Rapid online analysis of liquid slag is essential for optimizing the quality and energy efficiency of steel production. To investigate the key factors that affect the online measurement of refined slag using laser-ind...Rapid online analysis of liquid slag is essential for optimizing the quality and energy efficiency of steel production. To investigate the key factors that affect the online measurement of refined slag using laser-induced breakdown spectroscopy(LIBS), this study examined the effects of slag composition and temperature on the intensity and stability of the LIBS spectra. The experimental temperature was controlled at three levels: 1350℃, 1400℃, and 1450℃. The results showed that slag composition and temperature significantly affected the intensity and stability of the LIBS spectra. Increasing the Fe content and temperature in the slag reduces its viscosity, resulting in an enhanced intensity and stability of the LIBS spectra. Additionally, 42 refined slag samples were quantitatively analyzed for Fe, Si, Ca, Mg, Al, and Mn at 1350℃, 1400℃, and 1450℃.The normalized full spectrum combined with partial least squares(PLS) quantification modeling was used, using the Ca Ⅱ 317.91 nm spectral line as an internal standard. The results show that using the internal standard normalization method can significantly reduce the influence of spectral fluctuations. Meanwhile, a temperature of 1450℃ has been found to yield superior results compared to both 1350℃ and 1400℃, and it is advantageous to conduct a quantitative analysis of the slag when it is in a “water-like” state with low viscosity.展开更多
目的考察西尼地平片国内仿制药和原研药晶型和体外溶出情况。方法制备西尼地平2种晶型,采用激光共聚焦显微拉曼光谱仪测定2种晶型、原研药、仿制药的拉曼图谱,确定国内仿制药和原研药的晶型情况,并建立具有区分力的溶出度方法。结果国内...目的考察西尼地平片国内仿制药和原研药晶型和体外溶出情况。方法制备西尼地平2种晶型,采用激光共聚焦显微拉曼光谱仪测定2种晶型、原研药、仿制药的拉曼图谱,确定国内仿制药和原研药的晶型情况,并建立具有区分力的溶出度方法。结果国内A、B 2家企业产品为α晶型,原研药和国内C企业产品为无定型,所建立的溶出度方法(0.5%SDS的p H 6.8磷酸盐缓冲液为溶出介质,体积为900 m L,转速为75 r·min?1)可以有效区分国内仿制药和原研药。结论国内仿制药和原研药晶型与体外溶出存在一定差异。展开更多
基金financially supported by the National Key R&D Program Projects of China (No.2021YFB3202402)National Natural Science Foundation of China (No.62173321)。
文摘Rapid online analysis of liquid slag is essential for optimizing the quality and energy efficiency of steel production. To investigate the key factors that affect the online measurement of refined slag using laser-induced breakdown spectroscopy(LIBS), this study examined the effects of slag composition and temperature on the intensity and stability of the LIBS spectra. The experimental temperature was controlled at three levels: 1350℃, 1400℃, and 1450℃. The results showed that slag composition and temperature significantly affected the intensity and stability of the LIBS spectra. Increasing the Fe content and temperature in the slag reduces its viscosity, resulting in an enhanced intensity and stability of the LIBS spectra. Additionally, 42 refined slag samples were quantitatively analyzed for Fe, Si, Ca, Mg, Al, and Mn at 1350℃, 1400℃, and 1450℃.The normalized full spectrum combined with partial least squares(PLS) quantification modeling was used, using the Ca Ⅱ 317.91 nm spectral line as an internal standard. The results show that using the internal standard normalization method can significantly reduce the influence of spectral fluctuations. Meanwhile, a temperature of 1450℃ has been found to yield superior results compared to both 1350℃ and 1400℃, and it is advantageous to conduct a quantitative analysis of the slag when it is in a “water-like” state with low viscosity.
文摘目的考察西尼地平片国内仿制药和原研药晶型和体外溶出情况。方法制备西尼地平2种晶型,采用激光共聚焦显微拉曼光谱仪测定2种晶型、原研药、仿制药的拉曼图谱,确定国内仿制药和原研药的晶型情况,并建立具有区分力的溶出度方法。结果国内A、B 2家企业产品为α晶型,原研药和国内C企业产品为无定型,所建立的溶出度方法(0.5%SDS的p H 6.8磷酸盐缓冲液为溶出介质,体积为900 m L,转速为75 r·min?1)可以有效区分国内仿制药和原研药。结论国内仿制药和原研药晶型与体外溶出存在一定差异。
