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中国老年骨质疏松症诊疗指南(2018) 被引量:420
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作者 《中国老年骨质疏松症诊疗指南》(2018)工作组 中国老年学和老年医学学会骨质疏松分会 +15 位作者 马远征 王以朋 刘强 李春霖 马迅 王拥军 邓廉夫 贺良 杨乃龙 陈伯华 邱贵兴 朱汉民 陶天遵 秦岭 王亮 程晓光 《中国骨质疏松杂志》 CAS CSCD 北大核心 2018年第12期1541-1565,共25页
根据国内外循证医学指南制定标准化方法与步骤,组建多学科指南制定专家工作组,先后经过指南注册及指南计划书撰写、相关指南评价分析、临床问题遴选和确定、临床证据检索及评价、形成推荐意见等流程,经共识专家组3轮讨论,最终制定中国... 根据国内外循证医学指南制定标准化方法与步骤,组建多学科指南制定专家工作组,先后经过指南注册及指南计划书撰写、相关指南评价分析、临床问题遴选和确定、临床证据检索及评价、形成推荐意见等流程,经共识专家组3轮讨论,最终制定中国老年骨质疏松症诊疗指南(2018)。使用GRADE系统对证据体和推荐意见进行分级。同时考虑中国患者的偏好与价值观、干预措施的成本和利弊平衡为老年骨质疏松症的诊疗提供15条推荐意见。该指南涵盖了老年骨质疏松症的筛查、风险评估、诊断、基础措施、多种抗骨质疏松药物、疗效监测和评估等方面。本指南旨在为我国广大临床医生和患者提供科学依据。 展开更多
关键词 老年骨质疏松 诊断 治疗 指南
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数字孪生标准体系 被引量:163
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作者 陶飞 马昕 +25 位作者 胡天亮 黄祖广 程江峰 戚庆林 张萌 刘蔚然 张贺 王尚刚 薛瑞娟 黎晓东 韦莎 刘默 刘棣斐 周剑 张健 李勤 欧阳劲松 胡雯 葛军 闫丽娟 贺东东 陈录城 徐慧 刘魁 易旺民 陈虎 《计算机集成制造系统》 EI CSCD 北大核心 2019年第10期2405-2418,共14页
数字孪生(Digital Twin)作为实现数字化、智能化、服务化等先进理念的重要使能技术,当前备受学术界和工业界关注,如何在各领域落地应用更是关注的重点。但在数字孪生理论研究与落地应用过程中,发现缺乏数字孪生相关术语、系统架构、适... 数字孪生(Digital Twin)作为实现数字化、智能化、服务化等先进理念的重要使能技术,当前备受学术界和工业界关注,如何在各领域落地应用更是关注的重点。但在数字孪生理论研究与落地应用过程中,发现缺乏数字孪生相关术语、系统架构、适用准则等标准的参考,导致不同用户对数字孪生的理解与认识存在差异;缺乏数字孪生相关模型、数据、连接与集成、服务等标准的参考,导致模型间、数据间、模型与数据间集成难、一致性差等问题,造成新的孤岛;缺乏相关适用准则、实施要求、工具和平台等标准的参考,造成用户或企业不知如何使用数字孪生。为解决上述问题,亟需数字孪生相关标准来参考和指导。因此,首先从数字孪生概念的理解与沟通、关键技术研究与实施、行业落地应用3个角度对数字孪生标准的需求进行了分析。在此基础上,结合前期提出的数字孪生五维模型,与国内本领域相关标准技术委员会及应用企业(包括机床、卫星、发动机、工程机械装备等行业)共同建立了一套数字孪生标准体系架构。该标准体系主要由数字孪生基础共性标准、关键技术标准、工具/平台标准、测评标准、安全标准、行业应用标准6部分构成,期望相关工作能为数字孪生标准研究与制定人员提供参考,同时为数字孪生落地应用提供指导。 展开更多
关键词 数字孪生 标准体系 数字孪生五维模型 基础共性 关键技术 工具/平台 行业应用
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Chinese consensus guidelines for diagnosis and management of gastrointestinal stromal tumor 被引量:108
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作者 Jian Li Yingjiang Ye +14 位作者 Jian Wang Bo Zhang Shukui qins Yingqiang Shi Yulong he Xiaobo Liang Xiufeng Liu Ye Zhou Xin Wu Xinhua Zhang Ming Wang Zhidong Gao Tianlong Lin Hui Cao Lin Shen 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2017年第4期281-293,共13页
In order to further promote the standardization of diagnosis and treatment of gastrointestinal stromal tumor (GIST) in China, the members of Chinese Society of Clinical Oncology (CSCO) Expert Committee on GIST tho... In order to further promote the standardization of diagnosis and treatment of gastrointestinal stromal tumor (GIST) in China, the members of Chinese Society of Clinical Oncology (CSCO) Expert Committee on GIST thoroughly discussed the key contents of the consensus guidelines, and voted on the controversial issue. In final, the Chinese consensus guidelines for the diagnosis and management of GIST (2017 edition) was formed on the basis of 2013 edition consensus guidelines, which is hereby announced. The consensus included the pathological diagnosis, recurrence risk classification evaluation, targeted agent therapy, surgery and principles of surveillance of GIST. 展开更多
关键词 Gastrointestinal stromal tumor DIAGNOSIS THERAPY CONSENSUS
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Parkinson’s disease in China:a forty-year growing track of bedside work 被引量:68
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作者 Gen Li Jianfang Ma +4 位作者 Shishuang Cui Yixi he qin Xiao Jun Liu Shengdi Chen 《Translational Neurodegeneration》 SCIE CAS 2019年第1期270-278,共9页
The number and health burden of Parkinson’s disease increase rapidly in China.It is estimated that China will have nearly half of the Parkinson’s disease population in the world in 2030.In this review,we present an ... The number and health burden of Parkinson’s disease increase rapidly in China.It is estimated that China will have nearly half of the Parkinson’s disease population in the world in 2030.In this review,we present an overview of epidemiology and health economics status of Parkinson’s disease across China and discuss the risk factors of Parkinson’s disease and related complications.From the view of clinical research,we also discuss the current status of clinical trials,diagnostic biomarkers,treatment of Parkinson’s disease,tertiary network and post-occupation education in Chinese Parkinson’s disease clinics. 展开更多
关键词 Parkinson’s disease Tertiary network Clinical research Diagnosis
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农田土壤N2O排放的关键过程及影响因素 被引量:60
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作者 曹文超 宋贺 +4 位作者 王娅静 覃伟 郭景恒 陈清 王敬国 《植物营养与肥料学报》 CAS CSCD 北大核心 2019年第10期1781-1798,共18页
一氧化二氮(N2O)作为重要的温室气体之一,在全球气候变化研究中引人关注。随着氮肥使用量的增加,农田土壤N2O排放已经成为全球关注和研究的热点。人们普遍认为土壤硝化、反硝化过程是N2O产生的两个主导途径,而诸如施肥、灌水等农田管理... 一氧化二氮(N2O)作为重要的温室气体之一,在全球气候变化研究中引人关注。随着氮肥使用量的增加,农田土壤N2O排放已经成为全球关注和研究的热点。人们普遍认为土壤硝化、反硝化过程是N2O产生的两个主导途径,而诸如施肥、灌水等农田管理措施以及土壤pH、温度等环境因子均会影响农田土壤N2O产生和排放。本文系统论述了土壤N2O产生的各主要途径,并综述了氮源、碳源、水分含量、氧气含量、土壤pH和温度以及其他调控因子对N2O排放的影响,旨在阐明各过程对N2O排放的产生机制及主要环境因子的影响,以期为后续研究提供参考和理论依据。农田土壤硝化过程本身对N2O排放的直接贡献较小,N2O产生的主要来源是包含硝化细菌的反硝化、硝化–反硝化耦合作用在内的生物反硝化过程。真菌反硝化和化学反硝化在酸性土壤以及硝酸异化还原成铵过程在高有机质和厌氧土壤环境中对N2O排放具有重要作用。未来研究可从农田土壤N2O的产生和消耗机制、降低N2O/N2产物比、N2O的还原过程及相关影响因素进行深入研究。此外,利用新技术方法,探究土壤物理、化学和生物学因素对氮素转化过程的影响,重点关注N2O峰值排放及相关联微生物的响应,并构建土壤氮素平衡和N2O排放模型,可进一步加深对农田土壤N2O排放机制和影响因素的理解。 展开更多
关键词 农田土壤 氧化亚氮 硝化作用 反硝化作用 环境因子
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喜马拉雅琼嘉岗超大型伟晶岩锂矿的形成时代、源区特征及分异特征 被引量:58
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作者 赵俊兴 何畅通 +5 位作者 秦克章 施睿哲 刘小驰 胡方泱 余可龙 孙政浩 《岩石学报》 SCIE EI CAS CSCD 北大核心 2021年第11期3325-3347,共23页
喜马拉雅新生代淡色花岗岩带是近年来提出的与高度结晶分异、异地深成淡色花岗岩有关的稀有金属战略远景区,目前其金属组合以铍-铌-钽(-锡-钨)为主。秦克章等(2021a)报道了在高喜马拉雅带珠峰地区发现的琼嘉岗锂矿,是喜马拉雅首例具有... 喜马拉雅新生代淡色花岗岩带是近年来提出的与高度结晶分异、异地深成淡色花岗岩有关的稀有金属战略远景区,目前其金属组合以铍-铌-钽(-锡-钨)为主。秦克章等(2021a)报道了在高喜马拉雅带珠峰地区发现的琼嘉岗锂矿,是喜马拉雅首例具有工业价值的伟晶岩型锂矿。本次研究重点揭示喜马拉雅琼嘉岗伟晶岩型锂矿的成矿特征、形成时代和源区特征。琼嘉岗矿区矿石矿物主要为锂辉石、铌铁矿-铌锰矿、少量锡石和绿柱石,特征性长柱状锂辉石主要产于块体微斜长石+锂辉石带和分层细晶岩带内。琼嘉岗锂辉石伟晶岩各结构分带的K/Rb含量较为相似,锂含量从边部细粒钠长石带(~100×10^(-6))到分层细晶岩带(~1000×10^(-6)),再到块体微斜长石+锂辉石带(>3000×10^(-6))逐渐升高,而Cs含量逐渐降低。独居石和铌钽铁矿族矿物LA-ICPMS定年结果显示,琼嘉岗锂辉石伟晶岩形成于新喜马拉雅阶段早期(25~24Ma),与高喜马拉雅地区淡色花岗岩时代相近。矿物化学和独居石Nd同位素结果显示该稀有金属伟晶岩结晶于高度演化的花岗伟晶岩熔体,源区特征与高喜马拉雅结晶岩系一致。本研究所揭示的琼嘉岗成矿特征、形成时代和源区特征将为高喜马拉雅其它地区找寻大型花岗伟晶岩型锂矿提供重要借鉴意义。 展开更多
关键词 琼嘉岗锂矿 伟晶岩结构与成分 独居石和铌钽铁矿U-Pb定年 源区示踪 喜马拉雅淡色花岗岩带区域成矿
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2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents 被引量:57
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作者 Cheng Wang Yaqi Li +86 位作者 Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing he Zhixu he Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu 《Science Bulletin》 SCIE EI CAS CSCD 2018年第23期1558-1564,共7页
Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of eme... Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. 展开更多
关键词 CPCS CHILDREN ADOLESCENT SYNCOPE
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Effects of different resuscitation fluid on severe acute pancreatitis 被引量:57
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作者 Gang Zhao Jun-Gang Zhang +10 位作者 he-Shui Wu Jin Tao Qi qin Shi-Chang Deng Yang Liu Lin Liu Bo Wang Kui Tian Xiang Li Shuai Zhu Chun-You Wang 《World Journal of Gastroenterology》 SCIE CAS 2013年第13期2044-2052,共9页
AIM: To compare effects of different resuscitation fluid on microcirculation, inflammation, intestinal barrier and clinical results in severe acute pancreatitis (SAP). METHODS: One hundred and twenty patients with SAP... AIM: To compare effects of different resuscitation fluid on microcirculation, inflammation, intestinal barrier and clinical results in severe acute pancreatitis (SAP). METHODS: One hundred and twenty patients with SAP were enrolled at the Pancreatic Disease Institute between January 2007 and March 2010. The patients were randomly treated with normal saline (NS group), combination of normal saline and hydroxyethyl starch (HES) (SH group), combination of normal saline, hydroxyethyl starch and glutamine (SHG group) in resuscitation. The ratio of normal saline to HES in the SH and SHG groups was 3:1. The glutamine (20% glutamine dipeptide, 100 mL/d) was supplemented into the resuscitation liquid in the SHG group. Complications and outcomes including respiratory and abdominal infection, sepsis, abdominal hemorrhage, intra-abdominal hypertension, abdominal compartment syndrome (ACS), renal failure, acute respiratory distress syndrome (ARDS), multiple organ dysfunction syndrome (MODS), operation intervention, length of intensive care unit stay, length of hospital stay, and mortality at 60 d were compared. Moreover, blood oxygen saturation (SpO 2 ), gastric intramucosal pH value (pHi), intra-abdominal pressure (IAP), inflammation cytokines, urine lactulose/mannitol (L/M) ratio, and serum endotoxin were investigated to evaluate the inflammatory reaction and gut barrier. RESULTS: Compared to the NS group, patients in the SH and SHG groups accessed the endpoint more quickly (3.9 ± 0.23 d and 4.1 ± 0.21 d vs 5.8 ± 0.25 d, P < 0.05) with less fluid volume (67.26 ± 28.53 mL/kg/d, 61.79 ± 27.61 mL/kg per day vs 85.23 ± 21.27 mL/kg per day, P < 0.05). Compared to the NS group, incidence of renal dysfunction, ARDS, MODS and ACS in the SH and SHG groups was obviously lower. Furthermore, incidence of respiratory and abdominal infection was significantly decreased in the SH and SHG groups, while no significant difference in sepsis was seen. Moreover, less operation time was needed in the SH and SHG group than the NS group, but 展开更多
关键词 MICROCIRCULATION INTESTINAL barrier INFLAMMATORY reaction INTRA-ABDOMINAL hypertension CAPILLARY leakage syndrome
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Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study 被引量:54
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作者 Hui-Jia Lin Li-Zhong Du +33 位作者 Xiao-Lu Ma Li-Ping Shi Jia-Hua Pan Xiao-Mei Tong Qiu-Ping Li Jian-Guo Zhou Bing Yi Ling Liu Yun-Bing Chen Qiu-Fen Wei Hui-qing Wu Mei Li Cui-qing Li Xi-Rong Gao Shi-Wen Xia Wen-Bin Li Chao-Ying Ya Ling he Kun Liang Xiao-Yu Zhou Shu-Ping Han qin Lyu Yin-Ping Qiu Wen Li Dong-Mei Chen Hong-Ru Lu Xiao-Hong Liu Hong Liu Zhen-Lang Lin Li Liu Jia-Jun Zhu Hong Xiong Shao-Jie Yue Si-Qi Zhuang 《Chinese Medical Journal》 SCIE CAS CSCD 2015年第20期2743-2750,共8页
Background: With the progress ofperinatal medicine and neonatal technology, more and more extremely low birth weight (ELBW) survived all over the world. This study was designed to investigate the short-term ontcome... Background: With the progress ofperinatal medicine and neonatal technology, more and more extremely low birth weight (ELBW) survived all over the world. This study was designed to investigate the short-term ontcomes of ELBW infants during their Neonatal Intensive Care Unit (NICU) stay in the mainland of China. Methods: All infants admitted to 26 NICUs with a birth weight (BW) 〈1000 g were included between January 1,2011 and December 31,2011. All the data were collected retrospectively from clinical records by a prospectively designed questionnaire. The data collected from each NICU transmitted to the main institution where the results were aggregated and analyzed. Categorical variables were performed with Pearson Chi-square test. Binary Logistic regression analysis was used to detect risk factors. Results: A total of 258 ELBW infants were admitted to 26 NICUs, of whom the mean gestational age (GA) was 28.1 ± 2.2 weeks, and the mean BW was 868 ± 97 g. The overall survival rate at discharge was 50.0%. Despite aggressive treatment 60 infants (23.3%) died and another 69 infants (26.7%) died after medical care withdrawal. Furthermore, the survival rate was significantly higher in coastal areas than inland areas (53.6% vs. 35.3%, P = 0.019). BW 〈750 g and GA 〈28 weeks were the largest risk factors, and being small for gestational age was a protective factor related to mortality. Respiratory distress syndrome was the most common complication. The incidence of patent ductus arteriosus, intraventricular hemorrhage, periventricular leukomalacia, bronchopulmonary dysplasia, retinopathy of prematurity was 26.2%, 33.7%, 6.7%, 48.1%, and 41.4%, respectively. Ventilator associated pneumonia was the most common hospital acquired infection during hospitalization. Conclusions: Our study was the first survey that revealed the present status of ELBW infants in the mainland of China. The mortality and morbidity of ELBW infants remained high as compared to other developed countries. 展开更多
关键词 Extremely Low Birth Weight INFANT MORTALITY National Survey
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准噶尔盆地吉木萨尔凹陷陆相页岩油开发实践 被引量:51
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作者 高阳 叶义平 +3 位作者 何吉祥 钱根葆 覃建华 李映艳 《中国石油勘探》 CAS CSCD 北大核心 2020年第2期133-141,共9页
新疆准噶尔盆地吉木萨尔凹陷二叠系芦草沟组陆相页岩油资源丰富,估算资源量超过15.8×108t。为实现页岩油有效开发,近年来通过对芦草沟组陆相页岩油地质特征、工程技术、生产特征及规律等详细分析,结合开发实践的总结,取得了以下成... 新疆准噶尔盆地吉木萨尔凹陷二叠系芦草沟组陆相页岩油资源丰富,估算资源量超过15.8×108t。为实现页岩油有效开发,近年来通过对芦草沟组陆相页岩油地质特征、工程技术、生产特征及规律等详细分析,结合开发实践的总结,取得了以下成果及认识:①吉木萨尔凹陷芦草沟组页岩油是陆相咸化湖相细粒沉积的页岩,烃源岩品质优、厚度大,源储一体,页岩段原位聚集,"甜点"段邻源供烃为主、自生为辅的特征,是典型的陆相页岩油;②明确了页岩油体积压裂水平井裂缝控制区内游离孔隙度和游离油储量丰度是页岩油高产的基础;③随着埋深增大,水平两向应力差增大,压裂缝复杂性降低,是部分含油性好的"上甜点体"水平井低产的主要原因;④原油黏度是影响"下甜点体"水平井产量的关键因素;⑤优质"甜点"钻遇长度及压裂米加砂量是吉木萨尔页岩油水平井高产的工程关键因素;⑥页岩油压裂液与基质孔隙原油存在渗吸置换作用,压裂后适当焖井可以提高生产效果;⑦水力压裂缝长度有限,合理井距不应大于200m。通过持续研究和开发实践,页岩油开发取得了较好的效果,水平井单井最高年产突破1.3×10~4m^3,2019年已基本进入规模试验建产,为中国陆相页岩油的工业化开发积累了丰富的经验。 展开更多
关键词 吉木萨尔凹陷 页岩油 开发实践 地质特征 井距
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不同材料CAD/CAM髓超嵌体修复根管治疗后牙体缺损临床效果评价 被引量:49
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作者 周楠 丁梦 +2 位作者 何琴 刘亚华 杨卫东 《中国实用口腔科杂志》 CAS 2019年第2期87-91,共5页
目的评价计算机辅助设计与制造(computer aided design and computer aided manufacturing,CAD/CAM)新型纳米复合陶瓷Lava Ultimate髓超嵌体和长石质瓷Vita TriLuxe髓超嵌体修复根管治疗后牙体缺损的临床效果。方法选取2017年1—12月于... 目的评价计算机辅助设计与制造(computer aided design and computer aided manufacturing,CAD/CAM)新型纳米复合陶瓷Lava Ultimate髓超嵌体和长石质瓷Vita TriLuxe髓超嵌体修复根管治疗后牙体缺损的临床效果。方法选取2017年1—12月于南京市口腔医院牙体牙髓病科就诊的58例患者根管治疗后缺损磨牙60颗,随机均分为两组,其中观察组30颗,采用Lava Ultimate髓超嵌体修复;对照组30颗,采用Vita TriLuxe髓超嵌体修复。根据改良美国公共卫生署(United States Public Health Service,USPHS)标准,比较两组临床修复效果。结果 60颗修复体均效果良好,无修复体脱落,仅在对照组发现1例修复体折裂情况;观察组在边缘密合性、完整性、继发龋和牙龈炎症方面与对照组比较,差异无统计学意义(P> 0.05);但观察组的对颌牙磨耗情况轻于对照组,差异有统计学意义(P <0.05)。结论 Vita TriLuxe髓超嵌体和Lava Ultimate髓超嵌体皆可用于修复根管治疗后的牙体缺损,新型纳米复合陶瓷Lava Ultimate相较于长石质瓷Vita TriLuxe更能减少对颌牙的磨耗,值得临床推广应用。 展开更多
关键词 髓超嵌体 计算机辅助设计与制造 磨牙 根管治疗
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The Chinese Society of Clinical Oncology(CSCO)clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma 被引量:48
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作者 Ling-Long Tang Yu-Pei Chen +37 位作者 Chuan-Ben Chen Ming-Yuan Chen Nian-Yong Chen Xiao-Zhong Chen Xiao-Jing Du Wen-Feng Fang Mei Feng Jin Gao Fei Han Xia he Chao-Su Hu De-sheng Hu Guang-Yuan Hu Hao Jiang Wei Jiang Feng Jin Jin-Yi Lang Jin-Gao Li Shao-Jun Lin Xu Liu Qiu-Fang Liu Lin Ma Hai-Qiang Mai Ji-Yong qin Liang-Fang Shen Ying Sun Pei-Guo Wang Ren-Sheng Wang Ruo-Zheng Wang Xiao-Shen Wang Ying Wang Hui Wu Yun-Fei Xia Shao-Wen Xiao Kun-Yu Yang Jun-Lin Yi Xiao-Dong Zhu Jun Ma 《Cancer Communications》 SCIE 2021年第11期1195-1227,共33页
Nasopharyngeal carcinoma(NPC)is a malignant epithelial tumor originating in the nasopharynx and has a high incidence in Southeast Asia and North Africa.To develop these comprehensive guidelines for the diagnosis and m... Nasopharyngeal carcinoma(NPC)is a malignant epithelial tumor originating in the nasopharynx and has a high incidence in Southeast Asia and North Africa.To develop these comprehensive guidelines for the diagnosis and management of NPC,the Chinese Society of Clinical Oncology(CSCO)arranged a multi-disciplinary team comprising of experts from all sub-specialties of NPC to write,discuss,and revise the guidelines.Based on the findings of evidencebased medicine in China and abroad,domestic experts have iteratively developed these guidelines to provide proper management of NPC.Overall,the guidelines describe the screening,clinical and pathological diagnosis,staging and risk assessment,therapies,and follow-up of NPC,which aim to improve the management of NPC. 展开更多
关键词 Chinese Society of Clinical Oncology CSCO Nasopharyngeal carcinoma Diagnosis STAGING Risk RADIOTHERAPY CHEMOTHERAPY Surgery IMMUNOTHERAPY
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中国锂资源的主要类型、分布和开发利用现状:评述和展望 被引量:45
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作者 王核 黄亮 +6 位作者 白洪阳 王堃宇 王振宏 高昊 周金胜 秦艳 王焰 《大地构造与成矿学》 EI CAS CSCD 北大核心 2022年第5期848-866,共19页
作为核心战略金属资源,锂矿勘查与研究已成为当今矿产勘查和地学研究的热点。全球锂资源主要分布在南美洲“锂三角”地区(玻利维亚、智利和阿根廷)、美国、澳大利亚和中国。我国锂矿资源较为丰富,主要集中在新疆、青海、西藏、四川、江... 作为核心战略金属资源,锂矿勘查与研究已成为当今矿产勘查和地学研究的热点。全球锂资源主要分布在南美洲“锂三角”地区(玻利维亚、智利和阿根廷)、美国、澳大利亚和中国。我国锂矿资源较为丰富,主要集中在新疆、青海、西藏、四川、江西和云南6省(区),可划分为16个锂成矿带。锂矿类型包括卤水型、硬岩型和黏土型三种。卤水型锂矿又可分盐湖型和地下卤水型,其中盐湖型锂矿主要集中分布在青海和西藏,储量巨大;地下卤水型锂矿主要分布于四川盆地及潜江凹陷,数量较少。硬岩型锂矿又可分为伟晶岩型、花岗岩型和隐爆角砾岩型,其中伟晶岩型锂矿主要发育在阿尔泰、阿尔金、西昆仑、川西、喜马拉雅、东秦岭和南岭等区域,成矿时代主要集中在燕山期、印支期和加里东期;花岗岩型锂矿主要发育在武夷、南岭、江南和兴蒙等造山带,成矿时代主要集中在燕山期;隐爆角砾岩型锂矿发育在大兴安岭。黏土型锂矿在滇中、贵州、广西成矿潜力巨大。伟晶岩型锂矿的含锂矿物以锂辉石为主,矿石的锂品位较高,开采比较容易,是我国锂供给的重要来源。除扎布耶、结则茶卡等少数碳酸盐型盐湖锂矿外,我国多数盐湖锂矿Mg/Li值高,卤水提锂技术相对复杂,成本较高。黏土型锂矿在我国还不具备开采条件,提取尚处在小试阶段,但一旦实现提取技术突破,将具有重要的应用前景。 展开更多
关键词 锂矿床 盐湖型 伟晶岩型 矿床分布 提取技术
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振幅整合脑电图结合头颅MRI对窒息早产儿脑损伤的诊断及神经行为发育的预测 被引量:44
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作者 黄会芝 温晓红 +6 位作者 孙亚伟 何婷 秦璠玥 胡玉萍 潘龙凤 王水云 谢雪莲 《中华行为医学与脑科学杂志》 CAS CSCD 北大核心 2021年第1期22-26,共5页
目的探讨生后6 h、3 d振幅整合脑电图(amplitude-integrated electroencephalogram,aEEG)与磁共振成像(magnetic resonance imaging,MRI)预测窒息早产儿矫正年龄6个月时不良神经行为学发育的价值。方法对2017年12月至2019年6月在本院产... 目的探讨生后6 h、3 d振幅整合脑电图(amplitude-integrated electroencephalogram,aEEG)与磁共振成像(magnetic resonance imaging,MRI)预测窒息早产儿矫正年龄6个月时不良神经行为学发育的价值。方法对2017年12月至2019年6月在本院产科分娩、因窒息转入新生儿病房住院的50例早产儿,出生后6 h内进行aEEG监测,随后1次/d,至少4 h/次,矫正胎龄40周时行头颅MRI检查,矫正年龄6个月时行Gesell发育诊断量表评估婴儿的神经运动发育功能,分为预后良好组及预后不良组。运用SPSS 19.0软件进行统计学分析,采用独立样本t检验与χ^2检验分析2组之间的差异;分析aEEG分级与MRI之间的关系,及它们对矫正年龄6个月时不良神经行为学发育的预测价值。结果不同aEEG的临床分级的早产儿MRI上的脑白质损伤(H=24.896,P<0.01)及颅内出血(H=29.245,P<0.01)程度存在差异。出生后6 h及3 d,aEEG预测不良预后的敏感性分别为96.2%、97.8%,特异性分别为56.2%、62.5%,阴性预测值分别为98.2%、99.0%,阳性预测值分别为37.8%、52.3%,正确指数分别为52.4%、60.3%;aEEG结合MRI预测神经行为学预后的敏感性(90.0%、97.0%)、特异性(89.0%、99.0%)、阴性预测值(99.2%、99.5%)、阳性预测值(80.6%、88.5%)、正确指数(79.0%、96.0%)均有提高。结论采用aEEG与MRI影像学相结合,提高了对神经发育预后的预测价值,可以为窒息早产儿脑损伤的临床随访及干预提供更好的判断依据。 展开更多
关键词 振幅整合脑电图 磁共振 窒息早产儿 脑损伤 早期诊断 神经行为发育
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人工智能技术应用对就业的影响及作用机制研究——来自制造业企业的微观证据 被引量:42
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作者 何勤 李雅宁 +1 位作者 程雅馨 李晓宇 《中国软科学》 CSSCI CSCD 北大核心 2020年第S01期213-222,共10页
人工智能技术、智能场景在各领域的广泛应用给经济社会发展带来了新动力。人工智能对就业有何影响?其作用机制是什么?当前并未取得一致结论。本文以115家制造业企业为研究对象,依据创新扩散理论,构建出以产品创新和资本偏好为中介的人... 人工智能技术、智能场景在各领域的广泛应用给经济社会发展带来了新动力。人工智能对就业有何影响?其作用机制是什么?当前并未取得一致结论。本文以115家制造业企业为研究对象,依据创新扩散理论,构建出以产品创新和资本偏好为中介的人工智能技术采纳对就业的影响机制模型。研究发现:人工智能技术采纳对制造业员工数量有负向影响;对员工技能和收入有正向影响;产品创新与资本偏好在人工智能技术采纳对就业影响中存在中介效应。 展开更多
关键词 人工智能 就业 创新扩散
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Cell membrane-based nanoparticles: a new biomimetic platform for tumor diagnosis and treatment 被引量:41
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作者 Ruixiang Li Yuwei he +2 位作者 Shuya Zhang Jing qin Jianxin Wang 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2018年第1期14-22,共9页
Taking inspiration from nature, the biomimetic concept has been integrated into drug delivery systems in cancer therapy. Disguised with cell membranes, the nanoparticles can acquire various functions of natural cells.... Taking inspiration from nature, the biomimetic concept has been integrated into drug delivery systems in cancer therapy. Disguised with cell membranes, the nanoparticles can acquire various functions of natural cells. The cell membrane-coating technology has pushed the limits of common nano-systems(fast elimination in circulation) to more effectively navigate within the body. Moreover, because of the various functional molecules on the surface, cell membrane-based nanoparticles(CMBNPs) are capable of interacting with the complex biological microenvironment of the tumor. Various sources of cell membranes have been explored to camouflage CMBNPs and different tumor-targeting strategies have been developed to enhance the anti-tumor drug delivery therapy. In this review article we highlight the most recent advances in CMBNP-based cancer targeting systems and address the challenges and opportunities in this field. 展开更多
关键词 Cell membrane Biomimetic nanoparticle Drug delivery Cancer targeting CIRCULATION Molecular recognition
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创新驱动下实体企业数字化转型经济后果研究 被引量:40
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作者 何帆 秦愿 《东北财经大学学报》 2019年第5期45-52,共8页
创新驱动转型背景下,以数字化转型为核心内容的创新驱动模式得到广泛关注,为实体企业转型升级提供了新方向。本文利用A股主板上市公司2012—2017年数据,考察实体企业数字化转型的经济后果。研究发现:数字化转型显著提升了实体企业经济效... 创新驱动转型背景下,以数字化转型为核心内容的创新驱动模式得到广泛关注,为实体企业转型升级提供了新方向。本文利用A股主板上市公司2012—2017年数据,考察实体企业数字化转型的经济后果。研究发现:数字化转型显著提升了实体企业经济效益,采用PSM-DID法的回归结果依然稳健;渠道效应研究表明,数字化转型通过降低成本和提升效率,从而促进企业绩效的提升;数字化转型对企业绩效的促进作用在民营企业更为显著。研究结果对于提高实体企业创新有效性及高质量发展,有重要启示作用。 展开更多
关键词 数字化转型 创新驱动 经济后果 渠道效应
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神经内镜手术与小骨窗开颅手术治疗中量高血压脑出血临床疗效对比分析 被引量:39
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作者 李承科 何琴 +2 位作者 唐辉 冯浩 付安辉 《解放军医药杂志》 CAS 2018年第3期98-101,共4页
目的对比分析神经内镜手术与小骨窗开颅手术治疗中量高血压脑出血的临床效果。方法对2014年1月—2017年4月就诊治疗的96例中量高血压脑出血患者的临床资料进行回顾性分析,根据治疗方式的不同分为观察组和对照组,每组48例。观察组采用神... 目的对比分析神经内镜手术与小骨窗开颅手术治疗中量高血压脑出血的临床效果。方法对2014年1月—2017年4月就诊治疗的96例中量高血压脑出血患者的临床资料进行回顾性分析,根据治疗方式的不同分为观察组和对照组,每组48例。观察组采用神经内镜手术治疗,对照组采用小骨窗开颅手术治疗。比较并分析两组的手术时间、术中出血量、血肿清除率、术后并发症发生情况,并比较术前、术后3个月的临床神经功能缺损程度评分(NDS)和日常生活能力量表(ADL)评分以及术后3个月的预后情况。结果观察组的手术时间和术中出血量均少于对照组,血肿清除率明显高于对照组(P<0.01)。术后3个月,两组NDS评分低于术前,ADL评分高于术前(P<0.01);且观察组NDS评分低于对照组,ADL评分高于对照组(P<0.05)。观察组术后并发症总发生率低于对照组,术后3个月预后良好率高于对照组(P<0.05)。结论神经内镜手术治疗中量高血压脑出血较小骨窗开颅手术更为有效、安全、出血量少且预后和神经功能恢复更好。 展开更多
关键词 神经内镜手术 小骨窗开颅手术 颅内出血 高血压
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长江经济带水资源承载力评价及时空动态变化 被引量:38
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作者 何刚 夏业领 +2 位作者 秦勇 朱艳娜 王雯雯 《水土保持研究》 CSCD 北大核心 2019年第1期287-292,300,共7页
以长江经济带水资源承载力综合评价为中心,构建涵盖水资源、社会经济、生态等方面的水资源承载力综合评价指标体系。运用TOPSIS综合评价方法,测算研究了2007—2016年长江经济带11省市水资源承载力动态变化及区域差异,并利用ArcGIS 10.2... 以长江经济带水资源承载力综合评价为中心,构建涵盖水资源、社会经济、生态等方面的水资源承载力综合评价指标体系。运用TOPSIS综合评价方法,测算研究了2007—2016年长江经济带11省市水资源承载力动态变化及区域差异,并利用ArcGIS 10.2软件,可视化2007年与2016年长江经济带11省市水资源承载力等级分布。结果表明:2007—2016年长江经济带水资源承载力呈波动上升趋势,承载力水平基本维持在警戒和中级水平;经济发达的东段地区水资源承载力高于经济欠发达的中段和西段地区,近年来差距不断扩大;长江经济带11省市水资源承载力年均增长率位于前三的分别是贵州、上海和云南,而湖北、重庆、四川年均增长率为负值;长江经济带各省市水资源承载力整体水平仍较低,且各省市间水资源承载力均衡性差异并未随着时间推移而产生大的改观。 展开更多
关键词 长江经济带 水资源承载力 TOPSIS模型
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Computed tomography perfusion in evaluating the therapeutic effect of transarterial chemoembolization for hepatocellular carcinoma 被引量:35
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作者 Guang Chen Da-qing Ma Wen he Bao-Feng Zhang Li-qin Zhao 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第37期5738-5743,共6页
AIM: To prospectively assess the changes in parameters of computed tomography (CT) perfusion pre- and post-transarterial chemoembolization (TACE) of hepatocellular carcinoma (HCC) in different treatment respons... AIM: To prospectively assess the changes in parameters of computed tomography (CT) perfusion pre- and post-transarterial chemoembolization (TACE) of hepatocellular carcinoma (HCC) in different treatment response groups, and to correlate the changes with various responses of HCC to TACE. METHODS: Thirty-nine HCC patients underwent CT perfusion examinations pre-(1 d before TACE) and post-treatment (4 wk after TACE). The response evaluation criteria for solid tumors (RECIST) were referred to when treatment responses were distributed. Wilcoxon-signed ranks test was used to compare the differences in CT perfusion parameters pre- and post- TACE for different response groups. RESULTS: Only one case had treatment response to CR and the CT perfusion maps of post-treatment lesion displayed complete absence of signals. In the PR treatment response group, hepatic artery perfusion (HAP), hepatic arterial fracture (HAF) and hepatic blood volume (HBV) of viable tumors post-TACE were reduced compared with pre-TACE (P = 0.001, 0.030 and 0.001, respectively). In the SD group, all CT perfusion parameters were not significantly different pre- and post-TACE. In the PD group, HAP, HAl=, portal vein perfusion (PVP) and hepatic blood flow (HBF) of viable tumors post-TACE were significantly increased compared with pre-TACE (P = 0.005, 0.012, 0.035 and 0.005, respectively). CONCLUSION: Changes in CT perfusion parameters of viable tumors are correlated with different responses of HCC to TACE. Therefore, CT perfusion imaging is a feasible technique for monitoring response of HCC to TACE. 展开更多
关键词 Hepatocellular carcinoma Computed tomography Transarterial chemoembolization Digital subtraction arteriography Region of interest
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