世居高原藏族已形成独特的适应低氧环境的机制,低氧诱导因子(hypoxia-inducible factor,HIF)通路基因内皮PAS结构域蛋白1(endothelial PAS domain protein 1,EPAS1)的遗传变异已被阐明与其低氧适应密切相关.脑耗氧量高,因此最容易受到...世居高原藏族已形成独特的适应低氧环境的机制,低氧诱导因子(hypoxia-inducible factor,HIF)通路基因内皮PAS结构域蛋白1(endothelial PAS domain protein 1,EPAS1)的遗传变异已被阐明与其低氧适应密切相关.脑耗氧量高,因此最容易受到高原低氧的影响.本研究旨在探讨HIF通路基因遗传变异与世居高原藏族脑结构和功能网络的关系.本研究招募了135名世居高原藏族人(19.9±1.1岁)作为研究对象,匹配的65名平原汉族人作为基因遗传变异的对照人群.首先,根据文献选择EPAS1基因中12个单核苷酸多态性(single nucleotide polymorphism,SNP)位点进行基因分型.其次,通过脑磁共振成像(magnetic resonance imaging,MRI)扫描获得藏族脑T1结构像和静息态功能MRI(functional MRI,fMRI).藏族人群中单倍型GA和CAAA的频率显著高于平原汉族,具有这些高频率单倍型的适应较好藏族人群的脑皮层表面积在左中央后回、右距状旁回、右额中回和右后扣带回显著增加,皮层体积在左距状旁回和右颞上回显著增加,脑功能连接主要在躯体运动、腹侧注意、视觉和默认模式网络上显著增加.总之,本研究揭示了EPAS1基因适应性遗传变异与世居高原藏族脑结构和功能网络的关系,发现基因上适应较好的藏族人群脑的变化集中在功能活跃的视觉感知和运动控制脑区及其相关功能神经网络以及默认模式网络.脑的这些变化有助于调节藏族的高原活动.展开更多
Recently,wireless communication capacity has been witnessing unprecedented growth.Benefits from the optoelectronic components with large bandwidth,photonics-assisted terahertz(THz)communication links have been extensi...Recently,wireless communication capacity has been witnessing unprecedented growth.Benefits from the optoelectronic components with large bandwidth,photonics-assisted terahertz(THz)communication links have been extensively developed to accommodate the upcoming wireless transmission with a high data rate.However,limited by the available signalto-noise ratio and THz component bandwidth,single-lane transmission of beyond 100 Gbit/s data rate using a single pair of THz transceivers is still very challenging.In this study,a multicarrier THz photonic wireless communication link in the 300 GHz band is proposed and experimentally demonstrated.Enabled by subcarrier multiplexing,spectrally efficient modulation format,well-tailored digital signal processing routine,and broadband THz transceivers,a line rate of 72 Gbit/s over a wireless distance of 30 m is successfully demonstrated,resulting in a total net transmission capacity of up to 202.5 Gbit/s.The single-lane transmission of beyond 200 Gbit/s overall data rate with a single pair of transceivers at 300 GHz is considered a significant step toward a viable photonics-assisted solution for the next-generation information and communication technology (ICT) infrastructure.展开更多
为治理镉砷污染农田土壤,选取湘南某矿区镉砷复合污染稻田土壤,以水稻盆栽实验研究了复合改良剂HZB（羟基磷灰石＋沸石＋改性秸秆炭）对土壤中镉（Cd）、砷（As）赋存形态以及水稻累积转运Cd和As的影响。结果表明,施用HZB能提高土壤p H ...为治理镉砷污染农田土壤,选取湘南某矿区镉砷复合污染稻田土壤,以水稻盆栽实验研究了复合改良剂HZB（羟基磷灰石＋沸石＋改性秸秆炭）对土壤中镉（Cd）、砷（As）赋存形态以及水稻累积转运Cd和As的影响。结果表明,施用HZB能提高土壤p H 0.19~0.79个单位,阳离子交换量增加22.1%~60.4%;施用HZB使活性较大的酸提取态Cd含量降低了6.5%~22.9%,促进了Cd向难溶态的转变,可使有机结合态Cd增加2.5%~56.5%;施用HZB促进活性As向难溶型的钙型As转化,钙型As含量增加2.8%~53.3%,也可使交换态As含量降低7.0%~39.5%,但当施用量超过4.0 g kg-1时则会增加交换态As含量。水稻根系对Cd的富集系数在0.65~1.21之间,对As的富集系数在0.033~0.049之间,富集Cd的能力大于As;谷壳对Cd的转运能力最大,而根系对As的转运能力最大;施用HZB有降低水稻根系富集Cd和As的能力。施用0.5~2.0 g kg-1的HZB能降低水稻地上各部位中Cd和As含量;在2 g kg-1施用水平,水稻糙米中Cd和As含量均低于0.2 mg kg-1,达到国家食品污染物限量标准。展开更多
Objective:Pain is a health problem frequently reported in the clinical and general populations.Acupoint therapy is one of the most effective ways to treat pain;however,its mechanism remains unclear.Therefore,this stud...Objective:Pain is a health problem frequently reported in the clinical and general populations.Acupoint therapy is one of the most effective ways to treat pain;however,its mechanism remains unclear.Therefore,this study aimed to explore the relationship between distal acupoints,dorsal root ganglion(DRG)neurons,and spinal cord dorsal horn(SDH) neurons in neck acute inflammatory pain(NAIP).Methods:NAIP model rats were used to explore the relationship between acupoint sensitization and pain.Out of fourteen rats,ten rats were grouped into control and NAIP groups,five rats in control and five rats in NAIP.Mustard oil was subcutaneously injected on one side between the C4 and C7 vertebrae of the neck to establish an NAIP model.Evans blue(EB) was injected through the tail vein to detect sensitized acupoints after NAIP modeling.EB exudation in the body,Liè qūe(列缺 LU7),and Língdào(灵道 HT4) were evaluated.An immunofluorescence assay was conducted to detect the expression of calcitonin generelated peptide(CGRP),isolectin B4(IB4),and c-Fos in the dorsal root ganglion(DRG)and spinal cord dorsal medullae spinalis(CDMS).Four rats were used for the retrograde labeling of neurons of the LU7 region to the DRG and CDMS using CTB-488 and CTB-555 microinjection.Results:NAIP was shown to lead to oozing and pain sensitization in the LU7 and HT4 and increased the proportion of c-Fos^(+)/CGRP^(+)and c-Fos^(+)/IB4^(+)cells in both the DRG and CDMS.CTB-488 and CTB-555injected into the LU7 and sensitization point areas were observed in the DRG and CDMS regions of NAIP rats.Conclusions:Our study revealed that NAIP could lead to oozing and pain sensitization in the LU7 and HT4regions and that the pain point around LU7 might result from the transfer of peptidergic(CGRP-positive)and non-peptidergic(IB4-positive) neurons in the DRG and CDMS.展开更多
基金supported by the National Key Research and Development Program of China(Nos.2020YFB1805700,2018YFB1801503,and 2021YFB2800805)the National Natural Science Foundation of China(No.62101483)+1 种基金the Natural Science Foundation of Zhejiang Province(No.LQ21F010015)the Zhejiang Lab(No.2020LC0AD01)。
文摘Recently,wireless communication capacity has been witnessing unprecedented growth.Benefits from the optoelectronic components with large bandwidth,photonics-assisted terahertz(THz)communication links have been extensively developed to accommodate the upcoming wireless transmission with a high data rate.However,limited by the available signalto-noise ratio and THz component bandwidth,single-lane transmission of beyond 100 Gbit/s data rate using a single pair of THz transceivers is still very challenging.In this study,a multicarrier THz photonic wireless communication link in the 300 GHz band is proposed and experimentally demonstrated.Enabled by subcarrier multiplexing,spectrally efficient modulation format,well-tailored digital signal processing routine,and broadband THz transceivers,a line rate of 72 Gbit/s over a wireless distance of 30 m is successfully demonstrated,resulting in a total net transmission capacity of up to 202.5 Gbit/s.The single-lane transmission of beyond 200 Gbit/s overall data rate with a single pair of transceivers at 300 GHz is considered a significant step toward a viable photonics-assisted solution for the next-generation information and communication technology (ICT) infrastructure.
文摘为治理镉砷污染农田土壤,选取湘南某矿区镉砷复合污染稻田土壤,以水稻盆栽实验研究了复合改良剂HZB（羟基磷灰石＋沸石＋改性秸秆炭）对土壤中镉（Cd）、砷（As）赋存形态以及水稻累积转运Cd和As的影响。结果表明,施用HZB能提高土壤p H 0.19~0.79个单位,阳离子交换量增加22.1%~60.4%;施用HZB使活性较大的酸提取态Cd含量降低了6.5%~22.9%,促进了Cd向难溶态的转变,可使有机结合态Cd增加2.5%~56.5%;施用HZB促进活性As向难溶型的钙型As转化,钙型As含量增加2.8%~53.3%,也可使交换态As含量降低7.0%~39.5%,但当施用量超过4.0 g kg-1时则会增加交换态As含量。水稻根系对Cd的富集系数在0.65~1.21之间,对As的富集系数在0.033~0.049之间,富集Cd的能力大于As;谷壳对Cd的转运能力最大,而根系对As的转运能力最大;施用HZB有降低水稻根系富集Cd和As的能力。施用0.5~2.0 g kg-1的HZB能降低水稻地上各部位中Cd和As含量;在2 g kg-1施用水平,水稻糙米中Cd和As含量均低于0.2 mg kg-1,达到国家食品污染物限量标准。
基金Supported by the National Key Research and Development Program of China:2018YFC1704606。
文摘Objective:Pain is a health problem frequently reported in the clinical and general populations.Acupoint therapy is one of the most effective ways to treat pain;however,its mechanism remains unclear.Therefore,this study aimed to explore the relationship between distal acupoints,dorsal root ganglion(DRG)neurons,and spinal cord dorsal horn(SDH) neurons in neck acute inflammatory pain(NAIP).Methods:NAIP model rats were used to explore the relationship between acupoint sensitization and pain.Out of fourteen rats,ten rats were grouped into control and NAIP groups,five rats in control and five rats in NAIP.Mustard oil was subcutaneously injected on one side between the C4 and C7 vertebrae of the neck to establish an NAIP model.Evans blue(EB) was injected through the tail vein to detect sensitized acupoints after NAIP modeling.EB exudation in the body,Liè qūe(列缺 LU7),and Língdào(灵道 HT4) were evaluated.An immunofluorescence assay was conducted to detect the expression of calcitonin generelated peptide(CGRP),isolectin B4(IB4),and c-Fos in the dorsal root ganglion(DRG)and spinal cord dorsal medullae spinalis(CDMS).Four rats were used for the retrograde labeling of neurons of the LU7 region to the DRG and CDMS using CTB-488 and CTB-555 microinjection.Results:NAIP was shown to lead to oozing and pain sensitization in the LU7 and HT4 and increased the proportion of c-Fos^(+)/CGRP^(+)and c-Fos^(+)/IB4^(+)cells in both the DRG and CDMS.CTB-488 and CTB-555injected into the LU7 and sensitization point areas were observed in the DRG and CDMS regions of NAIP rats.Conclusions:Our study revealed that NAIP could lead to oozing and pain sensitization in the LU7 and HT4regions and that the pain point around LU7 might result from the transfer of peptidergic(CGRP-positive)and non-peptidergic(IB4-positive) neurons in the DRG and CDMS.
