研究黄酒对小鼠通便功能作用及便秘小鼠肠道菌群的影响。体质量、小肠墨汁推进率、首粒黑便排出时间、粪便质量实验结果表明,高剂量黄酒能够延缓小鼠体质量增长,黄酒未能显著促进便秘小鼠肠道蠕动、缩短首粒黑便排出时间,未能显著增加...研究黄酒对小鼠通便功能作用及便秘小鼠肠道菌群的影响。体质量、小肠墨汁推进率、首粒黑便排出时间、粪便质量实验结果表明,高剂量黄酒能够延缓小鼠体质量增长,黄酒未能显著促进便秘小鼠肠道蠕动、缩短首粒黑便排出时间,未能显著增加便秘小鼠粪便质量。16S r DNA测序分析结果显示,高剂量和中剂量组在物种丰富度上显著高于模型对照组(P<0.05);高剂量黄酒能够上调Akkermansia muciniphila、乳杆菌的比例;下调拟杆菌(Bacteroides)、肠球菌(Enterococcus)、梭菌(Clostridium)和变形杆菌(Proteus)的比例。在实验剂量下,未见黄酒具有明显的通便功能作用,黄酒对便秘小鼠肠道菌群结构有调节作用。展开更多
The integrated microwave photonic filter(MPF),as a compelling candidate for next-generation radio-frequency(RF)applications,has been widely investigated for decades.However,most integrated MPFs reported thus far have ...The integrated microwave photonic filter(MPF),as a compelling candidate for next-generation radio-frequency(RF)applications,has been widely investigated for decades.However,most integrated MPFs reported thus far have merely incorporated passive photonic components onto a chip-scale platform,while all necessary active devices are still bulk and discrete.Though few attempts to higher photonic integration of MPFs have been executed,the achieved filtering performances are fairly limited,which impedes the pathway to practical deployments.Here,we demonstrate,for the first time to our knowledge,an all-integrated MPF combined with high filtering performances,through hybrid integration of an In P chip-based laser and a monolithic silicon photonic circuit consisting of a dual-drive Mach–Zehnder modulator,a high-Q ring resonator,and a photodetector.This integrated MPF exhibits a high spectral resolution as narrow as 360 MHz,a wide-frequency tunable range covering the S-band to K-band(3 to 25 GHz),and a large rejection ratio of>40 d B.Moreover,the filtering response can be agilely switched between the bandpass and band-stop function with a transient respond time(48μs).Compared with previous MPFs in a similar integration level,the obtained spectral resolution in this work is dramatically improved by nearly one order of magnitude,while the valid frequency tunable range is broadened more than twice,which can satisfy the essential filtering requirements in actual RF systems.As a paradigm demonstration oriented to real-world scenarios,high-resolution RF filtering of realistic microwave signals aiming for interference rejection and channel selection is performed.Our work points out a feasible route to a miniaturized,high-performance,and cost-effective MPF leveraging hybrid integration approach,thus enabling a range of RF applications from wireless communication to radar toward the higher-frequency region,more compact size,and lower power consumption.展开更多
文摘研究黄酒对小鼠通便功能作用及便秘小鼠肠道菌群的影响。体质量、小肠墨汁推进率、首粒黑便排出时间、粪便质量实验结果表明,高剂量黄酒能够延缓小鼠体质量增长,黄酒未能显著促进便秘小鼠肠道蠕动、缩短首粒黑便排出时间,未能显著增加便秘小鼠粪便质量。16S r DNA测序分析结果显示,高剂量和中剂量组在物种丰富度上显著高于模型对照组(P<0.05);高剂量黄酒能够上调Akkermansia muciniphila、乳杆菌的比例;下调拟杆菌(Bacteroides)、肠球菌(Enterococcus)、梭菌(Clostridium)和变形杆菌(Proteus)的比例。在实验剂量下,未见黄酒具有明显的通便功能作用,黄酒对便秘小鼠肠道菌群结构有调节作用。
基金National Natural Science Foundation of China(61635001,62001010)National Key Research and Development Program of China(2020YFB2206100)+1 种基金Beijing Key Research and Development Project(Z19110004819006)China National Postdoctoral Program for Innovative Talents(BX20200017)。
文摘The integrated microwave photonic filter(MPF),as a compelling candidate for next-generation radio-frequency(RF)applications,has been widely investigated for decades.However,most integrated MPFs reported thus far have merely incorporated passive photonic components onto a chip-scale platform,while all necessary active devices are still bulk and discrete.Though few attempts to higher photonic integration of MPFs have been executed,the achieved filtering performances are fairly limited,which impedes the pathway to practical deployments.Here,we demonstrate,for the first time to our knowledge,an all-integrated MPF combined with high filtering performances,through hybrid integration of an In P chip-based laser and a monolithic silicon photonic circuit consisting of a dual-drive Mach–Zehnder modulator,a high-Q ring resonator,and a photodetector.This integrated MPF exhibits a high spectral resolution as narrow as 360 MHz,a wide-frequency tunable range covering the S-band to K-band(3 to 25 GHz),and a large rejection ratio of>40 d B.Moreover,the filtering response can be agilely switched between the bandpass and band-stop function with a transient respond time(48μs).Compared with previous MPFs in a similar integration level,the obtained spectral resolution in this work is dramatically improved by nearly one order of magnitude,while the valid frequency tunable range is broadened more than twice,which can satisfy the essential filtering requirements in actual RF systems.As a paradigm demonstration oriented to real-world scenarios,high-resolution RF filtering of realistic microwave signals aiming for interference rejection and channel selection is performed.Our work points out a feasible route to a miniaturized,high-performance,and cost-effective MPF leveraging hybrid integration approach,thus enabling a range of RF applications from wireless communication to radar toward the higher-frequency region,more compact size,and lower power consumption.
