The Severe Acute Respiratory Syndrome CoronaVirus 2(SARS-CoV-2)virus spread the novel CoronaVirus−19(nCoV-19)pandemic,resulting in millions of fatalities globally.Recent research demonstrated that the Protein-Protein ...The Severe Acute Respiratory Syndrome CoronaVirus 2(SARS-CoV-2)virus spread the novel CoronaVirus−19(nCoV-19)pandemic,resulting in millions of fatalities globally.Recent research demonstrated that the Protein-Protein Interaction(PPI)between SARS-CoV-2 and human proteins is accountable for viral pathogenesis.However,many of these PPIs are poorly understood and unexplored,necessitating a more in-depth investigation to find latent yet critical interactions.This article elucidates the host-viral PPI through Machine Learning(ML)lenses and validates the biological significance of the same using web-based tools.ML classifiers are designed based on comprehensive datasets with five sequence-based features of human proteins,namely Amino Acid Composition,Pseudo Amino Acid Composition,Conjoint Triad,Dipeptide Composition,and Normalized Auto Correlation.A majority voting rule-based ensemble method composed of the Random Forest Model(RFM),AdaBoost,and Bagging technique is proposed that delivers encouraging statistical performance compared to other models employed in this work.The proposed ensemble model predicted a total of 111 possible SARS-CoV-2 human target proteins with a high likelihood factor≥70%,validated by utilizing Gene Ontology(GO)and KEGG pathway enrichment analysis.Consequently,this research can aid in a deeper understanding of the molecular mechanisms underlying viral pathogenesis and provide clues for developing more efficient anti-COVID medications.展开更多
A regional climate model (RegCM3) nested within ERA40 re-analyzed data is used to investigate the climate effects of land use change over China. Two 15-year simulations (1987―2001), one with current land use and the ...A regional climate model (RegCM3) nested within ERA40 re-analyzed data is used to investigate the climate effects of land use change over China. Two 15-year simulations (1987―2001), one with current land use and the other with potential vegetation cover without human intervention, are conducted for a domain encompassing China. The climate impacts of land use change are assessed from the difference between the two simulations. Results show that the current land use (modified by anthropogenic ac- tivities) influences local climate as simulated by the model through the reinforcement of the monsoon circulation in both the winter and summer seasons and through changes of the surface energy budget. In winter, land use change leads to reduced precipitation and decreased surface air temperature south of the Yangtze River, and increased precipitation north of the Yangtze River. Land use change signifi- cantly affects summer climate in southern China, yielding increased precipitation over the region, de- creased temperature along the Yangtze River and increased temperature in the South China area (south-end of China). In summer, a reduction of precipitation over northern China and a temperature rise over Northwest China are also simulated. Both daily maximum and minimum temperatures are affected in the simulations. In general, the current land use in China leads to enhanced mean annual precipitation and decreased annual temperature over south China along with decreased precipitation over North China.展开更多
文摘The Severe Acute Respiratory Syndrome CoronaVirus 2(SARS-CoV-2)virus spread the novel CoronaVirus−19(nCoV-19)pandemic,resulting in millions of fatalities globally.Recent research demonstrated that the Protein-Protein Interaction(PPI)between SARS-CoV-2 and human proteins is accountable for viral pathogenesis.However,many of these PPIs are poorly understood and unexplored,necessitating a more in-depth investigation to find latent yet critical interactions.This article elucidates the host-viral PPI through Machine Learning(ML)lenses and validates the biological significance of the same using web-based tools.ML classifiers are designed based on comprehensive datasets with five sequence-based features of human proteins,namely Amino Acid Composition,Pseudo Amino Acid Composition,Conjoint Triad,Dipeptide Composition,and Normalized Auto Correlation.A majority voting rule-based ensemble method composed of the Random Forest Model(RFM),AdaBoost,and Bagging technique is proposed that delivers encouraging statistical performance compared to other models employed in this work.The proposed ensemble model predicted a total of 111 possible SARS-CoV-2 human target proteins with a high likelihood factor≥70%,validated by utilizing Gene Ontology(GO)and KEGG pathway enrichment analysis.Consequently,this research can aid in a deeper understanding of the molecular mechanisms underlying viral pathogenesis and provide clues for developing more efficient anti-COVID medications.
基金Supported jointly by the National Key Program for Developin Basic Sciences (2006CB400506)the Open Research Fund of Laboratory for Climate Studies, China Meteorological Administration
文摘A regional climate model (RegCM3) nested within ERA40 re-analyzed data is used to investigate the climate effects of land use change over China. Two 15-year simulations (1987―2001), one with current land use and the other with potential vegetation cover without human intervention, are conducted for a domain encompassing China. The climate impacts of land use change are assessed from the difference between the two simulations. Results show that the current land use (modified by anthropogenic ac- tivities) influences local climate as simulated by the model through the reinforcement of the monsoon circulation in both the winter and summer seasons and through changes of the surface energy budget. In winter, land use change leads to reduced precipitation and decreased surface air temperature south of the Yangtze River, and increased precipitation north of the Yangtze River. Land use change signifi- cantly affects summer climate in southern China, yielding increased precipitation over the region, de- creased temperature along the Yangtze River and increased temperature in the South China area (south-end of China). In summer, a reduction of precipitation over northern China and a temperature rise over Northwest China are also simulated. Both daily maximum and minimum temperatures are affected in the simulations. In general, the current land use in China leads to enhanced mean annual precipitation and decreased annual temperature over south China along with decreased precipitation over North China.
