A structure transition of Fe2O3 nanocrystal was studied by using DTA and TG thermal analysis and X-ray diffraction method. We found that size increase of the nanocrystals is larger after the structure transition than ...A structure transition of Fe2O3 nanocrystal was studied by using DTA and TG thermal analysis and X-ray diffraction method. We found that size increase of the nanocrystals is larger after the structure transition than that before the transition. It means that the structure transition is beneficial on growth of nanocrystals展开更多
Nanosized orthorhombic LiMnO2 was successfully synthesized using Mn2O3 and LiOH.H2O as starting materials.Not only the reaction temperature was lower, but the reaction time for synthesizing was notably shortened to 1 ...Nanosized orthorhombic LiMnO2 was successfully synthesized using Mn2O3 and LiOH.H2O as starting materials.Not only the reaction temperature was lower, but the reaction time for synthesizing was notably shortened to 1 h.In this hydrothermal process, the cations of the starting materials were capable of mixing and interacting in ionic scale, which resulted in the rapid formation of o-LiMnO2 powders at relatively low temperature. The particle size conformed by transmission electron microscopy is around 50-150 nm. Benefiting from its small particle size and good uniformity, the obtained o-LiMnO2 can reach the maximum discharge capacity of 163 mA-h.g^-1 at 0.1 C rate after several cycles. X-ray diffraction data and electrochemical properties suggested the phase transformation from orthorhombic LiMnO2 to defect-type spinel LiMn204 with minor Li2MnO3, which resulted in the capacity fading during cycling.展开更多
Single phase chromium-substituted orthorhombic LiMn1-xCrxO2 （0≤x≤0.05） were successfully synthesized by hydrothermal treatment of Mn2O3, Cr2O3 and lithium hydroxide aqueous solution. Structure and morphologies of ...Single phase chromium-substituted orthorhombic LiMn1-xCrxO2 （0≤x≤0.05） were successfully synthesized by hydrothermal treatment of Mn2O3, Cr2O3 and lithium hydroxide aqueous solution. Structure and morphologies of the o-LiMn1-xCrxO2 were characterized by X-ray diffraction and transmission electron microscopy. Compared to the particle size of o-LiMnO2 ranging from 50 to 150 nm, the Cr-doped one is larger with about 500 nm, which is agglomerated by small grains. There are high stacking faults in nanosized grains that cause easier phase transformation from the orthorhombic to the spinel-like structure on cycling. High-resolution transmission electron microscopy image analysis of electrochemically cycled o-LiMn1-xCrxO2 （x=0, 0.05） samples showed that the nanodomain structure in o-LiMn0.95Cr0.05O2 was comparatively perfect to that in o-LiMnO2. Particle agglomeration and the relatively perfect crystal structure are two key factors for improving cycle performance of o-LiMn0.95Cr0.05O2. The obtained o-LiMn0.95Cr0.05O2 can reach a maximum discharge capacity of 174 mA·h·g^-1 at 0.1 C rate in seventh cycle. The discharge capacity fade rate of the samples decreased with increasing Cr amount. Furthermore, o-LiMn0.95Cr0.05O2 gives a highest discharge capacity of 150 mA·h·g^-1 at a high current rate of 0.5 C, and retains 130 mA·h·g^-1 after 40 cycles.展开更多
Atmospheric humic-like substances （HULIS） are not only an unresolved mixture of macro- organic compounds but also powerful chelating agents in atmospheric particulate matters （PMs）; impacting on both the propertie...Atmospheric humic-like substances （HULIS） are not only an unresolved mixture of macro- organic compounds but also powerful chelating agents in atmospheric particulate matters （PMs）; impacting on both the properties of aerosol particles and health effects by generating reactive oxygen spedes （ROS）. Currently, the interests of HULIS are intensively shifting to the investigations of HULIS-metal synergic effects and kinetics modeling studies, as well as the development of HULIS quantification, findings of possible HULIS sources and generation of ROS from HULIS. In light of HULIS studies, we comprehensively review the current knowledge of isolation and physicochemical characterization of HULIS from atmospheric samples as well as HULIS properties （hygroscopic, surface activity, and colloidal） and possible sources of HULIS. This review mainly highlights the generation of reactive oxygen species （ROS） from PMs, HULIS and transition metals, especially iron. This review also summarized the mechanism of iron-organic complexation and recent findings of OH formation from HULIS-metal complexes. This review will be helpful to carry out the modeling studies that concern with HULIS-transition metals and for further studies in the generation of ROS from HULIS-metal complexes,展开更多
Although VEGF-B was discovered as a VEGF-A homolog a long time ago,the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different groups.Notwithstanding,drugs that inhibit V...Although VEGF-B was discovered as a VEGF-A homolog a long time ago,the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different groups.Notwithstanding,drugs that inhibit VEGF-B together with other VEGF family members are being used to treat patients with various neovascular diseases.It is therefore critical to have a better understanding of the angiogenic effect of VEGF-B and the underlying mechanisms.Using comprehensive in vitro and in vivo methods and models,we reveal here for the first time an unexpected and surprising function of VEGF-B as an endogenous inhibitor of angiogenesis by inhibiting the FGF2/FGFR1 pathway when the latter is abundantly expressed.Mechanistically,we unveil that VEGF-B binds to FGFR1,induces FGFR1/VEGFR1 complex formation,and suppresses FGF2-induced Erk activation,and inhibits FGF2-driven angiogenesis and tumor growth.Our work uncovers a previously unrecognized novel function of VEGF-B in tethering the FGF2/FGFR1 pathway.Given the anti-angiogenic nature of VEGF-B under conditions of high FGF2/FGFR1 levels,caution is warranted when modulating VEGF-B activity to treat neovascular diseases.展开更多
Advancing our understanding of global climate,particularly in polar regions,requires accurate detection of carbon dioxide(CO_(2))in ice cores and deep sea environments.However,detecting trace levels of CO_(2)in these ...Advancing our understanding of global climate,particularly in polar regions,requires accurate detection of carbon dioxide(CO_(2))in ice cores and deep sea environments.However,detecting trace levels of CO_(2)in these areas presents significant challenges.We introduce a novel preconcentration approach using functionalized zeolitic imidazolate framework,ZIF-8(CN),for the detection of ultra-low CO_(2).ZIF-8(CN)has small pores(4.4■and cyano groups(–CN),enabling highly selective adsorption of CO_(2)(36.2 cm^(3)g^(−1))over N_(2)(1.6 cm^(3)g^(−1))at 298 K.The mechanism involves unique–CN···CO_(2)···–CN interactions within the pore structure.When cast into a film on an aluminum substrate,ZIF-8(CN)demonstrates exceptional CO_(2)preconcentration capability(1 ppm in N_(2))with an extraordinary preconcentration factor of 748,outperforming traditional ZIF and zeolite materials.Additionally,a ZIF-8(CN)preconcentrator is designed and fabricated with bionic gas flow of fractal structure which optimizes the gas-film contact,and thus its performance is further improved by 115%.展开更多
OBJECTIVE:To evaluate the effectiveness and safety of Jinshuibao capsules(金水宝胶囊),a Traditional Chinese Medicine(TCM),in the treatment of residual cardiopulmonary symptoms in convalescent corona virus disease 2019...OBJECTIVE:To evaluate the effectiveness and safety of Jinshuibao capsules(金水宝胶囊),a Traditional Chinese Medicine(TCM),in the treatment of residual cardiopulmonary symptoms in convalescent corona virus disease 2019(COVID-19)patients.METHODS:A total of 200 participants with COVID-19 in convalescence phase were randomly assigned into two groups at a 1:1 ratio in this multicenter randomized,double-blind,placebo-controlled trial.One group received Jinshuibao capsules,and the other received placebo.The patients were followed up at one and two weeks of treatment.Five symptoms(dry cough,shortness of breath,sweating,chest tightness and palpitation)improvement rates and full recovery rates were compared.RESULTS:All baseline characteristics were comparable between the two groups.After two weeks of treatment,symptom improvement rates for dry cough(74.00%vs 50.00%,P=0.015),shortness of breath(78.95%vs 46.15%,P<0.001),sweating(80.00%vs 57.75%,P=0.004),chest tightness(87.06%vs 60.47%,P<0.001)and palpitation(82.50%vs 64.56%,P=0.010)were significantly higher in the Jinshuibao group compared with the control group.Meanwhile,Jinshuibao capsules treatment also displayed more satisfactory full recovery rates of all five symptoms(dry cough 58.00%vs 19.57%,shortness of breath 18.95%vs 7.69%,sweating 36.00%vs 19.72%,chest tightness 32.94%vs 13.95%,and palpitation 48.75%vs 29.11%)in participants with COVID-19 in convalescence phase compared with the control group(P<0.05).No severe adverse events were reported in either group.CONCLUSIONS:Jinshuibao capsules have the potential to improve residual cardiopulmonary symptoms in convalescent COVID-19 patients,with few adverse events.展开更多
文摘A structure transition of Fe2O3 nanocrystal was studied by using DTA and TG thermal analysis and X-ray diffraction method. We found that size increase of the nanocrystals is larger after the structure transition than that before the transition. It means that the structure transition is beneficial on growth of nanocrystals
基金supported by the National Natural Science Foundation of China under grant No.50372058.
文摘Nanosized orthorhombic LiMnO2 was successfully synthesized using Mn2O3 and LiOH.H2O as starting materials.Not only the reaction temperature was lower, but the reaction time for synthesizing was notably shortened to 1 h.In this hydrothermal process, the cations of the starting materials were capable of mixing and interacting in ionic scale, which resulted in the rapid formation of o-LiMnO2 powders at relatively low temperature. The particle size conformed by transmission electron microscopy is around 50-150 nm. Benefiting from its small particle size and good uniformity, the obtained o-LiMnO2 can reach the maximum discharge capacity of 163 mA-h.g^-1 at 0.1 C rate after several cycles. X-ray diffraction data and electrochemical properties suggested the phase transformation from orthorhombic LiMnO2 to defect-type spinel LiMn204 with minor Li2MnO3, which resulted in the capacity fading during cycling.
文摘Single phase chromium-substituted orthorhombic LiMn1-xCrxO2 （0≤x≤0.05） were successfully synthesized by hydrothermal treatment of Mn2O3, Cr2O3 and lithium hydroxide aqueous solution. Structure and morphologies of the o-LiMn1-xCrxO2 were characterized by X-ray diffraction and transmission electron microscopy. Compared to the particle size of o-LiMnO2 ranging from 50 to 150 nm, the Cr-doped one is larger with about 500 nm, which is agglomerated by small grains. There are high stacking faults in nanosized grains that cause easier phase transformation from the orthorhombic to the spinel-like structure on cycling. High-resolution transmission electron microscopy image analysis of electrochemically cycled o-LiMn1-xCrxO2 （x=0, 0.05） samples showed that the nanodomain structure in o-LiMn0.95Cr0.05O2 was comparatively perfect to that in o-LiMnO2. Particle agglomeration and the relatively perfect crystal structure are two key factors for improving cycle performance of o-LiMn0.95Cr0.05O2. The obtained o-LiMn0.95Cr0.05O2 can reach a maximum discharge capacity of 174 mA·h·g^-1 at 0.1 C rate in seventh cycle. The discharge capacity fade rate of the samples decreased with increasing Cr amount. Furthermore, o-LiMn0.95Cr0.05O2 gives a highest discharge capacity of 150 mA·h·g^-1 at a high current rate of 0.5 C, and retains 130 mA·h·g^-1 after 40 cycles.
基金the Natural Science Foundation of China under NSFC Grant No. 21477073, 41273127 for support to conduct this research
文摘Atmospheric humic-like substances （HULIS） are not only an unresolved mixture of macro- organic compounds but also powerful chelating agents in atmospheric particulate matters （PMs）; impacting on both the properties of aerosol particles and health effects by generating reactive oxygen spedes （ROS）. Currently, the interests of HULIS are intensively shifting to the investigations of HULIS-metal synergic effects and kinetics modeling studies, as well as the development of HULIS quantification, findings of possible HULIS sources and generation of ROS from HULIS. In light of HULIS studies, we comprehensively review the current knowledge of isolation and physicochemical characterization of HULIS from atmospheric samples as well as HULIS properties （hygroscopic, surface activity, and colloidal） and possible sources of HULIS. This review mainly highlights the generation of reactive oxygen species （ROS） from PMs, HULIS and transition metals, especially iron. This review also summarized the mechanism of iron-organic complexation and recent findings of OH formation from HULIS-metal complexes. This review will be helpful to carry out the modeling studies that concern with HULIS-transition metals and for further studies in the generation of ROS from HULIS-metal complexes,
基金This study is supported by the State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,and Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science,Guangzhou 510060,P.R.Chinathe National Natural Science Foundation of China(82150710555 and 82220108016 to X.Li,81970823 to Jin Yao and 81830013 to J.O.)+4 种基金a Key Research and Development Plan of Shandong Province(2016GSF201100)the Fundamental Research Funds for the Central Universities(19ykpy151)the long-term structural Methusalem funding by the Flemish Government,Belgiumthe Deutsche Forschungsge-meinschaft(Project No.:394046768-SFB1366)the DZHK partner site Mannheim/Heidelberg to H.F.L.,an ERA PerMed 2020 JTC grant“PROGRESS”.
文摘Although VEGF-B was discovered as a VEGF-A homolog a long time ago,the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different groups.Notwithstanding,drugs that inhibit VEGF-B together with other VEGF family members are being used to treat patients with various neovascular diseases.It is therefore critical to have a better understanding of the angiogenic effect of VEGF-B and the underlying mechanisms.Using comprehensive in vitro and in vivo methods and models,we reveal here for the first time an unexpected and surprising function of VEGF-B as an endogenous inhibitor of angiogenesis by inhibiting the FGF2/FGFR1 pathway when the latter is abundantly expressed.Mechanistically,we unveil that VEGF-B binds to FGFR1,induces FGFR1/VEGFR1 complex formation,and suppresses FGF2-induced Erk activation,and inhibits FGF2-driven angiogenesis and tumor growth.Our work uncovers a previously unrecognized novel function of VEGF-B in tethering the FGF2/FGFR1 pathway.Given the anti-angiogenic nature of VEGF-B under conditions of high FGF2/FGFR1 levels,caution is warranted when modulating VEGF-B activity to treat neovascular diseases.
基金supported by the National Natural Science Foundation of China(22375031,22131004,U21A20330,U22A20184 and 22208224)National Key R&D Program of China(2022YFB3805902 and 2023YFC2812603)+4 种基金“111”Program(B18012)Jilin Natural Science Fund for Excellent Young Scholars(20230508116RC)Science&Technology Department of Jilin Province(20230101023JC)Fundamental Research Funds for the Central Universities(JGPY202103 and 2412023YQ001)Excellent Youth Lift Plan from Shenyang University of Chemical Technology(2022YQ003)。
文摘Advancing our understanding of global climate,particularly in polar regions,requires accurate detection of carbon dioxide(CO_(2))in ice cores and deep sea environments.However,detecting trace levels of CO_(2)in these areas presents significant challenges.We introduce a novel preconcentration approach using functionalized zeolitic imidazolate framework,ZIF-8(CN),for the detection of ultra-low CO_(2).ZIF-8(CN)has small pores(4.4■and cyano groups(–CN),enabling highly selective adsorption of CO_(2)(36.2 cm^(3)g^(−1))over N_(2)(1.6 cm^(3)g^(−1))at 298 K.The mechanism involves unique–CN···CO_(2)···–CN interactions within the pore structure.When cast into a film on an aluminum substrate,ZIF-8(CN)demonstrates exceptional CO_(2)preconcentration capability(1 ppm in N_(2))with an extraordinary preconcentration factor of 748,outperforming traditional ZIF and zeolite materials.Additionally,a ZIF-8(CN)preconcentrator is designed and fabricated with bionic gas flow of fractal structure which optimizes the gas-film contact,and thus its performance is further improved by 115%.
基金Supported by National Administration of Traditional Chinese Medicine:a Randomized,Double Blinded,Controlled,Multicenter Clinical Trial to Improve the Symptoms of Pulmonary and Cardiac Function During the Convalescence of COVID-19(2020ZYLCYJ08-3)the State Administration of Traditional Chinese Medicine Special Project of Chinese Medicine Emergency Response to New Coronavirus Pneumonia(2020ZYLCYJ04-1)National Key R&D Program(2020YFC0845000)。
文摘OBJECTIVE:To evaluate the effectiveness and safety of Jinshuibao capsules(金水宝胶囊),a Traditional Chinese Medicine(TCM),in the treatment of residual cardiopulmonary symptoms in convalescent corona virus disease 2019(COVID-19)patients.METHODS:A total of 200 participants with COVID-19 in convalescence phase were randomly assigned into two groups at a 1:1 ratio in this multicenter randomized,double-blind,placebo-controlled trial.One group received Jinshuibao capsules,and the other received placebo.The patients were followed up at one and two weeks of treatment.Five symptoms(dry cough,shortness of breath,sweating,chest tightness and palpitation)improvement rates and full recovery rates were compared.RESULTS:All baseline characteristics were comparable between the two groups.After two weeks of treatment,symptom improvement rates for dry cough(74.00%vs 50.00%,P=0.015),shortness of breath(78.95%vs 46.15%,P<0.001),sweating(80.00%vs 57.75%,P=0.004),chest tightness(87.06%vs 60.47%,P<0.001)and palpitation(82.50%vs 64.56%,P=0.010)were significantly higher in the Jinshuibao group compared with the control group.Meanwhile,Jinshuibao capsules treatment also displayed more satisfactory full recovery rates of all five symptoms(dry cough 58.00%vs 19.57%,shortness of breath 18.95%vs 7.69%,sweating 36.00%vs 19.72%,chest tightness 32.94%vs 13.95%,and palpitation 48.75%vs 29.11%)in participants with COVID-19 in convalescence phase compared with the control group(P<0.05).No severe adverse events were reported in either group.CONCLUSIONS:Jinshuibao capsules have the potential to improve residual cardiopulmonary symptoms in convalescent COVID-19 patients,with few adverse events.
