Chronic pain often develops severe mood changes such as depression.However,how chronic pain leads to depression remains elusive and the mechanisms determining individuals’responses to depression are largely unexplore...Chronic pain often develops severe mood changes such as depression.However,how chronic pain leads to depression remains elusive and the mechanisms determining individuals’responses to depression are largely unexplored.Here we found that depression-like behaviors could only be observed in 67.9%of mice with chronic neuropathic pain,leaving 32.1%of mice with depression resilience.We determined that the spike discharges of the ventral tegmental area(VTA)-projecting lateral habenula(LHb)glutamatergic(Glu)neurons were sequentially increased in sham,resilient and susceptible mice,which consequently inhibited VTA dopaminergic(DA)neurons through a LHbGlu-VTAGABA-VTADA circuit.Furthermore,the LHbGlu-VTADA excitatory inputs were dampened via GABAB receptors in a pre-synaptic manner.Regulation of LHb-VTA pathway largely affected the development of depressive symptoms caused by chronic pain.Our study thus identifies a pivotal role of the LHb-VTA pathway in coupling chronic pain with depression and highlights the activity-dependent contribution of LHbGlu-to-VTADA inhibition in depressive behavioral regulation.展开更多
According to a study from World Health Organization’s Global Burden of Disease,mental and neurological disorders have accounted for 13%of global diseases in recent years and are on the rise.Neuropsychiatric condition...According to a study from World Health Organization’s Global Burden of Disease,mental and neurological disorders have accounted for 13%of global diseases in recent years and are on the rise.Neuropsychiatric conditions or neuroinflammatory disorders are linked by the presence of an exaggerated immune response both peripherally and in the central nervous system(CNS).Cognitive dysfunction(CD)encompasses a complex group of diseases and has frequently been described in the field of autoimmune diseases,especially in multiple non-CNS-related autoimmune diseases.Recent studies have provided various hypotheses regarding the occurrence of cognitive impairment in autoimmune diseases,including that abnormally activated immune cells can disrupt the integrity of the blood-brain barrier(BBB)to trigger a central neuroinflammatory response.When the BBB is intact,autoantibodies and pro-inflammatory molecules in peripheral circulation can enter the brain to activate microglia,inducing CNS inflammation and CD.However,the mechanisms explaining the association between the immune system and neural function and their contribution to diseases are uncertain.In this review,we used clinical statistics to illustrate the correlation between CD and autoimmune diseases that do not directly affect the CNS,summarized the clinical features and mechanisms by which autoimmune diseases trigger cognitive impairment,and explored existing knowledge regarding the link between CD and autoimmune diseases from the perspective of the field of neuroimmunology.展开更多
The quantity and morphology of spheroidal graphite have an important effect on the properties of ductile iron, and the characteristics of spheroidal graphite are determined by the solidification process. The aim of th...The quantity and morphology of spheroidal graphite have an important effect on the properties of ductile iron, and the characteristics of spheroidal graphite are determined by the solidification process. The aim of this work is to explore the precipitation and evolution of graphite nodules in hypoeutectic, eutectic, and hypereutectic ductile irons by thermal analysis, liquid quenching and metallographic technique. Results show that hypoeutectic ductile iron has the longest solidification time and the lowest eutectic temperature;eutectic ductile iron has the shortest solidification time;hypereutectic ductile iron has the highest eutectic temperature. After solidification is completed, hypoeutectic ductile iron has the lowest nodule count, nodularity and graphite fraction;eutectic ductile iron has the highest nodule count, nodularity and the smallest nodule diameter;hypereutectic has the highest nodule diameter and graphite fraction. The nucleation and growth of graphite nodules in hypereutectic ductile iron starts before bulk eutectic crystallization stage, however, the precipitation and evolution of graphite nodules of hypoeutectic and eutectic ductile irons mainly occur in the eutectic crystallization stage. The graphite precipitated in eutectic crystallization of hypoeutectic, eutectic, and hypereutectic ductile irons, are 61%, 68% and 43% of total graphite volume fraction, respectively. Simultaneously, there are plenty of austenite dendrites in hypoeutectic and hypereutectic ductile irons, which are prone to shrinkage defects. Therefore, the eutectic ductile iron has the smallest shrinkage tendency.展开更多
Objective： By applying moxibustion to the eight confluent points in different periods of time, to observe the changes in thermal pain threshold latency of acupoints based on Fei Teng Ba Fa. Methods： A total of 468 h...Objective： By applying moxibustion to the eight confluent points in different periods of time, to observe the changes in thermal pain threshold latency of acupoints based on Fei Teng Ba Fa. Methods： A total of 468 healthy college student volunteers received moxibustion at the eight confluent points in three different periods of time, i.e. Chen （7：00-9：00）, Wu （11：00-13：00） and Xu （19：00-21：00）. The thermal pain threshold latency was adopted to measure the changes in pain threshold of the eight confluent points under different conditions （different periods of time, different genders, different acupoints and different states of the acupoints） based on Fei Teng Ba Fa. Results： Finally, thirty subjects dropped out and 438 subjects were included. The comparison of thermal pain threshold latencies of the eight confluent points in the same opening or closing state based on Fei Teng Ba Fa： latencies of the closing points and adjunct points were significantly different in different periods of time （P〈0.05）, the latencies of the males were significantly longer than those of the females （P〈0.05）; there was no significant difference in the latency between the left and right sides （P〉0.05）; in the female group, there was a significant difference in the latency between the lower-limb points and the upper-limb points （P〈0.05）. The comparison of thermal point threshold latencies of the eight confluent points in different opening or closing state： in the period of Wu （11：00-13：00）, the latencies of the opening points were significantly longer than those of the closing points and adjunct points （P〈0.05）; for men, their opening and closing points had significantly longer thermal pain threshold latencies than their adjunct points （P〈0.05）; despite the gender, the latencies of the upper limb opening and closing points were significantly longer than the latency of the adjunct points （P〈0.05）; in the female group, the latencies of the lower-limb ope展开更多
Enormous research focusing on solid-state electrolyte promotes the development of solid-state batteries.Compared to lithium-ion batteries using liquid electrolyte,the solid-state batteries feature the hi gh energy den...Enormous research focusing on solid-state electrolyte promotes the development of solid-state batteries.Compared to lithium-ion batteries using liquid electrolyte,the solid-state batteries feature the hi gh energy density and non-flammability,which accelerates the revolution in portable electronics and transportation.Garnet-type Li_(7)La_(3)Zr_(2)O_(12)(LLZO)solid-state electrolyte is considered as the promising solid-state electrolyte due to high ionic conductivity,Li transference number and shear modulus.However,surface contaminant and poor contact with lithium inhibit its practical application in lithium metal batteries.The review provides a brief introduction about structure and properties of LLZO.Then,we conclude the modification strategies for increasing ionic conductivity,enhancing interfacial contact and inhibiting lithium dendrite.At last,the challenge and perspectives are discussed for development of LLZO in solid-state batteries.展开更多
The falling ball tests were carried out on theΦ125 mm diameter Carbidic Austempered Ductile Iron(CADI)grinding balls with Mn content of 2.0wt.%,2.3wt.%,2.6wt.%and 3.0wt.%,respectively,and the kind of grinding ball wi...The falling ball tests were carried out on theΦ125 mm diameter Carbidic Austempered Ductile Iron(CADI)grinding balls with Mn content of 2.0wt.%,2.3wt.%,2.6wt.%and 3.0wt.%,respectively,and the kind of grinding ball with the most serious spalling was selected for stress simulation.The stress distribution between four grinding balls in the elbow of the falling ball test device when they collided with each other was simulated based on ANSYS.Results of the falling ball tests show that the spalling and mass loss of a CADI grinding ball increases with the increase of Mn content,and the CADI grinding ball with 3.0wt.%Mn shows the most obvious spalling and mass loss.The simulation results of stress distribution of a CADI grinding ball show that the maximum impact stress does not appear in the center of the contact area,but in the annular area(inner diameter of^20 mm and outer diameter of^50 mm)in the section with a depth of 5-15 mm below the grinding ball surface.The actual spalling of the ball is consistent with the simulation results,and the oxide-based impurities in CADI grinding ball accelerate the spalling of the grinding ball in service.展开更多
基金This work was supported by the National Natural Science Foundation of China(32192410,32071000,81870866,81571074,82230037,81971226,81620108008,82130034)the Foundation for Distinguished Young Scholars of ShaanXi(2019JC-21,2021JC-33)+1 种基金Young Scholar Project of the First Affiliated Hospital of Nanchang University(YFYPY202109)the Boost Plan of Xijing Hospital(XJZT21J01).
文摘Chronic pain often develops severe mood changes such as depression.However,how chronic pain leads to depression remains elusive and the mechanisms determining individuals’responses to depression are largely unexplored.Here we found that depression-like behaviors could only be observed in 67.9%of mice with chronic neuropathic pain,leaving 32.1%of mice with depression resilience.We determined that the spike discharges of the ventral tegmental area(VTA)-projecting lateral habenula(LHb)glutamatergic(Glu)neurons were sequentially increased in sham,resilient and susceptible mice,which consequently inhibited VTA dopaminergic(DA)neurons through a LHbGlu-VTAGABA-VTADA circuit.Furthermore,the LHbGlu-VTADA excitatory inputs were dampened via GABAB receptors in a pre-synaptic manner.Regulation of LHb-VTA pathway largely affected the development of depressive symptoms caused by chronic pain.Our study thus identifies a pivotal role of the LHb-VTA pathway in coupling chronic pain with depression and highlights the activity-dependent contribution of LHbGlu-to-VTADA inhibition in depressive behavioral regulation.
基金supported by distinguished Young Scientist Fund of NSFC(82125016)National Natural Science Foundation of China,Key Program(82230061)+3 种基金Zhejiang Provincial Natural Science Foundation of China(LR19C080001,LQ21H030013)supported by the National Key Research and Development Program of China(2018YFD0500100)the National Natural Science Foundation of China(81572651/81771675)the 111 Program(D20036).
文摘According to a study from World Health Organization’s Global Burden of Disease,mental and neurological disorders have accounted for 13%of global diseases in recent years and are on the rise.Neuropsychiatric conditions or neuroinflammatory disorders are linked by the presence of an exaggerated immune response both peripherally and in the central nervous system(CNS).Cognitive dysfunction(CD)encompasses a complex group of diseases and has frequently been described in the field of autoimmune diseases,especially in multiple non-CNS-related autoimmune diseases.Recent studies have provided various hypotheses regarding the occurrence of cognitive impairment in autoimmune diseases,including that abnormally activated immune cells can disrupt the integrity of the blood-brain barrier(BBB)to trigger a central neuroinflammatory response.When the BBB is intact,autoantibodies and pro-inflammatory molecules in peripheral circulation can enter the brain to activate microglia,inducing CNS inflammation and CD.However,the mechanisms explaining the association between the immune system and neural function and their contribution to diseases are uncertain.In this review,we used clinical statistics to illustrate the correlation between CD and autoimmune diseases that do not directly affect the CNS,summarized the clinical features and mechanisms by which autoimmune diseases trigger cognitive impairment,and explored existing knowledge regarding the link between CD and autoimmune diseases from the perspective of the field of neuroimmunology.
基金This work was financially supported by the National Natural Science F oundation of China(NSFC)under Grant Nos.51601054 and 51775006the Natural Science Foundation of Hebei Province of China under Grant Nos.E2017202095 and E2016202100+1 种基金the Scientific and Technological Transformative Project of Tianjin Supporting Bijing-Tianjin-Hebei under Grant No.18YFCZZC00030the Central Government Guides I.ocal Science and Technology Development Fund Projects under Grant No.206Z 1005G.
文摘The quantity and morphology of spheroidal graphite have an important effect on the properties of ductile iron, and the characteristics of spheroidal graphite are determined by the solidification process. The aim of this work is to explore the precipitation and evolution of graphite nodules in hypoeutectic, eutectic, and hypereutectic ductile irons by thermal analysis, liquid quenching and metallographic technique. Results show that hypoeutectic ductile iron has the longest solidification time and the lowest eutectic temperature;eutectic ductile iron has the shortest solidification time;hypereutectic ductile iron has the highest eutectic temperature. After solidification is completed, hypoeutectic ductile iron has the lowest nodule count, nodularity and graphite fraction;eutectic ductile iron has the highest nodule count, nodularity and the smallest nodule diameter;hypereutectic has the highest nodule diameter and graphite fraction. The nucleation and growth of graphite nodules in hypereutectic ductile iron starts before bulk eutectic crystallization stage, however, the precipitation and evolution of graphite nodules of hypoeutectic and eutectic ductile irons mainly occur in the eutectic crystallization stage. The graphite precipitated in eutectic crystallization of hypoeutectic, eutectic, and hypereutectic ductile irons, are 61%, 68% and 43% of total graphite volume fraction, respectively. Simultaneously, there are plenty of austenite dendrites in hypoeutectic and hypereutectic ductile irons, which are prone to shrinkage defects. Therefore, the eutectic ductile iron has the smallest shrinkage tendency.
文摘Objective： By applying moxibustion to the eight confluent points in different periods of time, to observe the changes in thermal pain threshold latency of acupoints based on Fei Teng Ba Fa. Methods： A total of 468 healthy college student volunteers received moxibustion at the eight confluent points in three different periods of time, i.e. Chen （7：00-9：00）, Wu （11：00-13：00） and Xu （19：00-21：00）. The thermal pain threshold latency was adopted to measure the changes in pain threshold of the eight confluent points under different conditions （different periods of time, different genders, different acupoints and different states of the acupoints） based on Fei Teng Ba Fa. Results： Finally, thirty subjects dropped out and 438 subjects were included. The comparison of thermal pain threshold latencies of the eight confluent points in the same opening or closing state based on Fei Teng Ba Fa： latencies of the closing points and adjunct points were significantly different in different periods of time （P〈0.05）, the latencies of the males were significantly longer than those of the females （P〈0.05）; there was no significant difference in the latency between the left and right sides （P〉0.05）; in the female group, there was a significant difference in the latency between the lower-limb points and the upper-limb points （P〈0.05）. The comparison of thermal point threshold latencies of the eight confluent points in different opening or closing state： in the period of Wu （11：00-13：00）, the latencies of the opening points were significantly longer than those of the closing points and adjunct points （P〈0.05）; for men, their opening and closing points had significantly longer thermal pain threshold latencies than their adjunct points （P〈0.05）; despite the gender, the latencies of the upper limb opening and closing points were significantly longer than the latency of the adjunct points （P〈0.05）; in the female group, the latencies of the lower-limb ope
基金financially supported by the National Natural Science Foundation of China(Grant No.51672156)Local Innovative Research Teams Project of Guangdong Pearl River Talents Program(Grant No.2017BT01N111)Shenzhen Technical Plan Project(Grant Nos.JCYJ20170412170706047,JCYJ20170307153806471 and GJHS20170314165324888)
文摘Enormous research focusing on solid-state electrolyte promotes the development of solid-state batteries.Compared to lithium-ion batteries using liquid electrolyte,the solid-state batteries feature the hi gh energy density and non-flammability,which accelerates the revolution in portable electronics and transportation.Garnet-type Li_(7)La_(3)Zr_(2)O_(12)(LLZO)solid-state electrolyte is considered as the promising solid-state electrolyte due to high ionic conductivity,Li transference number and shear modulus.However,surface contaminant and poor contact with lithium inhibit its practical application in lithium metal batteries.The review provides a brief introduction about structure and properties of LLZO.Then,we conclude the modification strategies for increasing ionic conductivity,enhancing interfacial contact and inhibiting lithium dendrite.At last,the challenge and perspectives are discussed for development of LLZO in solid-state batteries.
基金the Natural Science Foundation of Hebei Province of China under Grant Nos.E2016202100 and E2017202095the National Natural Science Foundation of China(NSFC)under Grant No.51601054the Scientific and Technological Transformative Project of Tianjin Supporting Beijing-Tianjin-Hebei under Grant No.18YFCZZC00030。
文摘The falling ball tests were carried out on theΦ125 mm diameter Carbidic Austempered Ductile Iron(CADI)grinding balls with Mn content of 2.0wt.%,2.3wt.%,2.6wt.%and 3.0wt.%,respectively,and the kind of grinding ball with the most serious spalling was selected for stress simulation.The stress distribution between four grinding balls in the elbow of the falling ball test device when they collided with each other was simulated based on ANSYS.Results of the falling ball tests show that the spalling and mass loss of a CADI grinding ball increases with the increase of Mn content,and the CADI grinding ball with 3.0wt.%Mn shows the most obvious spalling and mass loss.The simulation results of stress distribution of a CADI grinding ball show that the maximum impact stress does not appear in the center of the contact area,but in the annular area(inner diameter of^20 mm and outer diameter of^50 mm)in the section with a depth of 5-15 mm below the grinding ball surface.The actual spalling of the ball is consistent with the simulation results,and the oxide-based impurities in CADI grinding ball accelerate the spalling of the grinding ball in service.
