Background： Acute kidney injury （AKI） frequently occurs in cardiopulmonary resuscitation patients. Studies comparing the effects of extracorporeal membrane oxygenation （ECMO） with conventional cardiopuhnonary res...Background： Acute kidney injury （AKI） frequently occurs in cardiopulmonary resuscitation patients. Studies comparing the effects of extracorporeal membrane oxygenation （ECMO） with conventional cardiopuhnonary resuscitation （CCPR） on AKI were rare. This study aimed to compare the effects of ECMO with those of CCPR on survival rate and AKI and explore the underlying mechanisms in a swine model of cardiac arrest （CA）. Methods： Sixteen male pigs were treated with ventricular fibrillation to establish CA model and then underwent CCPR （CCPR group, n = 8） or ECMO during cardiopulmonary resuscitation （ECPR group, n = 8）. The study endpoints were 6 h after return of spontaneous circulation （ROSC） or death. Serum and urine samples were collected at baseline and during the 6 h after ROSC. The biomarkers of AKI were detected by enzyme-linked immunosorbent assay. The apoptosis of renal tubular epithelial cells was discovered by transmission electron microscope （TEM） and terminal deoxynucleotidyl transferase dUTP nick end labeling assay. Apoptosis-related genes were detected by immune-staining and Western blotting. Data were compared by Student＇s t-test. Results： All pigs in ECPR group were successfully resuscitated with a higher 6-h survival rate （8/8） compared to CCPR group （6/8）. The expressions ofAKl biomarkers including neutrophil gelatinase-associated lipocalin （NGAL）, tissue inhibitor ofmetalloproteinase2 （TIMP2）, insulin-like growth factor-binding protein 7 （IGFBP7）, liver fatty acid-binding protein （LFABP）, and kidney injury molecule l （Kim-1） were all increased along with the time after ROSC in both groups and lower in ECPR group compared with CCPR group. Especially, products of urinary T1MP and IGFBP levels （TIMP＊IGFBP） were significantly lower at ROSC4 （0.58 ± 0.10 ng^2/ml^2 vs. 1.18 ± 0.38 ng^2/ml^2, t = 4.33, P =0.003） and ROSC6 （1.79 ±0.45 ng2^/ml^2 vs. 3.00 ±0.44 ng^2/ml^2, t = 5.49, P 〈 0.001）; urinary LFABP was significant展开更多
为解决当前5G无线网络中高速移动节点信号定位不准确和高稳定分布噪声(high stable distribution noise,HSDN)等特殊偏移噪声降低定位准确性的问题,提出基于电控旋转序列位移接收结构的5G无线网络信号定位算法。利用单一节点接收结构及...为解决当前5G无线网络中高速移动节点信号定位不准确和高稳定分布噪声(high stable distribution noise,HSDN)等特殊偏移噪声降低定位准确性的问题,提出基于电控旋转序列位移接收结构的5G无线网络信号定位算法。利用单一节点接收结构及环接收结构并采取分层方式,构建电控旋转序列位移接收结构;基于待定位信号与中央基站及各层接收节点之间的切线关系,初步估计待测信号方位;针对信号发射环境中的HSDN噪声频率漂移特性,通过信号定位差分机制,联合最优极大似然估计,构建基于差分方式的方位角精度优化机制,降低定位误差。仿真结果表明,与采取单一节点接收方式的GDAM算法及采取单层环接收方式的NUPOS-1算法相比,在HSDN噪声干扰环境下,该算法具有更低的信号定位误差。展开更多
基金The study was supported by me National Natural Science Foundation of China （No. 81372025） and the 2015 Annual Special Cultivation and Development Project for the Technology Innovation Base of the Beijing Key Laboratory Cardiopulmonary Cerebral Resuscitation （No.Z 151100001615056）.
文摘Background： Acute kidney injury （AKI） frequently occurs in cardiopulmonary resuscitation patients. Studies comparing the effects of extracorporeal membrane oxygenation （ECMO） with conventional cardiopuhnonary resuscitation （CCPR） on AKI were rare. This study aimed to compare the effects of ECMO with those of CCPR on survival rate and AKI and explore the underlying mechanisms in a swine model of cardiac arrest （CA）. Methods： Sixteen male pigs were treated with ventricular fibrillation to establish CA model and then underwent CCPR （CCPR group, n = 8） or ECMO during cardiopulmonary resuscitation （ECPR group, n = 8）. The study endpoints were 6 h after return of spontaneous circulation （ROSC） or death. Serum and urine samples were collected at baseline and during the 6 h after ROSC. The biomarkers of AKI were detected by enzyme-linked immunosorbent assay. The apoptosis of renal tubular epithelial cells was discovered by transmission electron microscope （TEM） and terminal deoxynucleotidyl transferase dUTP nick end labeling assay. Apoptosis-related genes were detected by immune-staining and Western blotting. Data were compared by Student＇s t-test. Results： All pigs in ECPR group were successfully resuscitated with a higher 6-h survival rate （8/8） compared to CCPR group （6/8）. The expressions ofAKl biomarkers including neutrophil gelatinase-associated lipocalin （NGAL）, tissue inhibitor ofmetalloproteinase2 （TIMP2）, insulin-like growth factor-binding protein 7 （IGFBP7）, liver fatty acid-binding protein （LFABP）, and kidney injury molecule l （Kim-1） were all increased along with the time after ROSC in both groups and lower in ECPR group compared with CCPR group. Especially, products of urinary T1MP and IGFBP levels （TIMP＊IGFBP） were significantly lower at ROSC4 （0.58 ± 0.10 ng^2/ml^2 vs. 1.18 ± 0.38 ng^2/ml^2, t = 4.33, P =0.003） and ROSC6 （1.79 ±0.45 ng2^/ml^2 vs. 3.00 ±0.44 ng^2/ml^2, t = 5.49, P 〈 0.001）; urinary LFABP was significant
文摘为解决当前5G无线网络中高速移动节点信号定位不准确和高稳定分布噪声(high stable distribution noise,HSDN)等特殊偏移噪声降低定位准确性的问题,提出基于电控旋转序列位移接收结构的5G无线网络信号定位算法。利用单一节点接收结构及环接收结构并采取分层方式,构建电控旋转序列位移接收结构;基于待定位信号与中央基站及各层接收节点之间的切线关系,初步估计待测信号方位;针对信号发射环境中的HSDN噪声频率漂移特性,通过信号定位差分机制,联合最优极大似然估计,构建基于差分方式的方位角精度优化机制,降低定位误差。仿真结果表明,与采取单一节点接收方式的GDAM算法及采取单层环接收方式的NUPOS-1算法相比,在HSDN噪声干扰环境下,该算法具有更低的信号定位误差。
