains is 21.17 MHz, and the pulse widths are 2.8 ps, 2.63 ps, and 6.66 ps, respectively.
