Limited evidence exists on the effect of submicronic particulate matter(PM_(1)) on hypertension hospitalization. Evidence based on causal inference and large cohorts is even more scarce. In 2015, 36,271 participants w...Limited evidence exists on the effect of submicronic particulate matter(PM_(1)) on hypertension hospitalization. Evidence based on causal inference and large cohorts is even more scarce. In 2015, 36,271 participants were enrolled in South China and followed up through 2020. Each participant was assigned single-year, lag0–1, and lag0–2 moving average concentration of PM_(1)and fine inhalable particulate matter(PM2.5) simulated based on satellite data at a 1-km resolution. We used an inverse probability weighting approach to balance confounders and utilized a marginal structural Cox model to evaluate the underlying causal links between PM_(1)exposure and hypertension hospitalization, with PM2.5-hypertension association for comparison. Several sensitivity studies and the analyses of effect modification were also conducted. We found that a higher hospitalization risk from both overall(HR: 1.13, 95% CI:1.05–1.22) and essential hypertension(HR: 1.15, 95% CI: 1.06–1.25) was linked to each 1 μg/m3increase in the yearly average PM_(1)concentration. At lag0–1 and lag0–2, we observed a 17%–21% higher risk of hypertension associated with PM_(1). The effect of PM_(1)was 6%–11% higher compared with PM2.5. Linear concentration-exposure associations between PM_(1)exposure and hypertension were identified, without safety thresholds. Women and participants that engaged in physical exercise exhibited higher susceptibility, with 4%–22% greater risk than their counterparts. This large cohort study identified a detrimental relationship between chronic PM_(1)exposure and hypertension hospitalization, which was more pronounced compared with PM2.5and among certain groups.展开更多
On the basis of novel properties of ferroelectric conducting domain walls,the domain wall nanoelectronics emerges and provides a brand-new dimension for the development of high-density,high-speed and energy-efficient ...On the basis of novel properties of ferroelectric conducting domain walls,the domain wall nanoelectronics emerges and provides a brand-new dimension for the development of high-density,high-speed and energy-efficient nanodevices.For in-memory computing,three-terminal devices with both logic and memory functions such as transistors purely based on ferroelectric domain walls are urgently required.Here,a prototype ferroelectric domain-wall transistor with a well-designed coplanar electrode geometry is demonstrated on epitaxial Bi Fe O_(3)thin films.For the logic function,the current switching between on/off states of the transistor depends on the creation or elimination of conducting domain walls between drain and source electrodes.For the data storage,the transistor can maintain nonvolatile on/off states after the write/erase operations,providing an innovative approach for the development of the domain wall nanoelectronics.展开更多
Mental disorder is one of the greatest health challenges of our time,attracting increasingly more public awareness and causing high disability and huge socioeconomic burdens.According to the 2019 Global Burden of Dise...Mental disorder is one of the greatest health challenges of our time,attracting increasingly more public awareness and causing high disability and huge socioeconomic burdens.According to the 2019 Global Burden of Disease led by the Institute for Health Metrics and Evaluation,12.5%of the global population has been suffering from a mental disorder.Globally,mental illness contributes to 32.4%of years lived with disability and 13.0%of disability-adjusted life-years[1].展开更多
Ferroelectric domain walls appear as sub-nanometer-thick topological interfaces separating two adjacent domains in different orientations,and can be repetitively created,erased,and moved during programming into differ...Ferroelectric domain walls appear as sub-nanometer-thick topological interfaces separating two adjacent domains in different orientations,and can be repetitively created,erased,and moved during programming into different logic states for the nonvolatile memory under an applied electric field,providing a new paradigm for highly miniaturized low-energy electronic devices.Under some specific conditions,the charged domain walls are conducting,differing from their insulating bulk domains.In the past decade,the emergence of atomic-layer scaling solid-state electronic devices is such demonstration,resulting in the rapid rise of domain wall nano-electronics.This review aims to the latest development of ferroelectric domain-wall memories with the presence of the challenges and opportunities and the roadmap to their future commercialization.展开更多
Sirtuin 1(SIRT1)is a protein deacetylase,which regulates various physiological activities by deacetylating different protein substrates.An increasing number of studies have revealed critical roles of SIRT1 in differen...Sirtuin 1(SIRT1)is a protein deacetylase,which regulates various physiological activities by deacetylating different protein substrates.An increasing number of studies have revealed critical roles of SIRT1 in different aspects of cancers including metabolism,proliferation,genomic instability,and chemotherapy resistance.Depending on the protein targets in a certain oncogenic context,SIRT1 may play a unique role in each individual blood cancer subtype.Our previous work showed that activation of SIRT1 in primitive leukemia cells of acute myeloid leukemia(AML)and chronic myelogenous leukemia(CML)promotes disease maintenance.On the other hand,an SIRT1 agonist was shown to disrupt maintenance of myelodysplastic syndrome(MDS)stem cells and holds promise as a potential therapeutic approach.Herein,we present a concise summary of the different functions of SIRT1 in hematologic malignancies.展开更多
基金supported by the National Key Research and Development Program of China (2022YFC3600804)the National Natural Science Foundation of China (82204162, 82204154)+4 种基金Young Elite Scientist Sponsorship Program by China Association for Science and Technology (2023QNRC001)Guangdong Provincial Pearl River Talents Program (0920220207)Basic and Applied Basic Research Foundation of Guangdong Province (2022A1515010823)Guangzhou Municipal Science and Technology Bureau (2023A04J2072)Fundamental Research Funds for the Central Universities, Sun Yat-sen University (23qnpy108)。
文摘Limited evidence exists on the effect of submicronic particulate matter(PM_(1)) on hypertension hospitalization. Evidence based on causal inference and large cohorts is even more scarce. In 2015, 36,271 participants were enrolled in South China and followed up through 2020. Each participant was assigned single-year, lag0–1, and lag0–2 moving average concentration of PM_(1)and fine inhalable particulate matter(PM2.5) simulated based on satellite data at a 1-km resolution. We used an inverse probability weighting approach to balance confounders and utilized a marginal structural Cox model to evaluate the underlying causal links between PM_(1)exposure and hypertension hospitalization, with PM2.5-hypertension association for comparison. Several sensitivity studies and the analyses of effect modification were also conducted. We found that a higher hospitalization risk from both overall(HR: 1.13, 95% CI:1.05–1.22) and essential hypertension(HR: 1.15, 95% CI: 1.06–1.25) was linked to each 1 μg/m3increase in the yearly average PM_(1)concentration. At lag0–1 and lag0–2, we observed a 17%–21% higher risk of hypertension associated with PM_(1). The effect of PM_(1)was 6%–11% higher compared with PM2.5. Linear concentration-exposure associations between PM_(1)exposure and hypertension were identified, without safety thresholds. Women and participants that engaged in physical exercise exhibited higher susceptibility, with 4%–22% greater risk than their counterparts. This large cohort study identified a detrimental relationship between chronic PM_(1)exposure and hypertension hospitalization, which was more pronounced compared with PM2.5and among certain groups.
基金supported by the Major Science and Technology Project of Gansu Province(22ZD6GA008)the National Natural Science Foundation of China(11764027 and 12204210)the support from the State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals,Lanzhou University of Technology,for theoretical simulations。
基金in part supported by the National Natural Science Foundation of China(42041004,41991231,and U2242206)the U.S.National Science Foundation(AGS-2032542 and AGS-2032532)+1 种基金the Climate Program Office of the National Oceanic and Atmospheric Administration(NA20OAR4310380)partly supported by a fellowship from China Scholarship Council(CSC No.201906180097)。
基金the National Key Basic Research Program of China(Grant No.2019YFA0308500)the National Natural Science Foundation of China(Grant No.61904034)。
文摘On the basis of novel properties of ferroelectric conducting domain walls,the domain wall nanoelectronics emerges and provides a brand-new dimension for the development of high-density,high-speed and energy-efficient nanodevices.For in-memory computing,three-terminal devices with both logic and memory functions such as transistors purely based on ferroelectric domain walls are urgently required.Here,a prototype ferroelectric domain-wall transistor with a well-designed coplanar electrode geometry is demonstrated on epitaxial Bi Fe O_(3)thin films.For the logic function,the current switching between on/off states of the transistor depends on the creation or elimination of conducting domain walls between drain and source electrodes.For the data storage,the transistor can maintain nonvolatile on/off states after the write/erase operations,providing an innovative approach for the development of the domain wall nanoelectronics.
基金supported by the STI2030-Major Projects(2021ZD0200800)。
文摘Mental disorder is one of the greatest health challenges of our time,attracting increasingly more public awareness and causing high disability and huge socioeconomic burdens.According to the 2019 Global Burden of Disease led by the Institute for Health Metrics and Evaluation,12.5%of the global population has been suffering from a mental disorder.Globally,mental illness contributes to 32.4%of years lived with disability and 13.0%of disability-adjusted life-years[1].
基金Project supported by the National Key Basic Research Program of China (Grant Nos.2019YFA0308500 and 2022YFA1402900)the National Natural Science Foundation of China (Grant No.61904034)。
文摘Ferroelectric domain walls appear as sub-nanometer-thick topological interfaces separating two adjacent domains in different orientations,and can be repetitively created,erased,and moved during programming into different logic states for the nonvolatile memory under an applied electric field,providing a new paradigm for highly miniaturized low-energy electronic devices.Under some specific conditions,the charged domain walls are conducting,differing from their insulating bulk domains.In the past decade,the emergence of atomic-layer scaling solid-state electronic devices is such demonstration,resulting in the rapid rise of domain wall nano-electronics.This review aims to the latest development of ferroelectric domain-wall memories with the presence of the challenges and opportunities and the roadmap to their future commercialization.
基金supported by the National Institutes of Health(No.R01HL141336),the Margaret E.Early Medical Research Trust Award,the Stop Cancer Research Career Development Award,V Scholar Award of Cancer Research,and the Gehr Family Center for Leukemia Research,USA
文摘Sirtuin 1(SIRT1)is a protein deacetylase,which regulates various physiological activities by deacetylating different protein substrates.An increasing number of studies have revealed critical roles of SIRT1 in different aspects of cancers including metabolism,proliferation,genomic instability,and chemotherapy resistance.Depending on the protein targets in a certain oncogenic context,SIRT1 may play a unique role in each individual blood cancer subtype.Our previous work showed that activation of SIRT1 in primitive leukemia cells of acute myeloid leukemia(AML)and chronic myelogenous leukemia(CML)promotes disease maintenance.On the other hand,an SIRT1 agonist was shown to disrupt maintenance of myelodysplastic syndrome(MDS)stem cells and holds promise as a potential therapeutic approach.Herein,we present a concise summary of the different functions of SIRT1 in hematologic malignancies.
