The RAS/mitogen-activated protein kinase(MAPK)pathway disorder induced by the missense mutations in the tyrosine-protein phosphatase non-receptor type 11(PTPN11)gene which resulted in the nonreceptor protein tyrosine ...The RAS/mitogen-activated protein kinase(MAPK)pathway disorder induced by the missense mutations in the tyrosine-protein phosphatase non-receptor type 11(PTPN11)gene which resulted in the nonreceptor protein tyrosine phosphatase SHP2 dysfunction has been reported in many lung cancer cases.Moreover,the Src homology region 2(SH2)-containing protein tyrosine phosphatase 2(SHP2)mutation or deletion triggers multiple signaling pathway dysfunctions including RAS/MAPK,RAS/extracellular-signal-regulated kinase(ERK),phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT),Janus kinase/signal transducers and activators of transcription(JAK/STAT)and Hippo/yes-associated protein(YAP)which affect the expression of growth factors,cytokines and hormones.In recent years,the developing of the small molecule SHP2 inhibitors received a lot of attention.In this review,we summarize the recent years'progresses of the SHP2 inhibitors development for the lung cancer treatment.展开更多
Large-scale dense wavelength division multiplexing(DWDM)multi-channel performance monitoring is one of the indispensable technologies for the flexible optical networks.The existing Labelbased monitoring scheme require...Large-scale dense wavelength division multiplexing(DWDM)multi-channel performance monitoring is one of the indispensable technologies for the flexible optical networks.The existing Labelbased monitoring scheme requires expensive optical demultiplexing components/equipment to avoid the influence of stimulated Raman scattering(SRS),which is not only costly and bulky,but also could not monitor the wavelength channels simultaneously.In this paper,a low-cost,high-accuracy monitoring scheme based on Optical Label Method is proposed for DWDM networks,where the optical channel power and node identification(ID),as the main monitoring targets that both can indicate or evaluate the channel connection status,could be efficiently monitored.In the scheme,a novel digital signal processing(DSP)method of SRS mitigation is proposed and demonstrated,and an asynchronous code-division multiple access(A-CDMA)based digital label encoding and decoding method is adopted to distinguish the node ID so that channel initial added node can be accurately verified,thereby wavelength connection status can be reliably monitored by combining the channel power and node ID information.The simulation results show that each wavelength channel power and node ID can be accurately monitored only by low bandwidth photoelectric detector(PD)under the condition of 80 wavelengths and 10 spans at C-band.展开更多
Social applications such as Weibo have provided a quick platform for information propagation, which have led to an explosive propagation for hot topic. User sentiments about propagation information play an important r...Social applications such as Weibo have provided a quick platform for information propagation, which have led to an explosive propagation for hot topic. User sentiments about propagation information play an important role in propagation speed, which receive more and more attention from data mining field. In this paper, we propose an sentiment-based hot topics prediction model called PHT-US. PHT-US firstly classifies a large amount of text data in Weibo into different topics, then converts user sentiments and time factors into embedding vectors that are input into recurrent neural networks (both LSTM and GRU), and predicts whether the target topic could be a hot spot. Experiments on Sina Weibo show that PHT-US can effectively predict the hot topics in the future. Social applications such as Weibo provide a platform for quick information propagation, which leads to an explosive propagation for hot topics. User sentiments about propagation information play an important role in propagation speed, and thus receive more attention from data mining field. In this paper, a sentiment-based hot topics prediction model called PHT-US is proposed. Firstly a large amount of text data in Weibo was classified into different topics, and then user sentiments and time factors were converted into embedding vectors that are input into recurrent neural networks (both LSTM and GRU), and future hotspots were predicted. Experiments on Sina Weibo show that PHT-US can effectively predict hot topics in the future.展开更多
Stibium(Sb)metal with high theoretic capacity,suitable negative working window and inexpensive nature are promising anode material for advanced aqueous alkaline batteries(AABs).However,the further development of Sb an...Stibium(Sb)metal with high theoretic capacity,suitable negative working window and inexpensive nature are promising anode material for advanced aqueous alkaline batteries(AABs).However,the further development of Sb anode is severely hindered by the low capacity and poor rate capability which is originated from deficient adsorption of[Sb(OH)_(4)]^(-)and its sluggish desolvation kinetics.Herein,a nitrogen doped carbon cages(NCCs)substrate is constructed as high capacity and rate capability anode by promoting the adsorption and following desolvation process of[Sb(OH)_(4)]^(-)via the enhanced attraction toward(OH)-in the solvated[Sb(OH)_(4)]^(-).Consequently,the designed Sb/NCCs anode delivers a high capacity of 627 m Ah g^(-1)with an average 95%Sb utilization,an outstanding coulombic efficiency(CE)of 95%and an impressive lifespan(>110 h).Meanwhile,the Ni_(3)Se_(2)//Sb/NCCs batteries show great capacity retention of 86.7%after 2000 cycles with an areal capacity of 0.52 m Ah cm^(-2).Implementation of the designed anode allows for the construction of Sb-based AABs with enhanced rate capability,energy density and cycling performance.展开更多
基金This work was supported by the National Natural Science Foundation of China(Nos.81904178,82073311)"Hundred Talents Program"of the Hospital of Chengdu University of Traditional Chinese Medicine(Nos.20-Q03,20-Q08).
文摘The RAS/mitogen-activated protein kinase(MAPK)pathway disorder induced by the missense mutations in the tyrosine-protein phosphatase non-receptor type 11(PTPN11)gene which resulted in the nonreceptor protein tyrosine phosphatase SHP2 dysfunction has been reported in many lung cancer cases.Moreover,the Src homology region 2(SH2)-containing protein tyrosine phosphatase 2(SHP2)mutation or deletion triggers multiple signaling pathway dysfunctions including RAS/MAPK,RAS/extracellular-signal-regulated kinase(ERK),phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT),Janus kinase/signal transducers and activators of transcription(JAK/STAT)and Hippo/yes-associated protein(YAP)which affect the expression of growth factors,cytokines and hormones.In recent years,the developing of the small molecule SHP2 inhibitors received a lot of attention.In this review,we summarize the recent years'progresses of the SHP2 inhibitors development for the lung cancer treatment.
基金supported by the National Natural Science Foundation of China(No.62001045)Fund of State Key Laboratory of IPOC(BUPT)(No.IPOC2021ZT17)。
文摘Large-scale dense wavelength division multiplexing(DWDM)multi-channel performance monitoring is one of the indispensable technologies for the flexible optical networks.The existing Labelbased monitoring scheme requires expensive optical demultiplexing components/equipment to avoid the influence of stimulated Raman scattering(SRS),which is not only costly and bulky,but also could not monitor the wavelength channels simultaneously.In this paper,a low-cost,high-accuracy monitoring scheme based on Optical Label Method is proposed for DWDM networks,where the optical channel power and node identification(ID),as the main monitoring targets that both can indicate or evaluate the channel connection status,could be efficiently monitored.In the scheme,a novel digital signal processing(DSP)method of SRS mitigation is proposed and demonstrated,and an asynchronous code-division multiple access(A-CDMA)based digital label encoding and decoding method is adopted to distinguish the node ID so that channel initial added node can be accurately verified,thereby wavelength connection status can be reliably monitored by combining the channel power and node ID information.The simulation results show that each wavelength channel power and node ID can be accurately monitored only by low bandwidth photoelectric detector(PD)under the condition of 80 wavelengths and 10 spans at C-band.
基金the National Natural Science Foundation of China (No. 61602159)the Natural Science Foundation of Heilongjiang Province (No. F201430)+1 种基金the Innovation Talents Project of Science and Technology Bureau of Harbin (No. 2017RAQXJ094)the fundamental research funds of universities in Heilongjiang Province, special fund of Heilongjiang University (No. HDJCCX-201608).
文摘Social applications such as Weibo have provided a quick platform for information propagation, which have led to an explosive propagation for hot topic. User sentiments about propagation information play an important role in propagation speed, which receive more and more attention from data mining field. In this paper, we propose an sentiment-based hot topics prediction model called PHT-US. PHT-US firstly classifies a large amount of text data in Weibo into different topics, then converts user sentiments and time factors into embedding vectors that are input into recurrent neural networks (both LSTM and GRU), and predicts whether the target topic could be a hot spot. Experiments on Sina Weibo show that PHT-US can effectively predict the hot topics in the future. Social applications such as Weibo provide a platform for quick information propagation, which leads to an explosive propagation for hot topics. User sentiments about propagation information play an important role in propagation speed, and thus receive more attention from data mining field. In this paper, a sentiment-based hot topics prediction model called PHT-US is proposed. Firstly a large amount of text data in Weibo was classified into different topics, and then user sentiments and time factors were converted into embedding vectors that are input into recurrent neural networks (both LSTM and GRU), and future hotspots were predicted. Experiments on Sina Weibo show that PHT-US can effectively predict hot topics in the future.
基金supported by the Guangdong Basic and Applied Basic Research Foundation(No.2019A1515110538)Dongguan Science and Technology of Social Development Program(No.20211800904642)+2 种基金the open research fund of Guangdong Provincial Key Laboratory of Distributed Energy Systems(No.2020DES2)Joint Science Foundation of Wuyi University and HK and Macao(2019WGALH14)Guangdong province innovation and strong school project(2020ZDZX2004)。
文摘Stibium(Sb)metal with high theoretic capacity,suitable negative working window and inexpensive nature are promising anode material for advanced aqueous alkaline batteries(AABs).However,the further development of Sb anode is severely hindered by the low capacity and poor rate capability which is originated from deficient adsorption of[Sb(OH)_(4)]^(-)and its sluggish desolvation kinetics.Herein,a nitrogen doped carbon cages(NCCs)substrate is constructed as high capacity and rate capability anode by promoting the adsorption and following desolvation process of[Sb(OH)_(4)]^(-)via the enhanced attraction toward(OH)-in the solvated[Sb(OH)_(4)]^(-).Consequently,the designed Sb/NCCs anode delivers a high capacity of 627 m Ah g^(-1)with an average 95%Sb utilization,an outstanding coulombic efficiency(CE)of 95%and an impressive lifespan(>110 h).Meanwhile,the Ni_(3)Se_(2)//Sb/NCCs batteries show great capacity retention of 86.7%after 2000 cycles with an areal capacity of 0.52 m Ah cm^(-2).Implementation of the designed anode allows for the construction of Sb-based AABs with enhanced rate capability,energy density and cycling performance.
