An experimental study on the angle of repose （AoR） of pulverized coal with different particle sizes and different moisture contents （MC） was conducted. Three different measurement methods, free-base piling, fixed-...An experimental study on the angle of repose （AoR） of pulverized coal with different particle sizes and different moisture contents （MC） was conducted. Three different measurement methods, free-base piling, fixed-base piling and sliding, were used. The data were analyzed by one-way and two-way analysis of variance. The results showed that the AoRs of pulverized coal with particle sizes smaller than 150 μm were in the range of 30-50°. The characterization of the flowability of pulverized coal was some cohesiveness or true cohesiveness. The increase of MC will increase AoR and thus decrease the flowability of the powder. However, the particle size effect is bifurcated. Below a critical size, the decrease of particle size decreases the flowability; while above the critical size, the decrease of particle size increases the flowability. It was found that the value of the critical size strongly depends on the powder density. Moreover, the AoR dependence on particle size could be linked with the Geldart＇s particle classification. The critical size at the turning point is on the boundary between Group A and Group B in Geldart＇s classification diagram. Based on the experimental results, there is no significant cross interaction between particle size and MC. The AoRs measured by free-base method and fixed-base method are close, but both remarkably smaller than that measured by the sliding method.展开更多
Understanding the controlling factor of groundwater quality can enhance promoting sustainable development of groundwater resources. To this end, multivariate statistical analysis（MA） and hydrochemical analysis were ...Understanding the controlling factor of groundwater quality can enhance promoting sustainable development of groundwater resources. To this end, multivariate statistical analysis（MA） and hydrochemical analysis were introduced in this work. The results indicate that the canonical discriminant function with 7 parameters was established using the discriminant analysis（DA） method, which can afford 100% correct assignation according to the 3 different clusters（good water（GW）, poor water（PW）, and very poor water（VPW）） obtained from cluster analysis（CA）. According to factor analysis（FA）, 8 factors were extracted from 25 hydrochemical elements and account for 80.897% of the total data variance, suggesting that groundwater with higher concentrations of sodium, calcium, magnesium, chloride, and sulfate in southeastern study area are mainly affected by the natural process; the higher level of arsenic and chromium in groundwater extracted from northwestern part of study area are derived by industrial activities; domestic and agriculture sewage have important contribution to copper, iron, iodine, and phosphate in the northern study area. Therefore, this work can help identify the main controlling factor of groundwater quality in North China plain so as to make better and more informed decisions about how to achieve groundwater resources sustainable development.展开更多
A series of environmental—geological problems have been caused by over-exploitation of deep groundwater（i.e.,confined aquifer water） in the North China Plain.In order to better understand the status of deep groundw...A series of environmental—geological problems have been caused by over-exploitation of deep groundwater（i.e.,confined aquifer water） in the North China Plain.In order to better understand the status of deep groundwater over-exploitation and the resultant environmental—geological problems on a regional scale,the over-exploitation of groundwater has been assessed by way of the groundwater exploitation potential coefficient（i.e.,the ratio of exploitable amount of deep groundwater to current exploitation）, cumulative land subsidence,and long-term average lowering rate of the groundwater table.There is a good correlation among the results calculated by the different methods.On a regional scale,deep groundwater has been over-exploited and there is no further exploitation potential under the current conditions.The groundwater exploitation degree index takes the exploitation in 2003 as the reference for the calculations, so the results mainly reflect the degree of current groundwater exploitation.The results of over-exploitation of deep groundwater obtained by land subsidence data and long-term average rate of depression of the water table mainly reflect environmental—geological problems caused by exploitation of deep groundwater.展开更多
Nanozyme is a new promising approach to cancer therapy for its ability to induce ferroptosis by activating H_(2)O_(2)via a traditional radical pathway and enhance cancer immunotherapy.However,short half-life period of...Nanozyme is a new promising approach to cancer therapy for its ability to induce ferroptosis by activating H_(2)O_(2)via a traditional radical pathway and enhance cancer immunotherapy.However,short half-life period of hydroxyl radical(·OH)results in unsatisfied effectiveness.Herein,we synthesized a single-atom iron nanozyme(Fe-SAzyme),which can activate H_(2)O_(2)via a non-radical pathway to generate Fe-based reactive oxygen species(ROS)(O=FeO_(3)=O)for promoting the ferroptosis of pancreatic cancer cells.This Fe-SAzyme could be specifically phagocytosed by pancreatic cancer cells,increasing ROS levels and inhibiting glutathione(GSH)synthesis,which activates ferroptosis.Tumor magnetic resonance imaging(MRI)showed decreased T2 signal after intravenous injection of RGD@Fe-AC(AC=activated carbon).Moreover,RGD@Fe-AC promoted dendritic cell(DC)maturation,overcame Treg-mediated immunosuppression,activated T cells to trigger adaptive immune responses,and enhanced the efficacy ofα-PD-L1 immunotherapy.Our research demonstrated that RGD@Fe-AC provided a straightforward,easily implemented,and selective approach for pancreatic cancer treatment and immunotherapy.展开更多
以国内外207份小麦种质为材料,利用660K SNP芯片对其进行基因型检测,并结合不同环境下表型数据和最佳线性无偏预测值(BLUP,Best linear unbiased prediction)对小麦籽粒镉元素含量进行全基因组关联分析。结果表明:与小麦籽粒镉元素含量...以国内外207份小麦种质为材料,利用660K SNP芯片对其进行基因型检测,并结合不同环境下表型数据和最佳线性无偏预测值(BLUP,Best linear unbiased prediction)对小麦籽粒镉元素含量进行全基因组关联分析。结果表明:与小麦籽粒镉元素含量显著关联的SNP 310个,这些SNP分布于除3D和4D外的19条染色体上,单个SNP解释变异率为10.95%~14.66%。不同环境下检测到的关联SNP结果存在差异,其中在原阳地区检测到186个SNP,开封地区检测到71个SNP。基于BLUP值分析获得53个SNP。基于SNP物理位置,将距离较近的SNP进行整合,共获得有效QTL位点52个。同时发现了7个在多环境下表现稳定的SNP,并对其进行单标记效应分析。最后对基于获得的关联SNP进行了候选基因预测,共获得7个与小麦籽粒镉元素含量相关的候选基因,其中TraesCS1B01G321700和TraesCS1B01G320200可能与镉元素调控相关基因转录有关,而TraesCS7B01G459000和TraesCS7B01G456900可能与镉元素的吸收和转运等代谢过程有关。还筛选出了对镉具有良好避性的部分小麦优异种质,如‘云麦51’‘郑麦379’‘白穗白’‘云麦53’‘双丰收’。展开更多
基金supports by National Basic Research Program of China(2010CB227006)National High-tech R&D Program(2009AA05Z216)
文摘An experimental study on the angle of repose （AoR） of pulverized coal with different particle sizes and different moisture contents （MC） was conducted. Three different measurement methods, free-base piling, fixed-base piling and sliding, were used. The data were analyzed by one-way and two-way analysis of variance. The results showed that the AoRs of pulverized coal with particle sizes smaller than 150 μm were in the range of 30-50°. The characterization of the flowability of pulverized coal was some cohesiveness or true cohesiveness. The increase of MC will increase AoR and thus decrease the flowability of the powder. However, the particle size effect is bifurcated. Below a critical size, the decrease of particle size decreases the flowability; while above the critical size, the decrease of particle size increases the flowability. It was found that the value of the critical size strongly depends on the powder density. Moreover, the AoR dependence on particle size could be linked with the Geldart＇s particle classification. The critical size at the turning point is on the boundary between Group A and Group B in Geldart＇s classification diagram. Based on the experimental results, there is no significant cross interaction between particle size and MC. The AoRs measured by free-base method and fixed-base method are close, but both remarkably smaller than that measured by the sliding method.
基金supported by the Major State Basic Research Development Program (No. 2010CB428800)the Geological Survey Projects Foundation of Institute of Hydrogeology and Environmental Geology (No. SK201308)
文摘Understanding the controlling factor of groundwater quality can enhance promoting sustainable development of groundwater resources. To this end, multivariate statistical analysis（MA） and hydrochemical analysis were introduced in this work. The results indicate that the canonical discriminant function with 7 parameters was established using the discriminant analysis（DA） method, which can afford 100% correct assignation according to the 3 different clusters（good water（GW）, poor water（PW）, and very poor water（VPW）） obtained from cluster analysis（CA）. According to factor analysis（FA）, 8 factors were extracted from 25 hydrochemical elements and account for 80.897% of the total data variance, suggesting that groundwater with higher concentrations of sodium, calcium, magnesium, chloride, and sulfate in southeastern study area are mainly affected by the natural process; the higher level of arsenic and chromium in groundwater extracted from northwestern part of study area are derived by industrial activities; domestic and agriculture sewage have important contribution to copper, iron, iodine, and phosphate in the northern study area. Therefore, this work can help identify the main controlling factor of groundwater quality in North China plain so as to make better and more informed decisions about how to achieve groundwater resources sustainable development.
基金sponsored by a research grant from the National Natural Foundation Committee:Groundwater Crisis Critical Signal and Groundwater Resources Adjustment and Control of State Project No.973(Grant No.2010CB428806)
文摘A series of environmental—geological problems have been caused by over-exploitation of deep groundwater（i.e.,confined aquifer water） in the North China Plain.In order to better understand the status of deep groundwater over-exploitation and the resultant environmental—geological problems on a regional scale,the over-exploitation of groundwater has been assessed by way of the groundwater exploitation potential coefficient（i.e.,the ratio of exploitable amount of deep groundwater to current exploitation）, cumulative land subsidence,and long-term average lowering rate of the groundwater table.There is a good correlation among the results calculated by the different methods.On a regional scale,deep groundwater has been over-exploited and there is no further exploitation potential under the current conditions.The groundwater exploitation degree index takes the exploitation in 2003 as the reference for the calculations, so the results mainly reflect the degree of current groundwater exploitation.The results of over-exploitation of deep groundwater obtained by land subsidence data and long-term average rate of depression of the water table mainly reflect environmental—geological problems caused by exploitation of deep groundwater.
基金the National Natural Science Foundation of China(Nos.U21A20374,82102903,and 52201285)Natural Science Foundation of Shanghai(No.23ZR1479300)+4 种基金Shanghai Municipal Science and Technology Major Project(No.21JC1401500)Scientific Innovation Project of Shanghai Education Committee(No.2019-01-07-00-07-E00057)Zhejiang Provincial Natural Science Foundation(No.LQ22H160005)Zhejiang Medical Health Science and Technology Program(No.2023RC031)Ningbo Yongjiang Talent Introduction Program(No.2021A-036-B).
文摘Nanozyme is a new promising approach to cancer therapy for its ability to induce ferroptosis by activating H_(2)O_(2)via a traditional radical pathway and enhance cancer immunotherapy.However,short half-life period of hydroxyl radical(·OH)results in unsatisfied effectiveness.Herein,we synthesized a single-atom iron nanozyme(Fe-SAzyme),which can activate H_(2)O_(2)via a non-radical pathway to generate Fe-based reactive oxygen species(ROS)(O=FeO_(3)=O)for promoting the ferroptosis of pancreatic cancer cells.This Fe-SAzyme could be specifically phagocytosed by pancreatic cancer cells,increasing ROS levels and inhibiting glutathione(GSH)synthesis,which activates ferroptosis.Tumor magnetic resonance imaging(MRI)showed decreased T2 signal after intravenous injection of RGD@Fe-AC(AC=activated carbon).Moreover,RGD@Fe-AC promoted dendritic cell(DC)maturation,overcame Treg-mediated immunosuppression,activated T cells to trigger adaptive immune responses,and enhanced the efficacy ofα-PD-L1 immunotherapy.Our research demonstrated that RGD@Fe-AC provided a straightforward,easily implemented,and selective approach for pancreatic cancer treatment and immunotherapy.
