Objective: This study aims to examine the causal relationship between inflammatory factors and the probability of developing vascular dementia (VD) using Mendelian Randomization (MR) and Chinese herbal medicine predic...Objective: This study aims to examine the causal relationship between inflammatory factors and the probability of developing vascular dementia (VD) using Mendelian Randomization (MR) and Chinese herbal medicine prediction method, and to screen potential Chinese herbal medicines for the prevention and treatment of VD. Methods: Single nucleotide polymorphisms (SNPs) that exhibit a strong association with vascular dementia (VD) were identified as instrumental variables from the summary statistics of genome-wide association studies (GWAS). The primary analytical method employed was inverse variance weighting (IVW), while auxiliary analyses included the MR-Egger method, weighted median method, simple model, and weighted model. A two-way Mendelian randomization analysis was conducted to assess the causal relationship between inflammatory factors and the risk of VD, thereby identifying the key inflammatory factors involved. The MR-Egger intercept test and Cochran’s Q test were employed to assess the horizontal polymorphism and heterogeneity of instrumental variables. A sensitivity analysis was conducted by excluding one method at a time. Ultimately, based on key inflammatory factors, predictions for the prevention and treatment using traditional Chinese medicine were made, along with the screening of homologous herbal remedies. Results: Based on the results of the forward MR, the probability of developing VD was elevated when the inflammatory factors CXCL10 and CXCL5 were expressed at higher levels, whereas the probability of developing VD decreased as the expression levels of IL-13 and IL-20RA increased. These findings were supported by the assessment of pleiotropy, heterogeneity, and sensitivity. The results of the reverse MR analysis showed that there was no causal relationship between VD, as an exposure dataset, and these four inflammatory factors. According to the key inflammatory factors, 37 Chinese herbal medicines such as Siraitia grosvenorii were selected. Their characteristics including four natures, five fl展开更多
目的计算上海市奉贤区60岁以上老年人的健康期望寿命(healthy life expectancy,HALE),分析HALE的主要影响因素。方法采用两阶段分层整群抽样的方法抽取1 696位奉贤区60岁以上老人进行问卷调查,采用Sullivan法计算HALE。结果 2015年奉贤...目的计算上海市奉贤区60岁以上老年人的健康期望寿命(healthy life expectancy,HALE),分析HALE的主要影响因素。方法采用两阶段分层整群抽样的方法抽取1 696位奉贤区60岁以上老人进行问卷调查,采用Sullivan法计算HALE。结果 2015年奉贤区男、女性60~岁组老年人HALE分别为19.44岁和20.46岁,HALE损失率分别为15.04%和25.06%。70岁以下年龄组女性HALE均高于男性,差异有统计学意义(P<0.05),但女性HALE损失率均大于同年龄组的男性。影响奉贤区老年人HALE的主要影响因素有性别、年龄、婚姻状况、合理体育锻炼、慢性病史,差异均有统计学意义(P<0.05)。中风等脑血管疾病导致的HALE平均损失率最大。结论为提高老年人的HALE,应提倡健康的生活方式,重点防治中风等脑血管疾病,加强老年人尤其是女性老年人的健康保健服务。展开更多
文摘Objective: This study aims to examine the causal relationship between inflammatory factors and the probability of developing vascular dementia (VD) using Mendelian Randomization (MR) and Chinese herbal medicine prediction method, and to screen potential Chinese herbal medicines for the prevention and treatment of VD. Methods: Single nucleotide polymorphisms (SNPs) that exhibit a strong association with vascular dementia (VD) were identified as instrumental variables from the summary statistics of genome-wide association studies (GWAS). The primary analytical method employed was inverse variance weighting (IVW), while auxiliary analyses included the MR-Egger method, weighted median method, simple model, and weighted model. A two-way Mendelian randomization analysis was conducted to assess the causal relationship between inflammatory factors and the risk of VD, thereby identifying the key inflammatory factors involved. The MR-Egger intercept test and Cochran’s Q test were employed to assess the horizontal polymorphism and heterogeneity of instrumental variables. A sensitivity analysis was conducted by excluding one method at a time. Ultimately, based on key inflammatory factors, predictions for the prevention and treatment using traditional Chinese medicine were made, along with the screening of homologous herbal remedies. Results: Based on the results of the forward MR, the probability of developing VD was elevated when the inflammatory factors CXCL10 and CXCL5 were expressed at higher levels, whereas the probability of developing VD decreased as the expression levels of IL-13 and IL-20RA increased. These findings were supported by the assessment of pleiotropy, heterogeneity, and sensitivity. The results of the reverse MR analysis showed that there was no causal relationship between VD, as an exposure dataset, and these four inflammatory factors. According to the key inflammatory factors, 37 Chinese herbal medicines such as Siraitia grosvenorii were selected. Their characteristics including four natures, five fl
文摘目的计算上海市奉贤区60岁以上老年人的健康期望寿命(healthy life expectancy,HALE),分析HALE的主要影响因素。方法采用两阶段分层整群抽样的方法抽取1 696位奉贤区60岁以上老人进行问卷调查,采用Sullivan法计算HALE。结果 2015年奉贤区男、女性60~岁组老年人HALE分别为19.44岁和20.46岁,HALE损失率分别为15.04%和25.06%。70岁以下年龄组女性HALE均高于男性,差异有统计学意义(P<0.05),但女性HALE损失率均大于同年龄组的男性。影响奉贤区老年人HALE的主要影响因素有性别、年龄、婚姻状况、合理体育锻炼、慢性病史,差异均有统计学意义(P<0.05)。中风等脑血管疾病导致的HALE平均损失率最大。结论为提高老年人的HALE,应提倡健康的生活方式,重点防治中风等脑血管疾病,加强老年人尤其是女性老年人的健康保健服务。
