分析发热伴血小板减少综合征(severe fever with thrombocytopenia syndrome,SFTS)患者凝血功能的临床变化特点及其与血小板减少的关系,探索其作为早期预测SFTS患者重症化趋势的价值。分析2014年1月至2020年7月华中科技大学同济医学院...分析发热伴血小板减少综合征(severe fever with thrombocytopenia syndrome,SFTS)患者凝血功能的临床变化特点及其与血小板减少的关系,探索其作为早期预测SFTS患者重症化趋势的价值。分析2014年1月至2020年7月华中科技大学同济医学院附属协和医院感染科收治的428例SFTS患者(其中死亡组70例,存活组358例)的临床资料,统计分析两组患者凝血相关指标以及弥散性血管内凝血(DIC)评分的差异。结果显示,SFTS患者凝血功能异常常见,死亡组较存活组更易出现出血症状(出血发生率41.4%比26.5%);死亡组D-二聚体水平显著高于正常水平,活化部分凝血酶时间(APTT)、凝血酶时间(TT)均显著延长。死亡组与存活组患者凝血酶原时间(PT)、TT、APTT、国际标准化比值(INR)、D-二聚体在第5~6天开始出现统计学差异;纤维蛋白原(FIB)水平在第7~8天开始出现统计学差异,均早于血小板计数水平在两组患者中出现差异的时间(第9~10天)。SFTS病死率随基线DIC评分升高而升高,当DIC评分达到6时,病死率达到66.67%。疾病过程中显著的凝血异常介导血小板消耗过多,凝血相关指标较血小板计数对早期识别SFTS重症化更有帮助。展开更多
有机集成化光电子器件兼具了小型化和多功能性的优势,如集成了有机发光和紫外探测的有机发光紫外探测器件(OLED-UVOPDs).这种器件中的有机光电材料的设计仍然面临重大的挑战.在本文中,以蒽为π桥,腈基苯为受体,三苯胺(TPA)和二甲基三苯...有机集成化光电子器件兼具了小型化和多功能性的优势,如集成了有机发光和紫外探测的有机发光紫外探测器件(OLED-UVOPDs).这种器件中的有机光电材料的设计仍然面临重大的挑战.在本文中,以蒽为π桥,腈基苯为受体,三苯胺(TPA)和二甲基三苯胺(2mTPA)分别为给体,设计并合成了两种可用于OLED-UVOPD器件的蓝色发光分子,TPA-AN和2mTPA-AN.它们的发光峰分别位于474和488 nm处,荧光量子产率为51.1%和46.6%.通过单载流子器件计算得到其电子迁移率分别为3.96×10^(-5)和6.63×10^(-7)cm^(2)V^(-1)s^(-1).基于TPA-AN的OLED器件表现出强的蓝光发射,最大亮度为43,110 cd m^(-2),最大外量子效率(EQE)为8.1%.它们在OLED-UVOPD集成器件中表现出优异的性能,紫外探测率分别为7.18×10^(11)和2.85×10^(12)Jones,最大EQE分别为8.7%和5.9%.展开更多
The Fushan depression is a classic lacustrine rifted sub-basin in the Beibuwan Basin, South China Sea. The Paleogene Liushagang sequence is the main hydrocarbon-bearing stratigraphic unit in the depression. Using thre...The Fushan depression is a classic lacustrine rifted sub-basin in the Beibuwan Basin, South China Sea. The Paleogene Liushagang sequence is the main hydrocarbon-bearing stratigraphic unit in the depression. Using three-dimensional （3-D） seismic data and logging data, we analyzed depositional setting of the Liushagang sequence. We use wave impedance inversion to describe progradational directions of provenance and the general distribution of sand body. The seismic facies was analyzed by using the seismic sedimentology approach based on 3-D seismic data, and summed into eight types of seismic facies which could be well related to sedimentary facies. Seismic attributes with six objective sequence boundaries were extracted. Consequently, four provenance system of Liushagang sequence in the study area were confirmed by the corresponding relationship between the geologic information and the warm color and higher value area of seismic attributes： （i） the Hainan uplift provenance area in the south, （ii） the Linggao uplift provenance area in the west, （iii） the Yunlong uplift provenance area in the east and （iv） the northern provenance area. The seismic sedimentology used in this study may provide new in- sizhts into a better understanding of depositional setting in continental lacustrine rifted basins.展开更多
文摘分析发热伴血小板减少综合征(severe fever with thrombocytopenia syndrome,SFTS)患者凝血功能的临床变化特点及其与血小板减少的关系,探索其作为早期预测SFTS患者重症化趋势的价值。分析2014年1月至2020年7月华中科技大学同济医学院附属协和医院感染科收治的428例SFTS患者(其中死亡组70例,存活组358例)的临床资料,统计分析两组患者凝血相关指标以及弥散性血管内凝血(DIC)评分的差异。结果显示,SFTS患者凝血功能异常常见,死亡组较存活组更易出现出血症状(出血发生率41.4%比26.5%);死亡组D-二聚体水平显著高于正常水平,活化部分凝血酶时间(APTT)、凝血酶时间(TT)均显著延长。死亡组与存活组患者凝血酶原时间(PT)、TT、APTT、国际标准化比值(INR)、D-二聚体在第5~6天开始出现统计学差异;纤维蛋白原(FIB)水平在第7~8天开始出现统计学差异,均早于血小板计数水平在两组患者中出现差异的时间(第9~10天)。SFTS病死率随基线DIC评分升高而升高,当DIC评分达到6时,病死率达到66.67%。疾病过程中显著的凝血异常介导血小板消耗过多,凝血相关指标较血小板计数对早期识别SFTS重症化更有帮助。
基金financially supported by the Joint Funds of the National Natural Science Foundation of China (NSFC,U21A20492)NSFC (61705156,60976018,and 61605138)+2 种基金the Key R&D program of Shanxi Province (International Cooperation,201903D421087,201903D121100)Shanxi Scholarship Council of China (2020-049)Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering (2021SX-FR007)。
文摘有机集成化光电子器件兼具了小型化和多功能性的优势,如集成了有机发光和紫外探测的有机发光紫外探测器件(OLED-UVOPDs).这种器件中的有机光电材料的设计仍然面临重大的挑战.在本文中,以蒽为π桥,腈基苯为受体,三苯胺(TPA)和二甲基三苯胺(2mTPA)分别为给体,设计并合成了两种可用于OLED-UVOPD器件的蓝色发光分子,TPA-AN和2mTPA-AN.它们的发光峰分别位于474和488 nm处,荧光量子产率为51.1%和46.6%.通过单载流子器件计算得到其电子迁移率分别为3.96×10^(-5)和6.63×10^(-7)cm^(2)V^(-1)s^(-1).基于TPA-AN的OLED器件表现出强的蓝光发射,最大亮度为43,110 cd m^(-2),最大外量子效率(EQE)为8.1%.它们在OLED-UVOPD集成器件中表现出优异的性能,紫外探测率分别为7.18×10^(11)和2.85×10^(12)Jones,最大EQE分别为8.7%和5.9%.
基金National Natural Science Foundation of China (NSFC) program (41472084)
文摘The Fushan depression is a classic lacustrine rifted sub-basin in the Beibuwan Basin, South China Sea. The Paleogene Liushagang sequence is the main hydrocarbon-bearing stratigraphic unit in the depression. Using three-dimensional （3-D） seismic data and logging data, we analyzed depositional setting of the Liushagang sequence. We use wave impedance inversion to describe progradational directions of provenance and the general distribution of sand body. The seismic facies was analyzed by using the seismic sedimentology approach based on 3-D seismic data, and summed into eight types of seismic facies which could be well related to sedimentary facies. Seismic attributes with six objective sequence boundaries were extracted. Consequently, four provenance system of Liushagang sequence in the study area were confirmed by the corresponding relationship between the geologic information and the warm color and higher value area of seismic attributes： （i） the Hainan uplift provenance area in the south, （ii） the Linggao uplift provenance area in the west, （iii） the Yunlong uplift provenance area in the east and （iv） the northern provenance area. The seismic sedimentology used in this study may provide new in- sizhts into a better understanding of depositional setting in continental lacustrine rifted basins.
