目的比较胸腔镜肺楔形切除术、胸腔镜下肺段切除术和胸腔镜肺叶切除术治疗早期肺癌的疗效。方法回顾性选取2017-06-01至2019-09-30东莞市人民医院心胸外科收治的早期肺癌患者112例为研究对象。根据手术方法将患者分为A组(胸腔镜肺楔形...目的比较胸腔镜肺楔形切除术、胸腔镜下肺段切除术和胸腔镜肺叶切除术治疗早期肺癌的疗效。方法回顾性选取2017-06-01至2019-09-30东莞市人民医院心胸外科收治的早期肺癌患者112例为研究对象。根据手术方法将患者分为A组(胸腔镜肺楔形切除术,38例)、B组(胸腔镜下肺段切除术,36例)、C组(胸腔镜肺叶切除术,38例)。比较三组患者手术情况(包括手术时间、术中出血量、引流量、引流时间、淋巴结清扫个数)及住院天数,术前、术后24 h和术后72 h视觉模拟评分法(VAS)评分,术前、术后3 d、术后1个月和术后3个月肺功能指标〔包括用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))〕和炎症指标(包括白细胞计数和中性粒细胞计数),预后情况和并发症发生情况。结果B组、C组患者引流量大于A组,引流时间、住院时间长于A组(P<0.05);C组患者引流量大于B组,引流时间、住院时间长于B组(P<0.05)。手术方法与时间在VAS评分上存在交互作用(P<0.05);手术方法、时间在VAS评分上主效应显著(P<0.05)。B组、C组患者术后24、72 h VAS评分高于A组(P<0.05);C组患者术后24、72 h VAS评分高于B组(P<0.05)。A组、B组、C组患者术后24、72 h VAS评分分别高于本组术前,术后72 h VAS评分分别低于本组术后24 h(P<0.05)。手术方法与时间在FVC、FEV_(1)、白细胞计数、中性粒细胞计数上存在交互作用(P<0.05);手术方法、时间在FVC、FEV_(1)、白细胞计数、中性粒细胞计数上主效应显著(P<0.05)。B组、C组患者术后1个月、术后3个月FVC、FEV_(1)低于A组,白细胞计数、中性粒细胞计数高于A组(P<0.05);C组患者术后1个月、术后3个月FVC、FEV_(1)低于B组,白细胞计数、中性粒细胞计数高于B组(P<0.05)。A组、B组、C组患者术后3 d FVC、FEV_(1)分别低于本组术前,白细胞计数、中性粒细胞计数分别高于本组术前(P<0.05);A组、B组、C组患者术后1个月、术后3�展开更多
The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance....The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a "whole genome shotgun" approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package展开更多
通过建立和应用基于临床决策支持系统(Clinical Decision Support System,CDSS)的电子护理文书质量控制录入系统,将护理记录信息项结构化、建立录入信息决策知识库、嵌入提醒与自动生成护理任务功能,保障了电子护理文书录入的规范性、...通过建立和应用基于临床决策支持系统(Clinical Decision Support System,CDSS)的电子护理文书质量控制录入系统,将护理记录信息项结构化、建立录入信息决策知识库、嵌入提醒与自动生成护理任务功能,保障了电子护理文书录入的规范性、完整性和连续性,提高了临床电子护理文书质量,同时也可有效地指导护士的临床决策,从而减少护理差错产生。展开更多
This paper explores the capability of the“surface-protected etching”process for the creation of rattle-type SiO_(2)@void@SiO_(2) colloidal structures featuring a mesoporous silica shell and a mesoporous movable sili...This paper explores the capability of the“surface-protected etching”process for the creation of rattle-type SiO_(2)@void@SiO_(2) colloidal structures featuring a mesoporous silica shell and a mesoporous movable silica core.The surface-protected etching process involves stabilization of the particle surface using a polymer ligand,and then selective etching of the interior to form hollow structures.In this paper,this strategy has been extended to the formation of rattle-like structures by etching SiO_(2)@SiO_(2) core shell particles which are synthesized by a two-step sol gel process.The key is to introduce a protecting polymer of polyvinylpyrrolidone(PVP)to the surface of both core and shell in order to tailor their relative stability against chemical etching.Upon reacting with NaOH,the outer layer silica becomes a hollow shell as only the surface layer is protected by PVP and the interior is removed,while the core remains its original size thanks to the protection of PVP on its surface.This process can be carried out at room temperature without the need of additional templates or complicated heterogeneous coating procedures.The etching process also results in the rattle-type colloids having mesoscale pores with two distinct average sizes.In our demonstration of a model drug delivery process,such mesoporous structures show an interesting two-step elution profile which is believed to be related to the unique porous rattle structures.展开更多
文摘目的比较胸腔镜肺楔形切除术、胸腔镜下肺段切除术和胸腔镜肺叶切除术治疗早期肺癌的疗效。方法回顾性选取2017-06-01至2019-09-30东莞市人民医院心胸外科收治的早期肺癌患者112例为研究对象。根据手术方法将患者分为A组(胸腔镜肺楔形切除术,38例)、B组(胸腔镜下肺段切除术,36例)、C组(胸腔镜肺叶切除术,38例)。比较三组患者手术情况(包括手术时间、术中出血量、引流量、引流时间、淋巴结清扫个数)及住院天数,术前、术后24 h和术后72 h视觉模拟评分法(VAS)评分,术前、术后3 d、术后1个月和术后3个月肺功能指标〔包括用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))〕和炎症指标(包括白细胞计数和中性粒细胞计数),预后情况和并发症发生情况。结果B组、C组患者引流量大于A组,引流时间、住院时间长于A组(P<0.05);C组患者引流量大于B组,引流时间、住院时间长于B组(P<0.05)。手术方法与时间在VAS评分上存在交互作用(P<0.05);手术方法、时间在VAS评分上主效应显著(P<0.05)。B组、C组患者术后24、72 h VAS评分高于A组(P<0.05);C组患者术后24、72 h VAS评分高于B组(P<0.05)。A组、B组、C组患者术后24、72 h VAS评分分别高于本组术前,术后72 h VAS评分分别低于本组术后24 h(P<0.05)。手术方法与时间在FVC、FEV_(1)、白细胞计数、中性粒细胞计数上存在交互作用(P<0.05);手术方法、时间在FVC、FEV_(1)、白细胞计数、中性粒细胞计数上主效应显著(P<0.05)。B组、C组患者术后1个月、术后3个月FVC、FEV_(1)低于A组,白细胞计数、中性粒细胞计数高于A组(P<0.05);C组患者术后1个月、术后3个月FVC、FEV_(1)低于B组,白细胞计数、中性粒细胞计数高于B组(P<0.05)。A组、B组、C组患者术后3 d FVC、FEV_(1)分别低于本组术前,白细胞计数、中性粒细胞计数分别高于本组术前(P<0.05);A组、B组、C组患者术后1个月、术后3�
基金This work was sponsored by the Chinese Academy of Sciences, the Commission for Economy Planning, the Ministry of Science and Technology, the National Natural Science Foundation of China, Beijing Municipal Government, Zhejiang Provincial Government, and H
文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a "whole genome shotgun" approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package
文摘通过建立和应用基于临床决策支持系统(Clinical Decision Support System,CDSS)的电子护理文书质量控制录入系统,将护理记录信息项结构化、建立录入信息决策知识库、嵌入提醒与自动生成护理任务功能,保障了电子护理文书录入的规范性、完整性和连续性,提高了临床电子护理文书质量,同时也可有效地指导护士的临床决策,从而减少护理差错产生。
文摘This paper explores the capability of the“surface-protected etching”process for the creation of rattle-type SiO_(2)@void@SiO_(2) colloidal structures featuring a mesoporous silica shell and a mesoporous movable silica core.The surface-protected etching process involves stabilization of the particle surface using a polymer ligand,and then selective etching of the interior to form hollow structures.In this paper,this strategy has been extended to the formation of rattle-like structures by etching SiO_(2)@SiO_(2) core shell particles which are synthesized by a two-step sol gel process.The key is to introduce a protecting polymer of polyvinylpyrrolidone(PVP)to the surface of both core and shell in order to tailor their relative stability against chemical etching.Upon reacting with NaOH,the outer layer silica becomes a hollow shell as only the surface layer is protected by PVP and the interior is removed,while the core remains its original size thanks to the protection of PVP on its surface.This process can be carried out at room temperature without the need of additional templates or complicated heterogeneous coating procedures.The etching process also results in the rattle-type colloids having mesoscale pores with two distinct average sizes.In our demonstration of a model drug delivery process,such mesoporous structures show an interesting two-step elution profile which is believed to be related to the unique porous rattle structures.
