目的评价心脑血管疾病患者围手术期抗栓药物治疗临床路径管理的干预效果。方法将2019年10月—2020年9月、2020年10月—2021年9月在北京朝阳医院外科治疗的心脑血管疾病住院患者分为常规治疗组和药师干预组。药师依据临床路径对患者用药...目的评价心脑血管疾病患者围手术期抗栓药物治疗临床路径管理的干预效果。方法将2019年10月—2020年9月、2020年10月—2021年9月在北京朝阳医院外科治疗的心脑血管疾病住院患者分为常规治疗组和药师干预组。药师依据临床路径对患者用药方案进行干预,并持续跟踪随访至患者出院。以围手术期抗栓药物使用适宜占比、药品不良事件发生率、住院天数、住院总费用、出院后3个月再入院发生率等为指标评价围手术期抗栓药物临床路径管理效果。结果常规治疗组121例,药师干预组202例,两组心脑血管事件(5.0%vs.5.0%)、静脉血栓栓塞症(2.5%vs.3.0%)、出血事件(3.3%vs.2.0%)的发生率差异均无统计学意义(P>0.05);药师干预组围手术期抗栓药物使用的各类适宜占比(术前抗血小板药物治疗61.9%vs.24.0%,术前抗凝药物治疗66.3%vs.39.7%,术后抗血小板药物治疗80.7%vs.10.0%,术后抗凝药物治疗89.6%vs.65.3%,P<0.001)、住院天数(13.00 d vs.10.00 d,P=0.004)、住院期西药费用(2692.97元vs.2110.76元,P=0.008)、住院期抗凝药物费用(406.20元vs.200.28元,P<0.001)均显著低于常规治疗组。结论心脑血管疾病患者围手术期抗栓药物治疗临床路径的建立及应用可能会改善心脑血管疾病患者围手术期抗栓药物使用不适宜情况,不增加药品不良事件发生率,且减轻了患者的经济负担。展开更多
We propose an efficient method for the generation of perfect W states on three microwave superconducting resonators,of which the two nearest neighbors are coupled by a symmetric direct current superconducting quantum ...We propose an efficient method for the generation of perfect W states on three microwave superconducting resonators,of which the two nearest neighbors are coupled by a symmetric direct current superconducting quantum interference device(dc-SQUID).With suitable external magnetic fluxes applied to the dc-SQUID symmetry loops,on-chip tunable interactions between neighboring resonators can be realized,and different perfect W states can be deterministically created on-demand in one step.Numerical simulations show that high-fidelity target states can be generated and our scheme is robust against imperfect parameter tuning and environment-induced decoherence.The present work may have potential applications for implementing quantum computation and quantum information processing based on microwave photons.展开更多
Objective: When nerve injury or inflammatory injury, different miRNA-mediated signal pathways are activated or inactivated, causing pain or hyperalgesia. Therefore, miRNA has become a new direction of pain mechanism r...Objective: When nerve injury or inflammatory injury, different miRNA-mediated signal pathways are activated or inactivated, causing pain or hyperalgesia. Therefore, miRNA has become a new direction of pain mechanism research. We aimed to investigate the effect and mechanism of miR-362-3p on neuropathic pain in rats with chronic sciatic nerve injury (CCI). Methods: Neuropathic pain CCI rat model was established. Real-time-quantitative polymerase chain reaction (RT-PCR), Western blot, immunofluorescence, intrathecal injection, Enzyme-linked immunosorbent assay (ELISA), and dual luciferase reporter gene assays were used to explore the role of miR-362-3p in neuropathic pain development and the relationship between miR-362-3p and JMJD1A (Jumonji domain-containing 1A). Results: In the CCI group, the miR-362-3p level was increased and JMJD1A level was reduced in spinal cords and isolated microglia. The paw withdrawal threshold (PWT) and paw withdrawal latency (PWL) values were increased, the secretion of inflammatory factors was reduced, and the microglial marker Iba1 expression was decreased after intrathecal administration of miR-362-3p. miR-362-3p was observed to target JMJD1A. JMJD1A elevation abolished the inhibitory effects of miR-362-3p on neuropathic pain development. Conclusion: Intrathecal administration of miR-362-3p significantly relieved neuropathic pain in CCI rats and inhibited neuroinflammation possibly through regulating JMJD1A.展开更多
A model of the photonic spin Hall effect(PSHE)in antisymmetric parity-time(APT)metamaterials with incidence of Gaussian beams is proposed here.We derive the displacement expression of the PSHE in APT metamaterials bas...A model of the photonic spin Hall effect(PSHE)in antisymmetric parity-time(APT)metamaterials with incidence of Gaussian beams is proposed here.We derive the displacement expression of the PSHE in APT metamaterials based on the transport properties of Gaussian beams in positive and negative refractive index materials.Furthermore,detailed discussions are provided on the APT scattering matrix,eigenstate ratio,and response near exceptional points in the case of loss or gain.In contrast to the unidirectional non-reflection in parity-time(PT)symmetric systems,the transverse shift that arises from both sides of the APT structure is consistent.By effectively adjusting the parameters of APT materials,we achieve giant displacements of the transverse shift.Finally,we present a multi-layer APT structure consisting of alternating left-handed and right-handed materials.By increasing the number of layers,Bragg oscillations can be generated,leading to an increase in resonant peaks in transverse shift.This study presents a new approach to achieving giant transverse shifts in the APT structure.This lays a theoretical foundation for the fabrication of related nano-optical devices.展开更多
文摘目的评价心脑血管疾病患者围手术期抗栓药物治疗临床路径管理的干预效果。方法将2019年10月—2020年9月、2020年10月—2021年9月在北京朝阳医院外科治疗的心脑血管疾病住院患者分为常规治疗组和药师干预组。药师依据临床路径对患者用药方案进行干预,并持续跟踪随访至患者出院。以围手术期抗栓药物使用适宜占比、药品不良事件发生率、住院天数、住院总费用、出院后3个月再入院发生率等为指标评价围手术期抗栓药物临床路径管理效果。结果常规治疗组121例,药师干预组202例,两组心脑血管事件(5.0%vs.5.0%)、静脉血栓栓塞症(2.5%vs.3.0%)、出血事件(3.3%vs.2.0%)的发生率差异均无统计学意义(P>0.05);药师干预组围手术期抗栓药物使用的各类适宜占比(术前抗血小板药物治疗61.9%vs.24.0%,术前抗凝药物治疗66.3%vs.39.7%,术后抗血小板药物治疗80.7%vs.10.0%,术后抗凝药物治疗89.6%vs.65.3%,P<0.001)、住院天数(13.00 d vs.10.00 d,P=0.004)、住院期西药费用(2692.97元vs.2110.76元,P=0.008)、住院期抗凝药物费用(406.20元vs.200.28元,P<0.001)均显著低于常规治疗组。结论心脑血管疾病患者围手术期抗栓药物治疗临床路径的建立及应用可能会改善心脑血管疾病患者围手术期抗栓药物使用不适宜情况,不增加药品不良事件发生率,且减轻了患者的经济负担。
基金Project supported by the National Natural Science Foundation of China(Grant No.12174300)the Natural Science Foundation of Hubei Province of China(Grant No.2020CFB748)+2 种基金the Natural Science Foundation of Shandong Province of China(Grant Nos.ZR2021MA042 and ZR2021MA078)the Program for Science and Technology Innovation Team in Colleges of Hubei Province of China(Grant No.T2021012)the Doctoral Scientific Research Foundation of Hubei University of Automotive Technology(Grant Nos.BK202113,BK201906,and BK202008)。
文摘We propose an efficient method for the generation of perfect W states on three microwave superconducting resonators,of which the two nearest neighbors are coupled by a symmetric direct current superconducting quantum interference device(dc-SQUID).With suitable external magnetic fluxes applied to the dc-SQUID symmetry loops,on-chip tunable interactions between neighboring resonators can be realized,and different perfect W states can be deterministically created on-demand in one step.Numerical simulations show that high-fidelity target states can be generated and our scheme is robust against imperfect parameter tuning and environment-induced decoherence.The present work may have potential applications for implementing quantum computation and quantum information processing based on microwave photons.
文摘Objective: When nerve injury or inflammatory injury, different miRNA-mediated signal pathways are activated or inactivated, causing pain or hyperalgesia. Therefore, miRNA has become a new direction of pain mechanism research. We aimed to investigate the effect and mechanism of miR-362-3p on neuropathic pain in rats with chronic sciatic nerve injury (CCI). Methods: Neuropathic pain CCI rat model was established. Real-time-quantitative polymerase chain reaction (RT-PCR), Western blot, immunofluorescence, intrathecal injection, Enzyme-linked immunosorbent assay (ELISA), and dual luciferase reporter gene assays were used to explore the role of miR-362-3p in neuropathic pain development and the relationship between miR-362-3p and JMJD1A (Jumonji domain-containing 1A). Results: In the CCI group, the miR-362-3p level was increased and JMJD1A level was reduced in spinal cords and isolated microglia. The paw withdrawal threshold (PWT) and paw withdrawal latency (PWL) values were increased, the secretion of inflammatory factors was reduced, and the microglial marker Iba1 expression was decreased after intrathecal administration of miR-362-3p. miR-362-3p was observed to target JMJD1A. JMJD1A elevation abolished the inhibitory effects of miR-362-3p on neuropathic pain development. Conclusion: Intrathecal administration of miR-362-3p significantly relieved neuropathic pain in CCI rats and inhibited neuroinflammation possibly through regulating JMJD1A.
基金the Natural Science Foundation of Guangdong Province(Grant Nos.2018A030313480 and 2022A1515012377)。
文摘A model of the photonic spin Hall effect(PSHE)in antisymmetric parity-time(APT)metamaterials with incidence of Gaussian beams is proposed here.We derive the displacement expression of the PSHE in APT metamaterials based on the transport properties of Gaussian beams in positive and negative refractive index materials.Furthermore,detailed discussions are provided on the APT scattering matrix,eigenstate ratio,and response near exceptional points in the case of loss or gain.In contrast to the unidirectional non-reflection in parity-time(PT)symmetric systems,the transverse shift that arises from both sides of the APT structure is consistent.By effectively adjusting the parameters of APT materials,we achieve giant displacements of the transverse shift.Finally,we present a multi-layer APT structure consisting of alternating left-handed and right-handed materials.By increasing the number of layers,Bragg oscillations can be generated,leading to an increase in resonant peaks in transverse shift.This study presents a new approach to achieving giant transverse shifts in the APT structure.This lays a theoretical foundation for the fabrication of related nano-optical devices.
