In the 5th generation(5G)wireless communication networks,network slicing emerges where network operators(NPs)form isolated logical slices by the same cellular network infrastructure and spectrum resource.In coverage r...In the 5th generation(5G)wireless communication networks,network slicing emerges where network operators(NPs)form isolated logical slices by the same cellular network infrastructure and spectrum resource.In coverage regions of access points(APs)shared by slices,device to device(D2D)communication can occur among different slices,i.e.,one device acts as D2D relay for another device serving by a different slice,which is defined as slice cooperation in this paper.Since selfish slices will not help other slices by cooperation voluntarily and unconditionally,this paper designs a novel resource allocation scheme to stimulate slice cooperation.The main idea is to encourage slice to perform cooperation for other slices by rewarding it with higher throughput.The proposed incentive scheme for slice cooperation is formulated by an optimal problem,where cooperative activities are introduced to the objective function.Since optimal solutions of the formulated problem are long term statistics,though can be obtained,a practical online slice scheduling algorithm is designed,which can obtain optimal solutions of the formulated maximal problem.Lastly,the throughput isolation indexes are defined to evaluate isolation performance of slice.According to simulation results,the proposed incentive scheme for slice cooperation can stimulate slice cooperation effectively,and the isolation of slice is also simulated and discussed.展开更多
Background and Aims:Transplantation of mesenchymal stem cells(MSCs)derived from bone marrow(BM)is an alternative treatment of acute liver failure(ALF)mainly be-cause of the resulting anti-inflammatory activity.It is n...Background and Aims:Transplantation of mesenchymal stem cells(MSCs)derived from bone marrow(BM)is an alternative treatment of acute liver failure(ALF)mainly be-cause of the resulting anti-inflammatory activity.It is not known how MSCs regulate local immune responses and liver regeneration.This study explored the effects of MSCs on hepatic macrophages and the Wnt signaling pathway in ALF.Methods:MSCs were isolated from BM aspirates of C57BL/6J mice,and transplanted in mice with ALF induced by D-galactosamine(D-Gal).The proliferation of hepato-cytes was assayed by immunohistochemical(IHC)staining of Ki-67 and proliferating cell nuclear antigen(PCNA).The levels of key proteins in the Wnt signaling pathway were assayed by western blotting and cytokines were determined enzyme-linked immunosorbent assays(ELISAs).A mac-rophage polarization assay characterized the M1/M2 ratio.The potential role of interleukin-4(IL-4)in the biological ac-tivity of MSCs was determined by silencing of IL-4.Results:Transplantation of allogeneic MSCs significantly attenuated D-Gal-induced hepatic inflammation and promoted liver re-generation.MSC transplantation significantly promoted a phenotypic switch from proinflamatory M1 macrophages to anti-inflammatory M2 macrophages,leading to significant Wnt-3a induction and activation of the Wnt signaling path-way in mice with D-Gal-induced ALF.Of the paracrine fac-tors secreted by MSCs(G-CSF,IL-6,IL-1 beta,IL-4,and IL-17A),IL-4 was specifically induced following transplantation in the ALF model mice.The silencing of IL-4 significantly ab-rogated the phenotypic switch to M2 macrophages and the protective effects of MSCs in both the ALF model mice and a co-culture model in an IL-4 dependent manner.Conclu-sions:In vivo and in vitro studies showed that MSCs ame-liorated ALF through an IL-4-dependent macrophage switch toward the M2 anti-inflammatory phenotype.The findings may have clinical implications in that overexpression of IL-4 may enhance the therapeutic effects of allogeneic MSC transplantation in展开更多
Objective: To investigate the effects of preoperative hepatic artery chemoembolization (TACE) and quality nursing interventions on the perioperative safety and short-term prognosis in patients with hepatocellular carc...Objective: To investigate the effects of preoperative hepatic artery chemoembolization (TACE) and quality nursing interventions on the perioperative safety and short-term prognosis in patients with hepatocellular carcinoma undergoing liver transplantation. Methods: The study period spanned from January 2021 to December 2023, and 125 patients with hepatocellular carcinoma admitted to our hospital were selected, all of whom underwent liver transplantation. They were randomly divided into an observation group (n = 63) and a control group (n = 62). The patients in the control group did not undergo TACE before the operation, and the patients in the observation group underwent TACE and quality nursing intervention before the operation. The operation time, intraoperative blood loss, length of hospitalization, liver- free period, complication rate, short-term prognosis, and liver function indexes between the two groups were compared. Results: There was no significant difference in operation time, intraoperative blood loss, and length of hospitalization between the two groups (P < 0.05). The liver-free period of patients in the observation group was longer than that of the control group (P < 0.05). The two groups had no significant difference in the incidence of biliary complications, vascular complications, and postoperative infections (P > 0.05). The rate of immune reactive complications in the observation group was lower than that of the control group (P < 0.05). There was no significant difference in the perioperative mortality rate, 1-year postoperative survival rate, and 2-year postoperative survival rate (P > 0.05). The two groups had no significant difference in postoperative liver function indexes (P > 0.05). Conclusion: Preoperative TACE and high-quality nursing intervention in patients with hepatocellular carcinoma had no adverse effect on the perioperative safety and short-term prognosis, prolonged the liver-free time, and reduced the incidence of immune-reactive complications.展开更多
The extremely poor prognosis of patients is largely due to hepatocyte growth factor(HGF)/MET signaling,which promotes migration and invasion of glioblastoma(IDH wildtype;GBM;WHO grade 4).1,2 Clinical trials targeting ...The extremely poor prognosis of patients is largely due to hepatocyte growth factor(HGF)/MET signaling,which promotes migration and invasion of glioblastoma(IDH wildtype;GBM;WHO grade 4).1,2 Clinical trials targeting MET,the only receptor of HGF,have yielded unimpressive results in GBM.3,4 Here we found that HGF induced strong chemotaxis on GBM cells,but MET expression was extremely low.We,therefore,used single-cell RNA sequencing(scRNA-seq)coupled with label-free proteome profiling to identify membrane proteins associated with HGF/MET signaling amplification in GBM and to provide a novel modulator,MPZL1,for HGF/MET-targeted therapy.展开更多
A Taylor series expansion(TSE) based design for minimum mean-square error(MMSE) and QR decomposition(QRD) of multi-input and multi-output(MIMO) systems is proposed based on application specific instruction set process...A Taylor series expansion(TSE) based design for minimum mean-square error(MMSE) and QR decomposition(QRD) of multi-input and multi-output(MIMO) systems is proposed based on application specific instruction set processor(ASIP), which uses TSE algorithm instead of resource-consuming reciprocal and reciprocal square root(RSR) operations.The aim is to give a high performance implementation for MMSE and QRD in one programmable platform simultaneously.Furthermore, instruction set architecture(ISA) and the allocation of data paths in single instruction multiple data-very long instruction word(SIMD-VLIW) architecture are provided, offering more data parallelism and instruction parallelism for different dimension matrices and operation types.Meanwhile, multiple level numerical precision can be achieved with flexible table size and expansion order in TSE ISA.The ASIP has been implemented to a 28 nm CMOS process and frequency reaches 800 MHz.Experimental results show that the proposed design provides perfect numerical precision within the fixed bit-width of the ASIP, higher matrix processing rate better than the requirements of 5G system and more rate-area efficiency comparable with ASIC implementations.展开更多
The centralized radio access cellular network infrastructure based on centralized Super Base Station(CSBS) is a promising solution to reduce the high construction cost and energy consumption of conventional cellular n...The centralized radio access cellular network infrastructure based on centralized Super Base Station(CSBS) is a promising solution to reduce the high construction cost and energy consumption of conventional cellular networks. With CSBS, the computing resource for communication protocol processing could be managed flexibly according the protocol load to improve the resource efficiency. Since the protocol load changes frequently and may exceed the capacity of processors, load balancing is needed. However, existing load balancing mechanisms used in data centers cannot satisfy the real-time requirement of the communication protocol processing. Therefore, a new computing resource adjustment scheme is proposed for communication protocol processing in the CSBS architecture. First of all, the main principles of protocol processing resource adjustment is concluded, followed by the analysis on the processing resource outage probability that the computing resource becomes inadequate for protocol processing as load changes. Following the adjustment principles, the proposed scheme is designed to reduce the processing resource outage probability based onthe optimized connected graph which is constructed by the approximate Kruskal algorithm. Simulation re-sults show that compared with the conventional load balancing mechanisms, the proposed scheme can reduce the occurrence number of inadequate processing resource and the additional resource consumption of adjustment greatly.展开更多
Novel centralized base station architectures integrating computation and communication functionalities have become important for the development of future mobile communication networks.Therefore,the development of dyn...Novel centralized base station architectures integrating computation and communication functionalities have become important for the development of future mobile communication networks.Therefore,the development of dynamic high-speed interconnections between baseband units(BBUs)and remote radio heads(RRHs)is vital in centralized base station design.Herein,dynamic high-speed switches(HSSs)connecting BBUs and RRHs were designed for a centralized base station architecture.We analyzed the characteristics of actual traffic and introduced a switch traffic model suitable for the super base station architecture.Then,we proposed a data-priority-aware(DPA)scheduling algorithm based on the traffic model.Lastly,we developed the dynamic HSS model based on the OPNET platform and the prototype based on FPGA.Our results show that the DPA achieves close to 100%throughput with lower latency and provides better run-time complexity than iOCF and HE-iSLIP,thereby demonstrating that the proposed switch system can be adopted in centralized base station architectures.展开更多
Objective Dilated cardiomyopathy(DCM) is generally considered to be accompanied by both left and right ventricular dysfunction,but most studies only analyze the left ventricular function. In this study,we evaluated th...Objective Dilated cardiomyopathy(DCM) is generally considered to be accompanied by both left and right ventricular dysfunction,but most studies only analyze the left ventricular function. In this study,we evaluated the effect of arotinolol on right ventricular function in patients with DCM. Methods Right ventricular ejection fraction(RVEF) and right ventricular diameter(RVD) were measured by two-dimensional echocardiography(2-DE) in 33 DCM patients;RVEF measured by first-pass radionuclide angiography(FPRA) was compared with that by 2-DE. Results The treatment with arotinolol for one year resulted in a reduction in the right ventricular diameter(baseline,23.0 ± 8.3 mm vs after one-year treatment,20.7 ± 5.4 mm;P=0.004 ) and an associated increase in ejection fraction(baseline,36.9 ± 10.3% vs after one-year treatment,45.8 ± 9.6%;P < 0.001 ) ;there is a high correlation between the 2-DE method and radionuclide ventriculographic method. The correlation coefficient is 0.933(P<0.001) . Conclusion Arotinolol therapy could not only improve left ventricular function,but also improve right ventricular function in DCM patients.展开更多
In centralized cellular network architecture,the concept of virtualized Base Station(VBS) becomes attracting since it enables all base stations(BSs) to share computing resources in a dynamic manner. This can significa...In centralized cellular network architecture,the concept of virtualized Base Station(VBS) becomes attracting since it enables all base stations(BSs) to share computing resources in a dynamic manner. This can significantly improve the utilization efficiency of computing resources. In this paper,we study the computing resource allocation strategy for one VBS by considering the non-negligible effect of delay introduced by switches. Specifically,we formulate the VBS's sum computing rate maximization as a set optimization problem. To address this problem,we firstly propose a computing resource schedule algorithm,namely,weight before one-step-greedy(WBOSG),which has linear computation complexity and considerable performance. Then,OSG retreat(OSG-R) algorithm is developed to further improve the system performance at the expense of computational complexity. Simulation results under practical setting are provided to validate the proposed two algorithms.展开更多
In a novel plasma-shade reactor for oxidative reforming of biogas(CH4/CO2=3/2),the effects of specific-energy-input (SEI) on CH4 and CO2 conversions and energy cost of syngas were investigated at O2/CH4ratios ranged f...In a novel plasma-shade reactor for oxidative reforming of biogas(CH4/CO2=3/2),the effects of specific-energy-input (SEI) on CH4 and CO2 conversions and energy cost of syngas were investigated at O2/CH4ratios ranged from 0.42 to 0.67.At each of O2/CH4 ratios,V-shape profiles of energy cost of syngas increasing with SEI were observed,reaching the lowest value at the optimal SEI(Opt-SEI).With the increase of O2/CH4 ratio,the Opt-SEI decreased significantly.Moreover,at the Opt-SEI,O2 and CH4 conversions and dry-basis concentration of syngas increased and energy cost of syngas decreased greatly with the increase of O2/CH4 ratio.展开更多
基金supported by Beijing Natural Science Foundation under Grant number L172049the National Science and CAS Engineering Laboratory for Intelligent Agricultural Machinery Equipment GC201907-02
文摘In the 5th generation(5G)wireless communication networks,network slicing emerges where network operators(NPs)form isolated logical slices by the same cellular network infrastructure and spectrum resource.In coverage regions of access points(APs)shared by slices,device to device(D2D)communication can occur among different slices,i.e.,one device acts as D2D relay for another device serving by a different slice,which is defined as slice cooperation in this paper.Since selfish slices will not help other slices by cooperation voluntarily and unconditionally,this paper designs a novel resource allocation scheme to stimulate slice cooperation.The main idea is to encourage slice to perform cooperation for other slices by rewarding it with higher throughput.The proposed incentive scheme for slice cooperation is formulated by an optimal problem,where cooperative activities are introduced to the objective function.Since optimal solutions of the formulated problem are long term statistics,though can be obtained,a practical online slice scheduling algorithm is designed,which can obtain optimal solutions of the formulated maximal problem.Lastly,the throughput isolation indexes are defined to evaluate isolation performance of slice.According to simulation results,the proposed incentive scheme for slice cooperation can stimulate slice cooperation effectively,and the isolation of slice is also simulated and discussed.
基金This work was funded by the National Natural Science Foundation of China(81872359)Jiangsu Provincial key research and development(BE2020752)+5 种基金the Natural Science Foundation of Jiangsu Province(BK20190114)the Nanjing Medical Science and Technique Development Foundation(QRX17129)Key Project supported by Medical Science and technology development Foundation,Nanjing Department of Health(JQX19002,YKK19070)the Nanjing Science and technology project(201911039)the Fundamental Research Funds for the Central Universities(0214-YG1312037)Project of Modern Hospital Management and Development Institute,Nanjing University and Aid project of Nanjing Drum Tower Hospital Health,Education&Research Foundation(NDYG2020047).
文摘Background and Aims:Transplantation of mesenchymal stem cells(MSCs)derived from bone marrow(BM)is an alternative treatment of acute liver failure(ALF)mainly be-cause of the resulting anti-inflammatory activity.It is not known how MSCs regulate local immune responses and liver regeneration.This study explored the effects of MSCs on hepatic macrophages and the Wnt signaling pathway in ALF.Methods:MSCs were isolated from BM aspirates of C57BL/6J mice,and transplanted in mice with ALF induced by D-galactosamine(D-Gal).The proliferation of hepato-cytes was assayed by immunohistochemical(IHC)staining of Ki-67 and proliferating cell nuclear antigen(PCNA).The levels of key proteins in the Wnt signaling pathway were assayed by western blotting and cytokines were determined enzyme-linked immunosorbent assays(ELISAs).A mac-rophage polarization assay characterized the M1/M2 ratio.The potential role of interleukin-4(IL-4)in the biological ac-tivity of MSCs was determined by silencing of IL-4.Results:Transplantation of allogeneic MSCs significantly attenuated D-Gal-induced hepatic inflammation and promoted liver re-generation.MSC transplantation significantly promoted a phenotypic switch from proinflamatory M1 macrophages to anti-inflammatory M2 macrophages,leading to significant Wnt-3a induction and activation of the Wnt signaling path-way in mice with D-Gal-induced ALF.Of the paracrine fac-tors secreted by MSCs(G-CSF,IL-6,IL-1 beta,IL-4,and IL-17A),IL-4 was specifically induced following transplantation in the ALF model mice.The silencing of IL-4 significantly ab-rogated the phenotypic switch to M2 macrophages and the protective effects of MSCs in both the ALF model mice and a co-culture model in an IL-4 dependent manner.Conclu-sions:In vivo and in vitro studies showed that MSCs ame-liorated ALF through an IL-4-dependent macrophage switch toward the M2 anti-inflammatory phenotype.The findings may have clinical implications in that overexpression of IL-4 may enhance the therapeutic effects of allogeneic MSC transplantation in
文摘Objective: To investigate the effects of preoperative hepatic artery chemoembolization (TACE) and quality nursing interventions on the perioperative safety and short-term prognosis in patients with hepatocellular carcinoma undergoing liver transplantation. Methods: The study period spanned from January 2021 to December 2023, and 125 patients with hepatocellular carcinoma admitted to our hospital were selected, all of whom underwent liver transplantation. They were randomly divided into an observation group (n = 63) and a control group (n = 62). The patients in the control group did not undergo TACE before the operation, and the patients in the observation group underwent TACE and quality nursing intervention before the operation. The operation time, intraoperative blood loss, length of hospitalization, liver- free period, complication rate, short-term prognosis, and liver function indexes between the two groups were compared. Results: There was no significant difference in operation time, intraoperative blood loss, and length of hospitalization between the two groups (P < 0.05). The liver-free period of patients in the observation group was longer than that of the control group (P < 0.05). The two groups had no significant difference in the incidence of biliary complications, vascular complications, and postoperative infections (P > 0.05). The rate of immune reactive complications in the observation group was lower than that of the control group (P < 0.05). There was no significant difference in the perioperative mortality rate, 1-year postoperative survival rate, and 2-year postoperative survival rate (P > 0.05). The two groups had no significant difference in postoperative liver function indexes (P > 0.05). Conclusion: Preoperative TACE and high-quality nursing intervention in patients with hepatocellular carcinoma had no adverse effect on the perioperative safety and short-term prognosis, prolonged the liver-free time, and reduced the incidence of immune-reactive complications.
基金the Natural Science Foundation of Guangdong Province,China(No.2022A1515012552)Shenzhen Science and Technology Innovation Committee of China(SZSTI+3 种基金No.JCYJ20220818102611025)Research Initiation Project of Shunde Hospital,Southern Medical University(No.CRSP2022002)Research Initiation Project of the First Affiliated Hospital of Gannan Medical University(No.QD202316)Beijing Sisco Clinical Oncology Research Foundation of China(No.Y-2022METAZMS-0118).
文摘The extremely poor prognosis of patients is largely due to hepatocyte growth factor(HGF)/MET signaling,which promotes migration and invasion of glioblastoma(IDH wildtype;GBM;WHO grade 4).1,2 Clinical trials targeting MET,the only receptor of HGF,have yielded unimpressive results in GBM.3,4 Here we found that HGF induced strong chemotaxis on GBM cells,but MET expression was extremely low.We,therefore,used single-cell RNA sequencing(scRNA-seq)coupled with label-free proteome profiling to identify membrane proteins associated with HGF/MET signaling amplification in GBM and to provide a novel modulator,MPZL1,for HGF/MET-targeted therapy.
基金Supported by the Industrial Internet Innovation and Development Project of Ministry of Industry and Information Technology (No.GHBJ2004)。
文摘A Taylor series expansion(TSE) based design for minimum mean-square error(MMSE) and QR decomposition(QRD) of multi-input and multi-output(MIMO) systems is proposed based on application specific instruction set processor(ASIP), which uses TSE algorithm instead of resource-consuming reciprocal and reciprocal square root(RSR) operations.The aim is to give a high performance implementation for MMSE and QRD in one programmable platform simultaneously.Furthermore, instruction set architecture(ISA) and the allocation of data paths in single instruction multiple data-very long instruction word(SIMD-VLIW) architecture are provided, offering more data parallelism and instruction parallelism for different dimension matrices and operation types.Meanwhile, multiple level numerical precision can be achieved with flexible table size and expansion order in TSE ISA.The ASIP has been implemented to a 28 nm CMOS process and frequency reaches 800 MHz.Experimental results show that the proposed design provides perfect numerical precision within the fixed bit-width of the ASIP, higher matrix processing rate better than the requirements of 5G system and more rate-area efficiency comparable with ASIC implementations.
基金supported in part by the National Science Foundationof China under Grant number 61431001the Beijing Talents Fund under Grant number 2015000021223ZK31
文摘The centralized radio access cellular network infrastructure based on centralized Super Base Station(CSBS) is a promising solution to reduce the high construction cost and energy consumption of conventional cellular networks. With CSBS, the computing resource for communication protocol processing could be managed flexibly according the protocol load to improve the resource efficiency. Since the protocol load changes frequently and may exceed the capacity of processors, load balancing is needed. However, existing load balancing mechanisms used in data centers cannot satisfy the real-time requirement of the communication protocol processing. Therefore, a new computing resource adjustment scheme is proposed for communication protocol processing in the CSBS architecture. First of all, the main principles of protocol processing resource adjustment is concluded, followed by the analysis on the processing resource outage probability that the computing resource becomes inadequate for protocol processing as load changes. Following the adjustment principles, the proposed scheme is designed to reduce the processing resource outage probability based onthe optimized connected graph which is constructed by the approximate Kruskal algorithm. Simulation re-sults show that compared with the conventional load balancing mechanisms, the proposed scheme can reduce the occurrence number of inadequate processing resource and the additional resource consumption of adjustment greatly.
基金the key project of the National Science and Technology Major Project(Grant No.2018ZX03001017)the project of the CAS engineering laboratory for intelligent agricultural machinery equipment(Grant No.GC201907-02).
文摘Novel centralized base station architectures integrating computation and communication functionalities have become important for the development of future mobile communication networks.Therefore,the development of dynamic high-speed interconnections between baseband units(BBUs)and remote radio heads(RRHs)is vital in centralized base station design.Herein,dynamic high-speed switches(HSSs)connecting BBUs and RRHs were designed for a centralized base station architecture.We analyzed the characteristics of actual traffic and introduced a switch traffic model suitable for the super base station architecture.Then,we proposed a data-priority-aware(DPA)scheduling algorithm based on the traffic model.Lastly,we developed the dynamic HSS model based on the OPNET platform and the prototype based on FPGA.Our results show that the DPA achieves close to 100%throughput with lower latency and provides better run-time complexity than iOCF and HE-iSLIP,thereby demonstrating that the proposed switch system can be adopted in centralized base station architectures.
文摘Objective Dilated cardiomyopathy(DCM) is generally considered to be accompanied by both left and right ventricular dysfunction,but most studies only analyze the left ventricular function. In this study,we evaluated the effect of arotinolol on right ventricular function in patients with DCM. Methods Right ventricular ejection fraction(RVEF) and right ventricular diameter(RVD) were measured by two-dimensional echocardiography(2-DE) in 33 DCM patients;RVEF measured by first-pass radionuclide angiography(FPRA) was compared with that by 2-DE. Results The treatment with arotinolol for one year resulted in a reduction in the right ventricular diameter(baseline,23.0 ± 8.3 mm vs after one-year treatment,20.7 ± 5.4 mm;P=0.004 ) and an associated increase in ejection fraction(baseline,36.9 ± 10.3% vs after one-year treatment,45.8 ± 9.6%;P < 0.001 ) ;there is a high correlation between the 2-DE method and radionuclide ventriculographic method. The correlation coefficient is 0.933(P<0.001) . Conclusion Arotinolol therapy could not only improve left ventricular function,but also improve right ventricular function in DCM patients.
基金funded by the key project of the National Natural Science Foundation of China (No.61431001)the National High-Tech R&D Program (863 Program 2015AA01A705)New Technology Star Plan of Beijing (No.xx2013052)
文摘In centralized cellular network architecture,the concept of virtualized Base Station(VBS) becomes attracting since it enables all base stations(BSs) to share computing resources in a dynamic manner. This can significantly improve the utilization efficiency of computing resources. In this paper,we study the computing resource allocation strategy for one VBS by considering the non-negligible effect of delay introduced by switches. Specifically,we formulate the VBS's sum computing rate maximization as a set optimization problem. To address this problem,we firstly propose a computing resource schedule algorithm,namely,weight before one-step-greedy(WBOSG),which has linear computation complexity and considerable performance. Then,OSG retreat(OSG-R) algorithm is developed to further improve the system performance at the expense of computational complexity. Simulation results under practical setting are provided to validate the proposed two algorithms.
基金supported by International Science&Technology Cooperation Program of China (2013DFG60060)
文摘In a novel plasma-shade reactor for oxidative reforming of biogas(CH4/CO2=3/2),the effects of specific-energy-input (SEI) on CH4 and CO2 conversions and energy cost of syngas were investigated at O2/CH4ratios ranged from 0.42 to 0.67.At each of O2/CH4 ratios,V-shape profiles of energy cost of syngas increasing with SEI were observed,reaching the lowest value at the optimal SEI(Opt-SEI).With the increase of O2/CH4 ratio,the Opt-SEI decreased significantly.Moreover,at the Opt-SEI,O2 and CH4 conversions and dry-basis concentration of syngas increased and energy cost of syngas decreased greatly with the increase of O2/CH4 ratio.
