There has recently been a dramatic renewal of interest in hadron spectroscopy and charm physics. This renaissance has been driven in part by the discovery of a plethora of charmonium-like XYZ states at BESⅢ and B fac...There has recently been a dramatic renewal of interest in hadron spectroscopy and charm physics. This renaissance has been driven in part by the discovery of a plethora of charmonium-like XYZ states at BESⅢ and B factories, and the observation of an intriguing proton-antiproton threshold enhancement and the possibly related X(1835) meson state at BESⅢ, as well as the threshold measurements of charm mesons and charm baryons. We present a detailed survey of the important topics in tau-charm physics and hadron physics that can be further explored at BESⅢ during the remaining operation period of BEPCⅡ. This survey will help in the optimization of the data-taking plan over the coming years, and provides physics motivation for the possible upgrade of BEPCⅡ to higher luminosity.展开更多
Background Acute kidney injury （AKI） has been recognized as a major healthcare problem affecting millions of patients worldwide.However,epidemiologic data concerning AKI in China are still lacking.The objectives of ...Background Acute kidney injury （AKI） has been recognized as a major healthcare problem affecting millions of patients worldwide.However,epidemiologic data concerning AKI in China are still lacking.The objectives of this study were to characterize AKI defined by RIFLE criteria,assess the association with hospital mortality,and evaluate the impact of AKI in the context of other risk factors.Methods This prospective multicenter observational study enrolled 3,063 consecutive patients from 1 July 2009 to 31 August 2009 in 22 ICUs across China's Mainland.We excluded patients who were admitted for less than 24 hours （n=1623）,younger than 18 years （n=127）,receiving chronic hemodialysis （n=29）,receiving renal transplantation （n=1） and unknown reasons （n=28）.There were 1255 patients in the final analysis.AKI was diagnosed and classified according to RIFLE criteria.Results There were 396 patients （31.6％） who had AKI,with RIFLE maximum class R,I,and F in 126 （10.0％）,91 （7.3％）,and 179 （14.3％） patients,respectively.Renal function deteriorated in 206 patients （16.4％）.In comparison with non AKI patients,patients in the risk class on ICU admission were more likely to progress to the injury class （odds ratio （OR） 3.564,95％ confidence interval （CI） 1.706-7.443,P =0.001],while patients in the risk class （OR 5.215,95％ CI 2.798-9.719,P ＜0.001） and injury class （OR 13.316,95％ CI 7.507-23.622,P ＜0.001） had a significantly higher probability of deteriorating into failure class.The adjusted hazard ratios for 90-day mortality were 1.884 for the risk group,3.401 for the injury group,and 5.306 for the failure group.Conclusions The prevalence of AKI was high among critically ill patients in Chinese ICUs.In comparison with non-AKI patients,patients with RIFLE class R or class I on ICU admission were more susceptibility to progression to class I or class F.The RIFLE criteria were robust and correlated well with clinical deterioration and mortality.展开更多
Using a dedicated data sample taken in 2018 on the J/ψpeak,we perform a detailed study of the trigger efficiencies of the BESIII detector.The efficiencies are determined from three representative physics processes,na...Using a dedicated data sample taken in 2018 on the J/ψpeak,we perform a detailed study of the trigger efficiencies of the BESIII detector.The efficiencies are determined from three representative physics processes,namely Bhabha scattering,dimuon production and generic hadronic events with charged particles.The combined efficiency of all active triggers approaches 100%in most cases,with uncertainties small enough not to affect most physics analyses.展开更多
The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of ...The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.展开更多
No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functi...No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functional disability in survivors require clinical evaluation.We performed a parallel assigned controlled,non-randomized,phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells(UC-MSCs)infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.The study enrolled 18 hospitalized patients with COVID-19(n=9 for each group).The treatment group received three cycles of intravenous infusion of UC-MSCs(3×107 cells per infusion)on days 0,3,and 6.Both groups received standard COVID-treatment regimens.Adverse events,duration of clinical symptoms,laboratory parameters,length of hospitalization,serial chest computed tomography(CT)images,the PaO2/FiO2 ratio,dynamics of cytokines,and IgG and IgM anti-SARS-CoV-2 antibodies were analyzed.No serious UC-MSCs infusion-associated adverse events were observed.Two patients receiving UC-MSCs developed transient facial flushing and fever,and one patient developed transient hypoxia at 12 h post UC-MSCs transfusion.Mechanical ventilation was required in one patient in the treatment group compared with four in the control group.All patients recovered and were discharged.Our data show that intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well tolerated.Phase 2/3 randomized,controlled,double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19.展开更多
What is already known about this topic?Acute liver failure,rhabdomyolysis,acute renal failure,and hemolysis caused by poisonous mushrooms are the most important mushroom poisoning threats to the Chinese population.The...What is already known about this topic?Acute liver failure,rhabdomyolysis,acute renal failure,and hemolysis caused by poisonous mushrooms are the most important mushroom poisoning threats to the Chinese population.The most notorious lethal mushrooms are the species from genera Amanita,Lepiota,and Galerina that cause acute liver failure,and Russula subnigricans that leads to rhabdomyolysis.What is added by this report?In 2020,the total number of investigations reached 676,involving an estimated 102 species of poisonous mushrooms,24 of which were newly recorded in China.Gyromitra venenata was newly discovered in incidents in Yunnan and Guizhou provinces and were the first reported poisonings due to gyromitrins in China since 2000.The rare poisoning Shiitake mushroom dermatitis was recorded in China.Hemolysis poisoning caused by Paxillus involutus was recorded for the second time since the beginning of the new century,resulting in one death in Inner Mongolia Autonomous Region.What are the implications for public health practice?Promoting knowledge about safe consumption of mushrooms is essential to reduce mushroom poisonings.It is not wise to collect and eat wild mushrooms.For southwestern provinces such as Yunnan,especially,caution must be exercised with unfamiliar mushroom species.展开更多
What is already known about this topic?Mushroom poisoning is becoming one of the most serious food safety issues in China,which is responsible for nearly a half of all oral poisoning deaths.What is added by this repor...What is already known about this topic?Mushroom poisoning is becoming one of the most serious food safety issues in China,which is responsible for nearly a half of all oral poisoning deaths.What is added by this report?In China,many mushrooms were previously“recorded”as poisonous.In this study,about 70 species obtained from mushroom poisoning incidents including several new records were confirmed accurately by morphological and molecular evidence in 2019,and spatial and temporal distribution characters of 13 lethal mushrooms were summarized systematically.What are the implications for public health practice?Precise and timely species identification is of pivotal importance in mushroom incidents.More efforts and cooperation are continued to be needed urgently for the governments,CDC staff,doctors and mycologists in future.展开更多
As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray as...As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results.展开更多
基金Supported in part by National Key Basic Research Program of China (2015CB856700)National Natural Science Foundation of China (NSFC) (11335008,11425524, 11625523, 11635010, 11735014, 11822506, 11935018)+18 种基金the Chinese Academy of Sciences (CAS) Large-Scale Scientific Facility Programthe CAS Center for Excellence in Particle Physics (CCEPP)Joint Large-Scale Scientific Facility Funds of the NSFC and CAS (U1532257, U1532258, U1732263)CAS Key Research Program of Frontier Science (QYZDJ-SSW-SLH003, QYZDJ-SSW-SLH040)100 Talents Program of CASCAS PIFIthe Thousand Talents Program of ChinaIN-PAC and Shanghai Key Laboratory for Particle Physics and CosmologyGerman Research Foundation DFG under Contracts NosCollaborative Research Center CRC 1044, FOR 2359Istituto Nazionale di Fisica Nucleare, ItalyKoninklijke Nederlandse Akademie van Wetenschappen (KNAW) (530-4CDP03)Ministry of Development of Turkey (DPT2006K-120470)National Science and Technology fundThe Knut and Alice Wallenberg Foundation (Sweden) (2016.0157)The Swedish Research CouncilU. S. Department of Energy (DE-FG02-05ER41374, DESC-0010118, DE-SC-0012069)University of Groningen (Ru G) and the Helmholtzzentrum fuer Schwerionenforschung Gmb H (GSI), Darmstadtthe Russian Ministry of Science and Higher Education (14.W03.31.0026).
文摘There has recently been a dramatic renewal of interest in hadron spectroscopy and charm physics. This renaissance has been driven in part by the discovery of a plethora of charmonium-like XYZ states at BESⅢ and B factories, and the observation of an intriguing proton-antiproton threshold enhancement and the possibly related X(1835) meson state at BESⅢ, as well as the threshold measurements of charm mesons and charm baryons. We present a detailed survey of the important topics in tau-charm physics and hadron physics that can be further explored at BESⅢ during the remaining operation period of BEPCⅡ. This survey will help in the optimization of the data-taking plan over the coming years, and provides physics motivation for the possible upgrade of BEPCⅡ to higher luminosity.
文摘Background Acute kidney injury （AKI） has been recognized as a major healthcare problem affecting millions of patients worldwide.However,epidemiologic data concerning AKI in China are still lacking.The objectives of this study were to characterize AKI defined by RIFLE criteria,assess the association with hospital mortality,and evaluate the impact of AKI in the context of other risk factors.Methods This prospective multicenter observational study enrolled 3,063 consecutive patients from 1 July 2009 to 31 August 2009 in 22 ICUs across China's Mainland.We excluded patients who were admitted for less than 24 hours （n=1623）,younger than 18 years （n=127）,receiving chronic hemodialysis （n=29）,receiving renal transplantation （n=1） and unknown reasons （n=28）.There were 1255 patients in the final analysis.AKI was diagnosed and classified according to RIFLE criteria.Results There were 396 patients （31.6％） who had AKI,with RIFLE maximum class R,I,and F in 126 （10.0％）,91 （7.3％）,and 179 （14.3％） patients,respectively.Renal function deteriorated in 206 patients （16.4％）.In comparison with non AKI patients,patients in the risk class on ICU admission were more likely to progress to the injury class （odds ratio （OR） 3.564,95％ confidence interval （CI） 1.706-7.443,P =0.001],while patients in the risk class （OR 5.215,95％ CI 2.798-9.719,P ＜0.001） and injury class （OR 13.316,95％ CI 7.507-23.622,P ＜0.001） had a significantly higher probability of deteriorating into failure class.The adjusted hazard ratios for 90-day mortality were 1.884 for the risk group,3.401 for the injury group,and 5.306 for the failure group.Conclusions The prevalence of AKI was high among critically ill patients in Chinese ICUs.In comparison with non-AKI patients,patients with RIFLE class R or class I on ICU admission were more susceptibility to progression to class I or class F.The RIFLE criteria were robust and correlated well with clinical deterioration and mortality.
基金Supported in part by National Key Basic Research Program of China(2015CB856700)National Natural Science Foundation of China(NSFC)(11625523,11635010,11735014,11822506,11835012,11935015,11935016,11935018,11961141012)+15 种基金the Chinese Academy of Sciences(CAS)Large-Scale Scientific Facility ProgramJoint Large-Scale Scientific Facility Funds of the NSFC and CAS(U 1732263,U 1832207)CAS Key Research Program of Frontier Sciences(QYZDJ-SSWSLH003,QYZDJ-SSW-SLH040)100 Talents Program of CASINPAC and Shanghai Key Laboratory for Particle Physics and CosmologyERC(758462)German Research Foundation DFG under Contracts Nos.Collaborative Research Center CRC 1044,FOR 2359Istituto Nazionale di Fisica Nucleare,ItalyMinistry of Development o f Turkey(DPT2006K-120470)National Science and Technology fundOlle Engkvist Foundation(200-0605)STFC(United Kingdom)The Knut and Alice Wallenberg Foundation(Sweden)(2016.0157)The Royal Society,UK(DH140054,DH160214)The Swedish Research CouncilU.S.Department of Energy(DEFG02-05ER41374,DE-SC-0012069)。
文摘Using a dedicated data sample taken in 2018 on the J/ψpeak,we perform a detailed study of the trigger efficiencies of the BESIII detector.The efficiencies are determined from three representative physics processes,namely Bhabha scattering,dimuon production and generic hadronic events with charged particles.The combined efficiency of all active triggers approaches 100%in most cases,with uncertainties small enough not to affect most physics analyses.
基金funded by the National Basic Research Program of China (973 Program, 2014CB845700)the National Natural Science Foundation of China (Grant Nos. 11390371)Funding for the project has been provided by the National Development and Reform Commission
文摘The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.
基金supported by The National Key R&D Program of China(2020YFC0841900,2020YFC0844000)The Innovation Groups of the National Natural Science Foundation of China(81721002)+2 种基金The National Science and Technology Major Project(2017YFA0105703)The Military Emergency Research Project for COVID-19(BWS20J006)The Project for Innovation of Military Medicine of China(16CXZ045).
文摘No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functional disability in survivors require clinical evaluation.We performed a parallel assigned controlled,non-randomized,phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells(UC-MSCs)infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.The study enrolled 18 hospitalized patients with COVID-19(n=9 for each group).The treatment group received three cycles of intravenous infusion of UC-MSCs(3×107 cells per infusion)on days 0,3,and 6.Both groups received standard COVID-treatment regimens.Adverse events,duration of clinical symptoms,laboratory parameters,length of hospitalization,serial chest computed tomography(CT)images,the PaO2/FiO2 ratio,dynamics of cytokines,and IgG and IgM anti-SARS-CoV-2 antibodies were analyzed.No serious UC-MSCs infusion-associated adverse events were observed.Two patients receiving UC-MSCs developed transient facial flushing and fever,and one patient developed transient hypoxia at 12 h post UC-MSCs transfusion.Mechanical ventilation was required in one patient in the treatment group compared with four in the control group.All patients recovered and were discharged.Our data show that intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well tolerated.Phase 2/3 randomized,controlled,double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19.
文摘What is already known about this topic?Acute liver failure,rhabdomyolysis,acute renal failure,and hemolysis caused by poisonous mushrooms are the most important mushroom poisoning threats to the Chinese population.The most notorious lethal mushrooms are the species from genera Amanita,Lepiota,and Galerina that cause acute liver failure,and Russula subnigricans that leads to rhabdomyolysis.What is added by this report?In 2020,the total number of investigations reached 676,involving an estimated 102 species of poisonous mushrooms,24 of which were newly recorded in China.Gyromitra venenata was newly discovered in incidents in Yunnan and Guizhou provinces and were the first reported poisonings due to gyromitrins in China since 2000.The rare poisoning Shiitake mushroom dermatitis was recorded in China.Hemolysis poisoning caused by Paxillus involutus was recorded for the second time since the beginning of the new century,resulting in one death in Inner Mongolia Autonomous Region.What are the implications for public health practice?Promoting knowledge about safe consumption of mushrooms is essential to reduce mushroom poisonings.It is not wise to collect and eat wild mushrooms.For southwestern provinces such as Yunnan,especially,caution must be exercised with unfamiliar mushroom species.
基金supported by the National Science Foundation of China(No.31501814)approved by the National Institute of Occupational Health and Poison Control Ethics Committee,Chinese Center for Disease Control and Prevention(NIOHP201904).
文摘What is already known about this topic?Mushroom poisoning is becoming one of the most serious food safety issues in China,which is responsible for nearly a half of all oral poisoning deaths.What is added by this report?In China,many mushrooms were previously“recorded”as poisonous.In this study,about 70 species obtained from mushroom poisoning incidents including several new records were confirmed accurately by morphological and molecular evidence in 2019,and spatial and temporal distribution characters of 13 lethal mushrooms were summarized systematically.What are the implications for public health practice?Precise and timely species identification is of pivotal importance in mushroom incidents.More efforts and cooperation are continued to be needed urgently for the governments,CDC staff,doctors and mycologists in future.
基金project funded by China National Space Administration(CNSA)and the Chinese Academy of Sciences(CAS)support from the National Key Research and Development Program of China(Grant No.2016YFA0400800)+1 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant Nos.XDA04010202,XDA04010300,and XDB23040400)the National Natural Science Foundation of China(Grant Nos.U1838201,and U1838102).
文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results.
