Developing low-power FETs holds significant importance in advancing logic circuits,especially as the feature size of MOSFETs approaches sub-10 nanometers.However,this has been restricted by the thermionic limitation o...Developing low-power FETs holds significant importance in advancing logic circuits,especially as the feature size of MOSFETs approaches sub-10 nanometers.However,this has been restricted by the thermionic limitation of SS,which is limited to 60 mV per decade at room temperature.Herein,we proposed a strategy that utilizes 2D semiconductors with an isolated-band feature as channels to realize subthermionic SS in MOSFETs.Through high-throughput calculations,we established a guiding principle that combines the atomic structure and orbital interaction to identify their sub-thermionic transport potential.This guides us to screen 192 candidates from the 2D material database comprising 1608 systems.Additionally,the physical relationship between the sub-thermionic transport performances and electronic structures is further revealed,which enables us to predict 15 systems with promising device performances for low-power applications with supply voltage below 0.5 V.This work opens a new way for the low-power electronics based on 2D materials and would inspire extensive interests in the experimental exploration of intrinsic steep-slope MOSFETs.展开更多
BACKGROUND:MicroRNAs(MiRNA) are a novel class of non-coding RNAs involved in the regulation of gene expression post-transcriptionally by cleavage or translational repression of their specific target miRNAs.Numerous st...BACKGROUND:MicroRNAs(MiRNA) are a novel class of non-coding RNAs involved in the regulation of gene expression post-transcriptionally by cleavage or translational repression of their specific target miRNAs.Numerous studies have demonstrated that circulating miRNAs are stable and abundant in blood and aberrantly expressed under pathological conditions,including cardiovascular diseases.The implications of circulating miRNAs in acute myocardial infarction have recently been recognized.This review will highlight the potential role of miRNA as a novel class of biomarkers in acute myocardial infarction.METHODS:This systemic review is based on our own work and other related reports.RESULTS:During diseases circulating miRNAs are derived from not only circulating blood cells but also other tissues affected by ongoing diseases.These disease-related miRNAs in the blood can serve as potential biomarkers.CONCLUSION:The circulating miRNAs can be used as novel biomarkers potentially offering more sensitive and specific tests than those currently available for diagnosis of acute myocardial infarction.展开更多
4CL(4-coumarate:coenzyme A ligase)是木质素合成途径关键酶,已被证明在生物和非生物胁迫、机械损伤抗性等生物过程中具有重要作用,但与柠檬酸分泌相关的耐铝功能还没有报道。本研究选择丹波黑大豆Gm4CL2,利用RT-PCR技术克隆其全长编...4CL(4-coumarate:coenzyme A ligase)是木质素合成途径关键酶,已被证明在生物和非生物胁迫、机械损伤抗性等生物过程中具有重要作用,但与柠檬酸分泌相关的耐铝功能还没有报道。本研究选择丹波黑大豆Gm4CL2,利用RT-PCR技术克隆其全长编码序列,蛋白质序列多重序列比对和进化树分析不同物种间的亲缘关系,农杆菌介导浸花法和叶盘法分别遗传转化拟南芥和紫花苜蓿,qRT-PCR技术检测基因的表达水平。序列分析结果发现,Gm4CL2全长编码序列为1668 bp,该基因编码555个氨基酸,为双子叶植物Ⅰ类4CL。Real-time PCR结果显示,50μmol·L^(-1) AlCl_(3)(pH 4.5)特异诱导Gm4CL2在丹波黑大豆幼苗0~2 cm的根尖组织表达;过表达Gm4CL2拟南芥,在铝处理条件下其根尖AtMATE、AtSTAR1和AtSTAR2表达量显著上调(P<0.05)。Al^(3+)胁迫条件下,过表达Gm4CL2拟南芥根相对伸长量、根尖SOD、POD活性和柠檬酸分泌量显著高于野生型,根尖伊文思蓝和铬天青S染色以及Al^(3+)、ROS、MDA含量显著低于野生型(P<0.05);过表达Gm4CL2紫花苜蓿根相对伸长率、根尖柠檬酸分泌量和生物量显著高于野生型,根尖Al^(3+)含量、伊文思蓝染色显著低于野生型(P<0.05)。细胞壁成分分析表明,Al^(3+)胁迫和非胁迫下,过表达Gm4CL2拟南芥根尖果胶、咖啡酸、阿魏酸比野生型显著降低(P<0.05);Al^(3+)胁迫下,过表达Gm4CL2拟南芥根尖木质素含量显著降低,但是4-香豆酸含量显著升高(P<0.05)。上述结果表明,Gm4CL2为耐铝基因,该基因通过促进细胞壁修饰和柠檬酸分泌提高拟南芥和紫花苜蓿的耐铝性。展开更多
基金supported by the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX22_0428)the Training Program of the Major Research Plan of the National Natural Science Foundation of China(91964103)+3 种基金the Natural Science Foundation of Jiangsu Province(BK20180071)the Fundamental Research Funds for the Central Universities(30919011109)sponsored by Qing Lan Project of Jiangsu Province,and the Six Talent Peaks Project of Jiangsu Province(XCL-035)Research Grant Council of Hong Kong(CRS_PolyU502/22).
文摘Developing low-power FETs holds significant importance in advancing logic circuits,especially as the feature size of MOSFETs approaches sub-10 nanometers.However,this has been restricted by the thermionic limitation of SS,which is limited to 60 mV per decade at room temperature.Herein,we proposed a strategy that utilizes 2D semiconductors with an isolated-band feature as channels to realize subthermionic SS in MOSFETs.Through high-throughput calculations,we established a guiding principle that combines the atomic structure and orbital interaction to identify their sub-thermionic transport potential.This guides us to screen 192 candidates from the 2D material database comprising 1608 systems.Additionally,the physical relationship between the sub-thermionic transport performances and electronic structures is further revealed,which enables us to predict 15 systems with promising device performances for low-power applications with supply voltage below 0.5 V.This work opens a new way for the low-power electronics based on 2D materials and would inspire extensive interests in the experimental exploration of intrinsic steep-slope MOSFETs.
基金supported grants from the National Natural Science Foundation of China(81000076)Priority Academic Program Development of Jiangsu Higher Education Institutions(JX10231081)
文摘BACKGROUND:MicroRNAs(MiRNA) are a novel class of non-coding RNAs involved in the regulation of gene expression post-transcriptionally by cleavage or translational repression of their specific target miRNAs.Numerous studies have demonstrated that circulating miRNAs are stable and abundant in blood and aberrantly expressed under pathological conditions,including cardiovascular diseases.The implications of circulating miRNAs in acute myocardial infarction have recently been recognized.This review will highlight the potential role of miRNA as a novel class of biomarkers in acute myocardial infarction.METHODS:This systemic review is based on our own work and other related reports.RESULTS:During diseases circulating miRNAs are derived from not only circulating blood cells but also other tissues affected by ongoing diseases.These disease-related miRNAs in the blood can serve as potential biomarkers.CONCLUSION:The circulating miRNAs can be used as novel biomarkers potentially offering more sensitive and specific tests than those currently available for diagnosis of acute myocardial infarction.
