To investigate the synergistic effects of 3′-azido-3′- deoxythymidine （AZT） and FA-2-b-β extracted from Ling Jin mushroom on apoptosis of gastric cancer cells MKN45 in vitro. METHODS： Ml-I- analysis was made to ...To investigate the synergistic effects of 3′-azido-3′- deoxythymidine （AZT） and FA-2-b-β extracted from Ling Jin mushroom on apoptosis of gastric cancer cells MKN45 in vitro. METHODS： Ml-I- analysis was made to examine the inhibition rate of MKN45 cells treated with AZT （2.5, 5, 10 and 20 mg/L） and FA-2-b-13 （5, 10, 20 and 40 mg/L） singly and combinatively for 24, 48 and 72 h. Apoptotic effects were evaluated by morphological methods, DNA agarose gel electrophoresis and flow cytometry, respectively. Telomerase activity was estimated by TRAP- ELISA. The mRNA expression of caspase-3 and Bcl-2 were detected by RT-PCR. RESULTS： AZT and FA-2-b-13 could significantly inhibit MKN45 cell proliferation and induce its apoptosis. MKN45 cells were inhibited in dose- and time- dependent manner. The inhibition effect of AZT combined with FA-2- b-β was obviously better than that used singly （0.469 ＋ 0.022 vs 1.075 4- 0.055, P 〈 0.05, 0.325 4- 0.029 vs 0.469 ＋ 0.022 P 〈 0.01）. AZT used singly and combination of FA-2-b-β could decrease the activity of tumor cell telomerase, and AZT has synergistic function with FA- 2-b-β. A certain concentration of AZT could up-regulate the expression of caspase-3 mRNA （r = 0.9969, P 〈 0.01）, which was positively related to apoptosis rate, and could down-regulate the expression of Bcl-2 mRNA, which was negatively related to apoptosis rate （r = 0.926, P 〈 0.01）. Furthermore, the effect of AZT combined with FA-2-b-13 was significantly higher than that used singly. CONCLUSION： Combination of AZT and FA-2-b-β has an obviously synergetic effect in the gastric cancer cells MKN45, which has provided a new approach to the treatment of gastric cancer clinically.展开更多
Hyperphosphorylated tau is the major protein component of neurofibrillary tangles in the brains of patients with Alzheimer’s disease(AD). However, the mechanism underlying tau hyperphosphorylation is not fully unders...Hyperphosphorylated tau is the major protein component of neurofibrillary tangles in the brains of patients with Alzheimer’s disease(AD). However, the mechanism underlying tau hyperphosphorylation is not fully understood. Here, we demonstrated that exogenously expressed wild-type human tau40 was detectable in the phosphorylated form at multiple AD-associated sites in cytoplasmic and nuclear fractions from HEK293 cells.Among these sites, tau phosphorylated at Thr205 and Ser214 was almost exclusively found in the nuclear fraction at the conditions used in the present study. With the intracellular tau accumulation, the Ca2+concentration was significantly increased in both cytoplasmic and nuclear fractions. Further studies using site-specific mutagenesis and pharmacological treatment demonstrated that phosphorylation of tau at Thr205 increased nuclear Ca2+concentration with a simultaneous increase in the phosphorylation of Ca2+/calmodulin-dependent protein kinase IV(Ca MKIV) at Ser196. On the other hand, phosphorylation of tau at Ser214 did not significantly change the nuclear Ca2+/Ca MKIV signaling. Finally, expressing calmodulin-binding protein-4 that disrupts formation ofthe Ca2+/calmodulin complex abolished the okadaic acidinduced tau hyperphosphorylation in the nuclear fraction.We conclude that the intracellular accumulation of phosphorylated tau, as detected in the brains of AD patients, can trigger nuclear Ca2+/Ca MKIV signaling, which in turn aggravates tau hyperphosphorylation. Our findings provide new insights for tauopathies: hyperphosphorylation of intracellular tau and an increased Ca2+concentration may induce a self-perpetuating harmful loop to promote neurodegeneration.展开更多
This study was to investigate the diagnostic value of the computed tomography（CT） histogram in thyroid benign solitary coarse calcification nodules（BSCNs）. A total of 89 thyroid solitary coarse calcification nodu...This study was to investigate the diagnostic value of the computed tomography（CT） histogram in thyroid benign solitary coarse calcification nodules（BSCNs）. A total of 89 thyroid solitary coarse calcification nodules（coarse calcification ≥5 mm, no definite soft tissue around calcification） confirmed either by surgery or histopathological examination in 86 cases enrolled from January 2009 to December 2015 were evaluated. These included 56 BSCNs and 33 malignant solitary coarse calcification nodules（MSCNs）. Overall, 27 cut-off values were calculated by N（4≤N≤30） times of 50 Hounsfield units（HU） in the range of 200 to 1500 HU, and each cut-off value and the differences in the corresponding area percentages in the CT histogram were recorded for BSCN and MSCN. The optimal cut-off value and the corresponding area percentage were established by receiver operating characteristic（ROC） curve analysis. In the 19 groups with an ROC area under curve（AUC） of more than 0.7, at a cut-off value of 800 HU and at an area percentage of no more than 93.8%, the ROC AUC reached the maximum of 0.79, and the accuracy, sensitivity, and specificity were 75.3%, 80.4%, and 66.7%, respectively. At a cut-off value of 1050 HU and at an area percentage of no more than 93.6%, the accuracy, sensitivity, and specificity were 71.9%, 60.7%, and 90.9%, respectively. At a cut-off of 1150 HU and area of no more than 98.4%, the accuracy, sensitivity, and specificity were 70.8%, 57.1%, and 93.9%, respectively. At a cut-off of 600 HU and area of no more than 12.1%, the accuracy, sensitivity, and specificity were 61.8%, 39.3%, and 100.0%, respectively. Compared with the cut-off value of 800 HU and an area percentage of no more than 93.8%, the sensitivity of cut-off values and minimum areas of 1050 HU and 93.6%, of 1150 HU and 98.4%, and of 600 HU and 12.1%, was gradually decreasing; however, their specificity was gradually increasing. This can provide an important basis for reducing the misdiagnosis and unnecessary surgi展开更多
Tungsten was plated on the surface of diamond by using thermal diffusion method.Different process parameters were employed to prepare the composites with tungsten,diamond and copper.The micro morphology of different s...Tungsten was plated on the surface of diamond by using thermal diffusion method.Different process parameters were employed to prepare the composites with tungsten,diamond and copper.The micro morphology of different samples was observed,and the thermal conductivity of samples was measured by laser flash method.The optimal process parameters for preparing diamond/copper composites with high thermal conductivity were investigated.The results indicated that plating tungsten on diamond could modify the interface bonding.When the diamond was plated for 60 min,the coating appeared intact,uniform and flat,and the thermal conductivity of the sample could reach as high as 486 W/(m·K).The integrity and uniformity were more important than thickness for the coating.When the tungsten-plated diamond was further annealed,the metallurgical bonding between the coating and the diamond was enhanced,and the thermal conductivity rose to 559 W/(m·K).展开更多
Primary hyperparathyroidism(PHPT) is rare during pregnancy. A case of twin pregnancy with three simultaneous parathyroid adenomas at the same time has not been reported. Multiple parathyroid lesions are difficult to d...Primary hyperparathyroidism(PHPT) is rare during pregnancy. A case of twin pregnancy with three simultaneous parathyroid adenomas at the same time has not been reported. Multiple parathyroid lesions are difficult to diagnose, as pregnant women who insist upon continuing a pregnancy are not able to undergo 99mTc-sestamibi scintigraphy, so cases of PHPT are easily unobserved and often can have serious consequences for the patient and the fetus. Therefore, we reported a case of a 28-year-old woman mid-pregnancy with twins, who had hypercalcemia and was eventually diagnosed with twin pregnancy with PHPT due to a triple parathyroid adenoma, had good pregnancy outcomes after undergoing surgery in mid-pregnancy. Twin pregnancy with PHPT due to a triple parathyroid adenoma, as presented in this case, is very rare and surgery in mid-pregnancy is demonstrated here as safe. Intraoperative parathormone monitoring was and remains key to a successful operation.展开更多
The evolutions of nano-twins and martensitic transformation in 316L austenitic stainless steel during large tensile deformation were studied by electron backscatter diffraction(EBSD)technology and transmission electro...The evolutions of nano-twins and martensitic transformation in 316L austenitic stainless steel during large tensile deformation were studied by electron backscatter diffraction(EBSD)technology and transmission electron microscopy(TEM)in detail.The results show that due to the low stacking fault energy of the steel,phase transformation induced plasticity(TRIP)and twinning induced plasticity(TWIP)coexist during the tensile deformation.The deformation firstly induces the formation of deformation twins,and dislocation pile-up is caused by the reduction of the dislocation mean free path(MFP)or grain refinement due to the twin boundaries,which further induces the martensitic transformation.With the increase of tensile deformation,a large number of nano-twins andα’-martensite appear,and the width of nano-twins decreases gradually,meanwhile the frequency of the intersecting deformation twins increases.The martensitic transformation can be divided into two types:γ-austenite→α’-martensite andγ-austenite→ε-martensite.α’-martensite is mainly distributed near the twin boundaries,especially at the intersection of twins,whileε-martensite and stacking faults exist in the form of transition products between the twins and the matrix.展开更多
Objective:To explore the effect of sodium ferulate in combined with atorvastatin on the renal interstitial fibrosis and inflammatory cytokines in patients with diabetic nephropathy (DN). Methods: A total of 111 patien...Objective:To explore the effect of sodium ferulate in combined with atorvastatin on the renal interstitial fibrosis and inflammatory cytokines in patients with diabetic nephropathy (DN). Methods: A total of 111 patients with DN who were admitted in our hospital from January, 2016 to April, 2017 were included in the study and randomized into the observation group and the control 1 and 2 group with 37 cases in each group. The patients in the control group were given routine blood sugar reducing, blood pressure reducing, and high quality low protein diet. On the above basis, the patients in the control 2 group were orally administrated with atorvastatin before sleep (20 mg). On the basis of treatments in the control 1 group, the patients in the observation group were given sodium ferulate (0.3 g) + 0.9% NaCl (250 mL), ivdrip, 1 time/d, and administrated with atorvastatin before sleep (20 mg). The fasting peripheral venous blood before and after treatment in the three groups was collected. The glycse oxidase (GOD) method was used to detect FPG. ELISA was used to detect SCr, TGF-β, AngⅡ, CTGF, hs-CRP, TNF-α, and IL-6. RIA was used to detect BUN and 24hUAER. The strengthened chemiluminescence immunoassay was used to detect CⅣ and PCⅢ. MAP was recorded. Results: FPG, MAP, BUN, 24hUAER, and SCr after treatment in the control 2 group were significantly lower than those in the control 1 group. FPG, MAP, BUN, 24hUAER, and SCr after treatment in the observation group were significantly lower than those in the control 2 group. AngⅡ, TGF-β, CTGF, PCⅢ, and CⅣ after treatment in the control 2 group were significantly lower than those in the control 1 group. AngⅡ, TGF-β, CTGF, PCⅢ, and CⅣ after treatment in the observation group were significantly lower than those in the control 2 group. TNF-α, IL-6, and hs-CRP after treatments in the control 2 group were significantly lower than those in the control 1 group. TNF-α, IL-6, and hs-CRP after treatment in the observation group were significantly lower than tho展开更多
The binding mode of the amino acid ethyl esters(guest) by 5 (2 carboxylphenyl) 10,15,20 triphenylporphyrinatozinc(Ⅱ)(host 1) was studied by means of 1H NMR spectra. The binding mode is the hydrogen bonding between th...The binding mode of the amino acid ethyl esters(guest) by 5 (2 carboxylphenyl) 10,15,20 triphenylporphyrinatozinc(Ⅱ)(host 1) was studied by means of 1H NMR spectra. The binding mode is the hydrogen bonding between the amino group of the guest and the carboxyl group of host 1 plus the coordination between the zinc atom of porphyrinatozinc(Ⅱ) and the carbonyl group of the guest. This is a novel binding mode of the metalloporphyrin to amino acid derivatives.展开更多
In this paper, we establish some new generalized KKM-type theorems based on weakly generalized KKM mapping without any convexity structure in topological spaces. As applications, some minimax inequalities and an exist...In this paper, we establish some new generalized KKM-type theorems based on weakly generalized KKM mapping without any convexity structure in topological spaces. As applications, some minimax inequalities and an existence theorem of equilibrium points for an abstract generalized vector equilibrium problem are proved in topological spaces. The results presented in this paper unify and generalize some known results in recent literature.展开更多
We give more efficient criteria to characterise prime ideal or primary ideal. Further, we obtain the necessary and sufficient conditions that an ideal is prime or primary in real field from the Grobner bases directly.
Let D = （V, E） be a primitive digraph. The vertex exponent of D at a vertex v∈ V, denoted by expD（v）, is the least integer p such that there is a v →u walk of length p for each u ∈ V. Following Brualdi and Liu,...Let D = （V, E） be a primitive digraph. The vertex exponent of D at a vertex v∈ V, denoted by expD（v）, is the least integer p such that there is a v →u walk of length p for each u ∈ V. Following Brualdi and Liu, we order the vertices of D so that exPD（V1） ≤ exPD（V2） …≤ exPD（Vn）. Then exPD（Vk） is called the k- point exponent of D and is denoted by exPD （k）, 1≤ k ≤ n. In this paper we define e（n, k） ：= max{expD （k） ｜ D ∈ PD（n, 2）} and E（n, k） ：= {exPD（k）｜ D ∈ PD（n, 2）}, where PD（n, 2） is the set of all primitive digraphs of order n with girth 2. We completely determine e（n, k） and E（n, k） for all n, k with n ≥ 3 and 1 ≤ k ≤ n.展开更多
The notion of weakly relatively prime and W-Gr6bner basis in K[x1, x2,…, xn] are given. The following results are obtained： for polynomials fl, f2, ..., fm, {f1^λ1, f2^λ2,…, fm^λm} is a GrSbner basis if and only...The notion of weakly relatively prime and W-Gr6bner basis in K[x1, x2,…, xn] are given. The following results are obtained： for polynomials fl, f2, ..., fm, {f1^λ1, f2^λ2,…, fm^λm} is a GrSbner basis if and only if f1, f2, …, fm are pairwise weakly relatively prime with λ1, λ2, …, λm arbitrary non-negative integers; polynomial composition by θ = （θ1,θ2, …, θn） commutes with monomial-Grobner bases computation if and only if θ1, θ2, , θm are pairwise weakly relatively prime.展开更多
A unitary right R-module MR satisfies acc on d-annihilators if for every sequence（a;）;of elements of R the ascending chain AnnM（a;）■ AnnM（a;a;）■AnnM（a;a;a;）■… of submodules of MR stabilizes. In this paper ...A unitary right R-module MR satisfies acc on d-annihilators if for every sequence（a;）;of elements of R the ascending chain AnnM（a;）■ AnnM（a;a;）■AnnM（a;a;a;）■… of submodules of MR stabilizes. In this paper we first investigate some triangular matrix extensions of modules with acc on d-annihilators. Then we show that under some additional conditions,the Ore extension module M[x]R[x;α,δ]over the Ore extension ring R[x;α,δ] satisfies acc on d-annihilators if and only if the module MR satisfies acc on d-annihilators. Consequently, several known results regarding modules with acc on d-annihilators are extended to a more general setting.展开更多
We investigate the time evolution of the wave function for a many-particle system in an external harmonic potential and a spatially homogeneous time-dependent driving field.The time-dependent wave function is found to...We investigate the time evolution of the wave function for a many-particle system in an external harmonic potential and a spatially homogeneous time-dependent driving field.The time-dependent wave function is found to be a phase factor times the shifted initial state wave function.This then provides a new proof of the harmonic-potential theorem.展开更多
Denoising of chaotic signal is a challenge work due to its wide-band and noise-like characteristics.The algorithm should make the denoised signal have a high signal to noise ratio and retain the chaotic characteristic...Denoising of chaotic signal is a challenge work due to its wide-band and noise-like characteristics.The algorithm should make the denoised signal have a high signal to noise ratio and retain the chaotic characteristics.We propose a denoising method of chaotic signals based on sparse decomposition and K-singular value decomposition(K-SVD)optimization.The observed signal is divided into segments and decomposed sparsely.The over-complete atomic library is constructed according to the differential equation of chaotic signals.The orthogonal matching pursuit algorithm is used to search the optimal matching atom.The atoms and coefficients are further processed to obtain the globally optimal atoms and coefficients by K-SVD.The simulation results show that the denoised signals have a higher signal to noise ratio and better preserve the chaotic characteristics.展开更多
文摘To investigate the synergistic effects of 3′-azido-3′- deoxythymidine （AZT） and FA-2-b-β extracted from Ling Jin mushroom on apoptosis of gastric cancer cells MKN45 in vitro. METHODS： Ml-I- analysis was made to examine the inhibition rate of MKN45 cells treated with AZT （2.5, 5, 10 and 20 mg/L） and FA-2-b-13 （5, 10, 20 and 40 mg/L） singly and combinatively for 24, 48 and 72 h. Apoptotic effects were evaluated by morphological methods, DNA agarose gel electrophoresis and flow cytometry, respectively. Telomerase activity was estimated by TRAP- ELISA. The mRNA expression of caspase-3 and Bcl-2 were detected by RT-PCR. RESULTS： AZT and FA-2-b-13 could significantly inhibit MKN45 cell proliferation and induce its apoptosis. MKN45 cells were inhibited in dose- and time- dependent manner. The inhibition effect of AZT combined with FA-2- b-β was obviously better than that used singly （0.469 ＋ 0.022 vs 1.075 4- 0.055, P 〈 0.05, 0.325 4- 0.029 vs 0.469 ＋ 0.022 P 〈 0.01）. AZT used singly and combination of FA-2-b-β could decrease the activity of tumor cell telomerase, and AZT has synergistic function with FA- 2-b-β. A certain concentration of AZT could up-regulate the expression of caspase-3 mRNA （r = 0.9969, P 〈 0.01）, which was positively related to apoptosis rate, and could down-regulate the expression of Bcl-2 mRNA, which was negatively related to apoptosis rate （r = 0.926, P 〈 0.01）. Furthermore, the effect of AZT combined with FA-2-b-13 was significantly higher than that used singly. CONCLUSION： Combination of AZT and FA-2-b-β has an obviously synergetic effect in the gastric cancer cells MKN45, which has provided a new approach to the treatment of gastric cancer clinically.
基金supported by the National Natural Science Foundation of China(91632305)the National Key Research and Development Program of China(2016YFC13058001)
文摘Hyperphosphorylated tau is the major protein component of neurofibrillary tangles in the brains of patients with Alzheimer’s disease(AD). However, the mechanism underlying tau hyperphosphorylation is not fully understood. Here, we demonstrated that exogenously expressed wild-type human tau40 was detectable in the phosphorylated form at multiple AD-associated sites in cytoplasmic and nuclear fractions from HEK293 cells.Among these sites, tau phosphorylated at Thr205 and Ser214 was almost exclusively found in the nuclear fraction at the conditions used in the present study. With the intracellular tau accumulation, the Ca2+concentration was significantly increased in both cytoplasmic and nuclear fractions. Further studies using site-specific mutagenesis and pharmacological treatment demonstrated that phosphorylation of tau at Thr205 increased nuclear Ca2+concentration with a simultaneous increase in the phosphorylation of Ca2+/calmodulin-dependent protein kinase IV(Ca MKIV) at Ser196. On the other hand, phosphorylation of tau at Ser214 did not significantly change the nuclear Ca2+/Ca MKIV signaling. Finally, expressing calmodulin-binding protein-4 that disrupts formation ofthe Ca2+/calmodulin complex abolished the okadaic acidinduced tau hyperphosphorylation in the nuclear fraction.We conclude that the intracellular accumulation of phosphorylated tau, as detected in the brains of AD patients, can trigger nuclear Ca2+/Ca MKIV signaling, which in turn aggravates tau hyperphosphorylation. Our findings provide new insights for tauopathies: hyperphosphorylation of intracellular tau and an increased Ca2+concentration may induce a self-perpetuating harmful loop to promote neurodegeneration.
文摘This study was to investigate the diagnostic value of the computed tomography（CT） histogram in thyroid benign solitary coarse calcification nodules（BSCNs）. A total of 89 thyroid solitary coarse calcification nodules（coarse calcification ≥5 mm, no definite soft tissue around calcification） confirmed either by surgery or histopathological examination in 86 cases enrolled from January 2009 to December 2015 were evaluated. These included 56 BSCNs and 33 malignant solitary coarse calcification nodules（MSCNs）. Overall, 27 cut-off values were calculated by N（4≤N≤30） times of 50 Hounsfield units（HU） in the range of 200 to 1500 HU, and each cut-off value and the differences in the corresponding area percentages in the CT histogram were recorded for BSCN and MSCN. The optimal cut-off value and the corresponding area percentage were established by receiver operating characteristic（ROC） curve analysis. In the 19 groups with an ROC area under curve（AUC） of more than 0.7, at a cut-off value of 800 HU and at an area percentage of no more than 93.8%, the ROC AUC reached the maximum of 0.79, and the accuracy, sensitivity, and specificity were 75.3%, 80.4%, and 66.7%, respectively. At a cut-off value of 1050 HU and at an area percentage of no more than 93.6%, the accuracy, sensitivity, and specificity were 71.9%, 60.7%, and 90.9%, respectively. At a cut-off of 1150 HU and area of no more than 98.4%, the accuracy, sensitivity, and specificity were 70.8%, 57.1%, and 93.9%, respectively. At a cut-off of 600 HU and area of no more than 12.1%, the accuracy, sensitivity, and specificity were 61.8%, 39.3%, and 100.0%, respectively. Compared with the cut-off value of 800 HU and an area percentage of no more than 93.8%, the sensitivity of cut-off values and minimum areas of 1050 HU and 93.6%, of 1150 HU and 98.4%, and of 600 HU and 12.1%, was gradually decreasing; however, their specificity was gradually increasing. This can provide an important basis for reducing the misdiagnosis and unnecessary surgi
基金supported by the National Natural Science Foundation of China(No.11802125)。
文摘Tungsten was plated on the surface of diamond by using thermal diffusion method.Different process parameters were employed to prepare the composites with tungsten,diamond and copper.The micro morphology of different samples was observed,and the thermal conductivity of samples was measured by laser flash method.The optimal process parameters for preparing diamond/copper composites with high thermal conductivity were investigated.The results indicated that plating tungsten on diamond could modify the interface bonding.When the diamond was plated for 60 min,the coating appeared intact,uniform and flat,and the thermal conductivity of the sample could reach as high as 486 W/(m·K).The integrity and uniformity were more important than thickness for the coating.When the tungsten-plated diamond was further annealed,the metallurgical bonding between the coating and the diamond was enhanced,and the thermal conductivity rose to 559 W/(m·K).
基金Supported by the Key Project of Scientific and Technological Innovation in Hangzhou,NO.20131813A08the Key Project of Medical Scientific and Technology Program in Hangzhou,NO.2013Z04+1 种基金the Traditional Chinese Medical Science Research Program of Zhejiang Province,NO.2018239534the Applied Research Project of Commonweal Technology in Zhejiang Province,NO.2017C33180
文摘Primary hyperparathyroidism(PHPT) is rare during pregnancy. A case of twin pregnancy with three simultaneous parathyroid adenomas at the same time has not been reported. Multiple parathyroid lesions are difficult to diagnose, as pregnant women who insist upon continuing a pregnancy are not able to undergo 99mTc-sestamibi scintigraphy, so cases of PHPT are easily unobserved and often can have serious consequences for the patient and the fetus. Therefore, we reported a case of a 28-year-old woman mid-pregnancy with twins, who had hypercalcemia and was eventually diagnosed with twin pregnancy with PHPT due to a triple parathyroid adenoma, had good pregnancy outcomes after undergoing surgery in mid-pregnancy. Twin pregnancy with PHPT due to a triple parathyroid adenoma, as presented in this case, is very rare and surgery in mid-pregnancy is demonstrated here as safe. Intraoperative parathormone monitoring was and remains key to a successful operation.
基金supported by the Natural Science Foundation of Shaanxi Province,China(No.2021JM-061).
文摘The evolutions of nano-twins and martensitic transformation in 316L austenitic stainless steel during large tensile deformation were studied by electron backscatter diffraction(EBSD)technology and transmission electron microscopy(TEM)in detail.The results show that due to the low stacking fault energy of the steel,phase transformation induced plasticity(TRIP)and twinning induced plasticity(TWIP)coexist during the tensile deformation.The deformation firstly induces the formation of deformation twins,and dislocation pile-up is caused by the reduction of the dislocation mean free path(MFP)or grain refinement due to the twin boundaries,which further induces the martensitic transformation.With the increase of tensile deformation,a large number of nano-twins andα’-martensite appear,and the width of nano-twins decreases gradually,meanwhile the frequency of the intersecting deformation twins increases.The martensitic transformation can be divided into two types:γ-austenite→α’-martensite andγ-austenite→ε-martensite.α’-martensite is mainly distributed near the twin boundaries,especially at the intersection of twins,whileε-martensite and stacking faults exist in the form of transition products between the twins and the matrix.
文摘Objective:To explore the effect of sodium ferulate in combined with atorvastatin on the renal interstitial fibrosis and inflammatory cytokines in patients with diabetic nephropathy (DN). Methods: A total of 111 patients with DN who were admitted in our hospital from January, 2016 to April, 2017 were included in the study and randomized into the observation group and the control 1 and 2 group with 37 cases in each group. The patients in the control group were given routine blood sugar reducing, blood pressure reducing, and high quality low protein diet. On the above basis, the patients in the control 2 group were orally administrated with atorvastatin before sleep (20 mg). On the basis of treatments in the control 1 group, the patients in the observation group were given sodium ferulate (0.3 g) + 0.9% NaCl (250 mL), ivdrip, 1 time/d, and administrated with atorvastatin before sleep (20 mg). The fasting peripheral venous blood before and after treatment in the three groups was collected. The glycse oxidase (GOD) method was used to detect FPG. ELISA was used to detect SCr, TGF-β, AngⅡ, CTGF, hs-CRP, TNF-α, and IL-6. RIA was used to detect BUN and 24hUAER. The strengthened chemiluminescence immunoassay was used to detect CⅣ and PCⅢ. MAP was recorded. Results: FPG, MAP, BUN, 24hUAER, and SCr after treatment in the control 2 group were significantly lower than those in the control 1 group. FPG, MAP, BUN, 24hUAER, and SCr after treatment in the observation group were significantly lower than those in the control 2 group. AngⅡ, TGF-β, CTGF, PCⅢ, and CⅣ after treatment in the control 2 group were significantly lower than those in the control 1 group. AngⅡ, TGF-β, CTGF, PCⅢ, and CⅣ after treatment in the observation group were significantly lower than those in the control 2 group. TNF-α, IL-6, and hs-CRP after treatments in the control 2 group were significantly lower than those in the control 1 group. TNF-α, IL-6, and hs-CRP after treatment in the observation group were significantly lower than tho
文摘The binding mode of the amino acid ethyl esters(guest) by 5 (2 carboxylphenyl) 10,15,20 triphenylporphyrinatozinc(Ⅱ)(host 1) was studied by means of 1H NMR spectra. The binding mode is the hydrogen bonding between the amino group of the guest and the carboxyl group of host 1 plus the coordination between the zinc atom of porphyrinatozinc(Ⅱ) and the carbonyl group of the guest. This is a novel binding mode of the metalloporphyrin to amino acid derivatives.
基金Supported by the National Natural Science Foundation of China (No. 10771058)the Hunan Provincial Natural Science Foundation (No. 09JJ6013)
文摘In this paper, we establish some new generalized KKM-type theorems based on weakly generalized KKM mapping without any convexity structure in topological spaces. As applications, some minimax inequalities and an existence theorem of equilibrium points for an abstract generalized vector equilibrium problem are proved in topological spaces. The results presented in this paper unify and generalize some known results in recent literature.
基金Supported by the National Natural Science Foundation of China (No. 11071062)Hunan provincial Natural Science Foundation of China (No. 10JJ3065)+1 种基金Scientific Research Fund of Hunan province education Department (No. 10A033)Hunan Provincial Degree and Education of Graduate Student Foundation (No. JG2009A017)
文摘We give more efficient criteria to characterise prime ideal or primary ideal. Further, we obtain the necessary and sufficient conditions that an ideal is prime or primary in real field from the Grobner bases directly.
基金Supported by the National Natural Science Foundation of China(No.10771061,No.10771058)SRF of Hunan Provincial Education Department(No.07C267).
文摘Let D = （V, E） be a primitive digraph. The vertex exponent of D at a vertex v∈ V, denoted by expD（v）, is the least integer p such that there is a v →u walk of length p for each u ∈ V. Following Brualdi and Liu, we order the vertices of D so that exPD（V1） ≤ exPD（V2） …≤ exPD（Vn）. Then exPD（Vk） is called the k- point exponent of D and is denoted by exPD （k）, 1≤ k ≤ n. In this paper we define e（n, k） ：= max{expD （k） ｜ D ∈ PD（n, 2）} and E（n, k） ：= {exPD（k）｜ D ∈ PD（n, 2）}, where PD（n, 2） is the set of all primitive digraphs of order n with girth 2. We completely determine e（n, k） and E（n, k） for all n, k with n ≥ 3 and 1 ≤ k ≤ n.
基金Supported by the NSFC (10771058, 11071062, 10871205), NSFH (10JJ3065)Scientific Research Fund of Hunan Provincial Education Department (10A033)Hunan Provincial Degree and Education of Graduate Student Foundation (JG2009A017)
文摘The notion of weakly relatively prime and W-Gr6bner basis in K[x1, x2,…, xn] are given. The following results are obtained： for polynomials fl, f2, ..., fm, {f1^λ1, f2^λ2,…, fm^λm} is a GrSbner basis if and only if f1, f2, …, fm are pairwise weakly relatively prime with λ1, λ2, …, λm arbitrary non-negative integers; polynomial composition by θ = （θ1,θ2, …, θn） commutes with monomial-Grobner bases computation if and only if θ1, θ2, , θm are pairwise weakly relatively prime.
基金The NSF(11471108) of Chinathe NSF(2015JJ2051,2016JJ2050) of Hunan Provincethe Teaching Reform Foundation(G21316) of Hunan Province
文摘A unitary right R-module MR satisfies acc on d-annihilators if for every sequence（a;）;of elements of R the ascending chain AnnM（a;）■ AnnM（a;a;）■AnnM（a;a;a;）■… of submodules of MR stabilizes. In this paper we first investigate some triangular matrix extensions of modules with acc on d-annihilators. Then we show that under some additional conditions,the Ore extension module M[x]R[x;α,δ]over the Ore extension ring R[x;α,δ] satisfies acc on d-annihilators if and only if the module MR satisfies acc on d-annihilators. Consequently, several known results regarding modules with acc on d-annihilators are extended to a more general setting.
基金Supported by the National Natural Science Foundation of China under Grant No 11275100the Natural Science Foundation of Zhejiang Province under Grant No R6090717the K C.Wong Magna Foundation of Ningbo University.
文摘We investigate the time evolution of the wave function for a many-particle system in an external harmonic potential and a spatially homogeneous time-dependent driving field.The time-dependent wave function is found to be a phase factor times the shifted initial state wave function.This then provides a new proof of the harmonic-potential theorem.
基金National Natural Science Foundation of China(Grant No.61872083)the Natural Science Foundation of Guangdong Province,China(Grant Nos.2017A030310659 and 2019A1515011123).
文摘Denoising of chaotic signal is a challenge work due to its wide-band and noise-like characteristics.The algorithm should make the denoised signal have a high signal to noise ratio and retain the chaotic characteristics.We propose a denoising method of chaotic signals based on sparse decomposition and K-singular value decomposition(K-SVD)optimization.The observed signal is divided into segments and decomposed sparsely.The over-complete atomic library is constructed according to the differential equation of chaotic signals.The orthogonal matching pursuit algorithm is used to search the optimal matching atom.The atoms and coefficients are further processed to obtain the globally optimal atoms and coefficients by K-SVD.The simulation results show that the denoised signals have a higher signal to noise ratio and better preserve the chaotic characteristics.
