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Artificial Hair-Like Sensors Inspired from Nature: A Review 被引量:9
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作者 Zhiwu Han Linpeng Liu +6 位作者 Kejun Wang honglie song Daobing Chen Ze Wang Shichao Niu Junqiu Zhang Luquan Ren 《Journal of Bionic Engineering》 SCIE EI CSCD 2018年第3期409-434,共26页
Nature creatures have evolved excellent receptors, such as sensory hairs in arthropods, lateral line system of fishes. Researchers inspired by nature creatures have developed various mechanical sensors. Here, we provi... Nature creatures have evolved excellent receptors, such as sensory hairs in arthropods, lateral line system of fishes. Researchers inspired by nature creatures have developed various mechanical sensors. Here, we provide an overview on the development of Artificial Hair-Like (AHL) sensors based on the inspiration of hair flow sensory receptors, especially sensory hairs in arthropods and lateral line systems of fishes. We classify the developed AHL sensors into several categories according to the operating principles they based on, for example, piezoresistive and piezoelectric effects. The current challenges and existing problems in the development of AHL sensors are also present, which were primarily restricted by the exploratory tools of sensing mechanism of creatures and current manufacturing technologies. In future, more efforts are required in order to further improve the performance of AHL sensors. We expect that intelligent multi-functional AHL sensors can be applied not only in applications like navigation of underwater automatic vehicles, underwater search and rescue, tap-water metering, air monitoring and even in medicare, but also potentially be used in space robots to detect complex to- pography. 展开更多
关键词 sensory receptors sensory hairs lateral line systems AHL sensors
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A Selective‑Response Hypersensitive Bio‑Inspired Strain Sensor Enabled by Hysteresis Effect and Parallel Through‑Slits Structures
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作者 Qun Wang Zhongwen Yao +8 位作者 Changchao Zhang honglie song Hanliang Ding Bo Li Shichao Niu Xinguan Huang Chuanhai Chen Zhiwu Han Luquan Ren 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第2期139-153,共15页
Flexible strain sensors are promising in sensing minuscule mechanical signals,and thereby widely used in various advanced fields.However,the effective integration of hypersensitivity and highly selective response into... Flexible strain sensors are promising in sensing minuscule mechanical signals,and thereby widely used in various advanced fields.However,the effective integration of hypersensitivity and highly selective response into one flexible strain sensor remains a huge challenge.Herein,inspired by the hysteresis strategy of the scorpion slit receptor,a bio-inspired flexible strain sensor(BFSS)with parallel through-slit arrays is designed and fabricated.Specifically,BFSS consists of conductive monolayer graphene and viscoelastic styrene–isoprene–styrene block copolymer.Under the synergistic effect of the bio-inspired slit structures and flexible viscoelastic materials,BFSS can achieve both hypersensitivity and highly selective frequency response.Remarkably,the BFSS exhibits a high gage factor of 657.36,and a precise identification of vibration frequencies at a resolution of 0.2 Hz through undergoing different morphological changes to high-frequency vibration and low-frequency vibration.Moreover,the BFSS possesses a wide frequency detection range(103 Hz)and stable durability(1000 cycles).It can sense and recognize vibration signals with different characteristics,including the frequency,amplitude,and waveform.This work,which turns the hysteresis effect into a"treasure,"can provide new design ideas for sensors for potential applications including human–computer interaction and health monitoring of mechanical equipment. 展开更多
关键词 Bio-inspired strain sensors Hysteresis effect HYPERSENSITIVITY Selective frequency response Health monitoring applications
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Morphable three-dimensional electronic mesofliers capable of on-demand unfolding 被引量:3
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作者 Ziyao Ji Jianzhong Zhao +12 位作者 honglie song Shiwei Xu Wenbo Pang Xiaonan Hu Fan Zhang Tianqi Jin Yumeng Shuai Yu Lan Di Cheng Wenwen Man Renheng Bo Zhaoguo Xue Yihui Zhang 《Science China Materials》 SCIE EI CAS CSCD 2022年第8期2309-2318,共10页
Development of miniaturized three-dimensional(3 D)fliers with integrated functional components has important implications to a diverse range of engineering areas.Among the various active and passive miniaturized 3 D f... Development of miniaturized three-dimensional(3 D)fliers with integrated functional components has important implications to a diverse range of engineering areas.Among the various active and passive miniaturized 3 D fliers reported previously,a class of 3 D electronic fliers inspired by wind-dispersed seeds show promising potentials,owing to the lightweight and noiseless features,aside from the stable rotational fall associated with a low falling velocity.While on-demand shape-morphing capabilities are essential for those 3 D electronic fliers,the realization of such miniaturized systems remains very challenging,due to the lack of fast-response 3 D actuators that can be seamlessly integrated with 3 D electronic fliers.Here we develop a type of morphable3 D mesofliers with shape memory polymer(SMP)-based electrothermal actuators,capable of large degree of actuation deformations,with a fast response(e.g.,~1 s).Integration of functional components,including sensors,controllers,and chip batteries,enables development of intelligent 3 D mesoflier systems that can achieve the on-demand unfolding,triggered by the processing of real-time sensed information(e.g.,acceleration and humidity data).Such intelligent electronic mesofliers are capable of both the low-air-drag rising and the low-velocity falling,and thereby,can be used to measure the humidity fields in a wide 3 D space by simple hand throwing,according to our demonstrations.The developed electronic mesofliers can also be integrated with other types of physical/chemical sensors for uses in different application scenarios. 展开更多
关键词 bioinspired mesofliers mechanically guided 3D assembly shape morphing low-air-drag throwing low-velocity falling flexible electronics
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Large Curvature Folding Strategies of Butterfly Proboscis 被引量:2
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作者 Daobing Chen honglie song +10 位作者 Qingping Liu Jie Gan Yang Liu Keyu Che' Chong Wang Shifeng Wen Yan Zhou Chunze Yan Junqiu Zhang Yusheng Shi Zhiwu Han 《Journal of Bionic Engineering》 SCIE EI CSCD 2020年第6期1239-1250,共12页
Due to its real-time control,high folding ratio,and structure self-locking,flexible large curvature self-folding devices have broad application prospects,such as foldable human implants,flexible electronics,and flexib... Due to its real-time control,high folding ratio,and structure self-locking,flexible large curvature self-folding devices have broad application prospects,such as foldable human implants,flexible electronics,and flexible robots.Driven by this background,flexible large curvature folding butterfly(Polyura eudamippus)proboscises were studied in this work.The folding ratio of the proboscises was about 15.The curvature of coiled proboscises ranged from about 150 m_1 to 880 m The external and internal structures of the proboscises were studied by different methods.Three main strategies for large-curvature folding of proboscises were identified:a gradual decrease in thickness,a lower elastic modulus,and(most importantly)large numbers of regular corrugated cracks arranged on the surface.These corrugated cracks can effectively accommodate the coiled strain and provide space for the large curvature folding of proboscises.Finally,a 4D printed coiled sample with corrugated cracks was fabricated to mimic the proboscises stretching process.Large-curvature folding strategies,based on these proboscises,provide insights for the biomimetic design of artificial highly folded components. 展开更多
关键词 butterfly proboscis large curvature folding corrugated crack 4D printing BIONIC
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Fine Structure of Scorpion Pectines for Odor Capture 被引量:1
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作者 Zhiwu Han Daobing Chen +5 位作者 Ka Zhang honglie song Kejun Wang Shichao Niu Junqiu Zhang Luquan Ren 《Journal of Bionic Engineering》 SCIE EI CSCD 2017年第4期589-599,共11页
The paper revealed the fine structure of the scorpion (Mesobuthus martensii) pectines and showed how the fine structure of the pecten influences odor flow. The first step of our investigation was to prove that scorp... The paper revealed the fine structure of the scorpion (Mesobuthus martensii) pectines and showed how the fine structure of the pecten influences odor flow. The first step of our investigation was to prove that scorpion pectines work as olfactory and this was done via experiments utilizing paraffin coverage. Subsequently, the location, morphology, section structure, and arrange- ment of the pectines were studied via stereomicroscopy and Scanning Electron Microscopy (SEM). The fine structure of pecten comprises a comb-like structure with 24-30 knife-like teeth and thousands of micron bowl-like pecten sensilla in staggered arrangement on the surface of the tooth. Computational Fluid Dynamics (CFD) was applied to predict odor flow around the pecten via the relevant Reynolds numbers. The comb-like structure amplified the odor flow velocity similar to an amplifier, transporting the odor flow of increased velocity to the micron pecten sensilla, improving transport efficiency of the odor flow. The staggered arrangement of the pecten sensilla generated a vortex, improving contact duration between pecten sensilla and odorant molecules. Thus, the pecten fine structure was likely acting as an effective comb with non-smooth teeth for the transport and capture of odorant molecules. 展开更多
关键词 scorpion pectines fluid dynamics odor capture fine structure BIOMIMETIC
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Vibrational Receptor of Scorpion(Heterometrus petersii):The Basitarsal Compound Slit Sensilla 被引量:1
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作者 Kejun Wang Junqiu Zhang +6 位作者 Linpeng Liu Daobing Chen honglie song Yinliang Wang Shichao Niu Zhiwu Han Luquan Ren 《Journal of Bionic Engineering》 SCIE EI CSCD 2019年第1期76-87,共12页
Recently,micro-vibrational perception mechanisms of nocturnal arthropods such as scorpions and spiders are attracting increasingly more attention and research.The relevant micro-vibrational receptors are exquisite,in ... Recently,micro-vibrational perception mechanisms of nocturnal arthropods such as scorpions and spiders are attracting increasingly more attention and research.The relevant micro-vibrational receptors are exquisite,in terms of their comprehensive performance such as sensitivity,stability,high anti-interference,and ultralow-power consumption.In this work,we find the Basitarsal Compound Slit Sensilla (BCSS) of scorpion (Heterometrus petersii) are composed of the crack-shaped slits as mechanosensory structure and can efficiently detect substrate-borne vibrational signal in complex natural environment.The study on microstructures and mechanical properties of tissue phases constituting the BCSS reveals that the strategy of tessellation is used to make crack-shaped slit amplify the tiny mechanical signal.In addition,the magnitude-frequency characteristics of electrophysiological signals caused by vibration stimulation with different frequencies indicate that the scorpion is sensitive to micro-vibrational signals at a certain frequency range.Meanwhile,the vibrational perception mechanism based on geometrical amplification and resonance is proposed to explain how scorpions detect the tiny biotic vibrational signal efficiently in noise environment.This finding not only promotes our further understanding of ultra-sensitive mechanism of the vibrational receptors,but also provides biological inspiration for the next generation of mechanosensor for a broad range of applications. 展开更多
关键词 SCORPION MECHANORECEPTOR basitarsal COMPOUND SLIT SENSILLA VIBRATIONAL perception
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A new bearing fault diagnosis method based on modified convolutional neural networks 被引量:42
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作者 Jiangquan ZHANG Yi SUN +3 位作者 Liang GUO hongli GAO Xin HONG hongliang song 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2020年第2期439-447,共9页
Fault diagnosis is vital in manufacturing system.However,the first step of the traditional fault diagnosis method is to process the signal,extract the features and then put the features into a selected classifier for ... Fault diagnosis is vital in manufacturing system.However,the first step of the traditional fault diagnosis method is to process the signal,extract the features and then put the features into a selected classifier for classification.The process of feature extraction depends on the experimenters’experience,and the classification rate of the shallow diagnostic model does not achieve satisfactory results.In view of these problems,this paper proposes a method of converting raw signals into twodimensional images.This method can extract the features of the converted two-dimensional images and eliminate the impact of expert’s experience on the feature extraction process.And it follows by proposing an intelligent diagnosis algorithm based on Convolution Neural Network(CNN),which can automatically accomplish the process of the feature extraction and fault diagnosis.The effect of this method is verified by bearing data.The influence of different sample sizes and different load conditions on the diagnostic capability of this method is analyzed.The results show that the proposed method is effective and can meet the timeliness requirements of fault diagnosis. 展开更多
关键词 BEARING Convolutional NEURAL networks Different load DOMAINS FAULT identification RAW SIGNALS FAULT diagnosis
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集体土地所有权归属主体的实践样态与规范解释 被引量:42
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作者 姜红利 宋宗宇 《中国农村观察》 CSSCI 北大核心 2017年第6期2-13,共12页
集体土地所有权归属主体的理论研究与地方实践,存在将农民集体、农村集体经济组织、村民委员会三者等同混用的情形,其根源在于对农民集体的集体土地所有权主体地位认识不到位。农村集体经济组织与农民集体的主体混同,既是政策和法律变... 集体土地所有权归属主体的理论研究与地方实践,存在将农民集体、农村集体经济组织、村民委员会三者等同混用的情形,其根源在于对农民集体的集体土地所有权主体地位认识不到位。农村集体经济组织与农民集体的主体混同,既是政策和法律变迁中本土概念与现代产权话语脱节的历史产物,又是解决农民集体无法独立行使所有权的无奈选择。但是,将二者等同为集体土地所有权主体并进行法人化改造的探索,存在集体土地所有权作为法人责任财产被转让的风险。如果禁止集体土地所有权成为法人的责任财产,则会违反法人以其全部财产对外承担责任的《公司法》规定。因此,农民集体是集体土地所有权的唯一主体,不宜直接进行法人化改造。农村集体经济组织是代表农民集体行使所有权的主体,不能被认定为集体土地所有权的归属主体,但作为特别法人可基于独立经营对外代表农民集体行使集体所有权。 展开更多
关键词 特别法人 集体土地所有权 农民集体 农村集体经济组织 村民委员会
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脑卒中病人家庭功能在日常生活能力与脑卒中后抑郁中的中介作用研究 被引量:25
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作者 刘宏丽 赵秋利 +2 位作者 王坤晓 宋姗姗 王婧 《护理研究》 北大核心 2019年第19期3350-3355,共6页
[目的]探索家庭功能在日常生活能力与卒中后抑郁中的中介作用,为预防或缓解卒中后抑郁,提供以家庭功能为导向的干预策略。[方法]采用抑郁自评量表(SDS)、家庭功能评价量表、日常生活能力评价量表和一般资料问卷对方便抽取的400例脑卒中... [目的]探索家庭功能在日常生活能力与卒中后抑郁中的中介作用,为预防或缓解卒中后抑郁,提供以家庭功能为导向的干预策略。[方法]采用抑郁自评量表(SDS)、家庭功能评价量表、日常生活能力评价量表和一般资料问卷对方便抽取的400例脑卒中住院病人进行问卷调查。运用结构方程模型理论及SPSS 17.0和AMOS 22.0软件构建以家庭功能为中介变量的结构方程模型。[结果]日常生活能力和家庭功能障碍是脑卒中后抑郁发生的独立危险因素且密切相关,其中脑卒中病人的家庭功能是日常生活能力和抑郁之间的中介变量。[结论]家庭功能是日常生活能力对脑卒中后抑郁产生影响的主要路径,应以家庭功能为干预的着力点,挖掘家庭对改善卒中后抑郁的深层潜力,开发以家庭为导向的护理干预方案,提高脑卒中病人的家庭功能水平,预防或降低脑卒中病人抑郁情绪的发生和发展。 展开更多
关键词 脑卒中 脑卒中后抑郁 家庭功能 日常生活能力 影响因素 影响路径
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人工智能大模型医学应用研究 被引量:12
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作者 郭华源 刘盼 +6 位作者 卢若谷 杨菲菲 徐洪丽 庄严 黄高 宋士吉 何昆仑 《中国科学:生命科学》 CSCD 北大核心 2024年第3期482-506,共25页
近年来,以自然语言处理和视频图像分析为主的人工智能大模型技术得到快速发展,其基本特征是聚焦相关应用领域的共性需求,通过大数据、强算力和复杂算法的高效协同与深度融合,构建通用预训练模型,广泛适配下游任务,有力提高模型的处理性... 近年来,以自然语言处理和视频图像分析为主的人工智能大模型技术得到快速发展,其基本特征是聚焦相关应用领域的共性需求,通过大数据、强算力和复杂算法的高效协同与深度融合,构建通用预训练模型,广泛适配下游任务,有力提高模型的处理性能与研发效率.因此,大模型技术为医学人工智能高质量发展提供了难得契机.本文通过全面梳理国内外大模型的研究进展、关键技术与核心算法,分析总结生物医学领域一系列标准数据集和预训练模型的发展特点,结合医学人工智能的研发实践,深入剖析医学领域大模型构建的应用需求、解决思路与研发经验,助力推动医学大模型创新发展. 展开更多
关键词 医学 人工智能 大模型 自然语言处理 医学图像分析
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何首乌及其常用制剂相关不良反应文献研究及风险因素分析 被引量:16
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作者 于洪礼 于冬梅 +1 位作者 宋海波 任经天 《中国药物警戒》 2018年第8期470-475,共6页
目的探究何首乌及其常用制剂不良反应发生规律和特点,分析其风险因素,以期为其临床用药安全提供参考。方法检索涉及何首乌及其常用制剂不良反应的相关文献资料,分析其不良反应特点及风险因素。结果共纳入69例个例;不良反应发生在用药后1... 目的探究何首乌及其常用制剂不良反应发生规律和特点,分析其风险因素,以期为其临床用药安全提供参考。方法检索涉及何首乌及其常用制剂不良反应的相关文献资料,分析其不良反应特点及风险因素。结果共纳入69例个例;不良反应发生在用药后10天至1个月的较多;累及系统-器官以肝胆系统损害最多,其次为胃肠系统损害;主要临床表现为巩膜及皮肤黄染、转氨酶升高、胆红素升高、尿黄等;多数不良反应停药或对症结合药物治疗后恢复正常。结论何首乌及其常用制剂的不良反应累及系统-器官主要为肝胆系统和胃肠系统损害,且停药或结合药物治疗后转归情况较好,但仍需开展深入研究,同时加强监管,确保用药安全。 展开更多
关键词 何首乌 不良反应 文献分析 风险因素
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基于16SrDNA的醋酸菌筛选及其发酵特性 被引量:14
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作者 姚洪礼 李兴江 +6 位作者 郑志 宋山 姜绍通 李顺 邓永东 潘丽军 吴学凤 《食品科学》 EI CAS CSCD 北大核心 2017年第4期6-12,共7页
醋酸菌是影响纯种液态酿醋效率的关键因素。为获得高质量浓度醋酸生产菌,本研究将常规筛选方法与分子生物学技术相结合进行优良醋酸菌的筛选。采用高质量浓度酒精和醋酸培养基富集,挑取醋酸菌膜初步分离目的菌;借助生理生化特征与16S r... 醋酸菌是影响纯种液态酿醋效率的关键因素。为获得高质量浓度醋酸生产菌,本研究将常规筛选方法与分子生物学技术相结合进行优良醋酸菌的筛选。采用高质量浓度酒精和醋酸培养基富集,挑取醋酸菌膜初步分离目的菌;借助生理生化特征与16S rDNA保守序列分析方法鉴定并获得一株产酸高的巴氏醋酸杆菌JST-S(Acetobacter pasteurianus JST-S,BJST-S);在与沪酿1.01(Acetobacter pasteurianus HN 1.01)进行发酵特性对比研究时发现,BJST-S在生长速率、产酸速率及耐醇和耐酸等方面均优于沪酿1.01;半连续发酵3批次BJST-S的产酸量维持在58.10~59.68 g/L,发酵强度维持在1.21~1.24 g/(L·h),说明该菌产酸特性稳定。研究结果可为醋酸工业化生产以及优良菌株的选育提供一定的理论参考。 展开更多
关键词 巴氏醋酸杆菌 菌膜 16SrDNA 半连续发酵
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卒中后抑郁患者家庭功能及家庭护理干预的研究进展 被引量:11
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作者 刘宏丽 赵秋利 +3 位作者 杨丽 王坤晓 宋姗姗 王婧 《现代临床护理》 2020年第1期71-75,共5页
卒中后抑郁(post-stroke depression,PSD)是指发生于卒中后,表现为一系列抑郁症状和相应躯体症状的综合征,是卒中后常见且可治疗的并发症之一,如未及时发现和治疗,将影响卒中后患者神经功能的恢复和日常生活能力,增加患者的致残率和死亡... 卒中后抑郁(post-stroke depression,PSD)是指发生于卒中后,表现为一系列抑郁症状和相应躯体症状的综合征,是卒中后常见且可治疗的并发症之一,如未及时发现和治疗,将影响卒中后患者神经功能的恢复和日常生活能力,增加患者的致残率和死亡率[1-3]。 展开更多
关键词 家庭功能 卒中后抑郁 家庭护理干预 综述
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基于Wnt/β-catenin通路探讨加味黄芪甘草汤对非小细胞肺癌细胞增殖、凋亡、侵袭、迁移及上皮间质转化的影响 被引量:8
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作者 滕港 张芮 +5 位作者 周静 芮红丽 胡燕灵 周雨婷 宋金香 张念志 《中国实验方剂学杂志》 CAS CSCD 北大核心 2022年第21期10-22,共13页
目的:探究加味黄芪甘草汤冻干粉对人非小细胞肺癌细胞A549、PC9增殖、凋亡、侵袭、迁移及上皮间质转化的影响及可能的机制。方法:采用细胞增殖与活性检测(CCK-8)法检测1.0,2.0,4.0,8.0,12.0 g·L^(-1)加味黄芪甘草汤冻干粉对非小细... 目的:探究加味黄芪甘草汤冻干粉对人非小细胞肺癌细胞A549、PC9增殖、凋亡、侵袭、迁移及上皮间质转化的影响及可能的机制。方法:采用细胞增殖与活性检测(CCK-8)法检测1.0,2.0,4.0,8.0,12.0 g·L^(-1)加味黄芪甘草汤冻干粉对非小细胞肺癌细胞增殖的影响;将A549、PC9细胞分为空白组和加味黄芪甘草汤低、中、高组(2.0,4.0,8.0 g·L^(-1));平板克隆检测加味黄芪甘草汤对细胞克隆能力的影响;Hoechst 33342染色检测加味黄芪甘草汤对细胞凋亡的影响;划痕实验和Transwell小室实验分别检测其迁移与侵袭能力;微球体形成实验观察加味黄芪甘草汤对肿瘤细胞成球能力的影响,实时荧光定量聚合酶链式反应(Real-time PCR)检测多能干细胞维持基因八聚体转录因子(Oct-4)、人性别决定区y框蛋白2(Sox2)、同源盒转录因子(Nanog)的mRNA表达水平,评估肿瘤干细胞活性;蛋白免疫印迹法(Western blot)检测B细胞淋巴瘤-2(Bcl-2),Bcl-2关联死亡启动子重组蛋白(Bad),Bcl-2相关X蛋白(Bax),活化与非活化的胱天蛋白酶-3(cleaved Caspase-3、Caspase-3),E-钙黏连蛋白(E-cadherin),N型钙黏蛋白(N-cadherin),波形蛋白(Vimentin),基质金属蛋白酶-2(MMP-2),β-连环蛋白(β-catenin),c-核蛋白类基因(c-Myc),细胞周期蛋白D(_(1)Cyclin D_(1)),锌指转录因子(Slug)蛋白表达水平。结果:与空白组比较,A549、PC9细胞经1.0,2.0,4.0,8.0,12.0 g·L^(-1)加味黄芪甘草汤冻干粉处理24、48 h,细胞增殖能力均被明显抑制,并呈浓度与时间依赖性(P<0.05,P<0.01);加味黄芪甘草汤低、中、高组均能抑制A549、PC9细胞的克隆能力(P<0.05,P<0.01);加味黄芪甘草汤高组均能诱导A549、PC9细胞凋亡(P<0.01);加味黄芪甘草汤低、中、高组均能抑制A549、PC9细胞侵袭、迁移能力(P<0.05,P<0.01);经加味黄芪甘草汤低、中、高组处理后,A549细胞的微球体体积明显缩小,A549、PC9细胞Oct-4、Sox2和Nanog mRNA表达量均降低(P<0.0 展开更多
关键词 加味黄芪甘草汤 非小细胞肺癌 增殖 凋亡 侵袭 迁移 上皮间质转化
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儿童急性细菌性扁桃体炎临床指南第一轮专家问卷分析 被引量:7
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作者 段晓征 易洪利 +4 位作者 刘爽 付彦 曹雪 宋鸽 高嵩 《中国中医药信息杂志》 CAS CSCD 2022年第6期110-114,共5页
目的对《中药单用/联合抗生素治疗儿童急性细菌性扁桃体炎临床指南》第一轮专家问卷结果进行分析及总结。方法采用德尔菲法,在文献检索、调研基础上,编制儿童急性细菌性扁桃体炎临床指南第一轮专家问卷,向全国40名儿科专家发送问卷调查... 目的对《中药单用/联合抗生素治疗儿童急性细菌性扁桃体炎临床指南》第一轮专家问卷结果进行分析及总结。方法采用德尔菲法,在文献检索、调研基础上,编制儿童急性细菌性扁桃体炎临床指南第一轮专家问卷,向全国40名儿科专家发送问卷调查,对中医病名、证候分类、分证治法、选方、抗生素使用最佳时机等指标意见进行统计分析。结果共回收问卷35份,回收率87.5%。儿童急性细菌性扁桃体炎的中医病名中“急乳蛾”“喉蛾”“烂乳蛾”3项指标的集中程度和协调程度高;证候分类指标中,“风热外犯证”“肺胃热盛证”“食积化热证”“湿邪疫毒证”4项指标的重要性较高,但后2项专家意见协调程度低,尚需进一步讨论;在抗生素使用最佳时机的各项指标中,“发病第一天”重要性低,专家意见协调程度差,余5项指标重要性及协调性高。结论专家对儿童急性细菌性扁桃体炎的中医病名指标意见的集中程度及协调程度较高,可根据统计结果将重要性高的3项指标列入下轮问卷。风热外犯证及肺胃热盛证重要性高、专家意见相对集中,食积化热证、湿邪疫毒证重要性高、协调程度较低,需第二轮问卷讨论。抗生素使用最佳时机中5项指标重要性高、协调程度高,均列入下轮问卷。 展开更多
关键词 儿童急性细菌性扁桃体炎 临床指南 德尔菲法 问卷调查
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基于固体食盐结构及成分设计的减盐策略及其研究进展 被引量:4
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作者 公奕夫 李星 +7 位作者 刘斌 肖红利 陈莎男 宋欣宇 闫惠苓 李泽坤 袁育 李媛 《食品科学》 EI CAS CSCD 北大核心 2023年第9期202-210,共9页
食盐是食品工业和居民日常生活中广泛使用的调味品,其主要成分氯化钠的过量摄入会增加高血压、胃癌、脑卒中等疾病的患病风险。如何在不影响食品口味的条件下减少含盐量是目前的研究热点。固体形式的氯化钠是日常膳食食盐摄入的重要部分... 食盐是食品工业和居民日常生活中广泛使用的调味品,其主要成分氯化钠的过量摄入会增加高血压、胃癌、脑卒中等疾病的患病风险。如何在不影响食品口味的条件下减少含盐量是目前的研究热点。固体形式的氯化钠是日常膳食食盐摄入的重要部分,改善固体氯化钠结构及食盐成分是开发低盐食品的有效方法。本文在详细探讨咸味感知机理和机体内钠吸收代谢机制的基础上,对近年来国内外与氯化钠结构调控及成分设计有关的减盐策略进行综述,讨论减少食品含盐量而不影响咸味的各项技术,如调控氯化钠物理结构(形貌和粒径)、包埋氯化钠、添加氯化钠替代物(咸味矿物盐、风味增强剂和天然呈味物质),并分析不同结构及成分食盐的减盐原理、缺点和适用场景,为未来设计新型食盐产品,开发减盐健康食品,减少居民膳食盐摄入量,提高居民健康水平提供理论依据和技术支撑。 展开更多
关键词 氯化钠 减盐策略 咸味感知 结构设计 健康饮食
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唐山市柴油车远程监控综合管控平台的开发及应用 被引量:8
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作者 田苗 王军方 +5 位作者 黄健畅 马帅 吉喆 王宏丽 宋国华 丁焰 《环境科学研究》 EI CAS CSCD 北大核心 2021年第1期132-140,共9页
柴油车排放是我国大气污染的重要来源之一,其排放量大且实际道路排放超标问题较严重,但缺少高效快捷的识别和定量技术.以柴油车精准管控以及重点行业运输需求调控为目的,该研究建立了以车辆车载诊断系统(OBD)、年检、路检路查、遥感等... 柴油车排放是我国大气污染的重要来源之一,其排放量大且实际道路排放超标问题较严重,但缺少高效快捷的识别和定量技术.以柴油车精准管控以及重点行业运输需求调控为目的,该研究建立了以车辆车载诊断系统(OBD)、年检、路检路查、遥感等监控信息为主,车辆行驶轨迹和加油信息为辅的柴油车远程监控综合管控平台,实现高排放车辆识别溯源和重点企业运输监控.以唐山市柴油车秋冬季管控的应用示范为例,分析平台的应用效果.结果表明:①唐山市秋冬季及重污染应急响应期间46家重点企业运输管控平均执行力度均在65%以上.②OBD数据分析得出,监控车辆76%的行驶里程发生在唐山市内,且主要物流通道呈“两纵四横”的特征;高排放车辆在中高速和高扭矩工况下NO x排放水平较高.③秋冬季对移动源的管控使46家重点企业秋冬季和重污染应急响应期间货车流量分别减少了15.9%和33.7%,交通流量减少显著.研究显示,柴油车远程监控综合管控平台可以有效监管企业秋冬季移动源政策实施,以及重型柴油货车运行和排放状况,为区域内重型柴油车动态化精准管控提供支持. 展开更多
关键词 远程监控平台 OBD 工业企业运输车队管控 实际排放 效果评估
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光诱导雨生红球藻虾青素积累的信号通路转录组分析 被引量:7
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作者 崔红利 许文鑫 +4 位作者 崔玉琳 季春丽 张春辉 秦松 李润植 《生物工程学报》 CAS CSCD 北大核心 2021年第4期1260-1276,共17页
雨生红球藻Haematococcuspluvialis在逆境胁迫条件下可大量积累虾青素,被认为自然界最理想的虾青素生产者。高光能有效诱导其虾青素的合成与积累,但藻细胞感知和转导光信号进而调控虾青素积累的机制尚不清楚。文中采用Illumina Hiseq 2... 雨生红球藻Haematococcuspluvialis在逆境胁迫条件下可大量积累虾青素,被认为自然界最理想的虾青素生产者。高光能有效诱导其虾青素的合成与积累,但藻细胞感知和转导光信号进而调控虾青素积累的机制尚不清楚。文中采用Illumina Hiseq 2000高通量测序技术分别获得正常、高白光及高蓝光处理组4.0 G、3.8 G及3.6 G的原始数据量,经质控与拼接之后获得51954条长度至少为200 bp的unigenes基因,经过比对分析,共有20537个unigenes在NR、NT、KO、SwissProt、PfamGO及KOG等数据库中的至少1个数据库中注释成功,达到39.52%。差异表达基因分析显示,高白光vs正常组共获得1255个DEGs;高蓝光vs正常组共获得1494个DEGs;高白光与高蓝光vs正常组共同的DEGs有1008个。KEGG富集分析显示,与对照组相比高白光与高蓝光共同的显著富集通路包括光合作用、类胡萝卜素合成、脂肪酸合成、氧化磷酸化、DNA复制、碳代谢及氮代谢等过程。通过对转录组数据进一步分析,挖掘鉴定了大量光受体及其信号转导通路中的互作蛋白。随机筛选DEGs基因15条,采用荧光定量PCR技术检测其转录水平,结果表明与转录组差异表达数据高度一致。光受体及其信号转导通路中的互作蛋白基因差异表达分析,推测"光信号→光受体→互作蛋白(互作蛋白→转录因子/转录调节子)→功能基因表达→虾青素积累"的信号转导通路可能参与上述调控过程,为深入解析光诱导虾青素合成的转录调控机制奠定了基础。 展开更多
关键词 雨生红球藻 高光 虾青素 转录组测序 光信号通路
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七氟醚后处理对脑缺血再灌注损伤大鼠的保护作用及对Toll样受体4/核因子-κB信号通路的影响 被引量:7
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作者 庞红利 宋俊杰 +1 位作者 范军朝 郑孝振 《新乡医学院学报》 CAS 2020年第1期21-25,29,共6页
目的探讨七氟醚后处理对脑缺血再灌注损伤(CIRI)大鼠的保护作用及对Toll样受体4(TLR4)/核因子-κB(NF-κB)信号通路的影响。方法将60只Sprague Dawley大鼠随机分为假手术组、CIRI组和七氟醚后处理组(Se组),每组20只。CIRI组和Se组大鼠... 目的探讨七氟醚后处理对脑缺血再灌注损伤(CIRI)大鼠的保护作用及对Toll样受体4(TLR4)/核因子-κB(NF-κB)信号通路的影响。方法将60只Sprague Dawley大鼠随机分为假手术组、CIRI组和七氟醚后处理组(Se组),每组20只。CIRI组和Se组大鼠采用线栓法制备CIRI损伤模型,假手术组大鼠不给予线栓。Se组大鼠于再灌注即刻给予体积分数2.5%七氟醚和氧气持续吸入30 min,氧流量1 L·min^-1;假手术组和CIRI组大鼠持续吸入氧气30 min,氧流量1 L·min^-1。再灌注24 h后采用改良神经功能缺损评分(m NSS)评估大鼠的神经功能,评估结束后取血并处死大鼠取出脑组织;检测各组大鼠脑梗死体积比、细胞凋亡指数、血清肿瘤坏死因子α(TNF-α)、白细胞介素(IL)-6、IL-10和IL-1β水平、脑组织中丙二醛(MDA)水平及超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)的活性。Western blot法检测大鼠脑组织中Caspase-3、Bax、Bcl-2、TLR4及NF-κB p65蛋白的表达水平。结果CIRI组和Se组大鼠m NSS评分、脑梗死体积比及细胞凋亡指数高于假手术组(P<0.05);Se组大鼠m NSS评分、脑梗死体积比、细胞凋亡指数低于CIRI组(P<0.05)。与假手术组比较,CIRI组和Se组大鼠血清TNF-α、IL-6和IL-1β水平升高,IL-10水平降低(P<0.05);与CIRI组比较,Se组大鼠血清TNF-α、IL-6和IL-1β水平降低,IL-10水平升高(P<0.05)。与假手术组比较,CIRI组和Se组大鼠脑组织中MDA水平及Caspase-3、Bax、TLR4、NF-κB p65蛋白表达水平显著升高,SOD、GSH-Px活性及Bcl-2蛋白表达水平显著降低(P<0.05);与CIRI组比较,Se组大鼠脑组织中MDA水平及Caspase-3、Bax、TLR4、NF-κB p65蛋白表达水平显著降低,SOD、GSH-Px活性及Bcl-2蛋白表达水平显著升高(P<0.05)。结论七氟醚对CIRI大鼠脑组织具有一定的保护作用,其作用机制可能是通过抑制TLR4/NF-κB介导的炎性级联反应,减少炎性因子的释放,降低炎症和氧化应激反应,从而抑� 展开更多
关键词 七氟醚 脑缺血再灌注损伤 TOLL样受体4 核因子-ΚB 炎症 氧化应激 凋亡
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A Novel Adaptive Kalman Filter Based on Credibility Measure 被引量:3
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作者 Quanbo Ge Xiaoming Hu +2 位作者 Yunyu Li hongli He Zihao song 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2023年第1期103-120,共18页
It is quite often that the theoretic model used in the Kalman filtering may not be sufficiently accurate for practical applications,due to the fact that the covariances of noises are not exactly known.Our previous wor... It is quite often that the theoretic model used in the Kalman filtering may not be sufficiently accurate for practical applications,due to the fact that the covariances of noises are not exactly known.Our previous work reveals that in such scenario the filter calculated mean square errors(FMSE)and the true mean square errors(TMSE)become inconsistent,while FMSE and TMSE are consistent in the Kalman filter with accurate models.This can lead to low credibility of state estimation regardless of using Kalman filters or adaptive Kalman filters.Obviously,it is important to study the inconsistency issue since it is vital to understand the quantitative influence induced by the inaccurate models.Aiming at this,the concept of credibility is adopted to discuss the inconsistency problem in this paper.In order to formulate the degree of the credibility,a trust factor is constructed based on the FMSE and the TMSE.However,the trust factor can not be directly computed since the TMSE cannot be found for practical applications.Based on the definition of trust factor,the estimation of the trust factor is successfully modified to online estimation of the TMSE.More importantly,a necessary and sufficient condition is found,which turns out to be the basis for better design of Kalman filters with high performance.Accordingly,beyond trust factor estimation with Sage-Husa technique(TFE-SHT),three novel trust factor estimation methods,which are directly numerical solving method(TFE-DNS),the particle swarm optimization method(PSO)and expectation maximization-particle swarm optimization method(EM-PSO)are proposed.The analysis and simulation results both show that the proposed TFE-DNS is better than the TFE-SHT for the case of single unknown noise covariance.Meanwhile,the proposed EMPSO performs completely better than the EM and PSO on the estimation of the credibility degree and state when both noise covariances should be estimated online. 展开更多
关键词 CREDIBILITY expectation maximization-particle swarm optimization method(EM-PSO) filter calculated mean square errors(MSE) inaccurate models Kalman filter Sage-Husa true MSE(TMSE)
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