Nattokinase(NK), which has been identified as a potent fibrinolytic protease, has remarkable potential in treatment of thrombolysis, and even has the ability to ameliorate chronic vein thrombosis. To reduce the hemorr...Nattokinase(NK), which has been identified as a potent fibrinolytic protease, has remarkable potential in treatment of thrombolysis, and even has the ability to ameliorate chronic vein thrombosis. To reduce the hemorrhagic risk from an intravenous injection of NK,nattokinase-tauroursodeoxycholate(NK-TUDCA) complex was prepared at different pH values and with different ratios of NK and TUDCA. When assessing survival time, survival state,tail injury, and the body weight of mice, it was found that the NK-TUDCA complex(NK: 10 k IU/ml; TUDCA: 10 mg/ml; pH 5.0) had a lower toxicity when administered at an NK dosage of 130 kIU/kg in the acute toxicity test and 13 kIU/kg in the repeated low-dose challenge. From the results of the in vitro thrombolytic test and characterization of NKTUDCA, we speculated that the delayed release of NK-TUDCA might be the main cause of toxicity reduction by the complex. This study described the preparation of an NK complex with low toxicity following intravenous administration, which could be utilized for further clinical study of NK.展开更多
Quasi-two-dimensional(2D)Ruddlesden‒Popper(RP)halide perovskites,as a kind of emerged two-dimensional layered materials,have recently achieved great attentions in lasing materials field owing to their large exciton bi...Quasi-two-dimensional(2D)Ruddlesden‒Popper(RP)halide perovskites,as a kind of emerged two-dimensional layered materials,have recently achieved great attentions in lasing materials field owing to their large exciton binding energy,high emission yield,large optical gain,and wide-range tuning of optical bandgap.This review will introduce research progresses of RP halide perovskites for lasing applications in aspects of materials,photophysics,and devices with emphasis on emission and lasing properties tailored by the molecular composition and interface.The materials,structures and fabrications are introduced in the first part.Next,the optical transitions and amplified spontaneous emission properties are discussed from the aspects of electronic structure,exciton,gain dynamics,and interface tailoring.Then,the research progresses on lasing devices are summarized and several types of lasers including VCSEL,DFB lasers,microlasers,random lasers,plasmonic lasers,and polariton lasers are discussed.At last,the challenges and perspectives would be provided.展开更多
文摘Nattokinase(NK), which has been identified as a potent fibrinolytic protease, has remarkable potential in treatment of thrombolysis, and even has the ability to ameliorate chronic vein thrombosis. To reduce the hemorrhagic risk from an intravenous injection of NK,nattokinase-tauroursodeoxycholate(NK-TUDCA) complex was prepared at different pH values and with different ratios of NK and TUDCA. When assessing survival time, survival state,tail injury, and the body weight of mice, it was found that the NK-TUDCA complex(NK: 10 k IU/ml; TUDCA: 10 mg/ml; pH 5.0) had a lower toxicity when administered at an NK dosage of 130 kIU/kg in the acute toxicity test and 13 kIU/kg in the repeated low-dose challenge. From the results of the in vitro thrombolytic test and characterization of NKTUDCA, we speculated that the delayed release of NK-TUDCA might be the main cause of toxicity reduction by the complex. This study described the preparation of an NK complex with low toxicity following intravenous administration, which could be utilized for further clinical study of NK.
基金Q.Z.acknowledges the funding support from the National Natural Science Foundation of China(Nos.52072006 and 51991344)the Natural Science Foundation of Beijing Municipality(No.JQ21004)+3 种基金F.L.acknowledges the funding support from the Hubei Province Science and Technology Major Project(No.2022AAA008)the National Natural Science Foundation of China(No.12374319)the Knowledge Innovation Program of Wuhan-Basic Research(No.2022010801010349)S.C.acknowledges the funding support from the Macao Science and Technology Development Fund(Nos.FDCT-0096/2020/A2 and FDCT-0082/2022/A2).
文摘Quasi-two-dimensional(2D)Ruddlesden‒Popper(RP)halide perovskites,as a kind of emerged two-dimensional layered materials,have recently achieved great attentions in lasing materials field owing to their large exciton binding energy,high emission yield,large optical gain,and wide-range tuning of optical bandgap.This review will introduce research progresses of RP halide perovskites for lasing applications in aspects of materials,photophysics,and devices with emphasis on emission and lasing properties tailored by the molecular composition and interface.The materials,structures and fabrications are introduced in the first part.Next,the optical transitions and amplified spontaneous emission properties are discussed from the aspects of electronic structure,exciton,gain dynamics,and interface tailoring.Then,the research progresses on lasing devices are summarized and several types of lasers including VCSEL,DFB lasers,microlasers,random lasers,plasmonic lasers,and polariton lasers are discussed.At last,the challenges and perspectives would be provided.
