The differential diagnosis of solitary pulmonary nodules （SPNs） remains a challenge. It is acknowledged that combining positron-emission tomography （PET） and computed tomography （CT） offers the most reliable non...The differential diagnosis of solitary pulmonary nodules （SPNs） remains a challenge. It is acknowledged that combining positron-emission tomography （PET） and computed tomography （CT） offers the most reliable noninvasive method for the diagnosis of SPNs. Since Townsend et al1 developed integrated PET/CT in 1999, this technique has increasingly been introduced into clinical practice. To date, nuclear medicine physicians have usually undertaken PET/CT diagnosis, but the question is surfacing as how to make full use of the information of CT image to improve the accuracy of SPN diagnosis. To answer this question, we performed a retrospective study on 60 patients with SPNs.展开更多
BACKGROUND Immunochemotherapy involving the combination of programmed cell death 1/programmed cell death ligand 1 inhibitors with chemotherapy has advanced the treatment of locally advanced esophageal squamous cell ca...BACKGROUND Immunochemotherapy involving the combination of programmed cell death 1/programmed cell death ligand 1 inhibitors with chemotherapy has advanced the treatment of locally advanced esophageal squamous cell carcinoma(ESCC).The use of corticosteroids as pretreatment might reduce immunotherapy efficacy.AIM To investigate the impact of baseline corticosteroid use on neoadjuvant immunochemotherapy(nIC)outcomes in locally advanced ESCC patients.METHODS Patients with locally advanced ESCC who received nIC at Sun Yat-sen University Cancer Center and the Third Affiliated Hospital of Sun Yat-sen University were included.Patients were divided into dexamethasone and antihistamine groups on the basis of the administered pretreatment.Antiallergic efficacy and safety were evaluated,as well as its impact on short-term efficacy[complete pathological response(pCR),major pathological response(MPR)]and long-term efficacy[overall survival(OS),progression-free survival(PFS)]of nIC.RESULTS From September 2019 to September 2023,142 patients were analyzed.No severe treatment-related adverse events or deaths were observed.Allergy occurrence was greater in the antihistamine group(P=0.014).Short-term efficacy was not significantly different:The pCR rates were 29.9%and 40.0%,and the MPR rates were 57.9%and 65.7%in the dexamethasone and antihistamine groups,respectively.The long-term efficacy was not significantly different:The 2 years OS rates were 95.2%and 93.5%,and the 2 years PFS rates were 90.3%and 87.8%.Subgroup analysis revealed no difference in OS between the 20 mg dexamethasone group and the<20 mg dexamethasone group,but PFS was significantly greater in the 20 mg dexamethasone group(93.9%vs 56.4%,P=0.001).CONCLUSION Dexamethasone or antihistamines can be used before nIC in locally advanced ESCC without affecting short-or long-term efficacy.Administering 20 mg dexamethasone before nIC may improve PFS in ESCC.展开更多
Treatment and functional reconstruction after central nervous system injury is a major medical and social challenge. An increasing number of researchers are attempting to use neural stem cells combined with artificial...Treatment and functional reconstruction after central nervous system injury is a major medical and social challenge. An increasing number of researchers are attempting to use neural stem cells combined with artificial scaffold materials, such as fibroin, for nerve repair. However, such approaches are challenged by ethical and practical issues. Amniotic tissue, a clinical waste product, is abundant, and amniotic epithe- lial cells are pluripotent, have low immunogenicity, and are not the subject of ethical debate. We hypothesized that amniotic epithelial cells combined with silk fibroin scaffolds would be conducive to the repair of spinal cord injury. To test this, we isolated and cultured amniotic epithelial cells, and constructed complexes of these cells and silk fibroin scaffolds. Implantation of the cell-scaffold complex into a rat model of spinal cord injury resulted in a smaller glial scar in the damaged cord tissue than in model rats that received a blank scaffold, or amniotic epithelial cells alone. In addition to a milder local immunological reaction, the rats showed less inflammatory cell infiltration at the trans- plant site, milder host-versus-graft reaction, and a marked improvement in motor function. These findings confirm that the transplantation of amniotic epithelial ceils combined with silk fibroin scaffold can promote the repair of spinal cord injury. Silk fibroin scaffold can provide a good nerve regeneration microenvironment for amniotic epithelial cells.展开更多
Purpose Compared with the iterative approximation solution,the analytically rigorous solution of the parameters of the accelerator alignment and surveying is the closed theoretical solution.To make the calculated erro...Purpose Compared with the iterative approximation solution,the analytically rigorous solution of the parameters of the accelerator alignment and surveying is the closed theoretical solution.To make the calculated error meet the negligible principle,in this paper,such examples of the zero,small angle and small translation,only large translation and no angle,only large angle without translation and large translation and large angle parameters under random errors are constructed.Methods Furthermore,Singular Value Decomposition,Eigen Value Decomposition,Polar Decomposition,Orthogonal Procrustes Analysis,and Successive Equivalent Differences Transformation are compared.Results In all the above examples,the mutual calculation deviation of Singular Value Decomposition,Eigen Value Decomposition,Polar Decomposition,and Orthogonal Procrustes analysis methods is less than 10 um.Its calculation accuracy is the highest,and Successive Equivalent Differences Transformation-3 has the largest calculation error,and Successive Equivalent Differences Transformation-N is in the middle.The results show that the coordinate residuals,parameters offsets and point position errors of the above solutions with random errors are all nearly zero.Conclusion It shows that the closed analytical solution is a rigorous solution.Moreover,it also shows that the constructed method of the coordinate point pairs is correct.展开更多
目的:系统评价质子泵抑制剂(PPI)改善慢性阻塞性肺疾病(COPD)患者的肺通气功能及对其急性加重次数的影响。方法:计算机检索PubMed,Cochrane library,SinoMed,中国知网和万方医学网数据库查找关于PPI治疗COPD相关的临床研究,检索时间均...目的:系统评价质子泵抑制剂(PPI)改善慢性阻塞性肺疾病(COPD)患者的肺通气功能及对其急性加重次数的影响。方法:计算机检索PubMed,Cochrane library,SinoMed,中国知网和万方医学网数据库查找关于PPI治疗COPD相关的临床研究,检索时间均为从建库至2019年4月20日。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行Meta分析。结果:最终共纳入6篇RCT,共计495例患者,Meta分析结果显示,PPI可改善COPD患者的第1秒用力呼气容积(Forced expiratory volume in one second,FEV1)[MD=0.35,95%CI:(0.19,0.52),P<0.0001];可降低COPD患者的急性加重次数[MD=-0.66,95%CI:(-1.18,-0.15),P=0.01],未发现不良反应。结论:PPI可改善COPD患者的FEV1,降低COPD患者急性加重次数,提高COPD患者的临床疗效,未发现不良反应。展开更多
Simultaneous red and blue light generation in an LiTaO_(3) crystal with a double grating structure is first reported.The double grating consists of two separate domain reversal sequences(superlattices)in series and is...Simultaneous red and blue light generation in an LiTaO_(3) crystal with a double grating structure is first reported.The double grating consists of two separate domain reversal sequences(superlattices)in series and is fabricated by field poling technique at room temperature.Using a picosecond 532 nm laser as a pump source,the red light at 631 nm and blue light at 460 nm are generated at the same time.A possible application of the superlattice crystal is presented.展开更多
文摘The differential diagnosis of solitary pulmonary nodules （SPNs） remains a challenge. It is acknowledged that combining positron-emission tomography （PET） and computed tomography （CT） offers the most reliable noninvasive method for the diagnosis of SPNs. Since Townsend et al1 developed integrated PET/CT in 1999, this technique has increasingly been introduced into clinical practice. To date, nuclear medicine physicians have usually undertaken PET/CT diagnosis, but the question is surfacing as how to make full use of the information of CT image to improve the accuracy of SPN diagnosis. To answer this question, we performed a retrospective study on 60 patients with SPNs.
文摘BACKGROUND Immunochemotherapy involving the combination of programmed cell death 1/programmed cell death ligand 1 inhibitors with chemotherapy has advanced the treatment of locally advanced esophageal squamous cell carcinoma(ESCC).The use of corticosteroids as pretreatment might reduce immunotherapy efficacy.AIM To investigate the impact of baseline corticosteroid use on neoadjuvant immunochemotherapy(nIC)outcomes in locally advanced ESCC patients.METHODS Patients with locally advanced ESCC who received nIC at Sun Yat-sen University Cancer Center and the Third Affiliated Hospital of Sun Yat-sen University were included.Patients were divided into dexamethasone and antihistamine groups on the basis of the administered pretreatment.Antiallergic efficacy and safety were evaluated,as well as its impact on short-term efficacy[complete pathological response(pCR),major pathological response(MPR)]and long-term efficacy[overall survival(OS),progression-free survival(PFS)]of nIC.RESULTS From September 2019 to September 2023,142 patients were analyzed.No severe treatment-related adverse events or deaths were observed.Allergy occurrence was greater in the antihistamine group(P=0.014).Short-term efficacy was not significantly different:The pCR rates were 29.9%and 40.0%,and the MPR rates were 57.9%and 65.7%in the dexamethasone and antihistamine groups,respectively.The long-term efficacy was not significantly different:The 2 years OS rates were 95.2%and 93.5%,and the 2 years PFS rates were 90.3%and 87.8%.Subgroup analysis revealed no difference in OS between the 20 mg dexamethasone group and the<20 mg dexamethasone group,but PFS was significantly greater in the 20 mg dexamethasone group(93.9%vs 56.4%,P=0.001).CONCLUSION Dexamethasone or antihistamines can be used before nIC in locally advanced ESCC without affecting short-or long-term efficacy.Administering 20 mg dexamethasone before nIC may improve PFS in ESCC.
基金supported by the Scientific Research Project Fund of Wuxi Municipal Health and Family Planning Commission,No.MS201402
文摘Treatment and functional reconstruction after central nervous system injury is a major medical and social challenge. An increasing number of researchers are attempting to use neural stem cells combined with artificial scaffold materials, such as fibroin, for nerve repair. However, such approaches are challenged by ethical and practical issues. Amniotic tissue, a clinical waste product, is abundant, and amniotic epithe- lial cells are pluripotent, have low immunogenicity, and are not the subject of ethical debate. We hypothesized that amniotic epithelial cells combined with silk fibroin scaffolds would be conducive to the repair of spinal cord injury. To test this, we isolated and cultured amniotic epithelial cells, and constructed complexes of these cells and silk fibroin scaffolds. Implantation of the cell-scaffold complex into a rat model of spinal cord injury resulted in a smaller glial scar in the damaged cord tissue than in model rats that received a blank scaffold, or amniotic epithelial cells alone. In addition to a milder local immunological reaction, the rats showed less inflammatory cell infiltration at the trans- plant site, milder host-versus-graft reaction, and a marked improvement in motor function. These findings confirm that the transplantation of amniotic epithelial ceils combined with silk fibroin scaffold can promote the repair of spinal cord injury. Silk fibroin scaffold can provide a good nerve regeneration microenvironment for amniotic epithelial cells.
文摘Purpose Compared with the iterative approximation solution,the analytically rigorous solution of the parameters of the accelerator alignment and surveying is the closed theoretical solution.To make the calculated error meet the negligible principle,in this paper,such examples of the zero,small angle and small translation,only large translation and no angle,only large angle without translation and large translation and large angle parameters under random errors are constructed.Methods Furthermore,Singular Value Decomposition,Eigen Value Decomposition,Polar Decomposition,Orthogonal Procrustes Analysis,and Successive Equivalent Differences Transformation are compared.Results In all the above examples,the mutual calculation deviation of Singular Value Decomposition,Eigen Value Decomposition,Polar Decomposition,and Orthogonal Procrustes analysis methods is less than 10 um.Its calculation accuracy is the highest,and Successive Equivalent Differences Transformation-3 has the largest calculation error,and Successive Equivalent Differences Transformation-N is in the middle.The results show that the coordinate residuals,parameters offsets and point position errors of the above solutions with random errors are all nearly zero.Conclusion It shows that the closed analytical solution is a rigorous solution.Moreover,it also shows that the constructed method of the coordinate point pairs is correct.
文摘目的:系统评价质子泵抑制剂(PPI)改善慢性阻塞性肺疾病(COPD)患者的肺通气功能及对其急性加重次数的影响。方法:计算机检索PubMed,Cochrane library,SinoMed,中国知网和万方医学网数据库查找关于PPI治疗COPD相关的临床研究,检索时间均为从建库至2019年4月20日。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行Meta分析。结果:最终共纳入6篇RCT,共计495例患者,Meta分析结果显示,PPI可改善COPD患者的第1秒用力呼气容积(Forced expiratory volume in one second,FEV1)[MD=0.35,95%CI:(0.19,0.52),P<0.0001];可降低COPD患者的急性加重次数[MD=-0.66,95%CI:(-1.18,-0.15),P=0.01],未发现不良反应。结论:PPI可改善COPD患者的FEV1,降低COPD患者急性加重次数,提高COPD患者的临床疗效,未发现不良反应。
基金Supported by the State Key Program from the National Science and Technology Commission of Chinathe National Advanced Material Commit tee of China,and the National Natural Science Foundation of China under Grant No.69938010.S.N.Zhu is also grateful for the support from a mono-grant RFPP.
文摘Simultaneous red and blue light generation in an LiTaO_(3) crystal with a double grating structure is first reported.The double grating consists of two separate domain reversal sequences(superlattices)in series and is fabricated by field poling technique at room temperature.Using a picosecond 532 nm laser as a pump source,the red light at 631 nm and blue light at 460 nm are generated at the same time.A possible application of the superlattice crystal is presented.
基金the National Natural Science Foundation of China,No.81503406the China Postdoctoral Science Foundation,No.2017M6232+1 种基金the Special Fund for Traditional Chinese Medicine by the Health Department of Guangxi Zhuang Autonomous Region,No.GZBZ16-07,GZLC16-23the Natural Science Foundation of Guangxi Zhuang Autonomous Region,No.2014GXNSFAA118177~~
