O-linked N-acetylglucosamine(O-GlcNAc)is a dynamic post-translational modification occurring on myriad proteins in the cell nucleus,cytoplasm,and mitochondria.The donor sugar for O-Glc NAcylation,uridine-diphosphate N...O-linked N-acetylglucosamine(O-GlcNAc)is a dynamic post-translational modification occurring on myriad proteins in the cell nucleus,cytoplasm,and mitochondria.The donor sugar for O-Glc NAcylation,uridine-diphosphate N-acetylglucosamine(UDP-Glc NAc),is synthesized from glucose through the hexosamine biosynthetic pathway(HBP).The recycling of O-GlcNAc on proteins is mediated by two enzymes in cells—O-GlcNAc transferase(OGT)and O-Glc NAcase(OGA),which catalyze the addition and removal of O-GlcNAc,respectively.O-GlcNAcylation is involved in a number of important cell processes including transcription,translation,metabolism,signal transduction,and apoptosis.Deregulation of O-GlcNAcylation has been reported to be associated with various human diseases such as cancer,diabetes,neurodegenerative diseases,and cardiovascular diseases.A better understanding of the roles of O-GlcNAcylation in physiopathological processes would help to uncover novel avenues for therapeutic intervention.The aim of this review is to discuss the recent updates on the mechanisms and impacts of O-GlcNAcylation on these diseases,and its potential as a new clinical target.展开更多
In order to cultivate excellent clinical medical talents with a solid foundation, strong literacy, refined skills, excellent communication abilities, innovative thinking, and a strong focus on practicality, functional...In order to cultivate excellent clinical medical talents with a solid foundation, strong literacy, refined skills, excellent communication abilities, innovative thinking, and a strong focus on practicality, functional experiments have undergone a series of reforms in areas such as constructing new curriculum systems, improving teaching content, updating teaching equipment, introducing new teaching models, and enhancing teaching evaluation systems.展开更多
基金supported by the National Natural Science Foundation of China(Nos.91753125,31270865,31322019,and 31570804)the National Key Research and Development Program of China(No.2016YFA0100303)the Zhejiang Provincial Natural Science Foundation of China(No.LR15C050001)
文摘O-linked N-acetylglucosamine(O-GlcNAc)is a dynamic post-translational modification occurring on myriad proteins in the cell nucleus,cytoplasm,and mitochondria.The donor sugar for O-Glc NAcylation,uridine-diphosphate N-acetylglucosamine(UDP-Glc NAc),is synthesized from glucose through the hexosamine biosynthetic pathway(HBP).The recycling of O-GlcNAc on proteins is mediated by two enzymes in cells—O-GlcNAc transferase(OGT)and O-Glc NAcase(OGA),which catalyze the addition and removal of O-GlcNAc,respectively.O-GlcNAcylation is involved in a number of important cell processes including transcription,translation,metabolism,signal transduction,and apoptosis.Deregulation of O-GlcNAcylation has been reported to be associated with various human diseases such as cancer,diabetes,neurodegenerative diseases,and cardiovascular diseases.A better understanding of the roles of O-GlcNAcylation in physiopathological processes would help to uncover novel avenues for therapeutic intervention.The aim of this review is to discuss the recent updates on the mechanisms and impacts of O-GlcNAcylation on these diseases,and its potential as a new clinical target.
文摘In order to cultivate excellent clinical medical talents with a solid foundation, strong literacy, refined skills, excellent communication abilities, innovative thinking, and a strong focus on practicality, functional experiments have undergone a series of reforms in areas such as constructing new curriculum systems, improving teaching content, updating teaching equipment, introducing new teaching models, and enhancing teaching evaluation systems.
