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抗癫癎药物应用指南Ⅰ:新型抗癫癎药物的药力和安全性:新发癫癎的治疗 美国神经病学学会治疗学和技术评定分委会和质量标准分委会及美国癫癎协会报告 被引量:5
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作者 高枚春 陆钦池 +23 位作者 j.A.French A.M.Kanner j.bautista B.Abou-Khalil T.Browne C.L.Harden W.H.Theodore C.Bazil j.Stern S.C.Schachter D.Bergen D.Hirtz G.D.Montouris M.Nespeca B.Gidal W.j.Marks W.R.Turk j.H.Fischer B.Bourgeois A.Wilner R.E.Faught R.C.Sachdeo A.Beydoun T.A.Glauser 《神经病学与神经康复学杂志》 2008年第3期190-197,共8页
目的对有关7种用以治疗儿童和成人新诊断部分性和全身性癫癎的新型抗癫癎药物(AEDs):加巴喷丁(gabapentin,GBP)、拉莫三嗪(lamotrigine,LTG)、托吡酯(topiramate,TPM)、噻加宾(tiagabine,TGB)、奥卡西平(oxcarbazepine,OXC)、左乙拉西坦... 目的对有关7种用以治疗儿童和成人新诊断部分性和全身性癫癎的新型抗癫癎药物(AEDs):加巴喷丁(gabapentin,GBP)、拉莫三嗪(lamotrigine,LTG)、托吡酯(topiramate,TPM)、噻加宾(tiagabine,TGB)、奥卡西平(oxcarbazepine,OXC)、左乙拉西坦(levetiracetam,LEV)和唑尼沙胺(zonisamide,ZNS)的药力(efficacy)、耐受性和安全性按序进行评估(这些药物已受到美国食品与药品管理局FDA的批准)。方法由23位成人神经病学家、儿科神经病学家、癫癎病学家及药理学家组成的,依据从1987年到2002年9月Medline,Current Contents和Cochrane上发表的相关文献和2003年以前的指南提供的证据进行专家组循证医学评估。结果有证据通过对照试验或剂量控制试验显示:加巴喷丁、拉莫三嗪、托吡酯和奥卡西平单药治疗对新诊断的青少年和成人部分性或混合性癫癎是有效的。亦有证据显示,拉莫三嗪对于新诊断的儿童失神发作有效。但尚缺乏证据证明新型抗癫癎药物对新诊断的其他类型的全身性癫癎综合征是否有效。结论循证医学评估结果提供了新诊断癫癎患者的抗癫癎药物应用指南,但尚需更多的证据用以鉴定其在癫癎的类型或综合征中的疗效。 展开更多
关键词 抗癫药物 新诊断 噻加宾 加巴喷丁 癫癎 卡马西平 托吡酯 妥泰 拉莫三嗪 利必通 抗癫癎药物 丙戊酸盐 苯妥英钠 抗心律失常药 奥卡西平 部分性 应用指南 技术评定 治疗学 临床医学 质量
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抗癫癎药物应用指南Ⅱ:新型抗癫癎药物的药力和耐受性:难治性癫癎的治疗美国神经病学学会治疗学和技术评定分委会和质量标准分委会及美国癫癎协会报告 被引量:1
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作者 陆钦池 冯智英 +27 位作者 李颖 季伟华 j.A.French A.M.Kanner j.bautista B.Abou-Khalil T.Browne C.L.Harden W.H.Theodore C.Bazil j.Stern S.C.Schachter D.Bergen D.Hirtz G.D.Montouris M.Nespeca B.Gidal W.j.Marks jr. W.R.Turk j.H.Fischer B.Bourgeois A.Wilner R.E.Faught jr. R.C.Sachdeo A.Beydoun T.A.Glauser 《神经病学与神经康复学杂志》 2008年第4期265-277,共13页
目的对有关7种用以治疗儿童和成人部分性和全面性难治性癫癎的新型抗癫癎药物(AEDs):加巴喷丁(gabapentin, GBP)、拉莫三嗪(lamotrigine,LTG)、托吡酯(topiramate,TPM)、噻加宾(tiagabine,TGB)、奥卡西平(oxcarbazepine,OXC)、左乙拉西... 目的对有关7种用以治疗儿童和成人部分性和全面性难治性癫癎的新型抗癫癎药物(AEDs):加巴喷丁(gabapentin, GBP)、拉莫三嗪(lamotrigine,LTG)、托吡酯(topiramate,TPM)、噻加宾(tiagabine,TGB)、奥卡西平(oxcarbazepine,OXC)、左乙拉西坦(levetiracetam,LEV)和唑尼沙胺(zonisamide,ZNS)的药力(efficacy)、耐受性和安全性进行评估。方法由23位成人神经病学家、小儿神经病学家、癫癎病学家和药理学家组成的专家组,依据从1987年到2002年9月Medline,Current Contents和Cochrane上发表的相关文献和2003年以前的指南提供的证据进行循证医学评估。结果所有新型抗癫癎药物都适用于成人难治性部分性癫癎的添加治疗,加巴喷丁对混合性癎性发作有效,加巴喷丁、拉莫三嗪、托吡酯和奥卡西平对儿童难治性部分性癫癎有效。有限的证据还表明,拉莫三嗪和托吡酯对成人和儿童特发性全面性发作和Lennox-Gastaut综合征的添加治疗也有效。结论抗癫癎药物的选择要考虑癫癎发作和/或癫癎综合征的类型、患者的年龄、合用的药物、药物的耐受性、安全性和药力等因素。循证医学评估结果提供了难治性癫癎患者的抗癫癎药物应用指南,但尚需更为有力的证据用以鉴定其在癫癎型或综合征中疗效。 展开更多
关键词 药物 应用指南 耐受性 难治性癫 治疗学 美国 神经病学 技术评定 质量 标准分 ANTIEPILEPTIC drugs new society american quality technology refractory epilepsy 拉莫三嗪 加巴喷丁 托吡酯
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添加粉煤灰和高炉矿渣对三元混凝土耐久性和氯离子渗透性的影响 被引量:1
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作者 W.Aperador A.Delgado +1 位作者 j.bautista-Ruiz 代顺发 《江西建材》 2018年第9期33-35,共3页
为研究硅酸盐水泥、粉煤灰和细磨粒化高炉矿渣对混凝土抗压强度和抗腐蚀性能的影响,本试验设计配置了掺合以上三种成分的三元混凝土。其中,部分硅酸盐水泥可采用水/水泥比例(w/c)为0.5的替代材料。通过抗压试验和半电池电位法来评估其... 为研究硅酸盐水泥、粉煤灰和细磨粒化高炉矿渣对混凝土抗压强度和抗腐蚀性能的影响,本试验设计配置了掺合以上三种成分的三元混凝土。其中,部分硅酸盐水泥可采用水/水泥比例(w/c)为0.5的替代材料。通过抗压试验和半电池电位法来评估其抗压强度和耐腐蚀性能。试验结果表明,粉煤灰和高炉矿渣可大幅度降低混凝土的氯离子渗透性,并提高混凝土的短期和长期抗腐蚀性能。综上所述,添加粉煤灰和高炉矿渣可有效控制因氯离子渗透引起的腐蚀。 展开更多
关键词 硅酸盐水泥 粉煤灰 高炉矿渣 三元混凝土 抗压强度 抗腐蚀性
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Application of Anodic Oxidation with Graphite Electrodes in Pretreated Leachates
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作者 T.j.Sanchez-Sanchez H.A.Najera-Aguilar +4 位作者 R.F.Gutierrez-Hernandez C.M.Garcia-Lara j.A.Araiza-Aguilar j.A.bautista-Ramirez j.H.Castanon-Gonzalez 《Open Journal of Applied Sciences》 2020年第3期69-77,共9页
Currently, landfills are the main method used for the final disposal of urban solid waste. The degradation processes that waste goes through in these sites, alongside rainwater that percolates through them, generate h... Currently, landfills are the main method used for the final disposal of urban solid waste. The degradation processes that waste goes through in these sites, alongside rainwater that percolates through them, generate highly polluting liquids (leachate). In the treatment of leachate, advanced oxidation processes (AOP) can significantly reduce the concentrations of different pollutants. Due to the high documented potential around AOPs, in this study, the effectiveness of anodic oxidation in the removal of the remaining organic load in leachates pretreated in a biological system was evaluated. Graphite electrodes were used as anode and cathode. The efficiency of anodic oxidation, in terms of the removal of chemical oxygen demand (COD) and color, was evaluated under different current densities (7, 12, 17 and 22 mA/cm2) and pH values (3, 4.5 and 6). Under the best conditions found (22 mA/cm2 and pH of 6) and with an oxidation time of 5 hours, a maximum removal of 68% in COD and 91% in color was achieved, which represented a quality in the final effluent of 271 mg/L and 151 Pt-Co in COD and color, respectively. Therefore, considering that graphite is an economic and widely available material, the results obtained show anodic oxidation, with the use of graphite electrodes, as a technically viable alternative as a final purification stage for pretreated leachates. 展开更多
关键词 Anodic Oxidation Graphite Electrodes Advanced Oxidation Processes
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Clinical and microbiological features of vulvovaginitis in Mexican girls
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作者 Mario I.Ortiz Edna j.Arreola-bautista +2 位作者 Beatriz A.Sánchez-Reyes Georgina Romo-Hernández Marco A.Escamilla-Acosta 《Open Journal of Obstetrics and Gynecology》 2013年第2期243-248,共6页
Study Objective: To determine the prevalence of vulvovaginitis, predisposing factors, microbial etiology and therapy in patients treated at the Hospital del Nino DIF, Pachuca, Hidalgo, Mexico. Design. This was an obse... Study Objective: To determine the prevalence of vulvovaginitis, predisposing factors, microbial etiology and therapy in patients treated at the Hospital del Nino DIF, Pachuca, Hidalgo, Mexico. Design. This was an observational and descriptive study from 2006 to 2009. Setting: Hospital del Nino DIF, Pachuca, Hidalgo, Mexico. Participants. Patients from 0 to 16 years, with vulvovaginitis and/or vaginal discharge were included. Interventions: None. Main Outcome Measures: Demographic data, etiology, clinical features, risk factors and therapy were analyzed. Results: Four hundred twenty seven patients with diagnosis of vulvovaginitis were included. The average prevalence to 4 years in the study period was 0.19%. The age group most affected was schoolchildren (225 cases: 52.69%). The main signs and symptoms presented were leucorrhea (99.3%), vaginal hyperemia (32.6%), vulvar itching (32.1%) and erythema (28.8%). Identified risk factors were poor hygiene (15.7%), urinary tract infection (14.7%), intestinal parasites (5.6%) and obesity or overweight (3.3%). The main microorganisms found in vaginal cultures were enterobacteriaceae (Escherichia coli, Klebsiella and Enterococcus faecalis), Staphylococcus spp, and Gardnerella vaginalis. Several inconsistent were found in the drug prescription of the patients. Conclusion: Vulvovaginitis prevalence in Mexican girls is low and this was caused mainly by opportunist microorganisms. The initial treatment of vulvovaginitis must include hygienic measure and an antimicrobial according to the clinical features and microorganism found. 展开更多
关键词 VULVOVAGINITIS PREVALENCE Etiologic Microorganisms Mexican Children and Adolescents
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