Thermal damage of malignant tissue is generally determined not only by the characteristics of bio-tissues and nanoparticles but also the nanofluid concentration distributions due to different injection methods during ...Thermal damage of malignant tissue is generally determined not only by the characteristics of bio-tissues and nanoparticles but also the nanofluid concentration distributions due to different injection methods during magnetic hyperthermia.The latter has more advantages in improving the therapeutic effect with respect to the former since it is a determining factor for the uniformity of nanofluid concentration distribution inside the tumor region.This study investigates the effect of bio-tissue deformation due to intratumoral injection on the thermal damage behavior and treatment temperature distribution during magnetic hyperthermia,in which both the bio-tissue deformation due to nanofluid injection and the mass diffusion after injection behavior are taken into consideration.The nanofluid flow behavior is illustrated by two different theoretical models in this study,which are Navier–Stokes equation inside syringe needle and modified Darcy’s law inside bio-tissue.The diffusion behavior after nanofluid injection is expressed by a modified convection–diffusion equation.A proposed three-dimensional liver model based on the angiographic data is set to be the research object in this study,in which all bio-tissues are assumed to be deformable porous media.Simulation results demonstrate that the injection point for syringe needle can generally achieve the maximum value in the tissue pressure,deformation degree,and interstitial flow velocity during the injection process,all of which then drop sharply with the distance away from the injection center.In addition to the bio-tissue deformation due to injection behavior,the treatment temperature is also highly relevant to determine both the diffusion duration and blood perfusion rate due to the thermal damage during the therapy.展开更多
目的:系统评价白藜芦醇治疗急性心肌梗死(AMI)动物模型的效果,并对其机制进行初步探索,为临床治疗提供基础循证参考。方法:检索PubMed、Embase、Cochrane图书馆、中国知网、维普、万方数据库,收集白藜芦醇干预AMI模型的随机对照试验,对...目的:系统评价白藜芦醇治疗急性心肌梗死(AMI)动物模型的效果,并对其机制进行初步探索,为临床治疗提供基础循证参考。方法:检索PubMed、Embase、Cochrane图书馆、中国知网、维普、万方数据库,收集白藜芦醇干预AMI模型的随机对照试验,对符合纳入标准的研究进行资料提取和质量评价,采用Rev Man 5.3统计软件对研究结局指标进行Meta分析。结果:共纳入21项RCT,合计469个动物模型。Meta分析结果显示,白藜芦醇干预组(实验组)心肌梗死面积[SMD=-2.80,95%CI(-3.32,-2.37)]、左室舒张末压(LVEDP)[SMD=4.13,95%CI(-6.66,-1.6)]、肌酸激酶(CK)[SMD=-3.15,95%CI(-4.47,-1.82)]、乳酸脱氢酶(LDH)[SMD=-4.27,95%CI(-6.22,-2.33)]、丙二醛(MDA)[SMD=-3.09,95%CI(-3.36,-2.55)]均低于心肌梗死模型组(对照组),左室舒张压(LVDP)[SMD=4.61,95%CI(1.81,7.42)]、左心室最大收缩速率(+dp/dt)[SMD=4.24,95%CI(1.88,6.6)]、超氧化物歧化酶(SOD)[SMD=3.00,95%CI(2.46,3.53)]均高于对照组,且差异有统计学意义(P<0.05)。对存在计量梯度的研究进行亚组分析发现,大剂量白藜芦醇干预后,梗死面积[SMD=-1.66,95%CI(-2.35,-0,97)]、LDH[SMD=-3.23,95%CI(-5.00,-1.47)]、CK[SMD=-1.39,95%CI(-2,24,-0.54)]均低于小剂量组,且差异有统计学意义(P<0.05)。结论:白藜芦醇能降低CK、LDH、MDA,增加SOD,从而减少心肌梗死面积,达到治疗心肌梗死的目的,且剂量越大,治疗效果越强。展开更多
An open quantum battery(QB)model of a single qubit system charging in a coherent auxiliary bath(CAB)consisting of a series of independent coherent ancillae is considered.According to the collision charging protocol we...An open quantum battery(QB)model of a single qubit system charging in a coherent auxiliary bath(CAB)consisting of a series of independent coherent ancillae is considered.According to the collision charging protocol we derive a quantum master equation and obtain the analytical solution of QB in a steady state.We find that the full charging capacity(or the maximal extractable work(MEW))of QB,in the weak QB-ancilla coupling limit,is positively correlated with the coherence magnitude of ancilla.Combining with the numerical simulations we compare with the charging properties of QB at finite coupling strength,such as the MEW,average charging power and the charging efficiency,when considering the bath to be a thermal auxiliary bath(TAB)and a CAB,respectively.We find that when the QB with CAB,in the weak coupling regime,is in fully charging,both its capacity and charging efficiency can go beyond its classical counterpart,and they increase with the increase of coherence magnitude of ancilla.In addition,the MEW of QB in the regime of relative strong coupling and strong coherent magnitude shows the oscillatory behavior with the charging time increasing,and the first peak value can even be larger than the full charging MEW of QB.This also leads to a much larger average charging power than that of QB with TAB in a short-time charging process.These features suggest that with the help of quantum coherence of CAB it becomes feasible to switch the charging schemes between the long-time slow charging protocol with large capacity and high efficiency and the short-time rapid charging protocol with highly charging power only by adjusting the coupling strength of QB-ancilla.This work clearly demonstrates that the quantum coherence of bath can not only serve as the role of“fuel”of QB to be utilized to improve the QB's charging performance but also provide an alternative way to integrate the different charging protocols into a single QB.展开更多
基金Project supported by the National Natural Science Foundation of China (Grant No. 62071124)the Natural Science Foundation of Fujian Province,China (Grant No. 2020J01464)+1 种基金the Education Department of Fujian Province,China (Grant No. JAT190013)the Conselho Nacional de Desenvolvimento Cientificoe Tecnoloico (BR)(CNPq)(Grant No. 309244/2018-8)
文摘Thermal damage of malignant tissue is generally determined not only by the characteristics of bio-tissues and nanoparticles but also the nanofluid concentration distributions due to different injection methods during magnetic hyperthermia.The latter has more advantages in improving the therapeutic effect with respect to the former since it is a determining factor for the uniformity of nanofluid concentration distribution inside the tumor region.This study investigates the effect of bio-tissue deformation due to intratumoral injection on the thermal damage behavior and treatment temperature distribution during magnetic hyperthermia,in which both the bio-tissue deformation due to nanofluid injection and the mass diffusion after injection behavior are taken into consideration.The nanofluid flow behavior is illustrated by two different theoretical models in this study,which are Navier–Stokes equation inside syringe needle and modified Darcy’s law inside bio-tissue.The diffusion behavior after nanofluid injection is expressed by a modified convection–diffusion equation.A proposed three-dimensional liver model based on the angiographic data is set to be the research object in this study,in which all bio-tissues are assumed to be deformable porous media.Simulation results demonstrate that the injection point for syringe needle can generally achieve the maximum value in the tissue pressure,deformation degree,and interstitial flow velocity during the injection process,all of which then drop sharply with the distance away from the injection center.In addition to the bio-tissue deformation due to injection behavior,the treatment temperature is also highly relevant to determine both the diffusion duration and blood perfusion rate due to the thermal damage during the therapy.
文摘目的:系统评价白藜芦醇治疗急性心肌梗死(AMI)动物模型的效果,并对其机制进行初步探索,为临床治疗提供基础循证参考。方法:检索PubMed、Embase、Cochrane图书馆、中国知网、维普、万方数据库,收集白藜芦醇干预AMI模型的随机对照试验,对符合纳入标准的研究进行资料提取和质量评价,采用Rev Man 5.3统计软件对研究结局指标进行Meta分析。结果:共纳入21项RCT,合计469个动物模型。Meta分析结果显示,白藜芦醇干预组(实验组)心肌梗死面积[SMD=-2.80,95%CI(-3.32,-2.37)]、左室舒张末压(LVEDP)[SMD=4.13,95%CI(-6.66,-1.6)]、肌酸激酶(CK)[SMD=-3.15,95%CI(-4.47,-1.82)]、乳酸脱氢酶(LDH)[SMD=-4.27,95%CI(-6.22,-2.33)]、丙二醛(MDA)[SMD=-3.09,95%CI(-3.36,-2.55)]均低于心肌梗死模型组(对照组),左室舒张压(LVDP)[SMD=4.61,95%CI(1.81,7.42)]、左心室最大收缩速率(+dp/dt)[SMD=4.24,95%CI(1.88,6.6)]、超氧化物歧化酶(SOD)[SMD=3.00,95%CI(2.46,3.53)]均高于对照组,且差异有统计学意义(P<0.05)。对存在计量梯度的研究进行亚组分析发现,大剂量白藜芦醇干预后,梗死面积[SMD=-1.66,95%CI(-2.35,-0,97)]、LDH[SMD=-3.23,95%CI(-5.00,-1.47)]、CK[SMD=-1.39,95%CI(-2,24,-0.54)]均低于小剂量组,且差异有统计学意义(P<0.05)。结论:白藜芦醇能降低CK、LDH、MDA,增加SOD,从而减少心肌梗死面积,达到治疗心肌梗死的目的,且剂量越大,治疗效果越强。
基金Project supported by the National Natural Science Foundation of China (Grant Nos.11775019 and 62173213)the Natural Science Foundation of Shandong Province,China (Grant No.ZR2011FL009)the Shandong Provincial Science and Technology Support Program of Youth Innovation Team in Colleges (Grant Nos.2019KJN041 and 2020KJN005)。
文摘An open quantum battery(QB)model of a single qubit system charging in a coherent auxiliary bath(CAB)consisting of a series of independent coherent ancillae is considered.According to the collision charging protocol we derive a quantum master equation and obtain the analytical solution of QB in a steady state.We find that the full charging capacity(or the maximal extractable work(MEW))of QB,in the weak QB-ancilla coupling limit,is positively correlated with the coherence magnitude of ancilla.Combining with the numerical simulations we compare with the charging properties of QB at finite coupling strength,such as the MEW,average charging power and the charging efficiency,when considering the bath to be a thermal auxiliary bath(TAB)and a CAB,respectively.We find that when the QB with CAB,in the weak coupling regime,is in fully charging,both its capacity and charging efficiency can go beyond its classical counterpart,and they increase with the increase of coherence magnitude of ancilla.In addition,the MEW of QB in the regime of relative strong coupling and strong coherent magnitude shows the oscillatory behavior with the charging time increasing,and the first peak value can even be larger than the full charging MEW of QB.This also leads to a much larger average charging power than that of QB with TAB in a short-time charging process.These features suggest that with the help of quantum coherence of CAB it becomes feasible to switch the charging schemes between the long-time slow charging protocol with large capacity and high efficiency and the short-time rapid charging protocol with highly charging power only by adjusting the coupling strength of QB-ancilla.This work clearly demonstrates that the quantum coherence of bath can not only serve as the role of“fuel”of QB to be utilized to improve the QB's charging performance but also provide an alternative way to integrate the different charging protocols into a single QB.
