Hemophagocytic lymphohistiocytosis(HLH)is a cytokine storm syndrome caused by an overactive but ineffective immune reaction.Without prompt diagnosis and treatment,HLH is life-threatening.However,presenting symptoms ar...Hemophagocytic lymphohistiocytosis(HLH)is a cytokine storm syndrome caused by an overactive but ineffective immune reaction.Without prompt diagnosis and treatment,HLH is life-threatening.However,presenting symptoms are often nonspecific,with fatigue and fever being the most common.A high index of suspicion is therefore critical for early diagnosis and timely management.A previously healthy,65-year-old female who initially presented with fever and abdominal pain developed abdominal compartment syndrome(ACS)requiring decompressive laparotomy on hospital day 6.Intraoperative frozen sections of biopsied liver showed intense portal lymphohistiocytic infiltrates.Epstein-Barr virus DNA copy numbers escalated from 600 copies/mL after admission to 134,000 copies/mL before death.The diagnostic criteria of HLH-2004 were met.Patient expired on hospital day 12.It is important to raise awareness of ACS being an unusual presentation of HLH.Recent changes in diagnostic criteria tailored to adult HLH cases are reviewed.展开更多
In this paper,we report a real-time Fast Radio Burst(FRB)searching system that has been successfully implemented with the 19 beam receiver of the Five-hundred-meter Aperture Spherical radio Telescope(FAST).The relativ...In this paper,we report a real-time Fast Radio Burst(FRB)searching system that has been successfully implemented with the 19 beam receiver of the Five-hundred-meter Aperture Spherical radio Telescope(FAST).The relatively small field of view of FAST makes the search for new FRBs challenging,but its high sensitivity significantly improves the accuracy of FRB localization and enables the detection of high-precision neutral hydrogen absorption lines generated by FRBs.Our goal is to develop an FRB searching system capable of realtime detection of FRBs that allows high-time resolution spectro-temporal studies among the repeated bursts,as well as detailed investigations of these bursts and exploration of FRB progenitor models.The data from each beam of the 19-beam receiver are fed into a high-performance computing node server,which performs real-time searches for pulses with a wide dispersion measure(DM)range of 20–10,000 pc cm^(-3) with step efficiency of 25%in real time.Then,the head node server aggregates all the candidate signals from each beam within a given time,determining their authenticity based on various criteria,including arrival time,pulse width,signal-to-noise ratio and coincidence patterns among the 19 beams.Within the 1.05–1.45 GHz operating bandwidth of the FAST 19beam receiver,the system achieves a frequency resolution of 122.07 kHz and a time resolution of 270.336μs.Subsequently,our team detected a series of bursts with a DM of 566 on 2019 August 30 confirming them as FRB121102.The FRB searching system enables the 19-beam receiver of FAST to detect repeated/one-off pulses/bursts in real time.展开更多
文摘Hemophagocytic lymphohistiocytosis(HLH)is a cytokine storm syndrome caused by an overactive but ineffective immune reaction.Without prompt diagnosis and treatment,HLH is life-threatening.However,presenting symptoms are often nonspecific,with fatigue and fever being the most common.A high index of suspicion is therefore critical for early diagnosis and timely management.A previously healthy,65-year-old female who initially presented with fever and abdominal pain developed abdominal compartment syndrome(ACS)requiring decompressive laparotomy on hospital day 6.Intraoperative frozen sections of biopsied liver showed intense portal lymphohistiocytic infiltrates.Epstein-Barr virus DNA copy numbers escalated from 600 copies/mL after admission to 134,000 copies/mL before death.The diagnostic criteria of HLH-2004 were met.Patient expired on hospital day 12.It is important to raise awareness of ACS being an unusual presentation of HLH.Recent changes in diagnostic criteria tailored to adult HLH cases are reviewed.
基金the International Partnership Program of the Chinese Academy of Sciences No.114A11-KYSB20200029the National Natural Science Foundation of China(NSFC,Grant No.12041301)the National Key R&D Program of China No.2020YC2201700。
文摘In this paper,we report a real-time Fast Radio Burst(FRB)searching system that has been successfully implemented with the 19 beam receiver of the Five-hundred-meter Aperture Spherical radio Telescope(FAST).The relatively small field of view of FAST makes the search for new FRBs challenging,but its high sensitivity significantly improves the accuracy of FRB localization and enables the detection of high-precision neutral hydrogen absorption lines generated by FRBs.Our goal is to develop an FRB searching system capable of realtime detection of FRBs that allows high-time resolution spectro-temporal studies among the repeated bursts,as well as detailed investigations of these bursts and exploration of FRB progenitor models.The data from each beam of the 19-beam receiver are fed into a high-performance computing node server,which performs real-time searches for pulses with a wide dispersion measure(DM)range of 20–10,000 pc cm^(-3) with step efficiency of 25%in real time.Then,the head node server aggregates all the candidate signals from each beam within a given time,determining their authenticity based on various criteria,including arrival time,pulse width,signal-to-noise ratio and coincidence patterns among the 19 beams.Within the 1.05–1.45 GHz operating bandwidth of the FAST 19beam receiver,the system achieves a frequency resolution of 122.07 kHz and a time resolution of 270.336μs.Subsequently,our team detected a series of bursts with a DM of 566 on 2019 August 30 confirming them as FRB121102.The FRB searching system enables the 19-beam receiver of FAST to detect repeated/one-off pulses/bursts in real time.
