Major and profound changes have taken place in China over the past 30 years. Rapid socioeconomic progress has exerted a great impact on lifestyle, ranging from food, clothing, working and living conditions, and means ...Major and profound changes have taken place in China over the past 30 years. Rapid socioeconomic progress has exerted a great impact on lifestyle, ranging from food, clothing, working and living conditions, and means of transportation to leisure activities and entertainment. At the same time, new health problems have emerged, and health services are facing new challenges. Presently, cardiovascular diseases （CVD） are among the top health problems of the Chinese people, and pose a serious challenge to all engaged in the prevention and control of these diseases. An epidemic of CVD in China is emerging as a result of lifestyle changes, urbanization and longevity. Both national policy decision-making and medical practice urgently need an authoritative report which comprehensively reflects the trends in the epidemic of CVD and current preventive measures. Since 2005, guided by the Bureau of Disease Prevention of the Ministry of Health of the People＇s Republic of China and the National Center for Cardiovascular Diseases of China, nationwide experts in the fields of epidemiology, clinical medicine and health economics in the realms of CVD, cerebrovascular disease, diabetes and chronic kidney disease, completed the Report on Cardiovascular Diseases in China every year. The report aims to provide a timely review of the trend of the epidemic and to assess the progress of prevention and control of CVD. In addition, as the report is authoritative, representative and readable, it will become an information platform in the CVD field and an important reference book for government, academic institutes, medical organizations and clinical physicians. This publication is expected to play a positive role in the prevention and control of CVD in China. We present an abstract from the Report on Cardiovascular Diseases in China （2010）, including trends in CVD, morbidity and mortality of major CVDs, up-to-date assessment of risk factors, as well as health resources for CVD, and a profile of medical expenditure, with the aim of p展开更多
Cooperative search-attack is an important application of unmanned aerial vehicle(UAV)swarm in military field.The coupling between path planning and task allocation,the heterogeneity of UAVs,and the dynamic nature of t...Cooperative search-attack is an important application of unmanned aerial vehicle(UAV)swarm in military field.The coupling between path planning and task allocation,the heterogeneity of UAVs,and the dynamic nature of task environment greatly increase the complexity and difficulty of the UAV swarm cooperative search-attack mission planning problem.Inspired by the collaborative hunting behavior of wolf pack,a distributed selforganizing method for UAV swarm search-attack mission planning is proposed.First,to solve the multi-target search problem in unknown environments,a wolf scouting behavior-inspired cooperative search algorithm for UAV swarm is designed.Second,a distributed self-organizing task allocation algorithm for UAV swarm cooperative attacking of targets is proposed by analyzing the flexible labor division behavior of wolves.By abstracting the UAV as a simple artificial wolf agent,the flexible motion planning and group task coordinating for UAV swarm can be realized by self-organizing.The effectiveness of the proposed method is verified by a set of simulation experiments,the stability and scalability are evaluated,and the integrated solution for the coupled path planning and task allocation problems for the UAV swarm cooperative search-attack task can be well performed.展开更多
In this study, mechanical tests were conducted oil a face-centered cubic FeCoNiCrMn high-entropy alloy, both in tension and compression, in a wide range of strain rates （10^-4-10^4 s^-1） to systematically investigat...In this study, mechanical tests were conducted oil a face-centered cubic FeCoNiCrMn high-entropy alloy, both in tension and compression, in a wide range of strain rates （10^-4-10^4 s^-1） to systematically investigate its dynamic response and underlying deformation mechanism. Materials with different grain sizes were tested to understand the effect of grain size, thus grain boundary volume, on the mechanical prop-erties. Microstructures of various samples both before and after deformation were examined using elec-tron backscatter diffraction and transmission electron microscopy. The dislocation structure as well as deformation-induced twins were analyzed and correlated with the measured mechanical properties. Plastic stability during tension of the current high-entropy alloy （HEA）, in particular, at dynamic strain rates, was discussed in lights of strain-rate sensitivity and work hardening rate. It was found that, under dynamic conditions, the strength and uniform ductility increased simultaneously as a result of the mas-sive formation of deformation twins. Specifically, an ultimate tensile strength of 734 MPa and uniform elongation of-63% are obtained at 2.3×10^3 s^-1, indicating that the alloy has great potential for energy absorption upon impact loading.展开更多
Background:Chemotherapy resistance is a primary reason of ovarian cancer therapy failure;hence it is important to investigate the underlying mechanisms of chemotherapy resistance and develop novel potential therapeuti...Background:Chemotherapy resistance is a primary reason of ovarian cancer therapy failure;hence it is important to investigate the underlying mechanisms of chemotherapy resistance and develop novel potential therapeutic targets.Methods:RNA sequencing of cisplatin-resistant and sensitive(chemoresis-tant and chemosensitive,respectively)ovarian cancer organoids was performed,followed by detection of the expression level of fibrillin-1(FBN1)in organoids and clinical specimens of ovarian cancer.Subsequently,glucose metabolism,angiogenesis,and chemosensitivity were analyzed in structural glycoprotein FBNl-knockout cisplatin-resistant ovarian cancer organoids and cell lines.To gain insights into the specific functions and mechanisms of action of FBN1 in ovarian cancer,immunoprecipitation,silver nitrate staining,mass spectrometry,immunofluorescence,Western blotting,and Forister resonance energy transfer-fluorescence lifetime imaging analyses were performed,followed by in vivo assays using vertebrate model systems of nude mice and zebrafish.Results:FBN1 expression was significantly enhanced in cisplatin-resistant ovar-ian cancer organoids and tissues,indicating that FBNI might be a key factor in chemoresistance of ovarian cancer.We also discovered that FBN1 sustained the energy stress and induced angiogenesis in vitro and in vivo,which promoted the cisplatin-resistance of ovarian cancer.Knockout of FBN1 combined with treat-ment of the antiangiogenic drug apatinib improved the cisplatin-sensitivity of ovarian cancer cells.Mechanistically,FBN1 mediated the phosphorylation of vascular endothelial growth factor receptor 2(VEGFR2)at the Tyrl054 residue,which activated its downstream focal adhesion kinase(FAK)/protein kinase B(PKB or AKT)pathway,induced the phosphorylation of signal transducer and activator of transcription 2(STAT2)at the tyrosine residue 690(Tyr690),pro-moted the nuclear translocation of STAT2,and ultimately altered the expression of genes associated with STAT2-mediated angiogenesis and glycolysis.Conclusions:T展开更多
On-site investigations consistently show that the rock burst inherent to coal seams varies greatly with coal seam thickness.In this study,impact factors related to coal seam thickness and surrounding rock strength wer...On-site investigations consistently show that the rock burst inherent to coal seams varies greatly with coal seam thickness.In this study,impact factors related to coal seam thickness and surrounding rock strength were analyzed and a corresponding rock burst risk assessment method was constructed.The model reflects the influence of coal seam thickness on the stress distribution of surrounding rock at the roadway.Based on the roadway excavation range,a stress distribution model of surrounding roadway rock is established and the influence of coal seam thickness on rock burst risk is analyzed accordingly.The proposed rock burst risk assessment method is based on the equivalent surrounding rock strength and coal seam bursting liability.The proposed method was tested in a 3500 mining area to find that it yields rock burst risk assessment results as per coal seam thickness that are in accordance with real-world conditions.The results presented here suggest that coal seam thickness is a crucial factor in effective rock burst risk assessment.展开更多
Dynamic task allocation of unmanned aerial vehicle swarms for ground targets is an important part of unmanned aerial vehicle(UAV)swarms task planning and the key technology to improve autonomy.The realization of dynam...Dynamic task allocation of unmanned aerial vehicle swarms for ground targets is an important part of unmanned aerial vehicle(UAV)swarms task planning and the key technology to improve autonomy.The realization of dynamic task allocation in UAV swarms for ground targets is very difficult because of the large uncertainty of swarms,the target and environment state,and the high real-time allocation requirements.Hence,dynamic task allocation of UAV swarms oriented to ground targets has become a key and difficult problem in the field of mission planning.In this work,a dynamic task allocation method for UAV swarms oriented to ground targets is comprehensively and systematically summarized from two aspects:the establishment of an allocation model and the solution of the allocation model.First,the basic concept and trigger scenario are introduced.Second,the research status and the advantages and disadvantages of the two allocation models are analyzed.Third,the research status and the advantages and disadvantages of several common dynamic task allocation algorithms,such as the algorithm based on market mechanisms,intelligent optimization algorithm,and clustering algorithm,are evaluated.Finally,the specific problems of the current UAV swarm dynamic task allocation method for ground targets are highlighted,and future research directions are established.This work offers important reference significance for fully understanding the current situation of UAV swarm dynamic task allocation technology.展开更多
Objective:To explore the progress and prospect of evaluation methods for infertility patients.Methods:From September 2017 to December 2020,199 cases of infertility patients who have accepted mini-hysteroscopy examinat...Objective:To explore the progress and prospect of evaluation methods for infertility patients.Methods:From September 2017 to December 2020,199 cases of infertility patients who have accepted mini-hysteroscopy examination in the Department of Gynecological Endocrinology,Beijing Obstetrics and Gynecology Hospital,Capital Medical University.The patients who had primary ovary insufficiency,tubal infertility were excluded;patients with hysteroscopy contradiction,such as acute or sub-acute vaginal tract inflammation,endometrium lesion or endometrium carcinoma,severe cardiovascular,liver or kidney insufficiency were excluded.40 patients were excluded and 15 patients lost follow up,144 patients were eventually included in the analysis.The patient’s age,body mass index,infertility etiology,preoperative and postoperative stimulate ovulation cycle,pregnancy state and pregnancy time were recorded.The effect of mini-hysteroscopy on ovulation induction cycle was analyzed in pregnant patients.Results:The average age of 144 patients was 32.10±4.67 years old.96(66.67%)patients were found to have intrauterine abnormalities,while 48(33.33%)patients were found to have normal intrauterine cavity.48 cases of pregnancy,accounting for 33.33%;the median and interquartile ranges[M(Q1,Q3)]of ovulation induction cycles before and after surgery were respectively[3(0,5)],[2(1,3)],the difference was statistically significant(P<0.05).Among the 48 pregnant patients,32 of them had no structural lesions in hysteroscopy,the ovulation induction cycle of these patients before and after hysteroscopy were respectively[5(0,9)],[1(0,3)],the difference was statistically significant(P<0.05).Conclusion:Uterine cavity evaluation is important for the assessments of fertility.As an advanced diagnosis instrument,mini-hysteroscopy can not only timely detect the intrauterine abnormalities of patients,hut also with great application value in shorten the ovulation cycle in infertility patients and increase the pregnancy rate.展开更多
It is difficult for the double suppression division algorithm of bee colony to solve the spatio-temporal coupling or have higher dimensional attributes and undertake sudden tasks.Using the idea of clustering,after clu...It is difficult for the double suppression division algorithm of bee colony to solve the spatio-temporal coupling or have higher dimensional attributes and undertake sudden tasks.Using the idea of clustering,after clustering tasks according to spatio-temporal attributes,the clustered groups are linked into task sub-chains according to similarity.Then,based on the correlation between clusters,the child chains are connected to form a task chain.Therefore,the limitation is solved that the task chain in the bee colony algorithm can only be connected according to one dimension.When a sudden task occurs,a method of inserting a small number of tasks into the original task chain and a task chain reconstruction method are designed according to the relative relationship between the number of sudden tasks and the number of remaining tasks.Through the above improvements,the algorithm can be used to process tasks with spatio-temporal coupling and burst tasks.In order to reflect the efficiency and applicability of the algorithm,a task allocation model for the unmanned aerial vehicle(UAV)group is constructed,and a one-to-one correspondence between the improved bee colony double suppression division algorithm and each attribute in the UAV group is proposed.Task assignment has been constructed.The study uses the self-adjusting characteristics of the bee colony to achieve task allocation.Simulation verification and algorithm comparison show that the algorithm has stronger planning advantages and algorithm performance.展开更多
In this paper,the fixed-time time-varying formation of heterogeneous multi-agent systems(MASs) based on tracking error observer under denial-of-service(DoS) attacks is investigated.Firstly,the dynamic pinning strategy...In this paper,the fixed-time time-varying formation of heterogeneous multi-agent systems(MASs) based on tracking error observer under denial-of-service(DoS) attacks is investigated.Firstly,the dynamic pinning strategy is used to reconstruct the communication channel for the system that suffers from DoS attacks to prevent the discontinuous transmission information of the communication network from affecting MASs formation.Then,considering that the leader state is not available to each follower under DoS attacks,a fixed-time distributed observer without velocity information is constructed to estimate the tracking error between followers and the leader.Finally,adaptive radial basis function neural network(RBFNN) is used to approximate the unknown ensemble disturbances in the system,and the fixed-time time-varying formation scheme is designed with the constructed observer.The effectiveness of the proposed control algorithm is demonstrated by the numerical simulation.展开更多
The rapid development of stretchable electronics made by circuits,microchips,and encapsulation elastomers has caused the production of a large amount of electronic waste(e-waste).The degradation of elastomers can high...The rapid development of stretchable electronics made by circuits,microchips,and encapsulation elastomers has caused the production of a large amount of electronic waste(e-waste).The degradation of elastomers can highly minimize the negative effects of e-wastes.However,chemicals that included acid,alkali,and organics were repeatedly used during the recycling process,which were environmentally unfriendly.Here,a water-modulation-degradation-reconstruction(WDR)polyvinylpyrrolidone(PVP)-honey composite(PHC)polymer-gel was developed and could be regarded as encapsulation elastomers to realize a fully recyclable water-degradable stretchable(WS)electronics with multi-functions.The stretchability of the PHC polymer-gel could be modulated by the change of its water retention.The Chip-integrated liquid metal(LM)circuits encapsulated with the modulated PHC encapsulation elastomer could withstand a strain value of~3000%.Moreover,we developed a WS biomedical sensor composed of PHC encapsulation elastomer,LM circuits,and microchips,which could be fully recycled by biodegrading it in water to reconstruct a new one.As before,the reconstructed WS biomedical sensor could still simultaneously realize the combination of ultra-stretchability,recycling,self-healing,self-adhesive,and self-conformal abilities.The results revealed that this study exercises a profound influence on the rational design of multi-functional WS electronics.展开更多
Optimization problems especially in a dynamic environment is a hot research area that has attracted notable attention in the past decades.It is clear from the dynamic optimization literatures that most of the efforts ...Optimization problems especially in a dynamic environment is a hot research area that has attracted notable attention in the past decades.It is clear from the dynamic optimization literatures that most of the efforts have been devoted to continuous dynamic optimization problems although the majority of the real-life problems are combinatorial.Moreover,many algorithms shown to be successful in stationary combinatorial optimization problems commonly have mediocre performance in a dynamic environment.In this study,based on binary wolf pack algorithm(BWPA),combining with flexible population updating strategy,a flexible binary wolf pack algorithm(FWPA)is proposed.Then,FWPA is used to solve a set of static multidimensional knapsack benchmarks and several dynamic multidimensional knapsack problems,which have numerous practical applications.To the best of our knowledge,this paper constitutes the first study on the performance of WPA on a dynamic combinatorial problem.By comparing two state-of-the-art algorithms with the basic BWPA,the simulation experimental results demonstrate that FWPA can be considered as a feasibility and competitive algorithm for dynamic optimization problems.展开更多
Water regulation of the Xiaolangdi Reservoir of the Yellow River was chosen as a case to investigate variations in concentrations and bioavailability of heavy metals caused by water conservancy projects in rivers. Wat...Water regulation of the Xiaolangdi Reservoir of the Yellow River was chosen as a case to investigate variations in concentrations and bioavailability of heavy metals caused by water conservancy projects in rivers. Water and suspended sediment（SPS） samples were collected at downstream sampling sites along the river during this period. Concentrations and speciation of Zn, Cr, Cu, Ni, and Pb in water and SPS samples were analyzed, and their bioaccumulation was studied with Daphnia magna. This study indicated that the exchangeable and carbonatebound fractions of heavy metals in SPS decreased along the studied stretch, and the dissolved heavy metal concentrations increased along the river with 1.6–15 folds. This is because sediment resuspension increased along the river during water regulation, giving rise to the increase of heavy metal release from SPS. The dissolved Zn, Cu, Ni, and Pb concentrations were significantly positively correlated with SPS concentrations, and their increase along the river was greater than Cr. The body burdens of heavy metals in D. magna exposed into samples collected from the reservoir outlet were 1.3–3.0 times lower than those from downstream stations, suggesting that the heavy metal bioavailability increased during water regulation.This should be considered in the reservoir operation.展开更多
Effective charge separation and transfer is deemed to be the contributing factor to achieve high photoelectrochemical(PEC)water splitting performance on photoelectrodes.Building a phase junction structure with control...Effective charge separation and transfer is deemed to be the contributing factor to achieve high photoelectrochemical(PEC)water splitting performance on photoelectrodes.Building a phase junction structure with controllable phase transition of WO_(3) can further improve the photocatalytic performance.In this work,we realized the transition from orthorhombic to monoclinic by regulating the annealing temperatures,and constructed an orthorhombic–monoclinic WO_(3)(o-WO_(3)/m-WO_(3))phase junction.The formation of oxygen vacancies causes an imbalance of the charge distribution in the crystal structure,which changes the W–O bond length and bond angle,accelerating the phase transition.As expected,an optimum PEC activity was achieved over the o-WO_(3)/m-WO_(3) phase junction in WO_(3)-450 photoelectrode,yielding the maximum O_(2) evolution rate roughly 32 times higher than that of pure WO_(3)-250 without any sacrificial agents under visible light irradiation.The enhancement of catalytic activity is attributed to the atomically smooth interface with a highly matched lattice and robust built-in electric field around the phase junction,which leads to a less-defective and abrupt interface and provides a smooth interfacial charge separation and transfer path,leading to improved charge separation and transfer efficiency and a great enhancement in photocatalytic activity.This work strikes out on new paths in the formation of an oxygen vacancy-induced phase transition and provides new ideas for the design of catalysts.展开更多
The production data in the industrialfield have the characteristics of multimodality,high dimensionality and large correlation differences between attributes.Existing data prediction methods cannot effectively capture ...The production data in the industrialfield have the characteristics of multimodality,high dimensionality and large correlation differences between attributes.Existing data prediction methods cannot effectively capture time series and modal features,which leads to prediction hysteresis and poor prediction stabil-ity.Aiming at the above problems,this paper proposes a time-series and modal fea-tureenhancementmethodbasedonadual-stageself-attentionmechanism(DATT),and a time series prediction method based on a gated feedforward recurrent unit(GFRU).On this basis,the DATT-GFRU neural network with a gated feedforward recurrent neural network and dual-stage self-attention mechanism is designed and implemented.Experiments show that the prediction effect of the neural network prediction model based on DATT is significantly improved.Compared with the traditional prediction model,the DATT-GFRU neural network has a smaller aver-age error of model prediction results,stable prediction performance,and strong generalization ability on the three datasets with different numbers of attributes and different training sample sizes.展开更多
In order to improve the thermal properties of polylactic acid（PLA） filament,nano-SiO_2 was applied to mix with PLA,then they were spun as composite filament by melt-spinning.The dispersion of nano SiO_2 and the frac...In order to improve the thermal properties of polylactic acid（PLA） filament,nano-SiO_2 was applied to mix with PLA,then they were spun as composite filament by melt-spinning.The dispersion of nano SiO_2 and the fracture surfaces of filaments were studied by scanning electron microscopy（SEM）.The properties of composite filament,such as orientation degree,mechanical properties,and surface friction properties,were analyzed.The thermal performances of composite filament were analyzed by differential scanning calorimetry（DSC） and thermo gravimetric analysis（TGA）.The results showed that the nano-SiO_2 modified by 5% KH-550 could disperse evenly and loosely in nano-scale,and 1 wt% and 3 wt% nano-SiO_2 dispersed throughout PLA evenly.As the quantity of nano-SiO_2 increased,the properties of composite filament,such as orientation degree,friction coefficient,thermal decomposition temperature,and glass transition temperature,increased more or less.The breaking tenacity increased when 1 wt% SiO_2 was added in PLA,but declined when 3 wt% SiO_2 was added.展开更多
Photocatalytic non-oxidative coupling of methane(PNOCM)is a mild and cost-effective method for the production of multicarbon compounds.However,the separation of photogenerated charges and activation of methane(CH4)are...Photocatalytic non-oxidative coupling of methane(PNOCM)is a mild and cost-effective method for the production of multicarbon compounds.However,the separation of photogenerated charges and activation of methane(CH4)are the main challenges for this reaction.Here,single crystal-like TiO_(2) nanotubes(VO-p-TNTs)with oxygen vacancies(VO)and preferential orientation were prepared and applied to PNOCM.The results demonstrate that the significantly enhanced photocatalytic performance is mainly related to the strong synergistic effect between preferential orientation and VO.The preferential orientation of VO-p-TNT along the[001]direction reduces the formation of complex centers at grain boundaries as the form of interfacial states and potential barriers,which improves the separation and transport of photogenerated carriers.Meanwhile,VO provides abundant coordination unsaturated sites for CH4 chemisorption and also acts as electron traps to hinder the recombination of electrons and holes,establishing an effective electron transfer channel between the adsorbed CH4 molecule and photocatalyst,thus weakening the C–H bond.In addition,the introduction of VO broadens the light absorption range.As a result,VO-p-TNT exhibits excellent PNOCM performance and provides new insights into catalyst design for CH4 conversion.展开更多
Background:Musculoskeletal ultrasound is used in clinical practice to evaluate gout patients and is an effective imaging tool for the detection of tophi.The aim of this study was to analyze the factors associated with...Background:Musculoskeletal ultrasound is used in clinical practice to evaluate gout patients and is an effective imaging tool for the detection of tophi.The aim of this study was to analyze the factors associated with ultrasound-detected tophi in gout patients and to construct a clinical model to predict its occurrence and improve the detection of hidden tophi.Methods:Data of gout patients admitted to Beijing Jishuitan Hospital from January 2015 to December 2021 were collected.The complete and detailed information from gout cases with completed musculoskeletal ultrasound was included in the analysis.Univariate and multivariate analyses were used to identify independent factors associated with ultrasound-detected tophi.A nomogram was used to visualize the clinical predictive models.Results:Among 517 gout patients,rheumatologists found that 67 patients(13.0%)had subcutaneous tophi by visual observation,while musculoskeletal ultrasound revealed that 123 patients(23.8%)had ultrasound-detected tophi with odds ratio[OR](95%confidence intervals[CIs])=2.20(1.81-2.67).Disease duration,upper limb joint flare(ULJF),persistent joint pain(PJP),uric acid,and homocysteine levels were independently associated with ultrasounddetected tophi,and they had ORs(95%CIs)of 1.092(1.050-1.136),3.732(2.312-6.025),1.864(1.086-3.200),1.003(1.001-1.004),and 1.015(1.000-1.030),respectively.After balancing the complexity and accuracy of the model,Model 2(incorporating disease duration,ULJF,PJP,and uric acid)was chosen to create a nomogram to predict the occurrence of ultrasound-detected tophi.The nomogram had good discrimination(consistency index[C-index]=0.774)and excellent calibration,demonstrated by calibration curves.Conclusion:Using easily available indicators,such as disease duration,the nature of the joint pain,and uric acid levels,we successfully developed an easy-to-use clinical model to improve the detection of hidden tophi.展开更多
It is difficult to comprehensively extract device status information for CNNs under a single source high-frequency timing signal,and CNNs cannot effec-tively achieve precise identification and classification based on the...It is difficult to comprehensively extract device status information for CNNs under a single source high-frequency timing signal,and CNNs cannot effec-tively achieve precise identification and classification based on the importance of multichannel features.This article proposes a CNN fault diagnosis method based on multi-channel weight adaptation.This methodfirst normalizes different data sources as input as different channels of CNN,and uses the characteristics of convolutional networks to achieve the characteristics of different data sources.Fusion and extraction.Then,the SNET module is embedded into the CNN net-work,adapted to the weight of each channel,and the accuracy of classification is improved.Finally,through comparative experiments,this method can further improve the accuracy of fault recognition.展开更多
Enhancer of zeste homolog 2(EZH2),an enzymatic subunit of PRC2 complex,plays an important role in tumor development and progression through its catalytic and noncatalytic activities.Overexpression or gain-of-function ...Enhancer of zeste homolog 2(EZH2),an enzymatic subunit of PRC2 complex,plays an important role in tumor development and progression through its catalytic and noncatalytic activities.Overexpression or gain-of-function mutations of EZH2 have been significantly associated with tumor cell proliferation of triple-negative breast cancer(TNBC)and diffuse large B-cell lymphoma(DLBCL).As a result,it has gained interest as a potential therapeutic target.The currently available EZH2 inhibitors,such as EPZ6438 and GSK126,are of benefit for clinical using or reached clinical trials.However,certain cancers are resistant to these enzymatic inhibitors due to its noncatalytic or transcriptional activity through modulating nonhistone proteins.Thus,it may be more effective to synergistically degrade EZH2 in addition to enzymatic inhibition.Here,through a rational design and chemical screening,we discovered a new irreversible EZH2 inhibitor,IHMT-337,which covalently bounds to and degrades EZH2 via the E3 ligase CHIP-mediated ubiquitination pathway.Moreover,we revealed that IHMT-337 affects cell cycle progression in TNBC cells through targeting transcriptional regulating of CDK4,a novel PRC2 complex-and enzymatic activity-independent function of EZH2.More significantly,our compound inhibits both DLBCL and TNBC cell proliferation in different preclinical models in vitro and in vivo.Taken together,our findings demonstrate that in addition to enzymatic inhibition,destroying of EZH2 by IHMT-337 could be a promising therapeutic strategy for TNBC and other malignancies that are independent of EZH2 enzymatic activity.展开更多
Cutavirus(CuV)is a novel protoparvovirus possibly associated with diarrhea and cutaneous T-cell lymphomas.Patients with rheumatic disease are immunosuppressed and may be more vulnerable to pathogenic viruses.A descrip...Cutavirus(CuV)is a novel protoparvovirus possibly associated with diarrhea and cutaneous T-cell lymphomas.Patients with rheumatic disease are immunosuppressed and may be more vulnerable to pathogenic viruses.A descriptive study was conducted among hospitalized patients with rheumatic diseases and individuals undergoing medical health check-ups between June 2019 and June 2022 in Guangzhou,China.Stool samples of subjects were tested for CuV DNA.Demographic and fecal examination data of patients were obtained from electronic medical records.A total of 505 patients with rheumatic diseases and 244 individuals who underwent medical health check-ups were included in the study.Of the patients with rheumatic disease,5.74%[95%confidence interval(CI):4.03%–8.12%]were positive for CuV DNA,while no individual in the medical health check-up group was positive,indicating a close correlation between CuV and rheumatic disease.Men and patients with rheumatoid arthritis or ankylosing spondylitis,according to the disease classification,were more susceptible to being infected with CuV(P<0.01).After adjustments,being male remained the only significant factor,with an adjusted odd ratio(OR)of 4.4(95%CI:1.7–11.4,P=0.002).Phylogenetic analysis of the CuV VP2 sequences showed three diverse clades,one of which was segregated to be a single branching independent of previously known sequences,which is possible a new genotype.展开更多
文摘Major and profound changes have taken place in China over the past 30 years. Rapid socioeconomic progress has exerted a great impact on lifestyle, ranging from food, clothing, working and living conditions, and means of transportation to leisure activities and entertainment. At the same time, new health problems have emerged, and health services are facing new challenges. Presently, cardiovascular diseases （CVD） are among the top health problems of the Chinese people, and pose a serious challenge to all engaged in the prevention and control of these diseases. An epidemic of CVD in China is emerging as a result of lifestyle changes, urbanization and longevity. Both national policy decision-making and medical practice urgently need an authoritative report which comprehensively reflects the trends in the epidemic of CVD and current preventive measures. Since 2005, guided by the Bureau of Disease Prevention of the Ministry of Health of the People＇s Republic of China and the National Center for Cardiovascular Diseases of China, nationwide experts in the fields of epidemiology, clinical medicine and health economics in the realms of CVD, cerebrovascular disease, diabetes and chronic kidney disease, completed the Report on Cardiovascular Diseases in China every year. The report aims to provide a timely review of the trend of the epidemic and to assess the progress of prevention and control of CVD. In addition, as the report is authoritative, representative and readable, it will become an information platform in the CVD field and an important reference book for government, academic institutes, medical organizations and clinical physicians. This publication is expected to play a positive role in the prevention and control of CVD in China. We present an abstract from the Report on Cardiovascular Diseases in China （2010）, including trends in CVD, morbidity and mortality of major CVDs, up-to-date assessment of risk factors, as well as health resources for CVD, and a profile of medical expenditure, with the aim of p
基金supported by the National Natural Science Foundation of China(61502534)the Shaanxi Provincial Natural Science Foundation(2020JQ-493)+2 种基金the Integrative Equipment Research Project of Armed Police Force(WJ20211A030018)the Military Science Project of the National Social Science Fund(WJ2019-SKJJ-C-092)the Theoretical Research Foundation of Armed Police Engineering University(WJY202148)。
文摘Cooperative search-attack is an important application of unmanned aerial vehicle(UAV)swarm in military field.The coupling between path planning and task allocation,the heterogeneity of UAVs,and the dynamic nature of task environment greatly increase the complexity and difficulty of the UAV swarm cooperative search-attack mission planning problem.Inspired by the collaborative hunting behavior of wolf pack,a distributed selforganizing method for UAV swarm search-attack mission planning is proposed.First,to solve the multi-target search problem in unknown environments,a wolf scouting behavior-inspired cooperative search algorithm for UAV swarm is designed.Second,a distributed self-organizing task allocation algorithm for UAV swarm cooperative attacking of targets is proposed by analyzing the flexible labor division behavior of wolves.By abstracting the UAV as a simple artificial wolf agent,the flexible motion planning and group task coordinating for UAV swarm can be realized by self-organizing.The effectiveness of the proposed method is verified by a set of simulation experiments,the stability and scalability are evaluated,and the integrated solution for the coupled path planning and task allocation problems for the UAV swarm cooperative search-attack task can be well performed.
基金supported by the National Natural Science Foundation of China(51671018,51531001,51422101,51371003,and 51671021)111 Project(B07003)+5 种基金International S&T Cooperation Program of China(2015DFG52600)Program for Changjiang Scholars and Innovative Research Team in University of China(IRT_14R05)the Projects of SKL-AMM-USTB(2016Z-04,2016-09,2016Z-16)the financial support from the Top-Notch Young Talents Programthe Fundamental Research Funds for the Central Universitiesthe financial support by US-NSF under contract DMR-1408722
文摘In this study, mechanical tests were conducted oil a face-centered cubic FeCoNiCrMn high-entropy alloy, both in tension and compression, in a wide range of strain rates （10^-4-10^4 s^-1） to systematically investigate its dynamic response and underlying deformation mechanism. Materials with different grain sizes were tested to understand the effect of grain size, thus grain boundary volume, on the mechanical prop-erties. Microstructures of various samples both before and after deformation were examined using elec-tron backscatter diffraction and transmission electron microscopy. The dislocation structure as well as deformation-induced twins were analyzed and correlated with the measured mechanical properties. Plastic stability during tension of the current high-entropy alloy （HEA）, in particular, at dynamic strain rates, was discussed in lights of strain-rate sensitivity and work hardening rate. It was found that, under dynamic conditions, the strength and uniform ductility increased simultaneously as a result of the mas-sive formation of deformation twins. Specifically, an ultimate tensile strength of 734 MPa and uniform elongation of-63% are obtained at 2.3×10^3 s^-1, indicating that the alloy has great potential for energy absorption upon impact loading.
基金Shanghai Municipal Health Commission,Grant/Award Number:20194Y0039Natural Science Foundation of China,Grant/Award Numbers:81872117,81502235funded by Project of the Shanghai Municipal Health Com-mission(No.20194Y0039 to HZ.S)and Natural Science Foundation of China(No.81872117 and 81502235 to ZL.W).
文摘Background:Chemotherapy resistance is a primary reason of ovarian cancer therapy failure;hence it is important to investigate the underlying mechanisms of chemotherapy resistance and develop novel potential therapeutic targets.Methods:RNA sequencing of cisplatin-resistant and sensitive(chemoresis-tant and chemosensitive,respectively)ovarian cancer organoids was performed,followed by detection of the expression level of fibrillin-1(FBN1)in organoids and clinical specimens of ovarian cancer.Subsequently,glucose metabolism,angiogenesis,and chemosensitivity were analyzed in structural glycoprotein FBNl-knockout cisplatin-resistant ovarian cancer organoids and cell lines.To gain insights into the specific functions and mechanisms of action of FBN1 in ovarian cancer,immunoprecipitation,silver nitrate staining,mass spectrometry,immunofluorescence,Western blotting,and Forister resonance energy transfer-fluorescence lifetime imaging analyses were performed,followed by in vivo assays using vertebrate model systems of nude mice and zebrafish.Results:FBN1 expression was significantly enhanced in cisplatin-resistant ovar-ian cancer organoids and tissues,indicating that FBNI might be a key factor in chemoresistance of ovarian cancer.We also discovered that FBN1 sustained the energy stress and induced angiogenesis in vitro and in vivo,which promoted the cisplatin-resistance of ovarian cancer.Knockout of FBN1 combined with treat-ment of the antiangiogenic drug apatinib improved the cisplatin-sensitivity of ovarian cancer cells.Mechanistically,FBN1 mediated the phosphorylation of vascular endothelial growth factor receptor 2(VEGFR2)at the Tyrl054 residue,which activated its downstream focal adhesion kinase(FAK)/protein kinase B(PKB or AKT)pathway,induced the phosphorylation of signal transducer and activator of transcription 2(STAT2)at the tyrosine residue 690(Tyr690),pro-moted the nuclear translocation of STAT2,and ultimately altered the expression of genes associated with STAT2-mediated angiogenesis and glycolysis.Conclusions:T
基金supported and financed from Special Funds for Basic Research Business Fees of China Academy of Safety Science and Technology(Nos.2016JBKY16,2017JBKY05)National Key Research and Development Program of China(No.2017YFC0804603)Subject of Beijing Science and Technology Commission(No.Z171100002317008)
文摘On-site investigations consistently show that the rock burst inherent to coal seams varies greatly with coal seam thickness.In this study,impact factors related to coal seam thickness and surrounding rock strength were analyzed and a corresponding rock burst risk assessment method was constructed.The model reflects the influence of coal seam thickness on the stress distribution of surrounding rock at the roadway.Based on the roadway excavation range,a stress distribution model of surrounding roadway rock is established and the influence of coal seam thickness on rock burst risk is analyzed accordingly.The proposed rock burst risk assessment method is based on the equivalent surrounding rock strength and coal seam bursting liability.The proposed method was tested in a 3500 mining area to find that it yields rock burst risk assessment results as per coal seam thickness that are in accordance with real-world conditions.The results presented here suggest that coal seam thickness is a crucial factor in effective rock burst risk assessment.
基金This work was partially supported by the Military Science Project of National Social Science Foundation(No.2019-SKJJ-C-092)the National Natural Science Foundation of China(No.61502534)+3 种基金the Natural Science Foundation of Shanxi Province(No.2020JQ-493)Military Equipment Research Project(No.WJ2020A020029)Military Theory Project of PAP(No.WJJY21JL0618)Research Foundation of Armed Police Force Engineering University(Nos.WJY202148 and JLY2020084).
文摘Dynamic task allocation of unmanned aerial vehicle swarms for ground targets is an important part of unmanned aerial vehicle(UAV)swarms task planning and the key technology to improve autonomy.The realization of dynamic task allocation in UAV swarms for ground targets is very difficult because of the large uncertainty of swarms,the target and environment state,and the high real-time allocation requirements.Hence,dynamic task allocation of UAV swarms oriented to ground targets has become a key and difficult problem in the field of mission planning.In this work,a dynamic task allocation method for UAV swarms oriented to ground targets is comprehensively and systematically summarized from two aspects:the establishment of an allocation model and the solution of the allocation model.First,the basic concept and trigger scenario are introduced.Second,the research status and the advantages and disadvantages of the two allocation models are analyzed.Third,the research status and the advantages and disadvantages of several common dynamic task allocation algorithms,such as the algorithm based on market mechanisms,intelligent optimization algorithm,and clustering algorithm,are evaluated.Finally,the specific problems of the current UAV swarm dynamic task allocation method for ground targets are highlighted,and future research directions are established.This work offers important reference significance for fully understanding the current situation of UAV swarm dynamic task allocation technology.
基金supported by:Beijing Municipal Administration of Hospitals Clinical medicine Development of special funding support,China(Grant No.XMLX201710)Beijing Municipality Health Technology High-level Talent,China(Grant No.2014-2-016)Beijing Natural Science Foundation of China(Grant No.7162062).
文摘Objective:To explore the progress and prospect of evaluation methods for infertility patients.Methods:From September 2017 to December 2020,199 cases of infertility patients who have accepted mini-hysteroscopy examination in the Department of Gynecological Endocrinology,Beijing Obstetrics and Gynecology Hospital,Capital Medical University.The patients who had primary ovary insufficiency,tubal infertility were excluded;patients with hysteroscopy contradiction,such as acute or sub-acute vaginal tract inflammation,endometrium lesion or endometrium carcinoma,severe cardiovascular,liver or kidney insufficiency were excluded.40 patients were excluded and 15 patients lost follow up,144 patients were eventually included in the analysis.The patient’s age,body mass index,infertility etiology,preoperative and postoperative stimulate ovulation cycle,pregnancy state and pregnancy time were recorded.The effect of mini-hysteroscopy on ovulation induction cycle was analyzed in pregnant patients.Results:The average age of 144 patients was 32.10±4.67 years old.96(66.67%)patients were found to have intrauterine abnormalities,while 48(33.33%)patients were found to have normal intrauterine cavity.48 cases of pregnancy,accounting for 33.33%;the median and interquartile ranges[M(Q1,Q3)]of ovulation induction cycles before and after surgery were respectively[3(0,5)],[2(1,3)],the difference was statistically significant(P<0.05).Among the 48 pregnant patients,32 of them had no structural lesions in hysteroscopy,the ovulation induction cycle of these patients before and after hysteroscopy were respectively[5(0,9)],[1(0,3)],the difference was statistically significant(P<0.05).Conclusion:Uterine cavity evaluation is important for the assessments of fertility.As an advanced diagnosis instrument,mini-hysteroscopy can not only timely detect the intrauterine abnormalities of patients,hut also with great application value in shorten the ovulation cycle in infertility patients and increase the pregnancy rate.
基金This work was supported by the National Natural Science and Technology Innovation 2030 Major Project of Ministry of Science and Technology of China(2018AAA0101200)the National Natural Science Foundation of China(61502522,61502534)+4 种基金the Equipment Pre-Research Field Fund(JZX7Y20190253036101)the Equipment Pre-Research Ministry of Education Joint Fund(6141A02033703)Shaanxi Provincial Natural Science Foundation(2020JQ-493)the Military Science Project of the National Social Science Fund(WJ2019-SKJJ-C-092)the Theoretical Research Foundation of Armed Police Engineering University(WJY202148).
文摘It is difficult for the double suppression division algorithm of bee colony to solve the spatio-temporal coupling or have higher dimensional attributes and undertake sudden tasks.Using the idea of clustering,after clustering tasks according to spatio-temporal attributes,the clustered groups are linked into task sub-chains according to similarity.Then,based on the correlation between clusters,the child chains are connected to form a task chain.Therefore,the limitation is solved that the task chain in the bee colony algorithm can only be connected according to one dimension.When a sudden task occurs,a method of inserting a small number of tasks into the original task chain and a task chain reconstruction method are designed according to the relative relationship between the number of sudden tasks and the number of remaining tasks.Through the above improvements,the algorithm can be used to process tasks with spatio-temporal coupling and burst tasks.In order to reflect the efficiency and applicability of the algorithm,a task allocation model for the unmanned aerial vehicle(UAV)group is constructed,and a one-to-one correspondence between the improved bee colony double suppression division algorithm and each attribute in the UAV group is proposed.Task assignment has been constructed.The study uses the self-adjusting characteristics of the bee colony to achieve task allocation.Simulation verification and algorithm comparison show that the algorithm has stronger planning advantages and algorithm performance.
文摘In this paper,the fixed-time time-varying formation of heterogeneous multi-agent systems(MASs) based on tracking error observer under denial-of-service(DoS) attacks is investigated.Firstly,the dynamic pinning strategy is used to reconstruct the communication channel for the system that suffers from DoS attacks to prevent the discontinuous transmission information of the communication network from affecting MASs formation.Then,considering that the leader state is not available to each follower under DoS attacks,a fixed-time distributed observer without velocity information is constructed to estimate the tracking error between followers and the leader.Finally,adaptive radial basis function neural network(RBFNN) is used to approximate the unknown ensemble disturbances in the system,and the fixed-time time-varying formation scheme is designed with the constructed observer.The effectiveness of the proposed control algorithm is demonstrated by the numerical simulation.
基金supported by the Natural Science Foundation of Ningbo city,China(Grant No.2023J010)Natural Science Foundation of China(Grant Nos.52275343,62074013 and U23A20363)supported by the Fundamental Research Funds for the Provincial Universities of Zhejiang(Grant No.SJLY2024007)
文摘The rapid development of stretchable electronics made by circuits,microchips,and encapsulation elastomers has caused the production of a large amount of electronic waste(e-waste).The degradation of elastomers can highly minimize the negative effects of e-wastes.However,chemicals that included acid,alkali,and organics were repeatedly used during the recycling process,which were environmentally unfriendly.Here,a water-modulation-degradation-reconstruction(WDR)polyvinylpyrrolidone(PVP)-honey composite(PHC)polymer-gel was developed and could be regarded as encapsulation elastomers to realize a fully recyclable water-degradable stretchable(WS)electronics with multi-functions.The stretchability of the PHC polymer-gel could be modulated by the change of its water retention.The Chip-integrated liquid metal(LM)circuits encapsulated with the modulated PHC encapsulation elastomer could withstand a strain value of~3000%.Moreover,we developed a WS biomedical sensor composed of PHC encapsulation elastomer,LM circuits,and microchips,which could be fully recycled by biodegrading it in water to reconstruct a new one.As before,the reconstructed WS biomedical sensor could still simultaneously realize the combination of ultra-stretchability,recycling,self-healing,self-adhesive,and self-conformal abilities.The results revealed that this study exercises a profound influence on the rational design of multi-functional WS electronics.
基金This work is supported by the National Science and Technology Innovation 2030 Major Project of the Ministry of Science and Technology of China(Grant No.2018AAA0101200)the National Natural Science Foundation of China(Grant No.61502534).
文摘Optimization problems especially in a dynamic environment is a hot research area that has attracted notable attention in the past decades.It is clear from the dynamic optimization literatures that most of the efforts have been devoted to continuous dynamic optimization problems although the majority of the real-life problems are combinatorial.Moreover,many algorithms shown to be successful in stationary combinatorial optimization problems commonly have mediocre performance in a dynamic environment.In this study,based on binary wolf pack algorithm(BWPA),combining with flexible population updating strategy,a flexible binary wolf pack algorithm(FWPA)is proposed.Then,FWPA is used to solve a set of static multidimensional knapsack benchmarks and several dynamic multidimensional knapsack problems,which have numerous practical applications.To the best of our knowledge,this paper constitutes the first study on the performance of WPA on a dynamic combinatorial problem.By comparing two state-of-the-art algorithms with the basic BWPA,the simulation experimental results demonstrate that FWPA can be considered as a feasibility and competitive algorithm for dynamic optimization problems.
基金supported by the National Key R&D Program of China(No.2017YFA0605001)the National Natural Science Foundation of China(No.91547207)the Fund for Innovative Research Group of the National Natural Science Foundation of China(No.51721093)
文摘Water regulation of the Xiaolangdi Reservoir of the Yellow River was chosen as a case to investigate variations in concentrations and bioavailability of heavy metals caused by water conservancy projects in rivers. Water and suspended sediment（SPS） samples were collected at downstream sampling sites along the river during this period. Concentrations and speciation of Zn, Cr, Cu, Ni, and Pb in water and SPS samples were analyzed, and their bioaccumulation was studied with Daphnia magna. This study indicated that the exchangeable and carbonatebound fractions of heavy metals in SPS decreased along the studied stretch, and the dissolved heavy metal concentrations increased along the river with 1.6–15 folds. This is because sediment resuspension increased along the river during water regulation, giving rise to the increase of heavy metal release from SPS. The dissolved Zn, Cu, Ni, and Pb concentrations were significantly positively correlated with SPS concentrations, and their increase along the river was greater than Cr. The body burdens of heavy metals in D. magna exposed into samples collected from the reservoir outlet were 1.3–3.0 times lower than those from downstream stations, suggesting that the heavy metal bioavailability increased during water regulation.This should be considered in the reservoir operation.
基金The financial support is gratefully acknowledged from the National Natural Science Foundation of China(Grant Nos.62004137,21878257,and 21978196)Natural Science Foundation of Shanxi Province(Grant No.20210302123102)+4 种基金Key Research and Development Program of Shanxi Province(Grant No.201803D421079)Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(Grant No.2019L0156)Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering(Grant No.2022SX-TD002)Shanxi Provincial Key Innovative Research Team in Science and Technology(Grant No.201605D13104510)Research Project Supported by Shanxi Scholarship Council of China(Grant No.2020-050).
文摘Effective charge separation and transfer is deemed to be the contributing factor to achieve high photoelectrochemical(PEC)water splitting performance on photoelectrodes.Building a phase junction structure with controllable phase transition of WO_(3) can further improve the photocatalytic performance.In this work,we realized the transition from orthorhombic to monoclinic by regulating the annealing temperatures,and constructed an orthorhombic–monoclinic WO_(3)(o-WO_(3)/m-WO_(3))phase junction.The formation of oxygen vacancies causes an imbalance of the charge distribution in the crystal structure,which changes the W–O bond length and bond angle,accelerating the phase transition.As expected,an optimum PEC activity was achieved over the o-WO_(3)/m-WO_(3) phase junction in WO_(3)-450 photoelectrode,yielding the maximum O_(2) evolution rate roughly 32 times higher than that of pure WO_(3)-250 without any sacrificial agents under visible light irradiation.The enhancement of catalytic activity is attributed to the atomically smooth interface with a highly matched lattice and robust built-in electric field around the phase junction,which leads to a less-defective and abrupt interface and provides a smooth interfacial charge separation and transfer path,leading to improved charge separation and transfer efficiency and a great enhancement in photocatalytic activity.This work strikes out on new paths in the formation of an oxygen vacancy-induced phase transition and provides new ideas for the design of catalysts.
基金This work is financially supported by:The National Key R&D Program of China(No.2020YFB1712600)The Fundamental Research Funds for Central University(No.3072022QBZ0601)+1 种基金The National Natural Science Foundation of China(No.62272126)The National Natural Science Foundation of China(No.61872104).
文摘The production data in the industrialfield have the characteristics of multimodality,high dimensionality and large correlation differences between attributes.Existing data prediction methods cannot effectively capture time series and modal features,which leads to prediction hysteresis and poor prediction stabil-ity.Aiming at the above problems,this paper proposes a time-series and modal fea-tureenhancementmethodbasedonadual-stageself-attentionmechanism(DATT),and a time series prediction method based on a gated feedforward recurrent unit(GFRU).On this basis,the DATT-GFRU neural network with a gated feedforward recurrent neural network and dual-stage self-attention mechanism is designed and implemented.Experiments show that the prediction effect of the neural network prediction model based on DATT is significantly improved.Compared with the traditional prediction model,the DATT-GFRU neural network has a smaller aver-age error of model prediction results,stable prediction performance,and strong generalization ability on the three datasets with different numbers of attributes and different training sample sizes.
基金Funded by the Shanxi Province Science Foundation for Youths of China[Nos.2014021020-2 and 2015021076]the Shanxi Province Higher School Science and Technology Innovation Project[No.2015125]+2 种基金the Project of Taiyuan University of Technology[Nos.2013T0202013T0212013T022]
文摘In order to improve the thermal properties of polylactic acid（PLA） filament,nano-SiO_2 was applied to mix with PLA,then they were spun as composite filament by melt-spinning.The dispersion of nano SiO_2 and the fracture surfaces of filaments were studied by scanning electron microscopy（SEM）.The properties of composite filament,such as orientation degree,mechanical properties,and surface friction properties,were analyzed.The thermal performances of composite filament were analyzed by differential scanning calorimetry（DSC） and thermo gravimetric analysis（TGA）.The results showed that the nano-SiO_2 modified by 5% KH-550 could disperse evenly and loosely in nano-scale,and 1 wt% and 3 wt% nano-SiO_2 dispersed throughout PLA evenly.As the quantity of nano-SiO_2 increased,the properties of composite filament,such as orientation degree,friction coefficient,thermal decomposition temperature,and glass transition temperature,increased more or less.The breaking tenacity increased when 1 wt% SiO_2 was added in PLA,but declined when 3 wt% SiO_2 was added.
基金The financial support was gratefully acknowledged from the National Natural Science Foundation of China(Grant Nos.62004137,21878257,and 21978196)Natural Science Foundation of Shanxi Province(Grant No.20210302123102)+3 种基金Key Research and Development Program of Shanxi Province(Grant No.201803D421079)the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(Grant No.2019L0156)Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering(Grant No.2022SX-TD002)Research Project Supported by Shanxi Scholarship Council of China(Grant No.2020-050).
文摘Photocatalytic non-oxidative coupling of methane(PNOCM)is a mild and cost-effective method for the production of multicarbon compounds.However,the separation of photogenerated charges and activation of methane(CH4)are the main challenges for this reaction.Here,single crystal-like TiO_(2) nanotubes(VO-p-TNTs)with oxygen vacancies(VO)and preferential orientation were prepared and applied to PNOCM.The results demonstrate that the significantly enhanced photocatalytic performance is mainly related to the strong synergistic effect between preferential orientation and VO.The preferential orientation of VO-p-TNT along the[001]direction reduces the formation of complex centers at grain boundaries as the form of interfacial states and potential barriers,which improves the separation and transport of photogenerated carriers.Meanwhile,VO provides abundant coordination unsaturated sites for CH4 chemisorption and also acts as electron traps to hinder the recombination of electrons and holes,establishing an effective electron transfer channel between the adsorbed CH4 molecule and photocatalyst,thus weakening the C–H bond.In addition,the introduction of VO broadens the light absorption range.As a result,VO-p-TNT exhibits excellent PNOCM performance and provides new insights into catalyst design for CH4 conversion.
文摘Background:Musculoskeletal ultrasound is used in clinical practice to evaluate gout patients and is an effective imaging tool for the detection of tophi.The aim of this study was to analyze the factors associated with ultrasound-detected tophi in gout patients and to construct a clinical model to predict its occurrence and improve the detection of hidden tophi.Methods:Data of gout patients admitted to Beijing Jishuitan Hospital from January 2015 to December 2021 were collected.The complete and detailed information from gout cases with completed musculoskeletal ultrasound was included in the analysis.Univariate and multivariate analyses were used to identify independent factors associated with ultrasound-detected tophi.A nomogram was used to visualize the clinical predictive models.Results:Among 517 gout patients,rheumatologists found that 67 patients(13.0%)had subcutaneous tophi by visual observation,while musculoskeletal ultrasound revealed that 123 patients(23.8%)had ultrasound-detected tophi with odds ratio[OR](95%confidence intervals[CIs])=2.20(1.81-2.67).Disease duration,upper limb joint flare(ULJF),persistent joint pain(PJP),uric acid,and homocysteine levels were independently associated with ultrasounddetected tophi,and they had ORs(95%CIs)of 1.092(1.050-1.136),3.732(2.312-6.025),1.864(1.086-3.200),1.003(1.001-1.004),and 1.015(1.000-1.030),respectively.After balancing the complexity and accuracy of the model,Model 2(incorporating disease duration,ULJF,PJP,and uric acid)was chosen to create a nomogram to predict the occurrence of ultrasound-detected tophi.The nomogram had good discrimination(consistency index[C-index]=0.774)and excellent calibration,demonstrated by calibration curves.Conclusion:Using easily available indicators,such as disease duration,the nature of the joint pain,and uric acid levels,we successfully developed an easy-to-use clinical model to improve the detection of hidden tophi.
基金This work is financially supported by:The National Key R&D Program of China(No.2020YFB1712600)The Fundamental Research Funds for Central University(No.3072022QBZ0601)The National Natural Science Foundation of China(No.62272126).
文摘It is difficult to comprehensively extract device status information for CNNs under a single source high-frequency timing signal,and CNNs cannot effec-tively achieve precise identification and classification based on the importance of multichannel features.This article proposes a CNN fault diagnosis method based on multi-channel weight adaptation.This methodfirst normalizes different data sources as input as different channels of CNN,and uses the characteristics of convolutional networks to achieve the characteristics of different data sources.Fusion and extraction.Then,the SNET module is embedded into the CNN net-work,adapted to the weight of each channel,and the accuracy of classification is improved.Finally,through comparative experiments,this method can further improve the accuracy of fault recognition.
基金This work was supported by the National Natural Science Foundation of China(Grant Nos.82104198,32171479,82104239)the Natural Science Foundation of Anhui Province(Grant Nos.2008085MH274,2108085QH377)+4 种基金the China Postdoctoral Science Foundation(Grant No.2020M671916)the Frontier Science Key Research Program of CAS(Grant No.QYZDB-SSW-SLH037)the Collaborative Innovation Program of Hefei Science Center,CAS(Grant No.2021HSC-CIP014)the CASHIPS Director’s Found(Grant Nos.BJPY2019A03,YZJJZX202011,YZJJ2021QN38)We are also grateful for the support of the Youth Innovation Promotion Association of CAS support(No.2019437)for H.W.A portion of this work was supported by the High Magnetic Field Laboratory of Anhui Province.
文摘Enhancer of zeste homolog 2(EZH2),an enzymatic subunit of PRC2 complex,plays an important role in tumor development and progression through its catalytic and noncatalytic activities.Overexpression or gain-of-function mutations of EZH2 have been significantly associated with tumor cell proliferation of triple-negative breast cancer(TNBC)and diffuse large B-cell lymphoma(DLBCL).As a result,it has gained interest as a potential therapeutic target.The currently available EZH2 inhibitors,such as EPZ6438 and GSK126,are of benefit for clinical using or reached clinical trials.However,certain cancers are resistant to these enzymatic inhibitors due to its noncatalytic or transcriptional activity through modulating nonhistone proteins.Thus,it may be more effective to synergistically degrade EZH2 in addition to enzymatic inhibition.Here,through a rational design and chemical screening,we discovered a new irreversible EZH2 inhibitor,IHMT-337,which covalently bounds to and degrades EZH2 via the E3 ligase CHIP-mediated ubiquitination pathway.Moreover,we revealed that IHMT-337 affects cell cycle progression in TNBC cells through targeting transcriptional regulating of CDK4,a novel PRC2 complex-and enzymatic activity-independent function of EZH2.More significantly,our compound inhibits both DLBCL and TNBC cell proliferation in different preclinical models in vitro and in vivo.Taken together,our findings demonstrate that in addition to enzymatic inhibition,destroying of EZH2 by IHMT-337 could be a promising therapeutic strategy for TNBC and other malignancies that are independent of EZH2 enzymatic activity.
基金the National Natural Science Foundation of China(Grant No.81973107).
文摘Cutavirus(CuV)is a novel protoparvovirus possibly associated with diarrhea and cutaneous T-cell lymphomas.Patients with rheumatic disease are immunosuppressed and may be more vulnerable to pathogenic viruses.A descriptive study was conducted among hospitalized patients with rheumatic diseases and individuals undergoing medical health check-ups between June 2019 and June 2022 in Guangzhou,China.Stool samples of subjects were tested for CuV DNA.Demographic and fecal examination data of patients were obtained from electronic medical records.A total of 505 patients with rheumatic diseases and 244 individuals who underwent medical health check-ups were included in the study.Of the patients with rheumatic disease,5.74%[95%confidence interval(CI):4.03%–8.12%]were positive for CuV DNA,while no individual in the medical health check-up group was positive,indicating a close correlation between CuV and rheumatic disease.Men and patients with rheumatoid arthritis or ankylosing spondylitis,according to the disease classification,were more susceptible to being infected with CuV(P<0.01).After adjustments,being male remained the only significant factor,with an adjusted odd ratio(OR)of 4.4(95%CI:1.7–11.4,P=0.002).Phylogenetic analysis of the CuV VP2 sequences showed three diverse clades,one of which was segregated to be a single branching independent of previously known sequences,which is possible a new genotype.
