Gastric cancer is one of the most common human malignancies, and its prevalence has been shown to be well-correlated with cancer-related deaths worldwide. Regrettably, the poor prognosis of this disease is mainly due ...Gastric cancer is one of the most common human malignancies, and its prevalence has been shown to be well-correlated with cancer-related deaths worldwide. Regrettably, the poor prognosis of this disease is mainly due to its late diagnosis at advanced stages after the cancer has already metastasized. Recent research has emphasized the identification of cancer biomarkers in the hope of diagnosing cancer early and designing targeted therapies to reverse cancer progression. One member of a family of growth-related nicotinamide adenine dinucleotide(NADH or hydroquinone) oxidases is tumor-associated NADH oxidase(t NOX; ENOX2). Unlike its counterpart CNOX(ENOX1), identified in normal rat liver plasma membranes and shown to be stimulated by growth factors and hormones, t NOX activity purified from rat hepatoma cells is constitutively active. Its activity is detectable in the sera of cancer patients but not in those of healthy volunteers, suggesting its clinical relevance. Interestingly, t NOX expression was shown to be present in an array of cancer cell lines. More importantly, inhibition of t NOX was well correlated with reduced cancer cell growth and induction of apoptosis. RNA interference targeting t NOX expression in cancer cells effectively restored non-cancerous phenotypes, further supporting the vital role of t NOX in cancer cells. Here, we review the regulatory role of t NOX in gastric cancer cell growth.展开更多
Local plasma phenomena in environment of Sun are observed closely by spacecrafts in recent years. We provide a new method to apply general relativity to astro-plasma physics in small local area. The relativistic dispe...Local plasma phenomena in environment of Sun are observed closely by spacecrafts in recent years. We provide a new method to apply general relativity to astro-plasma physics in small local area. The relativistic dispersion relations of Langmuir, electromagnetic and cyclotron waves are obtained. The red shifts of Langmuir and cyclotron frequencies are given analytically. A new equilibrium velocity distribution of particles soaked in local gravitational field is suggested. The gravitational effect of a neutron star is also estimated.展开更多
Fundamental quantum transport equation for impact-ionization processes in fusion plasmas is formulated in the actor-spectator description. The density-matrix formulism is adopted to treat both coherent and incoherent ...Fundamental quantum transport equation for impact-ionization processes in fusion plasmas is formulated in the actor-spectator description. The density-matrix formulism is adopted to treat both coherent and incoherent effects in a unified fashion. Quantum electrodynamic effects are also considered for high-temperature scenarios. Electron-impact ionization of uranium ion U91＋ and proton-impact ionization of hydrogen are given as examples.展开更多
基金Supported by the Ministry of Health and WelfareFeng Yuan Hospital Research Project 103-004+1 种基金the National Science CouncilNo.NSC 100-2320-B-005-005 and No.NSC 101-2320-B-005-003
文摘Gastric cancer is one of the most common human malignancies, and its prevalence has been shown to be well-correlated with cancer-related deaths worldwide. Regrettably, the poor prognosis of this disease is mainly due to its late diagnosis at advanced stages after the cancer has already metastasized. Recent research has emphasized the identification of cancer biomarkers in the hope of diagnosing cancer early and designing targeted therapies to reverse cancer progression. One member of a family of growth-related nicotinamide adenine dinucleotide(NADH or hydroquinone) oxidases is tumor-associated NADH oxidase(t NOX; ENOX2). Unlike its counterpart CNOX(ENOX1), identified in normal rat liver plasma membranes and shown to be stimulated by growth factors and hormones, t NOX activity purified from rat hepatoma cells is constitutively active. Its activity is detectable in the sera of cancer patients but not in those of healthy volunteers, suggesting its clinical relevance. Interestingly, t NOX expression was shown to be present in an array of cancer cell lines. More importantly, inhibition of t NOX was well correlated with reduced cancer cell growth and induction of apoptosis. RNA interference targeting t NOX expression in cancer cells effectively restored non-cancerous phenotypes, further supporting the vital role of t NOX in cancer cells. Here, we review the regulatory role of t NOX in gastric cancer cell growth.
文摘Local plasma phenomena in environment of Sun are observed closely by spacecrafts in recent years. We provide a new method to apply general relativity to astro-plasma physics in small local area. The relativistic dispersion relations of Langmuir, electromagnetic and cyclotron waves are obtained. The red shifts of Langmuir and cyclotron frequencies are given analytically. A new equilibrium velocity distribution of particles soaked in local gravitational field is suggested. The gravitational effect of a neutron star is also estimated.
文摘Fundamental quantum transport equation for impact-ionization processes in fusion plasmas is formulated in the actor-spectator description. The density-matrix formulism is adopted to treat both coherent and incoherent effects in a unified fashion. Quantum electrodynamic effects are also considered for high-temperature scenarios. Electron-impact ionization of uranium ion U91＋ and proton-impact ionization of hydrogen are given as examples.
