Lung cancer is the most prevalent and fatal cancer in China and even around the world, and many patients are found in the late stage of lung cancer. For the treatment of advanced lung cancer, in addition to traditiona...Lung cancer is the most prevalent and fatal cancer in China and even around the world, and many patients are found in the late stage of lung cancer. For the treatment of advanced lung cancer, in addition to traditional chemotherapy modalities, many emerging treatments are increasingly significant, such as immunotherapy, anti-angiogenic therapy, and targeted therapy. An increasing number of studies have now shown that anti-angiogenic therapy improves the immune microenvironment by enhancing tumor immunity through normalization of tumor vessels. Immunization combined with anti-angiogenic therapy can exert synergistic effects and improve the prognosis of patients. This article summarizes the extent of benefit, current clinical study data, and future prospects of immunotherapy combined with anti-angiogenic agents in the treatment of advanced NSCLC.展开更多
文摘Lung cancer is the most prevalent and fatal cancer in China and even around the world, and many patients are found in the late stage of lung cancer. For the treatment of advanced lung cancer, in addition to traditional chemotherapy modalities, many emerging treatments are increasingly significant, such as immunotherapy, anti-angiogenic therapy, and targeted therapy. An increasing number of studies have now shown that anti-angiogenic therapy improves the immune microenvironment by enhancing tumor immunity through normalization of tumor vessels. Immunization combined with anti-angiogenic therapy can exert synergistic effects and improve the prognosis of patients. This article summarizes the extent of benefit, current clinical study data, and future prospects of immunotherapy combined with anti-angiogenic agents in the treatment of advanced NSCLC.
基金supports from the National Natural Science Foundation of China(Nos.51974220,52001078,52104383,52034005)the National Key Research and Development Program of China(No.2021YFB3700902)+1 种基金the Shaanxi Provincial National Science Fund for Distinguished Young Scholars,China(No.2022JC-24)the Guangdong Basic and Applied Basic Research Foundation,China(No.2019B1515120016).
基金The authors gratefully acknowledge the sponsorship from the State Key Program of National Natural Science Foundation of China(Nos.U1760201,52034005)the National Natural Science Foundation of China(No.51974220)+2 种基金the Key Research and Development Program of Shaanxi Province,China(Nos.2020ZDLGY13-06,2017ZDXM-GY-037)the Innovation Capacity Support Project of Shaanxi Province,China(No.2020KJXX-077)the Education Department Foundation of Shaanxi Province,China(No.17JK0430).
