目的:探讨波及黄斑区的孔源性视网膜脱离(RRD)行巩膜扣带手术前后黄斑区三维光学相干断层扫描图像(3D-OCT)特征,分析其与视力的相关性。方法:回顾性系列病例,30例30眼波及黄斑区的RRD行巩膜扣带术治疗的临床资料,在术后2d,2wk,1、3、6m...目的:探讨波及黄斑区的孔源性视网膜脱离(RRD)行巩膜扣带手术前后黄斑区三维光学相干断层扫描图像(3D-OCT)特征,分析其与视力的相关性。方法:回顾性系列病例,30例30眼波及黄斑区的RRD行巩膜扣带术治疗的临床资料,在术后2d,2wk,1、3、6mo随诊时双眼均行3D-OCT检查,观察椭圆体带(EZ)、外界膜(ELM)、黄斑区视网膜下液高度(SRFH)、黄斑中心凹视网膜厚度(CRT)的变化,分析其与术后最佳矫正视力(BCVA)的关系。结果:术前,术后2d,2wk,1、3、6mo SRFH、CRT、BCVA均有差异(P<0.01),术后SRFH、CRT都有不同程度降低,术后BCVA都有不同程度升高,组内两两对比:除SRFH(2wk vs 1mo,P>0.05)、CRT(2d vs 2wk,P>0.05)、BCVA(2d vs术前,2wk vs术前,P>0.05)无统计学意义外,其余各项间的比较均有统计学意义(P<0.05)。EZ、ELM形态可分为:A:EZ和ELM均连续(EZ+ELM+),9眼;B:EZ断裂和ELM连续(EZ-ELM+),7眼;C:EZ连续和ELM断裂:EZ+ELM-,6眼;D:EZ和ELM均断裂(EZ-ELM-),8眼,术后6mo上述4种类型的BCVA分别为0.15±0.04、0.50±0.06、0.54±0.05、0.59±0.09(F=87.210,P<0.05),两两比较:除C vs B和C vs D差异无统计学意义(P>0.05)外,其余各组间的比较差异均有统计学意义(P<0.05)。术后2d的SRF发生率为87%,术后6mo仍有46.6%患者存在持续性SRF。术后CRT与术后SRFH具有正相关关系。结论:巩膜扣带术后黄斑微结构呈动态改变,SRF影响可能表现为BCVA延迟恢复,随着SRF缓慢吸收,CRT逐渐降低,BCVA逐渐升高;ELM或EZ连续提示有较好的BCVA,而ELM断裂可能提示视觉质量更差。展开更多
Objective: The purpose of this study is to evaluate the clinicopathologic characteristics and treatment outcomes of Papillary Thyroid Carcinomas (PTC) of the isthmus and to establish an appropriate surgical strategy. ...Objective: The purpose of this study is to evaluate the clinicopathologic characteristics and treatment outcomes of Papillary Thyroid Carcinomas (PTC) of the isthmus and to establish an appropriate surgical strategy. Methods: Thirty-four patients with PTC in isthmus are managed by surgery in National Cancer Center/Cancer Hospital of Chinese Academy of Medical Sciences, Peking Union Medical College from 1985-2008. Demographic data, surgical procedures, pathological features, stages and outcomes are analyzed. Results: Seven patients were men and 27 were women. The median age was 41 years (range, 20 - 71). Twenty-five patients were treated with thyroid isthmusectomy or wide field isthmusectomy, five with hemithyroidectomy (lobectomy and isthmusectomy) and four with hemithyroidectomy and partial resection of the contralateral lobe. Twenty-eight patients had a pathologically T1 lesion (pT1);two patients had a pT2 lesion and four had a pT3 lesion. Five patients (14.7%) had papillary carcinoma detected in one of the pretracheal lymph nodes. Thirty-two patients had a solitary lesion confined to the thyroid isthmus. One patient had two lesions in the thyroid isthmus and another one had two lesions located in the thyroid isthmus and right lobe respectively. With a median follow-up of 94 months (range, 12 - 274), two patients had a recurrence and both survived after a re-operation. There was no regional lymph node or distant organ recurrences. No deaths occurred. Conclusions: Isthmusectomy or wide field isthmusectomy could be a sufficient treatment for PTC confined to the thyroid isthmus. We also recommend that pretracheal lymph node dissection be considered.展开更多
Objective:To observe the effects of long-snake moxibustion on the hypothalamic-pituitary-adrenocortical(HPA)axis and hepatic 11β-hydroxy steroid dehydrogenase type 1(11β-HSD1)expression in rats with kidney yang defi...Objective:To observe the effects of long-snake moxibustion on the hypothalamic-pituitary-adrenocortical(HPA)axis and hepatic 11β-hydroxy steroid dehydrogenase type 1(11β-HSD1)expression in rats with kidney yang deficiency to provide a basis for later in-depth exploration of the action mechanism of longsnakemoxibustion on suchrats.Methods:Fifteen SPF-grade,male,SD rats were randomly divided into a blank control group,a model group,and a long-snake moxibustion treatment group,with five rats in each group.Hydrocortisone powder(30 mg/kg)was administered by gavage at a volume of 10 mL/kg to prepare the rat model of kidney yang deficiency.After successful modeling,the rats in the long-snake moxibustion treatment group underwent long-snake moxibustion treatment every other day along the governor vessel from Dazhui(GV14)to Shenshu(BL23),for a period of 14 days.The remaining two groups were secured in the same way as the long-snake moxibustion treatment group,although they did not receive any treatment.The body weight,rectal temperature,and spontaneous activity count of the rats,as well as serum levels of corticotropin releasing hormone(CRH)and corticosterone(CORT)were detected by ELISA before modeling,after modeling,and after treatment.The amount of 11β-HSD1 protein in rat liver was determined by immunohistochemistry and Western blot analysis.Results:Compared with the rats in the blank control group,those in the model group exhibited a significant decrease in the trend of body weight growth and in rectal temperature(P<0.05),as well as a slight yet non-significant decrease in spontaneous activity count(P>0.05);compared with the rats in the model group,the rats in the treatment group exhibited a significant increase in rectal temperature(P<0.05)and in spontaneous activity count(P<0.05).Moreover,after 14 days of treatment,compared with the rats in the blank,the rats in the model group exhibited a significant decrease in serum cORT content(P<0.05)and in the expression of 11β-HSD1 in the liver(P<0.05),as well as a slight 展开更多
文摘目的:探讨波及黄斑区的孔源性视网膜脱离(RRD)行巩膜扣带手术前后黄斑区三维光学相干断层扫描图像(3D-OCT)特征,分析其与视力的相关性。方法:回顾性系列病例,30例30眼波及黄斑区的RRD行巩膜扣带术治疗的临床资料,在术后2d,2wk,1、3、6mo随诊时双眼均行3D-OCT检查,观察椭圆体带(EZ)、外界膜(ELM)、黄斑区视网膜下液高度(SRFH)、黄斑中心凹视网膜厚度(CRT)的变化,分析其与术后最佳矫正视力(BCVA)的关系。结果:术前,术后2d,2wk,1、3、6mo SRFH、CRT、BCVA均有差异(P<0.01),术后SRFH、CRT都有不同程度降低,术后BCVA都有不同程度升高,组内两两对比:除SRFH(2wk vs 1mo,P>0.05)、CRT(2d vs 2wk,P>0.05)、BCVA(2d vs术前,2wk vs术前,P>0.05)无统计学意义外,其余各项间的比较均有统计学意义(P<0.05)。EZ、ELM形态可分为:A:EZ和ELM均连续(EZ+ELM+),9眼;B:EZ断裂和ELM连续(EZ-ELM+),7眼;C:EZ连续和ELM断裂:EZ+ELM-,6眼;D:EZ和ELM均断裂(EZ-ELM-),8眼,术后6mo上述4种类型的BCVA分别为0.15±0.04、0.50±0.06、0.54±0.05、0.59±0.09(F=87.210,P<0.05),两两比较:除C vs B和C vs D差异无统计学意义(P>0.05)外,其余各组间的比较差异均有统计学意义(P<0.05)。术后2d的SRF发生率为87%,术后6mo仍有46.6%患者存在持续性SRF。术后CRT与术后SRFH具有正相关关系。结论:巩膜扣带术后黄斑微结构呈动态改变,SRF影响可能表现为BCVA延迟恢复,随着SRF缓慢吸收,CRT逐渐降低,BCVA逐渐升高;ELM或EZ连续提示有较好的BCVA,而ELM断裂可能提示视觉质量更差。
基金supported by the National Natural Science Foundation of China(81571693,82171950,81871361,82271997,and 82003182)the National Science Foundation for Young Scientists of China(82102085)+4 种基金UNSW-CAS Collaborative Research Seed Program(GJHZ2072)Shanghai Science and Technology Program(21010500100,22140901700,22DZ2204700,and 22142202200)Basic Research Program of Shanghai Municipal Government(21JC1406002)Shanghai Municipal Health Commission(202140250)Pudong Health Bureau of Shanghai(PWRl201806)。
文摘Objective: The purpose of this study is to evaluate the clinicopathologic characteristics and treatment outcomes of Papillary Thyroid Carcinomas (PTC) of the isthmus and to establish an appropriate surgical strategy. Methods: Thirty-four patients with PTC in isthmus are managed by surgery in National Cancer Center/Cancer Hospital of Chinese Academy of Medical Sciences, Peking Union Medical College from 1985-2008. Demographic data, surgical procedures, pathological features, stages and outcomes are analyzed. Results: Seven patients were men and 27 were women. The median age was 41 years (range, 20 - 71). Twenty-five patients were treated with thyroid isthmusectomy or wide field isthmusectomy, five with hemithyroidectomy (lobectomy and isthmusectomy) and four with hemithyroidectomy and partial resection of the contralateral lobe. Twenty-eight patients had a pathologically T1 lesion (pT1);two patients had a pT2 lesion and four had a pT3 lesion. Five patients (14.7%) had papillary carcinoma detected in one of the pretracheal lymph nodes. Thirty-two patients had a solitary lesion confined to the thyroid isthmus. One patient had two lesions in the thyroid isthmus and another one had two lesions located in the thyroid isthmus and right lobe respectively. With a median follow-up of 94 months (range, 12 - 274), two patients had a recurrence and both survived after a re-operation. There was no regional lymph node or distant organ recurrences. No deaths occurred. Conclusions: Isthmusectomy or wide field isthmusectomy could be a sufficient treatment for PTC confined to the thyroid isthmus. We also recommend that pretracheal lymph node dissection be considered.
基金Supported by National Natural Science Foundation of China:81960900。
文摘Objective:To observe the effects of long-snake moxibustion on the hypothalamic-pituitary-adrenocortical(HPA)axis and hepatic 11β-hydroxy steroid dehydrogenase type 1(11β-HSD1)expression in rats with kidney yang deficiency to provide a basis for later in-depth exploration of the action mechanism of longsnakemoxibustion on suchrats.Methods:Fifteen SPF-grade,male,SD rats were randomly divided into a blank control group,a model group,and a long-snake moxibustion treatment group,with five rats in each group.Hydrocortisone powder(30 mg/kg)was administered by gavage at a volume of 10 mL/kg to prepare the rat model of kidney yang deficiency.After successful modeling,the rats in the long-snake moxibustion treatment group underwent long-snake moxibustion treatment every other day along the governor vessel from Dazhui(GV14)to Shenshu(BL23),for a period of 14 days.The remaining two groups were secured in the same way as the long-snake moxibustion treatment group,although they did not receive any treatment.The body weight,rectal temperature,and spontaneous activity count of the rats,as well as serum levels of corticotropin releasing hormone(CRH)and corticosterone(CORT)were detected by ELISA before modeling,after modeling,and after treatment.The amount of 11β-HSD1 protein in rat liver was determined by immunohistochemistry and Western blot analysis.Results:Compared with the rats in the blank control group,those in the model group exhibited a significant decrease in the trend of body weight growth and in rectal temperature(P<0.05),as well as a slight yet non-significant decrease in spontaneous activity count(P>0.05);compared with the rats in the model group,the rats in the treatment group exhibited a significant increase in rectal temperature(P<0.05)and in spontaneous activity count(P<0.05).Moreover,after 14 days of treatment,compared with the rats in the blank,the rats in the model group exhibited a significant decrease in serum cORT content(P<0.05)and in the expression of 11β-HSD1 in the liver(P<0.05),as well as a slight
基金supported by the National Natural Science Foundation of China(No.22173052 and No.21933002)the Shandong Provincial Natural Sci-ence Foundation(No.ZR2019BB069).
