Background Transcatheter closure of coronary artery fistula （CAF） has emerged as a successful alternative to surgery. We described our experiences in 10 children patients who were accepted for transcatheter closure ...Background Transcatheter closure of coronary artery fistula （CAF） has emerged as a successful alternative to surgery. We described our experiences in 10 children patients who were accepted for transcatheter closure of CAF. Methods Ten children were 3-10 years old （seven males） with CAF who underwent percutaneous transcatheter closure between October 1995 and April 2008. Sites of origin of these fistulas were： right coronary artery in seven, left anterior descending coronary artery in two, and left circumflex coronary artery in one patient. Drainage sites of these fistulas were： right atrium in seven, right ventricle in two and left ventricle in one patient. All of these fistulas were congenital and had only one orificium fistula.Results A Cook coil was used in four patients and an Amplatzer patent ductus arteriosus （PDA） occluder was used in six patients. Checking the angiogram after the procedure revealed complete occlusion in nine patients （90%） and minimal residual flow in one （10%） patient. Technical success was achieved in all patients. Follow-up studies at short term showed complete abolition of shunt in all patients with no evidence of recanalization leading to recurrence of shunt. Conclusions Transcatheter therapy using either Cook coil or Amplatzer PDA occluder is suggested to be a safe and effective method of occlusion. The midterm outcome of the intervention for CAF is satisfactory.展开更多
Background Bare stent implantation in the treatment for native and recurrent coarctation of the aorta （CoA） has become established as an alternative to surgery and balloon angioplasty. However, this modality still e...Background Bare stent implantation in the treatment for native and recurrent coarctation of the aorta （CoA） has become established as an alternative to surgery and balloon angioplasty. However, this modality still encounters significant complications during the procedure and/or follow-up. The covered Cheatham-Platinum （CP） stent commonly used to be chosen as a rescue treatment in these patients. The purpose of this study was to evaluate the use of covered CP stent as the primary modality in the treatment for native CoA. Methods Twenty-five covered CP stents and 2 bare CP stents were implanted in 25 patients with native CoA. All patients after the intervention were invited for follow-up examinations. Results The peak systolic gradient across the lesion decreased significantly from a median value of 67.5 mmHg （quartile range, 19.3 mmHg） to 2 mmHg （quartile range, 4.0 mmHg） （P 〈0.0001）. Stenotic segment diameter increased from a median value of 5.0 mm （quartile range, 1.5 mm） to 17.9 mm （quartile range, 2.5 mm） （P 〈0.0001）. The median ratio of diameter of the coarctation postprocedure to preprocedure was 4.2 （quartile range, 1.6）. All of the CP stents were placed in the suitable position without any acute complications. During a follow-up period of up to 72 months, no complications were encountered. Most of the patients （21/25） were normotensive, apart from four patients requiring antihypertensive medication during the follow-up. Conclusion The implantation of covered CP stent as the primary modality is safe and effective in the treatment for native CoA in adolescents and adults.展开更多
The prognosis of aortic pseudoaneurysm is bad because it usually threats to life by hemorrhea.Conventional surgical repair is usually associated with high morbidity and mortality, especially in patients with poor cond...The prognosis of aortic pseudoaneurysm is bad because it usually threats to life by hemorrhea.Conventional surgical repair is usually associated with high morbidity and mortality, especially in patients with poor condition. Recent reports have shown promising results with endovascular treatment as a less invasive alternative to surgery. Fourteen patients with aortic pseudoaneurysms were treated by interventional procedure in our hospital.展开更多
Background Little is known about the influence of metabolic syndrome （MetS） on coronary artery calcification （CAC） in China. In this article, we aimed to explore the distribution of CAC in populations with and wit...Background Little is known about the influence of metabolic syndrome （MetS） on coronary artery calcification （CAC） in China. In this article, we aimed to explore the distribution of CAC in populations with and without MetS, and estimate the influence of MetS and its components on CAC in a community-based population of Beijing. Methods A total of 1647 local residents of Beijing, age 40-77 years, were recruited for a cardiovascular risk factors survey and were determined fasting plasma glucose （FPG）, blood lipids, and 64 multi-detector computed tomography （64-MDCT） coronary artery calcium score （CACS） measurement （Agatston scoring）. The distribution of CAC was described, and the influence of MetS components on CAC was evaluated. Results In this population, the prevalence and extent of CAC increased with increasing age and both were higher in MetS subjects compared to nonMetS subjects （all P 〈0.05）, with the exception of those older than 65 years old. The risk of CAC increased with increasing numbers of MetS components, and the odds ratios for predicting positive CAC in subjects with 1, 2, 3, and 〉4 MetS components were 1.60, 1.84, 2.12, and 3.12, respectively （all P 〈0.05）. Elevated blood pressure, elevated FPG, elevated triglycerides, and overweight increased the risk of CAC, yielding odds ratios of 2.64, 1.67, 1.32, and 1.37, respectively （all P 〈0.05）. Conclusions In the Beijing community-based population, MetS increases the risk of CAC. The risk of CAC increases with increasing numbers of MetS components. Not only the number, but also the variety of risk factors for MetS is correlated with the risk of CAC. Elevated blood pressure, hyperglycemia, hypertriglyceridemia and overweight increase the risk of CAC.展开更多
Transcatheter closure of congenital perimembranous ventricular septal defect （VSD） has always been a problem for cardiologists in the past decade because of the risks for interference with the valves and conduction ...Transcatheter closure of congenital perimembranous ventricular septal defect （VSD） has always been a problem for cardiologists in the past decade because of the risks for interference with the valves and conduction system. Some devices designed for other lesions have been used for closure of perimembranous VSD,^1-3 but the result is unsatisfactory because they are difficult to use and have a high incidence of complications. Until 2002,展开更多
Background Femoral artery thrombosis is one of the most common complications of catheterizations in infants and young children. This study was conducted to investigate the feasibility and effectiveness of thrombolytic...Background Femoral artery thrombosis is one of the most common complications of catheterizations in infants and young children. This study was conducted to investigate the feasibility and effectiveness of thrombolytic therapy for femoral artery thrombosis after left cardiac catheterization in children. Methods Thrombolytic therapy with urokinase was carried out in children with femoral artery thrombosis after left cardiac catheterization. Each patient was given a bolus injection of heparin （100 U/kg）. A bolus of urokinase （30 000 - 100 000 U） was injected intravenously, and then a continuous infusion of 10 000-50 000 U/h was administered. Transcatheter thrombolysis was performed once previous procedures failed. Results Eight patients （aged （3.1±2.3） years （8 months to 7 years）, body weight （13.1±4.2） kg （7 to 20 kg）） presented lower limbs ischemia after left cardiac catheterizations was performed. Seven patients accepted thrombolytic therapy with urokinase. In 5 patients, peripheral intravenous thrombolysis was successful with restoration of a normal pulse. In the other 3 cases, peripheral intravenous thrombolysis failed, followed by successful transcatheter thrombolysis. The average duration of therapy was （7.25±5.31） hours （1-17 hours）. The average doses of heparin and urokinase were （1600±723） U （800-3000 U） and （268 571±177 240） U （50 000-500 000 U）, respectively. There were no statistically significant differences in partial thromboplastin time before and during urokinase therapy （（40.6±22.3） to （49.9±39.2） seconds）. However, the prothrombin time was significantly longer （（12.7±2.58） to （48.1±18.6） seconds, P〈0.05）. Patency of the target vessel was evaluated in all the patients for 2 weeks and no occlusion recurred. Conclusion Thrombolytic therapy with urokinase is a safe and useful modality in children with femoral artery thrombosis after left cardiac catheterization.展开更多
Potential behavior prediction involves understanding the latent human behavior of specific groups,and can assist organizations in making strategic decisions.Progress in information technology has made it possible to a...Potential behavior prediction involves understanding the latent human behavior of specific groups,and can assist organizations in making strategic decisions.Progress in information technology has made it possible to acquire more and more data about human behavior.In this paper,we examine behavior data obtained in realworld scenarios as an information network composed of two types of objects(humans and actions)associated with various attributes and three types of relationships(human-human,human-action,and action-action),which we call the heterogeneous behavior network(HBN).To exploit the abundance and heterogeneity of the HBN,we propose a novel network embedding method,human-action-attribute-aware heterogeneous network embedding(a4 HNE),which jointly considers structural proximity,attribute resemblance,and heterogeneity fusion.Experiments on two real-world datasets show that this approach outperforms other similar methods on various heterogeneous information network mining tasks for potential behavior prediction.展开更多
文摘Background Transcatheter closure of coronary artery fistula （CAF） has emerged as a successful alternative to surgery. We described our experiences in 10 children patients who were accepted for transcatheter closure of CAF. Methods Ten children were 3-10 years old （seven males） with CAF who underwent percutaneous transcatheter closure between October 1995 and April 2008. Sites of origin of these fistulas were： right coronary artery in seven, left anterior descending coronary artery in two, and left circumflex coronary artery in one patient. Drainage sites of these fistulas were： right atrium in seven, right ventricle in two and left ventricle in one patient. All of these fistulas were congenital and had only one orificium fistula.Results A Cook coil was used in four patients and an Amplatzer patent ductus arteriosus （PDA） occluder was used in six patients. Checking the angiogram after the procedure revealed complete occlusion in nine patients （90%） and minimal residual flow in one （10%） patient. Technical success was achieved in all patients. Follow-up studies at short term showed complete abolition of shunt in all patients with no evidence of recanalization leading to recurrence of shunt. Conclusions Transcatheter therapy using either Cook coil or Amplatzer PDA occluder is suggested to be a safe and effective method of occlusion. The midterm outcome of the intervention for CAF is satisfactory.
文摘Background Bare stent implantation in the treatment for native and recurrent coarctation of the aorta （CoA） has become established as an alternative to surgery and balloon angioplasty. However, this modality still encounters significant complications during the procedure and/or follow-up. The covered Cheatham-Platinum （CP） stent commonly used to be chosen as a rescue treatment in these patients. The purpose of this study was to evaluate the use of covered CP stent as the primary modality in the treatment for native CoA. Methods Twenty-five covered CP stents and 2 bare CP stents were implanted in 25 patients with native CoA. All patients after the intervention were invited for follow-up examinations. Results The peak systolic gradient across the lesion decreased significantly from a median value of 67.5 mmHg （quartile range, 19.3 mmHg） to 2 mmHg （quartile range, 4.0 mmHg） （P 〈0.0001）. Stenotic segment diameter increased from a median value of 5.0 mm （quartile range, 1.5 mm） to 17.9 mm （quartile range, 2.5 mm） （P 〈0.0001）. The median ratio of diameter of the coarctation postprocedure to preprocedure was 4.2 （quartile range, 1.6）. All of the CP stents were placed in the suitable position without any acute complications. During a follow-up period of up to 72 months, no complications were encountered. Most of the patients （21/25） were normotensive, apart from four patients requiring antihypertensive medication during the follow-up. Conclusion The implantation of covered CP stent as the primary modality is safe and effective in the treatment for native CoA in adolescents and adults.
文摘The prognosis of aortic pseudoaneurysm is bad because it usually threats to life by hemorrhea.Conventional surgical repair is usually associated with high morbidity and mortality, especially in patients with poor condition. Recent reports have shown promising results with endovascular treatment as a less invasive alternative to surgery. Fourteen patients with aortic pseudoaneurysms were treated by interventional procedure in our hospital.
文摘Background Little is known about the influence of metabolic syndrome （MetS） on coronary artery calcification （CAC） in China. In this article, we aimed to explore the distribution of CAC in populations with and without MetS, and estimate the influence of MetS and its components on CAC in a community-based population of Beijing. Methods A total of 1647 local residents of Beijing, age 40-77 years, were recruited for a cardiovascular risk factors survey and were determined fasting plasma glucose （FPG）, blood lipids, and 64 multi-detector computed tomography （64-MDCT） coronary artery calcium score （CACS） measurement （Agatston scoring）. The distribution of CAC was described, and the influence of MetS components on CAC was evaluated. Results In this population, the prevalence and extent of CAC increased with increasing age and both were higher in MetS subjects compared to nonMetS subjects （all P 〈0.05）, with the exception of those older than 65 years old. The risk of CAC increased with increasing numbers of MetS components, and the odds ratios for predicting positive CAC in subjects with 1, 2, 3, and 〉4 MetS components were 1.60, 1.84, 2.12, and 3.12, respectively （all P 〈0.05）. Elevated blood pressure, elevated FPG, elevated triglycerides, and overweight increased the risk of CAC, yielding odds ratios of 2.64, 1.67, 1.32, and 1.37, respectively （all P 〈0.05）. Conclusions In the Beijing community-based population, MetS increases the risk of CAC. The risk of CAC increases with increasing numbers of MetS components. Not only the number, but also the variety of risk factors for MetS is correlated with the risk of CAC. Elevated blood pressure, hyperglycemia, hypertriglyceridemia and overweight increase the risk of CAC.
文摘Transcatheter closure of congenital perimembranous ventricular septal defect （VSD） has always been a problem for cardiologists in the past decade because of the risks for interference with the valves and conduction system. Some devices designed for other lesions have been used for closure of perimembranous VSD,^1-3 but the result is unsatisfactory because they are difficult to use and have a high incidence of complications. Until 2002,
文摘Background Femoral artery thrombosis is one of the most common complications of catheterizations in infants and young children. This study was conducted to investigate the feasibility and effectiveness of thrombolytic therapy for femoral artery thrombosis after left cardiac catheterization in children. Methods Thrombolytic therapy with urokinase was carried out in children with femoral artery thrombosis after left cardiac catheterization. Each patient was given a bolus injection of heparin （100 U/kg）. A bolus of urokinase （30 000 - 100 000 U） was injected intravenously, and then a continuous infusion of 10 000-50 000 U/h was administered. Transcatheter thrombolysis was performed once previous procedures failed. Results Eight patients （aged （3.1±2.3） years （8 months to 7 years）, body weight （13.1±4.2） kg （7 to 20 kg）） presented lower limbs ischemia after left cardiac catheterizations was performed. Seven patients accepted thrombolytic therapy with urokinase. In 5 patients, peripheral intravenous thrombolysis was successful with restoration of a normal pulse. In the other 3 cases, peripheral intravenous thrombolysis failed, followed by successful transcatheter thrombolysis. The average duration of therapy was （7.25±5.31） hours （1-17 hours）. The average doses of heparin and urokinase were （1600±723） U （800-3000 U） and （268 571±177 240） U （50 000-500 000 U）, respectively. There were no statistically significant differences in partial thromboplastin time before and during urokinase therapy （（40.6±22.3） to （49.9±39.2） seconds）. However, the prothrombin time was significantly longer （（12.7±2.58） to （48.1±18.6） seconds, P〈0.05）. Patency of the target vessel was evaluated in all the patients for 2 weeks and no occlusion recurred. Conclusion Thrombolytic therapy with urokinase is a safe and useful modality in children with femoral artery thrombosis after left cardiac catheterization.
基金Project supported by the National Natural Science Foundation of China(Nos.U1509206,61625107,and U1611461)the Key Program of Zhejiang Province,China(No.2015C01027).
文摘Potential behavior prediction involves understanding the latent human behavior of specific groups,and can assist organizations in making strategic decisions.Progress in information technology has made it possible to acquire more and more data about human behavior.In this paper,we examine behavior data obtained in realworld scenarios as an information network composed of two types of objects(humans and actions)associated with various attributes and three types of relationships(human-human,human-action,and action-action),which we call the heterogeneous behavior network(HBN).To exploit the abundance and heterogeneity of the HBN,we propose a novel network embedding method,human-action-attribute-aware heterogeneous network embedding(a4 HNE),which jointly considers structural proximity,attribute resemblance,and heterogeneity fusion.Experiments on two real-world datasets show that this approach outperforms other similar methods on various heterogeneous information network mining tasks for potential behavior prediction.
