本文研究广义部分线性单指标模型(generalized partially linear single-index models,GPLSIMs)的模型平均问题.在实际应用中,GPLSIMs由于其灵活性和易解释性受到广泛关注.然而,GPLSIMs在应用中存在两类不确定性:变量的不确定性和单指...本文研究广义部分线性单指标模型(generalized partially linear single-index models,GPLSIMs)的模型平均问题.在实际应用中,GPLSIMs由于其灵活性和易解释性受到广泛关注.然而,GPLSIMs在应用中存在两类不确定性:变量的不确定性和单指标连接函数光滑度的不确定性.为了解决该不确定性问题,本文提出一种GPLSIMs的最优模型平均方法,该方法通过最大交叉验证准则得到数据驱动的权重.在模型误设定假设和发散模型空间的框架下,本文证明在最小化Kullback-Leibler(KL)损失准则下,所提出的模型平均估计渐近最优.同时,当候选模型集中存在伪真模型时,本文证明基于交叉验证准则得到的权重渐近地集中在伪真模型上.此外,基于提出的模型平均方法,本文为GPLSIMs构建了一种变量重要性度量,并证明该度量可以渐近识别所有真实模型中的变量.模拟研究和两个实际数据分析均展示了本文提出的方法相对于几种现有方法的优势.展开更多
Objective: The partial inferior turbinectomy and septoplasty was applied to treat the allergic perennial rhinitis (APR), and to observe the ultrastructure changes of the nasal mucosa before and after the operations. M...Objective: The partial inferior turbinectomy and septoplasty was applied to treat the allergic perennial rhinitis (APR), and to observe the ultrastructure changes of the nasal mucosa before and after the operations. Methods: For 36 cases of research objects diagnosed with APR, the partial inferior turbinectomy and septoplasty was administered. For 6 APR cases among them, the pre- and postoperative observation of anterior nasal mucosa of the inferior turbinate on the same side under the electron microscope was conducted for one year respectively. In addition, their pathological alterations of tissues were also conducted. Results: In the pre-operative observation under the electron microscope, it was found that the nasal mucosae epithelium cells were nude without cilia. The lamina propria had edema, and mesenchyme presented the infiltration of substantial eosinophilic granulocytes, basophilic granulocytes, plasmacytes and mast cells. Additionally, abundant degranulation and vacuolation of cytoplasts were observed. The plentiful glands, duct ectasia, edema and structural changes were also found. Some gland cells had degenerated. After the operation, it was found that the epithelium nudity still existed and the deficiency of cilia was not improved. Only a very small amount of microvilli existed. The edema of lamina propria was improved and eosinophilic granulocytes were rarely observed in mesenchyme. However, the infiltration of basophilic granulocytes, plasmocytes and mast cells was still observed. The particle structure was generally stable and the central crystal was clear without degranulation. Meanwhile, the amount of glands was reduced and the tissue structure tended to be recovered. Overall, the nasal mucosa showed changes as chronic inflammation. Conclusions: For the treatment of APR with the methods presented by our research institution, in one year before and after the operation, ultrastructural changes of inferior turbinate mucosa tissues were observed from the preoperatively pathological changes of typica展开更多
数字化信息系统实验室(Digital Information System Laboratory)(简称DISLab)的引入可以简化物理实验的操作、加快数据采集与处理的速度并提高精度,因此,将DISLab用于课堂演示和微课制作,可以使抽象的理论更加形象化、实验过程动态化,...数字化信息系统实验室(Digital Information System Laboratory)(简称DISLab)的引入可以简化物理实验的操作、加快数据采集与处理的速度并提高精度,因此,将DISLab用于课堂演示和微课制作,可以使抽象的理论更加形象化、实验过程动态化,更易于学生对知识的理解和接受。本文以向心力研究实验为例,说明了通过DISLab实验的微课的设计和录制,可以训练物理师范生从学生视角出发,设计教学内容和教学思想、引导学生跟随实验过程进行思考,提高物理师范生的教学技能。展开更多
文摘本文研究广义部分线性单指标模型(generalized partially linear single-index models,GPLSIMs)的模型平均问题.在实际应用中,GPLSIMs由于其灵活性和易解释性受到广泛关注.然而,GPLSIMs在应用中存在两类不确定性:变量的不确定性和单指标连接函数光滑度的不确定性.为了解决该不确定性问题,本文提出一种GPLSIMs的最优模型平均方法,该方法通过最大交叉验证准则得到数据驱动的权重.在模型误设定假设和发散模型空间的框架下,本文证明在最小化Kullback-Leibler(KL)损失准则下,所提出的模型平均估计渐近最优.同时,当候选模型集中存在伪真模型时,本文证明基于交叉验证准则得到的权重渐近地集中在伪真模型上.此外,基于提出的模型平均方法,本文为GPLSIMs构建了一种变量重要性度量,并证明该度量可以渐近识别所有真实模型中的变量.模拟研究和两个实际数据分析均展示了本文提出的方法相对于几种现有方法的优势.
文摘Objective: The partial inferior turbinectomy and septoplasty was applied to treat the allergic perennial rhinitis (APR), and to observe the ultrastructure changes of the nasal mucosa before and after the operations. Methods: For 36 cases of research objects diagnosed with APR, the partial inferior turbinectomy and septoplasty was administered. For 6 APR cases among them, the pre- and postoperative observation of anterior nasal mucosa of the inferior turbinate on the same side under the electron microscope was conducted for one year respectively. In addition, their pathological alterations of tissues were also conducted. Results: In the pre-operative observation under the electron microscope, it was found that the nasal mucosae epithelium cells were nude without cilia. The lamina propria had edema, and mesenchyme presented the infiltration of substantial eosinophilic granulocytes, basophilic granulocytes, plasmacytes and mast cells. Additionally, abundant degranulation and vacuolation of cytoplasts were observed. The plentiful glands, duct ectasia, edema and structural changes were also found. Some gland cells had degenerated. After the operation, it was found that the epithelium nudity still existed and the deficiency of cilia was not improved. Only a very small amount of microvilli existed. The edema of lamina propria was improved and eosinophilic granulocytes were rarely observed in mesenchyme. However, the infiltration of basophilic granulocytes, plasmocytes and mast cells was still observed. The particle structure was generally stable and the central crystal was clear without degranulation. Meanwhile, the amount of glands was reduced and the tissue structure tended to be recovered. Overall, the nasal mucosa showed changes as chronic inflammation. Conclusions: For the treatment of APR with the methods presented by our research institution, in one year before and after the operation, ultrastructural changes of inferior turbinate mucosa tissues were observed from the preoperatively pathological changes of typica
文摘数字化信息系统实验室(Digital Information System Laboratory)(简称DISLab)的引入可以简化物理实验的操作、加快数据采集与处理的速度并提高精度,因此,将DISLab用于课堂演示和微课制作,可以使抽象的理论更加形象化、实验过程动态化,更易于学生对知识的理解和接受。本文以向心力研究实验为例,说明了通过DISLab实验的微课的设计和录制,可以训练物理师范生从学生视角出发,设计教学内容和教学思想、引导学生跟随实验过程进行思考,提高物理师范生的教学技能。
